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Ozempic and Wegovy could double as kidney disease treatment, study suggests

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Ozempic and Wegovy could double as kidney disease treatment, study suggests

Semaglutide medications — including Ozempic and Wegovy — have been shown to reduce the risk of kidney failure and the risk of death among people with kidney disease and type 2 diabetes.

In a trial led by UNSW Sydney between June 2019 and May 2021, researchers found that a small weekly dose of semaglutide lessened the likelihood of “major kidney events” by 24%, according to a press release.

The study, funded by Novo Nordisk and published in The New England Journal of Medicine, included more than 3,500 participants with type 2 diabetes and chronic kidney disease from 28 countries.

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The participants received 1.0 mg per week of semaglutide, which is less than what is typically prescribed for weight loss or diabetes, the release noted. 

The median follow-up was 3.4 years.

Semaglutide medications — including Ozempic and Wegovy — have been shown to reduce the risk of kidney failure and the risk of death among people with kidney disease and type 2 diabetes. (iStock)

“It’s the same chemical compound, but we used a lower dose … we did that deliberately because people with kidney disease tend to be more sensitive to the effects and side effects of drugs,” said the study’s lead author, professor Vlado Perkovic of UNSW Sydney, in the release.

“That’s helpful in terms of being able to perhaps have the drug more widely used than might have otherwise been the case given the current supply limitations.”

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The group of people taking semaglutide were also 18% less likely to experience a heart attack, stroke and other cardiovascular events, the study found.

Why does semaglutide have this effect?

Patients with type 2 diabetes and chronic kidney disease are at a significant risk for kidney failure, cardiovascular events and death, according to Dr. Brett Osborn, a neurologist and longevity expert in Florida.

“The recent study published in the New England Journal of Medicine highlights semaglutide’s potential to mitigate these risks,” Osborn, who was not involved in the study, told Fox News Digital. 

Dr. Brett Osborn, a neurologist and longevity expert in Florida, noted that patients with type 2 diabetes and chronic kidney disease are at a significant risk for kidney failure, cardiovascular events and death.  (Dr. Brett Osborn)

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Semaglutide works by improving glycemic control, Osborn noted — which is crucial in mitigating diabetic nephropathy (kidney disease). 

“It also lowers inflammation — particularly within the blood vessel lining,” he said. 

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This reduces blood vessel damage and improves blood flow through the kidneys.

“Overall, semaglutide offers substantial renal and cardiovascular protection for patients with type 2 diabetes and chronic kidney disease,” Osborn said.

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“At a base level, semaglutide, through indirect mechanisms, improves vascular health. The better blood flow to your organs — be it your heart, brain or kidneys — the longer you are likely to live.”

Semaglutide works by improving glycemic control, one doctor noted, which is crucial in mitigating diabetic nephropathy (kidney disease).  (Getty Images)

Outside the spectrum of diabetes, Osborn said he believes these medications will have a major impact on human health, comparing them to the advent of antibiotics at the turn of the century.

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, also said this was a “very important” study.

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“This lifesaving result is likely due to the metabolic effects of the drug, which helps with reducing inflammation, overcoming insulin resistance, and improving insulin function and glucose metabolism at the cellular level,” Siegel told Fox News Digital. 

“This study has broader implications for all patients who have kidney failure.”

“Improved kidney function means improved heart function, and pressure on the heart from failed kidneys is a major cause of heart attack and death.”

Siegel added, “This study has broader implications for all patients who have kidney failure or are at risk for it.”

Novo Nordisk, the Denmark-based company that makes Ozempic and Wegovy, announced the positive primary results from the trial at the European Renal Association (ERA) Congress in Sweden last week. (LISELOTTE SABROE/Scanpix Denmark/AFP via Getty Images)

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Novo Nordisk, the Denmark-based company that makes Ozempic and Wegovy, announced the positive primary results from the trial at the European Renal Association (ERA) Congress in Sweden last week.

“FLOW is the first ever renal outcomes trial with a GLP-1 receptor agonist, and demonstrated a statistically significant reduction in kidney disease progression, cardiovascular death, and all-cause mortality risk with semaglutide 1 mg,” Michael Radin, executive medical director for diabetes at Novo Nordisk, said in a statement sent to Fox News Digital. 

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“This study highlights our drive to make a meaningful difference in the lives of people living with type 2 diabetes and CKD and to deliver innovations to address current unmet medical needs in CKD pending FDA approval.”

Wegovy is an injectable prescription weight loss medicine that has helped people with obesity. (Michael Siluk/UCG/Universal Images Group via Getty Images)

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To leverage semaglutide as a treatment for kidney disease, there is a need to overcome supply shortages and conduct research about combining the medication with other therapies, the researchers stated in the release.

Novo Nordisk will also need to seek regulatory approval for the drug to be used for chronic kidney disease patients.

“The challenge is to get these results into clinical practice, to get the drug used by the people who will benefit from it, who will live longer without dialysis, without heart attacks, without strokes, if they take this drug,” Perkovic said.

For more Health articles, visit www.foxnews.com/health.

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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SuperAger Ralph Rehbock sits with his wife in his home.  (Shane Collins, Northwestern University)

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Stat of the week

More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.

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Heart disease threat projected to climb sharply for key demographic

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Heart disease threat projected to climb sharply for key demographic

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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.

The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.

More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.

The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.

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As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.

The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)

Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.

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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”

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“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.

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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”

Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)

Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”

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The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.

The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.

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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”

Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.

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Moving more is one part of protecting a healthy heart, according to experts. (iStock)

Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.

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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.

The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.

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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”

“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”

“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)

“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”

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The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.

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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.

“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”

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