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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

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Exercise Scientist Reveals His System for Ranking Muscle-Building Supplements

Dr. Eric Trexler, PhD – researcher, coach, and professional bodybuilder – recently appeared on the Renaissance Periodization podcast to share his evidence-based tier system for ranking muscle-building supplements. He emphasised that supplement rankings are goal-dependent, varying based on what you’re aiming to achieve with your training and supplementation.

Dr. Trexler then outlined his tiered approach specifically for those focused on gaining muscle and building strength, categorising supplements into five distinct tiers and providing examples of each along the way.

Tier-1 Supplements

‘Tier-1 basically means we have strong evidence. We know what this thing does, and what it does is good,’ says Dr. Trexler, who explains that for muscle-building, tier-1 supplements are in a class of their own. ‘It’s a short list – it’s creatine [assuming you’re not a non-responder] and it’s protein.’

Dr. Trexler caveats that protein supplements could be redundant if you’re able to get enough of the macronutrient from your diet. ‘If you’re eating enough from your food, who cares, forget it.’

Tier-2 Supplements

Dr. Trexler believes tier-2 supplements are the most interesting. ‘There is some evidence related to the supplement for the outcome we’re interested in, and it actually looks pretty good, but it’s not on tier-one because it has some shortcoming,’ he says. ‘Maybe the initial evidence is pretty good, but I’d like to see more of it before I get super stoked.’

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He adds that in some cases, the evidence for a supplement may be very strong, but in the real world, its effects are small and inconsistent, or only work in people with deficiencies. ‘You can have a really solid evidence-based justification for this. However, you’re likely going to have to acknowledge this is a really marginal effect. Maybe this only matters for a competitive athlete.’

The supplements Dr. Trexler would include in tier-2 are: sodium bicarbonate, citrulline malate and nitric oxide supplements.

Controversially, Trexler says he would also put caffeine, one of the most heavily relied-on ergogenic aids in existence, into tier-2. ‘There are meta-analyses and umbrella reviews indicating it should have a positive effect on things like strength, strength endurance, and power. But caffeine is probably better for endurance sport than it is for resistance exercise.’

He does point out the potential dark side of becoming too reliant on the pre-workout shot of espresso. ‘We don’t know when you get to that point when you say, “I wouldn’t dare work out without my pre-workout.” Is that because it’s still giving you an ergogenic [performance-enhancing] effect? Or is it because caffeine withdrawal gives you an ergolytic effect and your performance sucks?’

(Ergolytic is science-talk for something that negatively impacts your performance.)

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Tier-3 Supplements

‘Tier-3 is where the vast majority of supplements live’, Trexler says. ’It’s the tier where I tell someone I do not have enough evidence to say that there is a defensible use case for this but I also don’t have enough hard evidence to tell you there is no way this will work.’

So, if it’s not in any of the other tiers, with enough evidence for or against it’s use, consider it tier-3.

While Dr. Trexler doesn’t clearly define tier-3 supplements as he does with other tiers, examples might include Beta-alanine, which shows some promise for improving endurance but has inconsistent effects on muscle-building and strength, or Branched-chain amino acids (BCAAs). Once highly popular, recent research suggests their benefits are limited compared to complete proteins or essential amino acids, placing them in the tier-3 category.

Tier-4 Supplements

Dr. Trexler believes tier-4 is a tricky one – it’s the first category where we should consider actively swerving the compounds in question. ‘This is where we have evidence of a null effect. I can look at studies on it and say this is not going to achieve what you want it to achieve,’ says Dr. Trexler. His host, Dr. Mike Israetel, also an exercise scientist, offers a more concise and memorable definition: ‘It’s not hurting you; it just doesn’t do shit

When it comes to building strength and size, Trexler would include previously popular supplements like glutamine in tier-4. ‘For getting jacked and performing better, I think we’ve pretty much shut the book on glutamine.’

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He’d also place arginine – an amino acid that was once popular in pre-workout mixtures and touted as a ‘pump enhancer’ – in tier-4, alongside some testosterone boosters and modern ‘new-and-improved’ creatines like ethyl ester and alkaline varieties, saying they don’t justify their cost when tier-1’s cheaply available creatine monohydrate is an option.

Tier-5 Supplements

Tier-5 is the group that Dr. Trexler strongly advises you avoid. ‘[These are] supplements where we have evidence that one of two things is going to happen – either this is going to literally harm your performance, or it is going to harm you.’

Trexler says he would include compounds like DMAA, a chemical extract previously included in now-banned pre-workout supplements such as the highly-memed JACK-3D. He jokes that although these compounds were widely available and not previously banned, the aim of manufacturers at the time seemed to be to get as close as possible to the effects of methamphetamine.

Another tier-5 chemical that was once the stimulant of choice for many bodybuilders is ephedrine. ‘It was the era of [high stimulant] pre-workouts. However, there were serious adverse events reported. I believe that there were a couple of deaths.’ Thankfully, sporting organisations and federations have helped to pave the way to a slightly safer supplement industry. ‘Once it’s banned by all the big federations, I say all right, we’re going to tier-5…’

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With almost 18 years in the health and fitness space as a personal trainer, nutritionist, breath coach and writer, Andrew has spent nearly half of his life exploring how to help people improve their bodies and minds.    

As our fitness editor he prides himself on keeping Men’s Health at the forefront of reliable, relatable and credible fitness information, whether that’s through writing and testing thousands of workouts each year, taking deep dives into the science behind muscle building and fat loss or exploring the psychology of performance and recovery.   

Whilst constantly updating his knowledge base with seminars and courses, Andrew is a lover of the practical as much as the theory and regularly puts his training to the test tackling everything from Crossfit and strongman competitions, to ultra marathons, to multiple 24 hour workout stints and (extremely unofficial) world record attempts.   

 You can find Andrew on Instagram at @theandrew.tracey, or simply hold up a sign for ‘free pizza’ and wait for him to appear.

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Higher fitness levels linked to lower risk of depression, dementia – Harvard Health

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Higher fitness levels linked to lower risk of depression, dementia – Harvard Health
research review

People with high cardiorespiratory fitness were 36% less likely to experience depression and 39% less likely to develop dementia than those with low cardiorespiratory fitness. Even small improvements in fitness were linked to a lower risk. Experts believe that exercise’s ability to boost blood flow to the brain, reduce bodywide inflammation, and improve stress regulation may explain the connection.

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These 20-Minute Burpee Workouts Replaced His Entire Gym Routine – and Transformed His Physique

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These 20-Minute Burpee Workouts Replaced His Entire Gym Routine – and Transformed His Physique

While many swear by them, most people see burpees as a form of punishment – usually dished out drill sergeant-style by overzealous bootcamp PTs. Often the final blow in an already brutal workout, burpees are designed to test cardiovascular fitness, muscular endurance and mental grit. Love them or loathe them, they deliver every time.

For Max Edwards – aka Busy Dad Training on YouTube – they became a simple but highly effective way to stay fit and lean during lockdown. Once a committed powerlifter, spending upwards of 80 minutes a day in the gym, he was forced to overhaul his approach due to fatherhood, lockdown and a schedule that no longer allowed for long, structured lifting sessions.

‘Even though I was putting in hours and hours into the gym and even though my physique was pretty good, I wasn’t becoming truly excellent at any physical discipline,’ he explained in a YouTube video.

‘I loved the intentionality of training,’ says Edwards. ‘The fact that every session has a point, every rep in every set is helping you get towards a training goal, and I loved that there was a clear way of gauging progression – feeling like I was developing competence and moving towards mastery.’

Why He Walked Away From Powerlifting

Despite that structure, Edwards began to question whether powerlifting was sustainable long-term.

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‘My sessions were very taxing on my central nervous system. I was exhausted between sessions. It felt as if I needed at least nine hours of sleep each night just to function.’

He also noted that his appetite was consistently high.

But the biggest drawback was time.

‘I could not justify taking 80 minutes a day away from my family for what felt like a self-centred pursuit,’ he says.

A Simpler Approach That Stuck

‘Over the course of that year I fixed my relationship with alcohol and I developed, for the first time in my adult life, a relationship with physical training,’ says Edwards.

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With limited time and no access to equipment, he turned to burpees. Just two variations, four times a week, with each session lasting 20 minutes.

‘My approach in each workout was very simple. On a six-count training day I would do as many six-counts as I possibly could within 20 minutes. On a Navy Seal training day I would do as many Navy Seal burpees as I could within 20 minutes – then in the next workout I would simply try to beat the number I had managed previously.’

This style of training is known as AMRAP – as many reps (or rounds) as possible.

The Results

Edwards initially saw the routine as nothing more than a six-month stopgap to stay in shape. But that quickly changed.

‘I remember catching sight of myself in the mirror one morning and I was utterly baffled by the man I saw looking back at me.’

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He found himself in the best shape of his life. His energy levels improved, his resting heart rate dropped and his physique changed in ways that powerlifting hadn’t quite delivered.

‘It has been five years since I have set foot in a gym,’ he says. ‘That six-month training practice has become the defining training practice of my life – and for five years I have trained for no more than 80 minutes per week.’

The Burpee Workouts

1/ 6-Count Burpees

20-minute AMRAP, twice a week

How to do them:

  • Start standing, feet shoulder-width apart
  • Crouch down and place your hands on the floor (count 1)
  • Jump your feet back into a high plank (count 2)
  • Lower into the bottom of a push-up (count 3)
  • Push back up to plank (count 4)
  • Jump your feet forward to your hands (count 5)
  • Stand up straight (count 6)

20-minute AMRAP, twice a week

How to do them:

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  • Start standing, feet shoulder-width apart
  • Crouch down and place your hands on the floor
  • Jump your feet back into a high plank
  • Perform a push-up (chest to floor)
  • At the top, bring your right knee to your right elbow, then return
  • Perform another push-up
  • Bring your left knee to your left elbow, then return
  • Perform a third push-up
  • Jump your feet forward
  • Stand or jump to finish

Headshot of Kate Neudecker

Kate is a fitness writer for Men’s Health UK where she contributes regular workouts, training tips and nutrition guides. She has a post graduate diploma in Sports Performance Nutrition and before joining Men’s Health she was a nutritionist, fitness writer and personal trainer with over 5k hours coaching on the gym floor. Kate has a keen interest in volunteering for animal shelters and when she isn’t lifting weights in her garden, she can be found walking her rescue dog.

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Six ways your smartwatch is lying to you, according to science

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Six ways your smartwatch is lying to you, according to science

You check your smartwatch after a run. Your fitness score has dropped. You’ve burnt hardly any calories. Your recovery score is really low. It’s telling you to take the next 72 hours off exercise.

The worst bit? The whole run felt amazing.

So why is your watch telling you the opposite?

Ultimately, it’s because smartwatches and other fitness trackers aren’t always accurate.

Smartwatches can shape how you exercise

Using wearable fitness technology, such as smartwatches, has been one of the top fitness trends for close to a decade. Millions of people around the world use them daily.

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These devices shape how people think about health and exercise. For example, they provide data about how many calories you’ve burnt, how fit you are, how recovered you are after exercise, and whether you’re ready to exercise again.

But your smartwatch doesn’t measure most of these metrics directly. Instead, many common metrics are estimates. In other words, they’re not as accurate as you might think.

1. Calories burned

Calorie tracking is one of the most popular features on smartwatches. However, the accuracy leaves a lot to be desired.

Wearable devices can under- or overestimate energy expenditure (often expressed as calories burned) by more than 20 per cent. These errors also vary between activities. For example, strength training, cycling and high-intensity interval training can lead to even larger errors.

This matters because people often use these numbers to guide how much they eat.

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For example, if your watch overestimates calories burned, you might think you need to eat more food than you really need, which could result in weight gain. Conversely, if your watch underestimates calories burned, it could lead you to under-eat, negatively impacting your exercise performance.

2. Step counts

Step counts are a great way to measure general physical activity, but wearables don’t capture them perfectly.

Smartwatches can under-count steps by about 10 per cent under normal exercise conditions. Activities such as pushing a pram, carrying weights, or walking with limited arm swing likely make step counts less accurate, as smartwatches rely on arm movement to register steps.

For most people, this isn’t a major problem, and step counts are still useful for tracking general activity levels. But view them as a guide, rather than a precise measure.

3. Heart rate

Smartwatches estimate your heart rate using sensors that measure changes in blood flow through the veins in your wrist.

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This method is accurate at rest or low intensities, but gets less accurate as you increase exercise intensity.

Arm movement, sweat, skin tone and how tightly you wear the watch can also impact the heart rate measure it spits out. This means the accuracy can vary between people.

This can be problematic for people who use heart rate zones to guide their training, as small errors can lead to training at the wrong intensity.

4. Sleep tracking

Almost every smartwatch on the market gives you a “sleep score” and breaks your night into stages of light, deep and REM sleep.

The gold standard for measuring sleep is polysomnography. This is a lab-based test that records brain activity. But smartwatches estimate sleep using movement and heart rate.

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This means they can detect when you’re asleep or awake reasonably well. But they are much less accurate at identifying sleep stages.

So even if your watch says you had “poor deep sleep”, this may not be the case.

5. Recovery scores

Most smartwatches track heart rate variability and use this, with your sleep score, to create a “readiness” or “recovery” score.

Heart rate variability reflects how your body responds to stress. In the lab it is measured using an electrocardiogram. But smartwatches estimate it using wrist-based sensors, which are much more prone to measurement errors.

This means most recovery metrics are based on two inaccurate measures (heart rate variability and sleep quality). This results in a metric that may not meaningfully reflect your recovery.

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As a result, if your watch says you’re not recovered, you might skip training — even if you feel good (and are actually good to go).

6. VO₂max

Most devices estimate your VO₂max — which indicates your maximal fitness. It’s the maximum amount of oxygen your body can use during exercise.

The best way to measure VO₂max involves wearing a mask to analyse the amount of oxygen you breathe in and out, to determine how much oxygen you’re using to create energy.

But your watch cannot measure oxygen use. It estimates it based on your heart rate and movement.

But smartwatches tend to overestimate VO₂max in less active people and underestimate VO₂max in fitter ones.

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This means the number on your watch may not reflect your true fitness.

What should you do?

While the data from your smartwatch is prone to errors, that doesn’t mean it is completely worthless. 

These devices still offer a way to help you track general trends over time, but you should not pay attention to daily fluctuations or specific numbers.

It’s also important you pay attention to how you feel, how you perform and how you recover. This is likely to give you even more insight than what your smartwatch says.

Hunter Bennett is a lecturer in exercise science at Adelaide University. This piece first appeared on The Conversation.

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