Health
Woman with muscular dystrophy completes 12 marathons in wheelchair for charity: ‘Won’t let it define me’
Born with a rare form of muscular dystrophy, Peri Finkelstein has never let her disorder define her.
Instead, the 24-year-old New Yorker has used her challenges as a springboard to make the world a better place, completing 12 marathons to raise funds for charity.
In January 2024, Finkelstein’s nonprofit organization — the Team Peri Foundation — exceeded the $1 million fundraising milestone for its Chai Lifeline project, which offers support to families following an illness diagnosis or trauma.
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Making an impact
Muscular dystrophy is a group of more than 30 genetic conditions that affect the functioning of the muscles, according to Cleveland Clinic.
Peri Finkelstein, 24, has raised more than $1 million to help children with deadly diseases, partly through her marathon events. (Team Peri Foundation)
Finkelstein’s form of the condition, called nemaline rod myopathy, causes severe muscle weakness and affects her speech and mobility.
Despite her physical limitations, she was inspired to start doing marathons in 2010 when her mother and brother began running them for charity.
“After watching everybody do the marathon and cheering from the sidelines, I knew that I wanted to make more of an impact,” she said during an interview with Fox News Digital.
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For the first few years, Finkelstein’s mother pushed her in a jogging stroller with all the necessary medical equipment secured to the bottom.
Then, in 2016, Finkelstein decided it was time to stand up and walk a few steps over the finish line, with the help of her physical therapist and her parents.
Finkelstein heads toward the finish line of a marathon in Miami, Florida, in February 2024. (Team Peri Foundation)
“At that moment, it felt as if I could do anything that I put my mind to,” she said.
“It was a defining moment, when I realized the only person who could get in my way was myself — and that it was up to me to change my life.”
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In subsequent marathons, those initial steps turned into walking more than 1,000 steps, then a mile, and then a mile and a half, forwards and backwards across the finish line.
After several years of pushing that “extra mile,” Finkelstein experienced medical challenges in 2022 that made her unable to compete.
“It never dawned on me that part of my life would be over,” she said.
“You have to push yourself to the limit for each mile marker, as nothing will ever come easily.”
“Once I officially lost that part of myself, I realized that I couldn’t allow this setback to get to me — I knew that I had to keep moving.”
Instead of competing physically, Finkelstein now funnels her energy into her foundation’s fundraising efforts.
Finkelstein’s form of muscular dystrophy, nemaline rod myopathy, causes severe muscle weakness and affects her speech and mobility. “Not every day is all rainbows and sunshine,” she said. (Claudio Papapietro)
“Since I was 8 years old, my dream was to launch a nonprofit organization of my own,” she said.
“The same mindset that I used to prepare both physically and mentally for a marathon is what I carry into my daily life as an entrepreneur.”
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The Team Peri Foundation strives to make the world a “more connected and inclusive place for all,” Finkelstein said, with the mission to “educate others on the power of inclusion and to disrupt the stereotypical views revolving around disability.”
‘Not all rainbows and sunshine’
While Finkelstein strives to stay positive and focus on her goals, she acknowledges that her day-to-day life isn’t always easy.
Finkelstein’s family and friends support her during a marathon in Miami. (Team Peri Foundation)
“Not every day is all rainbows and sunshine — some days are harder than others, to the point where severe migraines, fatigue and pain keep me from doing what I have to do,” she said.
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Finkelstein undergoes different forms of therapy multiple times a week, has frequent doctor’s appointments and is “always in pain,” she shared.
Her social media posts highlight the highs and lows.
Finkelstein is pictured with her parents, Paul and Lori Finkelstein, on the day her foundation hit the $1 million fundraising mark in January 2024. (Team Peri Foundation)
“My hope is that by sharing bits and pieces of my world — portraying all the different sides of me, whether it’s rather dark or filled with light — I can portray that people with disabilities can live a full life and step out of line in ways that can change the course of their future,” she said.
To other people living with a disabling condition, Finkelstein advises them, “Use your rareness to your advantage.”
“My time is precious and I still have a lot more to accomplish.”
“Growing up, I would give anything to blend in and become invisible, as being ‘different’ put a lot of labels on me that caused me to be bullied severely by students and teachers alike,” she said.
“But as I’ve gotten older, I’ve realized it’s OK to be rare.”
Finkelstein is pictured with her siblings, Katy Finkelstein (right) and Joel Finkelstein, in January 2024. She credits her family with supporting her through all her endeavors. (Barbara Quagliard)
Life itself can be compared to the dozen marathons she has competed in, according to Finkelstein.
“You have to push yourself to the limit for each mile marker, as nothing will ever come easily,” she said.
“All the pain, traumas and setbacks are what enable you to keep going and keep hustling.”
“You have to power through the pain, because there is no other option.”
Future goals
Since hitting the $1 million milestone, Finkelstein and her foundation have launched new projects, including a scholarship fund in partnership with Adelphi University, where she earned her MBA in marketing.
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She also works to boost awareness and education through speaking engagements, social media and podcasting, and hosts various fundraising events throughout the year.
Finkelstein plans to write and publish a memoir to share her life’s journey with the world.
“It’s always in the back of my mind that I cannot wait to live my life — because of physical disability and medical challenges, it could be cut short,” Finkelstein said. (Team Peri Foundation)
“While I used to be an athlete, I am still just as competitive and am somewhat of an overachiever in the real world,” Finkelstein said.
The entrepreneur is also acutely aware that life is short.
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“It’s always in the back of my mind that I cannot wait to live my life — because of physical disability and medical challenges, it could be cut short,” she said.
“My time is precious, and I still have a lot more to accomplish.”
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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