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Use of Wegovy and other weight-loss drugs soars among kids and young adults

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Use of Wegovy and other weight-loss drugs soars among kids and young adults

At 17, Israel McKenzie was so burdened by obesity that he stopped going to high school in person and was embarrassed to speak to people at his restaurant job.

“I was in a really dark place,” says McKenzie, whose weight had climbed to 335 pounds on his 6-foot-1 frame, despite repeated efforts to diet and exercise. “I had given up hope.”

But last year, the weight-loss drug Wegovy helped him shed 110 pounds in nine months, making the rural Tennessee teen part of a surge of adolescents and young adults using diabetes and obesity medications known as GLP-1 receptor agonists, new research shows.

Even as millions of older adults clamor for drugs such as Ozempic and Wegovy, monthly use of the medications soared in people aged 12 to 25. That’s according to the new analysis of dispensing records from nearly 94% of U.S. retail pharmacies from 2020 to 2023.

The report, published in the journal JAMA on Wednesday, used the IQVIA prescription database to compile the first look at the national uptake of GLP-1 drugs among that age group. Nearly 31,000 children aged 12 to 17 and more than 162,000 people aged 18 to 25 used the medications in 2023 alone, said Dr. Joyce Lee, a University of Michigan pediatrician and diabetes expert who led the research.

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“What it’s suggesting is that it’s one of the tools in the toolbox and there are more providers prescribing this medication for the population,” she said.

The report shows that the number of 12- to 25-year-olds using any GLP-1 drug — including older medications first approved to treat diabetes in 2005 and for weight loss in 2014 — climbed from about 8,700 a month in 2020 to more than 60,000 a month in 2023, a nearly 600% increase. The rise occurred even as prescriptions of other drugs among those patients fell by about 3%.

Those who received the drugs were just a fraction of young people who struggle with obesity, Lee noted. About 20% of U.S. children and adolescents and about 42% of adults have the chronic disease, according to the U.S. Centers for Disease Control and Prevention.

In early 2023, the American Academy of Pediatrics recommended that children and teens with obesity be evaluated early and treated aggressively, including with surgery and medication if warranted.

McKenzie, the Tennessee teen, said he began gaining weight five years ago, during puberty.

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“I started turning to food for all of my problems,” he said.

The extra weight made his asthma worse and put him in danger of developing diabetes, his doctor said. He tried to follow medical advice by cutting out sugary soda and snack foods and exercising more, but the efforts failed to make a difference.

“My old doctor told me there was nothing he could do,” he said. “He told me it was my fault.”

In early 2023, McKenzie connected with Dr. Joani Jack, a pediatric obesity specialist at Children’s Hospital at Erlanger in Chattanooga, Tennessee, who regularly prescribes GLP-1 drugs for kids.

“I told him I’ve seen 10 other people just like you today and we have lots of tools and treatment options,” Jack said. Those typically include intensive behavioral and nutrition interventions combined with medication, if necessary.

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In McKenzie’s case, Jack prescribed the weight-loss drug Wegovy, which in late 2022 was approved for use in U.S. children over age 12. More than 6,000 kids in that age group received Wegovy in 2023, the new data show. More than 7,600 received Ozempic, which is approved to treat diabetes in adults, but can be used off-label in adolescents. Others received older GLP-1 drugs such as Saxenda and Trulicity.

McKenzie said he had no notable side effects from the medication, but Lee noted that some young people report nausea, vomiting or constipation, including symptoms so serious that they stop the drugs.

It’s important to understand the surging use of these medications in young people, Lee said. The drugs are meant for continuing use, so “we really need to think about the long-term safety and effectiveness of these medications for this population,” she said.

In addition, the drugs are expensive and often difficult to obtain, either because of supply problems or because they’re not covered by insurance.

Notably, government-run Medicaid plans paid for nearly half of the GLP-1 drugs prescribed to 12- to 17-year-olds and about a quarter of those used by people aged 18 to 25, the research found. Commercial insurance covered care for nearly 44% of the younger kids and about two-thirds of those who were older.

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Today, McKenzie says his asthma is better and he looks forward to interacting with co-workers and friends.

“I have a lot of self-confidence now, a lot more than I used to,” he said. “It has changed everything.”

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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The sea is higher than we thought and millions more are at risk, study finds

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The sea is higher than we thought and millions more are at risk, study finds

Climate change’s rising seas may threaten tens of millions more people than scientists and government planners originally thought because of mistaken research assumptions on how high coastal waters already are, a new study said.

Researchers studied hundreds of scientific studies and hazard assessments, calculating that about 90% of them underestimated baseline coastal water heights by an average of 1 foot (30 centimeters), according to Wednesday’s study in the journal Nature. It’s a far more frequent problem in the Global South, the Pacific and Southeast Asia, and less so in Europe and along Atlantic coasts.

The cause is a mismatch between the way sea and land altitudes are measured, said study co-author Philip Minderhoud, a hydrogeology professor at Wageningen University & Research in the Netherlands. And he attributed that to a “methodological blind spot” between the different ways those two things are measured.

Each way measures their own areas properly, he said. But where sea meets land, there’s a lot of factors that often don’t get accounted for when satellites and land-based models are used. Studies that calculate sea level rise impact usually “do not look at the actual measured sea level so they used this zero-meter” figure as a starting point, said lead author Katharina Seeger of the University of Padua in Italy. In some places in the Indo-Pacific, it’s close to 3 feet (1 meter), Minderhoud said.

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Dilrukshan Kumara looks at the ocean as he stands by the remains of his family’s home in Iranawila, Sri Lanka, June 15, 2023. (AP Photo/Eranga Jayawardena, File)

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One simple way to understand that is that many studies assume sea levels without waves or currents, when the reality at the water’s edge is of oceans constantly roiled by wind, tides, currents, changing temperatures and things like El Niño, said Minderhoud and Seeger.

Adjusting to a more accurate coastal height baseline means that if seas rise by a little more than 3 feet (1 meter) — as some studies suggest will happen by the end of the century — waters could inundate up to 37% more land and threaten 77 million to 132 million more people, the study said.

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That would trigger problems in planning and paying for the impacts of a warming world.

People at risk

“You have a lot of people here for whom the risk of extreme flooding is much higher than people thought,’’ said Anders Levermann, a climate scientist at the Potsdam Institute for Climate Impacts Research in Germany, who wasn’t part of the study. And Southeast Asia, where the study finds the biggest discrepancy, has the most people already threatened by sea level rise, he said.

Minderhoud pointed to island nations in that region as an area where the reality of discrepancy hits home.

Children play on an uprooted tree along a beach in Mele, Vanuatu, July 19, 2025, that was once lined with vegetation, now largely lost to storms, erosion and other environmental pressures. (AP Photo/Annika Hammerschlag, File)

Children play on an uprooted tree along a beach in Mele, Vanuatu, July 19, 2025, that was once lined with vegetation, now largely lost to storms, erosion and other environmental pressures. (AP Photo/Annika Hammerschlag, File)

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For 17-year-old climate activist Vepaiamele Trief, the projections aren’t abstract. On her island home in the South Pacific archipelago of Vanuatu, the shoreline has visibly retreated within her short lifetime, with beaches eroded, coastal trees uprooted and some homes now barely 3 feet (about 1 meter) from the sea at high tide. On her grandmother’s island of Ambae, a coastal road from the airport to her village has been rerouted inland because of encroaching water. Graves have been submerged and entire ways of life feel under threat.

“These studies, they aren’t just words on a paper. They aren’t just numbers. They’re people’s actual livelihoods,” she said. “Put yourself in the shoes of our coastal communities — their lives are going to be completely overturned because of sea level rise and climate change.”

Paying attention to the starting point

This new study is pretty much about what is the truth on the ground.

Calculations that may be correct for the seas overall or for the land aren’t quite right at that key intersection point of water and land, Seeger and Minderhoud said. It’s especially true in the Pacific.

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Gravestones sit submerged in water on Pele Island, Vanuatu, a country heavily affected by rising seas July 18, 2025. (AP Photo/Annika Hammerschlag, File)

Gravestones sit submerged in water on Pele Island, Vanuatu, a country heavily affected by rising seas July 18, 2025. (AP Photo/Annika Hammerschlag, File)

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“To understand how much higher a piece of land is than the water, you need to know the land elevation and the water elevation. And what this paper says the vast majority of studies have done is to just assume that zero in your land elevation dataset is the level of the water. When in fact, it’s not,” said sea level rise expert Ben Strauss, CEO of Climate Central. His 2019 study was one of the few the new paper said got it right.

“It’s just the baseline that you start from that people are getting wrong,” said Strauss, who wasn’t part of the research.

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Maybe not so bad, some scientists say

Other outside scientists said that Minderhoud and Seeger may be making too much of the problem.

“I think they’re exaggerating the implications for impact studies a bit — the problem is actually well understood, albeit addressed in a way that could probably be improved,” said Gonéri Le Cozannet, a scientist at the French geological survey. Most local planners know their coastal issues and plan accordingly, Rutgers University sea level expert Robert Kopp said.

That’s true in Vietnam in the high-impact area, Minderhoud said. They have an accurate sense of elevation, he said.

The findings come as a new UNESCO report warns of major gaps in understanding how much carbon the ocean absorbs. That report said that models differ by 10% to 20% in estimating the size of that carbon sink, raising questions about the accuracy of global climate projections that rely on them.

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The coastline of Efate Island, Vanuatu is visible on July 19, 2025. (AP Photo/Annika Hammerschlag, File)

The coastline of Efate Island, Vanuatu is visible on July 19, 2025. (AP Photo/Annika Hammerschlag, File)

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Together, the studies suggest governments may be planning for coastal and climate risks with an incomplete picture of how the ocean is changing.

“When the ocean comes closer, it takes away more than just the land we used to enjoy,” said Thompson Natuoivi, a climate advocate for Save the Children Vanuatu.

“Sea level rise is not just changing our coastline, it’s changing our lives. We are not talking about the future — we’re talking about the right now.”

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The Associated Press receives support from the Walton Family Foundation for coverage of water and environmental policy. The AP is solely responsible for all content. For all of AP’s environmental coverage, visit https://apnews.com/hub/climate-and-environment

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Israel hammers Iranian internal security command centers to open door to uprising

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Israel hammers Iranian internal security command centers to open door to uprising

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The Israeli military’s latest wave of airstrikes in Iran dealt a serious blow to the country’s brutal internal security apparatus, opening the door for a potential uprising.

During the strikes, Israel “dropped dozens of munitions on the Basij and internal security command centers that are subject to the Iranian terror regime,” the Israel Defense Forces (IDF) said in a statement on Wednesday. “The targeted command centers were used by the Iranian regime to maintain control throughout Iran and maintain the regime’s situational assessments.”

Since the start of Operation Epic Fury, the U.S. has hit nearly 2,000 targets as it carries out a sweeping military campaign aimed at dismantling the regime’s security apparatus and neutralizing threats. Adm. Brad Cooper of U.S. Central Command confirmed the number of targets hit in a video message.

The Islamic Revolutionary Guard Corps (IRGC) and the Basij militia, Iran’s volunteer paramilitary force, were behind the violent crackdown on protesters in January. The bloody crackdown saw regime actors firing on crowds and conducting mass arrests of Iranian protesters. Some had seen the protests as a sign that regime change in Iran was getting nearer, though it did not occur.

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Smoke rises from central Tehran following reported U.S. and Israeli strikes on Iran’s capital, on March 3, 2026. (Fatemeh Bahrami/Anadolu via Getty Images)

Israeli and U.S. officials have hinted at the possibility of regime change in Iran as both countries take aim at Tehran’s military and security sites.

Israeli Prime Minister Benjamin Netanyahu said in a video message announcing the launch of Operation Epic Fury, which Israel calls Operation Rising Lion, that it was time for Iranians “to rid themselves of the yoke of tyranny.” Similarly, President Donald Trump said in a message to the Iranian people on Feb. 28 that “the hour of your freedom is at hand.”

“When we are finished, take over your government. It will be yours to take. This will be, probably, your only chance for generations,” Trump said.

Plumes of smoke rise following reported explosions in Tehran on March 3, 2026, after Iranian Supreme Leader Ayatollah Ali Khamenei was killed in joint U.S. and Israeli strikes on Feb. 28, 2026. (Negar/Middle East Images / AFP via Getty Images)

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ISRAELI MINISTER OUTLINES IRAN MISSION GOALS, SAYS IRANIAN PEOPLE NOW HAVE CHANCE TO ‘REGAIN THEIR FREEDOM’

“America is backing you with overwhelming strength and devastating force. Now is the time to seize control of your destiny, and to unleash the prosperous and glorious future that is close within your reach. This is the moment for action. Do not let it pass,” the president added.

Ali Vaez, director of the Iran project at the International Crisis Group, told The Wall Street Journal that the path to regime change through foreign airstrikes and popular uprising on the ground has “a bet that rests on no clear historical model.” Vaez also warned that the idea “ignores the resilience of entrenched authoritarian systems like the Islamic Republic.”

The IDF said on Monday that Israel had hit headquarters, bases and regional command centers that belonged to the regime’s internal security apparatus.

“These bodies were responsible for, among other things, suppressing protests against the regime through violent measures and civilian arrests,” the IDF said.

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A group of men inspects the ruins of a police station struck amid the U.S.–Israeli military campaign in Tehran, Iran, on Tuesday, March 3, 2026. (Vahid Salemi/AP)

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It is unclear who will lead Iran after Supreme Leader Ayatollah Ali Khamenei was killed on the first day of the operation. Since then, Israel and the U.S. have made it clear that regime leaders chosen to replace him would be targets. Israeli Defense Minister Israel Katz warned on Wednesday that anyone chosen to replace Khamenei would be considered “a target for elimination” if they continued to threaten Israel, the U.S. and regional allies.

The killing of key leaders might not be enough to cause an uprising, as the regime has a monopoly on weapons in most of Iran, the WSJ reported, adding that Basij militants are still patrolling the streets.

Fox News Digital’s Morgan Phillips and Efrat Lachter contributed to this report.

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Which oil and gas facilities in the Gulf have been attacked?

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Which oil and gas facilities in the Gulf have been attacked?

Global energy markets remain in a state of high alert after several Gulf states suspended oil and gas production following escalating tensions in the region.

Since Saturday’s attacks by the United States and Israel, Tehran has targeted various sites in Israel and across several Gulf countries.

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Initially, these Iranian attacks focused primarily on US military assets, but Gulf states have reported that Iran has since broadened its scope to target civilian infrastructure, including hotels, airports and energy facilities. Iranian officials have publicly denied targeting Gulf energy facilities, however.

The Middle East remains the world’s dominant source of hydrocarbon reserves and a major driver of crude oil and natural gas output.

How much oil and gas does the Middle East have?

Nearly half of the world’s oil reserves and exports come from the Middle East, which contains five of the seven largest oil reserves in the world.

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Once refined, crude oil is used to make various products, including petrol, diesel, jet fuel and a wide range of household items such as cleaning products, plastics and even lotions.

After Venezuela, which has 303 billion barrels, Saudi Arabia holds the world’s second-largest proven crude oil reserves, estimated at 267 billion barrels.

The Middle East’s largest oil reserves:

  • Saudi Arabia: 267 billion barrels
  • Iran: 209 billion barrels
  • Iraq: 145 billion barrels
  • UAE: 113 billion barrels
  • Kuwait: 102 billion barrels

Saudi Arabia is also the world’s top oil exporter with an estimated $187bn of crude in 2024, according to data from the Observatory of Economic Complexity (OEC).

The Middle East’s top oil exporters:

  • Saudi Arabia: $187bn
  • UAE: $114bn
  • Iraq: $98bn
  • Iran: $47bn – largely sold at a discount due to US sanctions
  • Kuwait: 29bn

Other Middle Eastern countries with sizeable oil exports include: Oman ($28.9bn), Kuwait ($28.8bn) and Qatar ($21bn).

(Al Jazeera)

In addition to crude oil, the Middle East is a global powerhouse for natural gas, accounting for nearly 18 percent of global production and approximately 40 percent of the world’s proven reserves.

Natural gas is primarily used for electricity generation, industrial heating, and in chemicals and fertilisers.

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The heart of Middle Eastern gas is a single, massive underwater reservoir called the South Pars/North Dome field. It is the largest gasfield in the world, and it is shared directly between Qatar and Iran.

Gas is transported either through pipelines or by tankers. When using pipelines, the gas is pressurised and moved through steel networks. When pipelines are not feasible, such as across oceans, Liquefied Natural Gas (LNG) is used.

To create LNG, the gas is cooled to approximately -162C (-260F), shrinking its volume and allowing it to be safely loaded onto specialised tanker ships for global transport.

To transport oil and gas, tankers from various Gulf states must navigate the narrow waterway known as the Strait of Hormuz. Approximately one-fifth of global oil and gas passes through this strait, primarily heading to major markets in Asia, including China, Japan, South Korea and India, as well as to Europe.

INTERACTIVE - Strait of Hormuz - FEB24, 2026-1772104775
(Al Jazeera)

Which energy facilities have been attacked?

Here are the facilities which have recorded damage as of Wednesday:

Saudi Arabia – Ras Tanura oil refinery

On Monday, one of the world’s largest oil refining complexes, the Ras Tanura oil refinery owned by Saudi Aramco, was forced to halt operations after debris from intercepted Iranian drones caused a small fire.

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This handout satellite image courtesy of Vantor taken and released on March 2, 2026, shows damage at the Saudi Aramco's Ras Tanura refinery.
This handout satellite image, courtesy of Vantor, released on March 2, 2026, shows damage at Saudi Aramco’s Ras Tanura refinery [AFP]

Saudi Aramco is one of the world’s largest companies, with a market capitalisation exceeding $1.7 trillion and revenue of $480bn. Headquartered in Dhahran, in eastern Saudi Arabia, Aramco controls 12 percent of global oil production, with a capacity of more than 12 million barrels per day (bpd).

On Wednesday, Saudi defence officials reported a second drone attempt on the facility but this was successfully intercepted with no damage or disruption to operations reported.

Qatar – Ras Laffan Industrial City LNG facilities

On Monday, Qatar’s Ministry of Defence reported that Iranian drones had targeted an energy facility in Ras Laffan belonging to QatarEnergy, the world’s largest LNG producer.

While no casualties were reported, QatarEnergy suspended the production of LNG and other products at the impacted sites.

RAS LAFFAN INDUSTRIAL CITY, QATAR - MARCH 3: A picture of Qatar Energy's operating facilities on March 3, 2026 in Ras Laffan Industrial City, Qatar. Qatar Energy announced a complete halt to liquefied natural gas (LNG) production at its Ras Laffan and Mesaieed facilities on March 2, 2026, after Iranian attacks targeted energy facilities. (Photo by Getty Images)
QatarEnergy’s operating facilities on March 3, 2026, in Ras Laffan Industrial City, Qatar [Getty Images]

QatarEnergy’s 81 million metric tonnes of LNG exports are mostly bound for Asian markets, including China, Japan, India, South Korea, Pakistan and other countries in the region. The halt in production hiked global gas prices to a three-year high this week.

Qatar – Mesaieed Industrial City

Qatar’s Defence Ministry said the country was attacked by a second drone launched from Iran on Monday, targeting a water tank belonging to a power plant in Mesaieed, without reporting any casualties.

On Tuesday, QatarEnergy also stopped production of some downstream products like urea, polymers, methanol, aluminium and others.

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UAE – Fujairah and Mussafah oil terminals

On Monday, a fire broke out at Mussafah Fuel Terminal in southwest Abu Dhabi after it was struck by a drone.

On Tuesday, falling debris from a drone interception caused a fire at the Fujairah Oil Terminal along the eastern coast of the United Arab Emirates. No injuries were reported.

Large fire and plume of smoke is visible after, according to the authorities, debris of an Iranian intercepted drone hit the Fujairah oil facility, in Fujairah, United Arab Emirates, Tuesday, March 3, 2026. (AP Photo/Altaf Qadri)
A large fire and plume of smoke are visible after debris from an intercepted Iranian drone hit the Fujairah oil facility, in Fujairah, United Arab Emirates, on Tuesday, March 3, 2026, according to authorities [Altaf Qadri/AP Photos]

Oman – ports of Duqm and Salalah

On Tuesday, multiple Iranian drones struck fuel tanks and a tanker at the port of Duqm, with at least one direct hit on a fuel storage tank, causing an explosion.

On the same day, a drone strike was recorded at the Port of Salalah, which handles fuel and industrial minerals.

Athe Nova – oil tanker

On Monday, the Athe Nova, a Honduran-flagged tanker positioned off the coast of Khor Fakkan, UAE, was struck by Iranian drones as it was transiting the Strait of Hormuz, setting it ablaze. Despite the fire, the vessel managed to exit the chokepoint into the Gulf of Oman, and no casualties were reported.

Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed responsibility for the strike, identifying the Athe Nova as an “ally of the United States”.

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On the same day as the attack, Iran declared the Strait of Hormuz closed, warning that any ship attempting to pass would be “set ablaze”.

Since then, several other tankers have been hit.

INTERACTIVE_IRAN_GCC_OIL AND GAS SUPPLY-ATHE_NOVA_MARCH4_2026
(Al Jazeera)

Other regional energy disruptions

Although not directly targeted, the following energy sites suspended operations in response to Iranian retaliatory attacks:

Israeli offshore gasfields – Major gas production fields such as Leviathan and Tamar were shut down as a precaution following regional drone and missile launches linked to Iran.

Oil fields in semiautonomous Iraqi Kurdistan – Producers including DNO, Gulf Keystone and Dana Gas halted output as a safety measure amid the escalation.

Rumaila oilfield – Operations at Iraq’s largest oilfield – operated by BP – in southern Iraq were halted on Tuesday as a security precaution due to its proximity to the escalation zone.

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