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Use of Wegovy and other weight-loss drugs soars among kids and young adults

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Use of Wegovy and other weight-loss drugs soars among kids and young adults

At 17, Israel McKenzie was so burdened by obesity that he stopped going to high school in person and was embarrassed to speak to people at his restaurant job.

“I was in a really dark place,” says McKenzie, whose weight had climbed to 335 pounds on his 6-foot-1 frame, despite repeated efforts to diet and exercise. “I had given up hope.”

But last year, the weight-loss drug Wegovy helped him shed 110 pounds in nine months, making the rural Tennessee teen part of a surge of adolescents and young adults using diabetes and obesity medications known as GLP-1 receptor agonists, new research shows.

Even as millions of older adults clamor for drugs such as Ozempic and Wegovy, monthly use of the medications soared in people aged 12 to 25. That’s according to the new analysis of dispensing records from nearly 94% of U.S. retail pharmacies from 2020 to 2023.

The report, published in the journal JAMA on Wednesday, used the IQVIA prescription database to compile the first look at the national uptake of GLP-1 drugs among that age group. Nearly 31,000 children aged 12 to 17 and more than 162,000 people aged 18 to 25 used the medications in 2023 alone, said Dr. Joyce Lee, a University of Michigan pediatrician and diabetes expert who led the research.

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“What it’s suggesting is that it’s one of the tools in the toolbox and there are more providers prescribing this medication for the population,” she said.

The report shows that the number of 12- to 25-year-olds using any GLP-1 drug — including older medications first approved to treat diabetes in 2005 and for weight loss in 2014 — climbed from about 8,700 a month in 2020 to more than 60,000 a month in 2023, a nearly 600% increase. The rise occurred even as prescriptions of other drugs among those patients fell by about 3%.

Those who received the drugs were just a fraction of young people who struggle with obesity, Lee noted. About 20% of U.S. children and adolescents and about 42% of adults have the chronic disease, according to the U.S. Centers for Disease Control and Prevention.

In early 2023, the American Academy of Pediatrics recommended that children and teens with obesity be evaluated early and treated aggressively, including with surgery and medication if warranted.

McKenzie, the Tennessee teen, said he began gaining weight five years ago, during puberty.

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“I started turning to food for all of my problems,” he said.

The extra weight made his asthma worse and put him in danger of developing diabetes, his doctor said. He tried to follow medical advice by cutting out sugary soda and snack foods and exercising more, but the efforts failed to make a difference.

“My old doctor told me there was nothing he could do,” he said. “He told me it was my fault.”

In early 2023, McKenzie connected with Dr. Joani Jack, a pediatric obesity specialist at Children’s Hospital at Erlanger in Chattanooga, Tennessee, who regularly prescribes GLP-1 drugs for kids.

“I told him I’ve seen 10 other people just like you today and we have lots of tools and treatment options,” Jack said. Those typically include intensive behavioral and nutrition interventions combined with medication, if necessary.

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In McKenzie’s case, Jack prescribed the weight-loss drug Wegovy, which in late 2022 was approved for use in U.S. children over age 12. More than 6,000 kids in that age group received Wegovy in 2023, the new data show. More than 7,600 received Ozempic, which is approved to treat diabetes in adults, but can be used off-label in adolescents. Others received older GLP-1 drugs such as Saxenda and Trulicity.

McKenzie said he had no notable side effects from the medication, but Lee noted that some young people report nausea, vomiting or constipation, including symptoms so serious that they stop the drugs.

It’s important to understand the surging use of these medications in young people, Lee said. The drugs are meant for continuing use, so “we really need to think about the long-term safety and effectiveness of these medications for this population,” she said.

In addition, the drugs are expensive and often difficult to obtain, either because of supply problems or because they’re not covered by insurance.

Notably, government-run Medicaid plans paid for nearly half of the GLP-1 drugs prescribed to 12- to 17-year-olds and about a quarter of those used by people aged 18 to 25, the research found. Commercial insurance covered care for nearly 44% of the younger kids and about two-thirds of those who were older.

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Today, McKenzie says his asthma is better and he looks forward to interacting with co-workers and friends.

“I have a lot of self-confidence now, a lot more than I used to,” he said. “It has changed everything.”

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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Armed men fire on Haiti hospital reopening, killing at least 2

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Armed men fire on Haiti hospital reopening, killing at least 2
At least two people were killed and others injured on Tuesday when armed men opened fire on a group of journalists who gathered for a government press conference set to announce the reopening of Haiti’s largest public hospital, a witness to the attack told Reuters.
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US citizen imprisoned in Russia given new 15-year sentence in wake of espionage conviction

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US citizen imprisoned in Russia given new 15-year sentence in wake of espionage conviction

A Russian-born U.S. citizen who was already behind bars in Russia on a bribery conviction has been handed a second sentence for espionage.

Eugene Spector was sentenced to a new 15-year term for his espionage conviction, according to Russian news agencies. Spector was born and raised in Leningrad, Russia, but later moved to the U.S. and became a citizen.

A Moscow court brought espionage charges against Spector in August of last year, although details surrounding the case were not made publicly available.

RUSSIA ARRESTS US CITIZEN ON ESPIONAGE CHARGES: REPORT

Eugene Spector, a Russian-born U.S. citizen already imprisoned in Russia on a bribery conviction, has been handed a second 15-year jail term for espionage. (AP)

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The U.S. State Department said it was aware of reports of a U.S. citizen in Russia being sentenced and that it was monitoring the situation.

Spector, a former executive at a medical equipment company in Russia, was sentenced in September 2022 to three and a half years in prison for enabling bribes to an aide of former Russian Deputy Prime Minister Arkady Dvorkovich.

WALL STREET JOURNAL’S EVAN GERSHKOVICH REVEALS SHADOWY KREMLIN FIGURE BEHIND IMPRISONMENT IN RUSSIA

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A Moscow court brought espionage charges against Spector in August of last year. (iStock)

The aide, Anastasia Alekseyeva, was sentenced to 12 years in April for accepting bribes of two expensive overseas vacation trips.

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Dvorkovich was a deputy prime minister under former Russian Prime Minister Dmitry Medvedev in 2012 to 2018. Dvorkovich is currently head of the international chess federation FIDE.

The Associated Press contributed to this report.

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Passenger plane crashes in Kazakhstan: Emergencies ministry

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Passenger plane crashes in Kazakhstan: Emergencies ministry

BREAKING,

Passenger plane crashed near the city of Aktau.

An passenger plane flying from Azerbaijan to Russia crashed near the city of Aktau in Kazakhstan, the Central Asian country’s Emergencies Ministry said in a statement.

Fourteen people had survived the crash and had been hospitalised, according to the local health officials.

“At the moment, 14 survivors have been taken to the regional hospital, including five in intensive care,” the health ministry’s regional department said in a statement. The Emergencies Ministry said fire services had put out the blaze

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Azerbaijan Airlines said the Embraer 190 aircraft, with flight number J2-8243, had been flying from Baku to Grozny, the capital of Russia’s Chechnya, but had been forced to make an emergency landing approximately 3 km (1.8 miles) from the Kazakh city of Aktau.

Russian news agencies said the plane had been rerouted due to fog in Grozny.

Authorities in Kazakhstan said they had begun looking into different possible versions of what had happened, including a technical problem, Russia’s Interfax news agency reported.

More to follow.

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