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New prostate cancer medication 'shows promise' in treating aggressive disease, study finds

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New prostate cancer medication 'shows promise' in treating aggressive disease, study finds

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There may be a “promising new strategy” in combating aggressive forms of prostate cancer, according to a new study.

Researchers at Flinders University and the University of South Australia investigated how the novel drug, CDKI-73, has the potential to tackle drug-resistant prostate cancer.

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This drug reportedly “defies conventional therapies,” as noted in the study findings, which were published in the British Journal of Cancer.

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Prostate cancer is the second-leading cause of cancer death in American men, following lung cancer, according to the American Cancer Society (ACS).

In 2024, around 299,010 new cases will be diagnosed and more than 35,000 men will die from the disease, per the ACS.

Prostate cancer is the second-leading cause of cancer death in American men, following lung cancer, according to the American Cancer Society. (iStock)

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The disease “frequently evolves into aggressive forms that do not respond to standard hormone therapies,” according to Flinders University.

The researchers, including professors Luke Selth and Shudong Wang, targeted cyclin-dependent kinase 9 (CDK9) – a protein responsible for the growth and survival of prostate cancer cells.

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Selth, of Flinders University, confirmed in a press release that the CDKI-73 inhibitor has shown to be effective in blocking prostate cancer growth in models and tumor samples.

“Our research demonstrates that CDKI-73 potently blocks the growth of prostate cancer, even aggressive subtypes of the disease that are resistant to current treatments,” he said.

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The drug being orally available may help “facilitate its use as a new treatment,” one of the researchers said. (iStock)

“Importantly, CDKI-73 targets cancer cells specifically without harming normal cells.”

In an email sent to Fox News Digital, Selth said the drug is orally available as a tablet, which could help “facilitate its use as a new treatment.”

“We still need to do a lot more work to fully understand the potential of CDK9 inhibitors and to deliver a new treatment for patients.”

Selth said he considers the study results a “significant step forward in understanding the role of CDK9 in aggressive prostate cancer.”

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“Having said that, we still need to do a lot more work to fully understand the potential of CDK9 inhibitors and to deliver a new treatment for patients,” he added.

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Wang, who developed CDKI-73, said in the release that the drug is a “promising candidate for treating solid tumors, such as prostate cancer.”

“Our proof-of-principle study is an important step toward future clinical trials, and these findings will inform future studies on the use and efficacy of CDKI-73 as a prostate cancer treatment,” he went on.

One of the researchers called the drug a “promising candidate for treating solid tumors, such as prostate cancer.” (iStock)

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CDKI-73 is currently being investigated in phase 2 clinical trials in patients with relapsed and therapy-resistant acute myeloid leukemia (AML), a type of blood cancer that affects the bone marrow and blood cells, according to Flinders University.

While the research is an “important step forward,” Wang said, the research team plans to complete more trials to assess the efficacy and safety of the drug before it is given to patients.

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Selth encouraged all men over the age of 50 — and those over 40 who have a family history of prostate cancer — to talk to their providers about getting screened during regular check-ups.

Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, was not involved in the study, but commented on the drug’s potential. 

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The new drug “shows promise in treating advanced or aggressive prostate cancer,” a doctor told Fox News Digital. (iStock)

“We know that CDK 9 is an enzyme associated with prostate cancer growth,” he told Fox News Digital.

“In this new study, an inhibitor of CDK 9 (CDKI-73) was found to inhibit growth and lead to death in human prostate cancer cells in the laboratory, and also in animals and models.”

“The drug has not been used yet in human subjects and clinical trials may be the next step,” Siegel went on. “It shows promise in treating advanced or aggressive prostate cancer.”

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Fox News Digital reached out to oncologists for comment on the experimental drug.

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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