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Superbugs due to antibiotic resistance could kill 39 million people by 2050, large study finds

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Superbugs due to antibiotic resistance could kill 39 million people by 2050, large study finds

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Resistance to antibiotics has led to one million worldwide deaths each year since 1990, for a total of 36 million.

It is expected to cause more than 39 million more fatalities by 2050 — three per minute.

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That’s according to a large study led by the Global Research on Antimicrobial Resistance (GRAM) Project, a partnership between the University of Oxford and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.

NEW ANTIBIOTIC KILLS DEADLY, DRUG-RESISTANT BACTERIA IN ‘SCIENTIFIC BREAKTHROUGH’

After analyzing 520 million health records, the researchers provided future estimates for 22 pathogens, 84 pathogen-drug combinations and 11 infectious syndromes across 204 countries and territories, according to a GRAM press release. 

Resistance to antibiotics has led to one million worldwide deaths each year since 1990, for a total of 36 million. (iStock)

Findings from the study were published in The Lancet on Monday.

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What is antimicrobial resistance?

Antimicrobial resistance (AMR) occurs when bacteria and other types of germs become stronger than the medications given to treat them, creating so-called “superbugs.” 

This can make infections difficult or impossible to treat, per the U.S. Centers for Disease Control and Prevention (CDC).

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“In modern medicine, the use of antibiotics has allowed us to successfully perform organ transplants, complex surgical procedures and care for extremely preterm infants,” Jasmine Riviere Marcelin, MD, a fellow of the Infectious Diseases Society of America and infectious diseases professor at the University of Nebraska — who was not involved in the study — told Fox News Digital.

“These interventions have been successful because antibiotics have allowed us to prevent and treat infections in these critically ill patients.”

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Antimicrobial resistance occurs when bacteria and other types of germs become stronger than the medications given to treat them, creating so-called “superbugs.”  (iStock)

Now, antibiotic-resistant bacteria pose a “significant health risk,” she warned, because they prevent the ability to treat or prevent infections. 

“Not only will our advancements in medicine be at risk, but we may find ourselves back to where we were in the pre-antibiotic era, when mortality from simple skin/soft tissue infections was significant,” Marcelin added.

“We may find ourselves back to where we were in the pre-antibiotic era.”

Maureen Tierney, MD, associate dean of clinical research and public health at Creighton University School of Medicine in Omaha, Nebraska, was also not involved in the study, but confirmed that it is “the most comprehensive attempt to determine the burden of antimicrobial resistance [in terms of] disability and death.” 

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“This was an enormous effort using all different sources of data in countries around the world to estimate the number of deaths caused by microorganisms resistant to several types of antibiotics,” she told Fox News Digital.

Marking key shifts

Since 1990, the infection that caused the biggest increase was MRSA (methicillin-resistant S. aureus), a type of staph bacteria that has become resistant to some antibiotics. 

Annual MRSA-related deaths increased from 57,200 in 1990 to 130,000 in 2021, the study found.

Despite the overall increase in AMR-related mortality, deaths among kids younger than 5 were cut in half between 1990 and 2021.

Since 1990, the infection that caused the biggest increase was MRSA (methicillin-resistant S. aureus), a type of staph bacteria that has become resistant to some antibiotics. (iStock)

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The researchers attributed this to childhood vaccination programs and wider access to drinking water, sanitation and hygiene practices.

The sharpest increase was among adults 70 and older, who saw a more than 80% uptick in AMR deaths.

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“Researchers expect these trends to continue in the coming decades, with AMR deaths among children under 5 projected to halve by 2050 globally, as deaths among people 70 years and older more than double,” the press release stated.

Geographically, deaths rose the most in western sub-Saharan Africa, tropical Latin America, high-income North America, Southeast Asia and South Asia.

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Combating antimicrobial resistance

Next week, global health leaders plan to meet at the UN General Assembly in New York to discuss new strategies for addressing AMR.

Potential interventions include “infection prevention and control measures, such as new vaccines and antimicrobials, and improved access to water and sanitation — as well as deeper investments across health systems in diagnostics, training and new technologies,” the release stated.

“The most important ways to decrease the incidence of antibiotic resistance are vaccination for pneumonia, influenza, COVID, measles and other diseases,” an infectious diseases expert told Fox News Digital. (Jeff Kowalsky/AFP via Getty Images))

“The most important ways to decrease the incidence of antibiotic resistance are vaccination for pneumonia, influenza, COVID, measles and other diseases,” Tierney from Creighton University told Fox News Digital. 

   

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Tierney also calls for “antimicrobial stewardship” – which she defines as “the judicious use of antibiotics in humans, animals and farming” – as well as infection prevention practices, especially in health care facilities, and the development of new antibiotics.

“Antibiotics are a shared natural resource that we must all protect.”

While creating new drugs is one way to combat AMR, Marcelin warned that relying only on drug discovery would be “futile,” given the length of time it takes for new medications to be developed, tested and approved.

“The number of new or repurposed antibiotics in late-stage clinical development is very small, and no single antibiotic candidate claims to have activity against those bacteria resistant to all currently available drugs,” she told Fox News Digital. 

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“If we can’t make new drugs easily, we can combat resistance by controlling the spread of resistant organisms, which is the principle of infection control.”

To prevent resistance, experts say that antibiotics should be prescribed and used “only when they are indicated, for the optimal duration, and at the right timing and dosing regimen.” (iStock)

To prevent resistance, Marcelin agrees that antibiotics should be prescribed and used “only when they are indicated, for the optimal duration, and at the right timing and dosing regimen.”

She added, “Antibiotics are a shared natural resource that we must all protect, so that we can continue to live in a world where we make medical advances and reduce mortality from bacterial infections.”

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Fox News Digital reached out to GRAM researchers requesting comment.

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Doctors reveal what ‘reasonable’ drinking looks like — and who should avoid alcohol

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Doctors reveal what ‘reasonable’ drinking looks like — and who should avoid alcohol

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With 40% of adults resolving to drink less alcohol in 2026, according to a recent survey, some may be struggling to find a healthy balance.

Health experts agree that each person’s relationship with alcohol is unique, based on history, tolerance and lifestyle.

Dr. Ezekiel Emanuel, a Pennsylvania-based oncologist and author of the new book “Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life,” has noted that indulging in certain activities – like eating ice cream or drinking alcohol – may not be healthy to do every day, but can provide some benefits in moderation.

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“There has been a lot of research on alcohol,” he said in a recent interview with “CBS Sunday Morning.” “The safest level is probably zero. There are some studies … where it’s half a cup a day, three cups a week.”

“On the other hand, 60% [to] 65% of the public drinks,” he went on. “You’re not going from 65% to zero, so you have to give people reasonable advice.”

A doctor shared “reasonable” drinking advice for striking a balanced relationship with alcohol. (iStock)

Emanuel advised against binge-drinking or drinking alone, both of which are “really bad for you.”

“[But] if you’re using alcohol as a lubricant for social interaction, which many people do, that’s probably good,” he said. “You’re getting some benefit from the social interaction.”

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When social drinking becomes risky

While drinking’s stress-relieving factors may be helpful for some, indulging in alcoholic drinks can be risky for those with a pre-disposition to addiction, experts caution.

In a recent episode of “The Huberman Lab” podcast, Dr. Andrew Huberman and guest Dr. Keith Humphreys, professor of psychiatry and behavioral sciences at Stanford School of Medicine, discussed the fine line between indulging for pleasure and potentially fostering an issue.

Experiences with alcohol can be different for every individual, experts say. (iStock)

According to Huberman, who is also a Stanford University neuroscientist, up to 10% of people experience alcohol as a “dopaminergic,” making them feel “spectacularly good.”

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Others may drink and experience a cue to stop, like dizziness, nausea, “blacking out,” severe hangovers or other negative effects.

“The safest level is probably zero.”

“Some people really can drink five or six drinks, and then the next day they’re at work hammering away,” he said. “The conversation becomes very difficult to have, because it sounds like it’s highly individual how people will react.”

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High-risk groups

One of the greatest risk factors for becoming an alcoholic is having your first drink before the age of 14, according to Huberman.

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“I find that some people will have their first drink, and it’s like a magic elixir for their physiology,” he said. “And there are very few things that can get somebody like that to stop drinking, except the risk of losing everything.”

While drinking’s stress-relieving factors may be helpful for some, indulging in alcoholic drinks can be risky for those with a pre-disposition to addiction, experts caution. (iStock)

Humphreys said the biggest indicator of personal risk is whether alcoholism runs in someone’s family — particularly if their parents were alcoholics.

“The father-to-son link is the strongest one you see in genetics,” he said. “Men drink more than women do … whether they’ve got an alcohol problem or not.”

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Drinking alcohol has been shown to be particularly harmful for women, as the risk of developing hormone-related cancers substantially increases.

Risk vs. benefit

For those who are not predisposed to addiction, Huberman noted that some studies suggest that certain types of consumption are OK in moderation, such as drinking red wine or having a maximum of two drinks per week.

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“I would love to believe [red wine] is healthy,” Humphreys responded. “It’s not … Why would there be a benefit to red wine that wasn’t in other alcoholic beverages?”

“There might be some cardiac benefits, but we don’t get to live our lives as single organs. We have a whole body,” he went on. “If that’s true, it’s smaller than the cancer risk. So, your net is you’re not going to get any mortality reduction from drinking alcohol.”

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“I would love to believe [red wine] is healthy,” one expert said. “It’s not … Why would there be a benefit to red wine that wasn’t in other alcoholic beverages?” (iStock)

Drinking two drinks per week — such as a 12-ounce beer, 4-ounce glass of wine or a 1-ounce shot of liquor — poses only a “very small risk” of health complications, but it’s not something Humphreys would recommend, as it’s “just not good for you,” he said.

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Despite the risks, however, the experts acknowledged the stress-relieving and social benefits of having a drink.

“Getting together with friends is enjoyable, enriching,” Humphreys said. “Good food and good wine taste good, and I value those things. And there are many other decisions we make like that where we endure some risk because we care about something else.”

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“It’s dangerous for someone my age to hike up a mountainside probably, but if the view is spectacular, I can say, ‘Oh, I’m going to accept that risk.’”

“Good food and good wine taste good, and I value those things.”

What’s become most dangerous about social drinking, according to Humphreys, is that some people feel they need to explain themselves when they stop.

Huberman echoed, “If you don’t drink at parties, or you refuse an offer of alcohol, people think there’s something wrong with you.”

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Given recent data on the risks of alcohol consumption, Humphreys said it should be simple to say no, much like opting not to smoke a cigarette.

“Health is a reason people still accept, I think, as a legitimate [reason] for changing behavior,” he added.

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Early peanut exposure in babies tied to sharp drop in food allergy diagnoses

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Early peanut exposure in babies tied to sharp drop in food allergy diagnoses

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Historically, parents were advised to avoid feeding peanuts to babies for the first few years of life, but emerging research has confirmed that introducing them sooner — as early as infancy — could help stave off food allergies.

A 2025 study led by the Children’s Hospital of Philadelphia analyzed medical records from dozens of pediatric practices across the U.S., finding that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies.

The latest research also found that eggs had surpassed peanuts as the most common food allergen in the children studied. Beyond peanuts, other common food allergens include milk, egg and wheat.

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The new research — published in Pediatrics, the journal of the American Academy of Pediatrics, in October 2025 — focused on a two-year period after new guidance was issued by the National Institute of Allergy and Infectious Diseases, which first advised parents to introduce peanuts earlier. 

Emerging research has confirmed that introducing peanuts as early as infancy could help stave off food allergies. (iStock)

That updated guidance was based on a landmark 2015 study — the Learning Early About Peanut Allergy (LEAP) trial — which found that for infants who had severe eczema or an egg allergy, exposing them to peanuts when they were between 4 and 11 months old could reduce peanut allergy risk by 81%.

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The guidelines were updated again in 2021, encouraging the introduction of peanut, egg and other major food allergens as early as 4 to 6 months for all children — including those without a history of prior reaction, according to health experts.

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“Everyone has been wondering whether these landmark public health interventions have had an impact on reducing rates of IgE-mediated food allergies in the United States,” said first author Stanislaw Gabryszewski, M.D., Ph.D., an attending physician in the Division of Allergy and Immunology at the Children’s Hospital of Philadelphia, in a statement.

A 2025 study led by the Children’s Hospital of Philadelphia found that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies. (iStock)

“We now have data that suggest the effect of this landmark public health intervention is occurring.”

The latest findings “are supportive of efforts to increase education and advocacy related to early food introduction practices,” the study authors wrote.

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“If confirmed, these findings would represent a meaningful public health advance — affirming that clinical research, when coupled with clear guidelines and committed dissemination, can indeed shift the trajectory of childhood food allergy.”

Study limitations

The study only included data through early 2019 and did not consider the guidance released in 2021, which recommended early introduction of multiple allergens regardless of risk, the researchers acknowledged.

It also relied on allergy diagnoses from electronic health records, which may miss some cases. Also, the researchers did not capture individual feeding patterns.

Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens. (iStock)

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Because the study was observational, it cannot prove cause and effect, but only association, the researchers noted. Other factors may influence the outcome.

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In some children, peanut allergy can trigger severe, life-threatening reactions, including difficulty breathing, swelling of the throat and a dangerous drop in blood pressure, according to Mayo Clinic. These reactions require immediate treatment with epinephrine, a life-saving allergy medication.

Not all parents may be comfortable with these revised guidelines, health experts say.

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“Not everyone has followed those guidelines, but this is further evidence that this early introduction is effective at preventing food allergies,” Dr. Susan Schuval, chief of the Division of Pediatric Allergy and Immunology at Stony Brook Children’s Hospital in New York, previously told Fox News Digital.

Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens.

Amy McGorry contributed reporting.

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