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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

Dr. Eric Trexler, PhD – researcher, coach, and professional bodybuilder – recently appeared on the Renaissance Periodization podcast to share his evidence-based tier system for ranking muscle-building supplements. He emphasised that supplement rankings are goal-dependent, varying based on what you’re aiming to achieve with your training and supplementation.

Dr. Trexler then outlined his tiered approach specifically for those focused on gaining muscle and building strength, categorising supplements into five distinct tiers and providing examples of each along the way.

Tier-1 Supplements

‘Tier-1 basically means we have strong evidence. We know what this thing does, and what it does is good,’ says Dr. Trexler, who explains that for muscle-building, tier-1 supplements are in a class of their own. ‘It’s a short list – it’s creatine [assuming you’re not a non-responder] and it’s protein.’

Dr. Trexler caveats that protein supplements could be redundant if you’re able to get enough of the macronutrient from your diet. ‘If you’re eating enough from your food, who cares, forget it.’

Tier-2 Supplements

Dr. Trexler believes tier-2 supplements are the most interesting. ‘There is some evidence related to the supplement for the outcome we’re interested in, and it actually looks pretty good, but it’s not on tier-one because it has some shortcoming,’ he says. ‘Maybe the initial evidence is pretty good, but I’d like to see more of it before I get super stoked.’

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He adds that in some cases, the evidence for a supplement may be very strong, but in the real world, its effects are small and inconsistent, or only work in people with deficiencies. ‘You can have a really solid evidence-based justification for this. However, you’re likely going to have to acknowledge this is a really marginal effect. Maybe this only matters for a competitive athlete.’

The supplements Dr. Trexler would include in tier-2 are: sodium bicarbonate, citrulline malate and nitric oxide supplements.

Controversially, Trexler says he would also put caffeine, one of the most heavily relied-on ergogenic aids in existence, into tier-2. ‘There are meta-analyses and umbrella reviews indicating it should have a positive effect on things like strength, strength endurance, and power. But caffeine is probably better for endurance sport than it is for resistance exercise.’

He does point out the potential dark side of becoming too reliant on the pre-workout shot of espresso. ‘We don’t know when you get to that point when you say, “I wouldn’t dare work out without my pre-workout.” Is that because it’s still giving you an ergogenic [performance-enhancing] effect? Or is it because caffeine withdrawal gives you an ergolytic effect and your performance sucks?’

(Ergolytic is science-talk for something that negatively impacts your performance.)

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Tier-3 Supplements

‘Tier-3 is where the vast majority of supplements live’, Trexler says. ’It’s the tier where I tell someone I do not have enough evidence to say that there is a defensible use case for this but I also don’t have enough hard evidence to tell you there is no way this will work.’

So, if it’s not in any of the other tiers, with enough evidence for or against it’s use, consider it tier-3.

While Dr. Trexler doesn’t clearly define tier-3 supplements as he does with other tiers, examples might include Beta-alanine, which shows some promise for improving endurance but has inconsistent effects on muscle-building and strength, or Branched-chain amino acids (BCAAs). Once highly popular, recent research suggests their benefits are limited compared to complete proteins or essential amino acids, placing them in the tier-3 category.

Tier-4 Supplements

Dr. Trexler believes tier-4 is a tricky one – it’s the first category where we should consider actively swerving the compounds in question. ‘This is where we have evidence of a null effect. I can look at studies on it and say this is not going to achieve what you want it to achieve,’ says Dr. Trexler. His host, Dr. Mike Israetel, also an exercise scientist, offers a more concise and memorable definition: ‘It’s not hurting you; it just doesn’t do shit

When it comes to building strength and size, Trexler would include previously popular supplements like glutamine in tier-4. ‘For getting jacked and performing better, I think we’ve pretty much shut the book on glutamine.’

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He’d also place arginine – an amino acid that was once popular in pre-workout mixtures and touted as a ‘pump enhancer’ – in tier-4, alongside some testosterone boosters and modern ‘new-and-improved’ creatines like ethyl ester and alkaline varieties, saying they don’t justify their cost when tier-1’s cheaply available creatine monohydrate is an option.

Tier-5 Supplements

Tier-5 is the group that Dr. Trexler strongly advises you avoid. ‘[These are] supplements where we have evidence that one of two things is going to happen – either this is going to literally harm your performance, or it is going to harm you.’

Trexler says he would include compounds like DMAA, a chemical extract previously included in now-banned pre-workout supplements such as the highly-memed JACK-3D. He jokes that although these compounds were widely available and not previously banned, the aim of manufacturers at the time seemed to be to get as close as possible to the effects of methamphetamine.

Another tier-5 chemical that was once the stimulant of choice for many bodybuilders is ephedrine. ‘It was the era of [high stimulant] pre-workouts. However, there were serious adverse events reported. I believe that there were a couple of deaths.’ Thankfully, sporting organisations and federations have helped to pave the way to a slightly safer supplement industry. ‘Once it’s banned by all the big federations, I say all right, we’re going to tier-5…’

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With almost 18 years in the health and fitness space as a personal trainer, nutritionist, breath coach and writer, Andrew has spent nearly half of his life exploring how to help people improve their bodies and minds.    

As our fitness editor he prides himself on keeping Men’s Health at the forefront of reliable, relatable and credible fitness information, whether that’s through writing and testing thousands of workouts each year, taking deep dives into the science behind muscle building and fat loss or exploring the psychology of performance and recovery.   

Whilst constantly updating his knowledge base with seminars and courses, Andrew is a lover of the practical as much as the theory and regularly puts his training to the test tackling everything from Crossfit and strongman competitions, to ultra marathons, to multiple 24 hour workout stints and (extremely unofficial) world record attempts.   

 You can find Andrew on Instagram at @theandrew.tracey, or simply hold up a sign for ‘free pizza’ and wait for him to appear.

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Reward yourself by exercising regularly at One to One Fitness | CWRU Newsroom | Case Western Reserve University

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Reward yourself by exercising regularly at One to One Fitness | CWRU Newsroom | Case Western Reserve University

Now is the time to recommit to your health in time to feel your best for all your summer activities! One to One Fitness Center offers several ways to save in March.

Members of the Case Western Reserve University community can take advantage of sign-up specials designed to reward themselves for creating healthy habits.

Individuals can get 50% off the initiation fee (regularly $50 plus tax) and earn back what they do pay by exercising eight or more days in both April and May. Learn more online about this deal on initiation fees.

Students also can get additional savings:

  • Graduate students who are enrolled for the spring semester receive summer membership free.
  • With Spartan Shape Up memberships, affiliate students pay just $40 per month for membership from now through May, and no initiation fee or security deposit is required.
  • Students also can pay $44 plus tax per month with a month-to-month, ongoing plan. No initiation fee or security deposit required.

One to One Fitness Center, owned and operated by CWRU, is known for offering personal, professional, friendly and clean services. Memberships include full access to the 28,000-square-foot fitness center, group exercise classes, validated parking in Lot 53, towel and locker service, and member discounts on programs and services.

Members also can add their spouse or partner to their account for $30 plus tax per month. The center also offers personal training, Pilates Reformer, massage therapy and sound bath therapy, swim lessons, and more.

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Visit the One to One Fitness Center website, email onetoone@case.edu or call 216.368.1121 for more information.

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A 3-Step Plan to Give Your Diet, Fitness Routine and Mindset a Reset for Spring

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A 3-Step Plan to Give Your Diet, Fitness Routine and Mindset a Reset for Spring

To help you do this, we’ve tapped our Start TODAY experts for simple tips to lighten up meals, move in ways that boost metabolism and and refocus our mindset to get motivated to keep working toward your goals. Apply their strategies and finish the month feeling lighter, more energized and motivated to move forward. Here’s the plan to make it happen:

>>Download the 31-day calendar here

31-Day HIIT & Walking Challenge

This month’s workout plan is focused on short workouts that pack a punch. “HIIT workouts give you a bigger bang for your workout buck! They provide a more efficient workout because you’re alternating the pace and intensity rather than sticking to a steady, moderate pace,” says Mansour. “Changing things up with HIIT prevents boredom and keeps your muscles guessing. This is how we can get the body to change — whether that change is speeding up your metabolism, burning more calories, building muscle, losing weight, or just improving overall health — keeping your body guessing is the magic ticket to seeing results!”

Active recovery days include stretching to improve flexibility and walking for a cardiovascular workout that aids muscle recovery. When weather permits, Mansour encourages people to get outside on walking days. “Walking outdoors isn’t just a workout, it’s a chance to breathe in fresh air and get out of the house to change your environment,” she says. “Each time you go outside on a walk, even if you go on the same path, you’ll see or feel something different. Maybe it’s a change in weather, plants or flowers, people or things. Prioritizing taking your walk outside can hugely benefit your mental health. Getting out of your regular environment and into nature can be a form of meditation, too.”

Get the full 31-day workout plan with unique workouts sent to you daily — plus, walking podcasts, healthy spring recipes and mindfulness tools — in the Start TODAY app!

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Start TODAY Spring Asparagus Pasta recipe
Lighten up comfort food favorites by adding seasonal ingredients, like in this Spring Asparagus Pasta.

3 Simple Spring Diet Tips

In addition to mixing up your workout routine, use spring as an opportunity to start lightening up your meals by packing them with seasonal ingredients. Start TODAY dietitian Natalie Rizzo shares her top tips:

  1. Incorporate more seasonal foods. After a long winter of eating the same foods, your palate is ready for a change! Aim to add at least one spring fruit or vegetable to your meals each day, like asparagus, peas, spinach, radishes, citrus or strawberries. This Spring Asparagus Pasta is a simple weeknight dinner that feels both light and comforting. Seasonal produce is fresher, more flavorful, and an easy way to naturally boost vitamins and fiber. Plus, seasonal produce is more affordable than other items in the produce section.
  2. Use fresh herbs to brighten up your dishes. Fresh herbs like basil, cilantro, parsley, mint, or dill can instantly upgrade simple meals without extra salt or heavy sauces. Sprinkle them on salads, roasted veggies, eggs, soups, or grain bowls for a burst of spring flavor. Cilantro is the perfect finish to this Mexican Stuffed Sweet Potato, while herbs are blended into cottage cheese in this Herby Cottage Cheese Toast with Tomato recipe for a pop of fresh flavor.
  3. Shift from heavy comfort meals to balanced plates. As the weather warms up, it’s time to move away from heavy comfort foods and embrace lightened up spring dishes. Build plates with a mix of lean protein, whole grains or starchy veggies, and plenty of colorful produce. Think roasted veggie grain bowls, hearty salads like this BBQ Chicken Quinoa Salad, or simple stir-fries instead of creamy casseroles or heavy stews.
Start TODAY Mexican Stuffed Sweet Potato
A sprinkle of fresh cilantro is the perfect finish to this Mexican Stuffed Sweet Potato.

Spring Clean Your Mindset with This Mental Health Exercise

Yes, we are working to propel ourselves forward toward our health goals, but an important part of that process is slowing down and reflecting.

Getting permission not to rush in a world that feels like it’s moving faster than we can keep up is a reminder that most of us need.

Yasmine Cheyenne, start TODAY mindfulness expert

“Getting permission not to rush in a world that feels like it’s moving faster than we can keep up is a reminder that most of us need, but how often would we admit that?” says Cheyenne. “ When the to-do list feels long, and we’re trying to get everything done, we often say the opposite, disregarding how we feel, and push ourselves. Yes, we all have deadlines and things that need to be done. But we also need the reminder to take care while handling our responsibilities.”

This can be easier said than done. So Cheyenne offers up a simple exercise to help: Write down the words you need to hear each day to make yourself a priority and work toward your goals. Put them somewhere you see often, like your fridge or bathroom mirror, and recite them out loud daily.

“This is a perfect example of a reminder that seems small, but can come at the perfect time and help us care for ourselves,” she explains. “One of my favorite examples is: Take it slow and don’t rush, your nervous system deserves peace.”

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“When you tell yourself the thing you’ve been needing to hear, it allows you to admit the quiet rumbling within you and take the steps you need. It might be admitting ‘I’m tired and will give myself an early night this week.’ Or you’re saying ‘I’m so proud of the way I’ve committed to moving my body everyday.’ Whether you’re cheering yourself on or reminding yourself of what you need, we don’t always slow down enough to hear what we need from ourselves, and this practice is a great way to start.”

Talking out loud to yourself may feel strange at first, but Cheyenne says over time it will help shift your mindset and translate those words into action. “When we hear ourselves recite these words, it’s like we’re planting positive seeds within us. The more we say what we need, the more we remember it, and we’re more likely to follow through and care for ourselves,” she says. “Our actions really start with the words we say to ourselves. Reading them out loud helps us rewire the way we talk to ourselves and that inner shift is exactly what opens the door to transformation.”

Join our live “Spring Reset Workshop” on March 22 to get one-on-one coaching from Yasmine Cheyenne and connect with other Start TODAY members. Sign up here!

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Exercise scientist says ‘eating more’ is key to losing weight in perimenopause – here’s why

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Exercise scientist says ‘eating more’ is key to losing weight in perimenopause – here’s why

If you’ve ever wanted to lose weight, you’ve probably heard the phrase ‘calories in versus calories out’. While it’s true to a degree, losing weight in menopause isn’t about eating less, but rather eating differently.

Speaking to fitness coach Loretta Hogg, Dr Stacy Sims says: “One of the first things that women often do, because we grew up in an era of calories in, calories out, less calories means fat loss. That is not true because if you are not eating enough, your body holds on to fat.”

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