The NFL’s Week 6 will kick off with a “Thursday Night Football” matchup between two teams coming off head-scratching losses: the San Francisco 49ers (2-3) and Seattle Seahawks (3-2).

Last week’s second half was one to forget for San Francisco. After leading the Arizona Cardinals by 13 at halftime, the 49ers failed to score in the final 30 minutes while the Cardinals stormed back to steal one on the road. Holding onto leads has been an issue for San Francisco, and something that’ll need to be fixed soon if it wants to contend.

Not many people expected Daniel Jones to survive the hostile Seattle crowd, but the New York Giants quarterback stepped up and delivered a surprising win in the Pacific Northwest. Seattle has now lost two-in-a-row, and in a middling NFC West, the Seahawks need a win to keep their lead.

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Seahawks vs. 49ers odds, moneyline, over/under

The 49ers are favorites to defeat the Seahawks, according to BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

• Spread: 49ers (-3.5)
• Moneyline: 49ers (-190); Seahawks (+155)
• Over/under: 47.5

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NFL Week 6 odds, predictions and picks

Seahawks vs. 49ers | Bears vs. Jaguars | Ravens vs. Commanders | Packers vs. Cardinals | Patriots vs. Texans | Saints vs. Buccaneers | Eagles vs. Browns | Titans vs. Colts | Broncos vs. Chargers | Raiders vs. Steelers | Panthers vs. Falcons | Cowboys vs. Lions | Giants vs. Bengals  | Jets vs. Bills

Lorenzo Reyes: 49ers 25, Seahawks 17

There is some concern over San Francisco’s recent issues finishing games, but the good news for the Niners is many of the issues cropped up because of self-inflicted errors. The 49ers are very talented and should be able to increase their discipline and focus. This could also serve as a wake-up call and might be a nice buy-low chance. And Seattle is too unreliable.

Tyler Dragon: 49ers 25, Seahawks 20

Are the 49ers in the midst of a Super Bowl hangover? They had a two-score lead at home in the second half against Arizona last week and still managed to lose. San Francisco is underachieving at the moment. Seattle at 3-2 is the only team in the NFC West with a winning record. But the Seahawks have lost five consecutive games versus San Francisco.

Jordan Mendoza: 49ers 26, Seahawks 20

Two teams needing to turn the page, expect the defenses to hold up early before each offense breaks through. Even if it’s in Seattle, the 49ers have won two-straight at Lumen Field. Make it three-in-a-row to put a tie on top of the NFC West.

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