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Arizona Cardinals vs San Francisco 49ers picks, predictions: Who wins NFL Week 5 game?

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Arizona Cardinals vs San Francisco 49ers picks, predictions: Who wins NFL Week 5 game?


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The Arizona Cardinals and San Francisco 49ers play on Sunday, Oct. 6, at Levi’s Stadium in a game on the NFL Week 5 schedule.

Which team will win the NFL Week 5 game?

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Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, which can be seen at 1:05 p.m. MST on FOX (stream with free trial from FUBO).

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook.

San Francisco is -375 on the moneyline, while Arizona is +300.

The over/under (point total) is set at 49.5 points.

Watch Cardinals at 49ers live with FUBO (free trial)

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Jeremy Cluff writes: “The 49ers are the biggest favorite of the week. Can the Cardinals shock San Francisco? Can they even keep this game close? Not the way they are playing.”

NFL power rankings Week 5: Where are the 49ers, Cardinals now?

Bookies.com: Bet the Cardinals with the points vs 49ers

Bill Speros writes: “The 49ers active roster remains in flux. But their defense will be enough to win this one at home. But a full TD cover might be too much to ask, especially given how the Cardinals can score big-yardage-play TDs with Kyler Murray and Marvin Harrison Jr. Especially in garbage time.”

NFL Week 5 odds: Point spreads, moneylines, over/unders for betting on NFL games this week

The site’s formula predicts that the Cardinals will win the NFL Week 5 game against the 49ers.

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NFL Week 5 schedule: Television channels, how to watch, stream games

ESPN: 49ers have a 70.5% chance to beat Cardinals on Sunday

The site gives the Cardinals a 29.2% shot at winning the NFL Week 5 game, with the remaining percentage accounting for a tie.

Super Bowl odds 2025: Who are the betting favorites now?

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Dimers: 49ers 26, Cardinals 19

It writes: “After extensive simulations, our model gives the Cardinals a win probability of 23%, while the 49ers have a win probability of 77%.”

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We occasionally recommend interesting products and services. If you make a purchase by clicking one of the links, we may earn an affiliate fee. USA TODAY Network newsrooms operate independently, and this doesn’t influence our coverage.

NFL’s highest paid players in 2024: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Highest paid players: Overall | By position | By team

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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San Francisco, CA

Yes, an $8 Burger Exists in Downtown San Francisco

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Yes, an  Burger Exists in Downtown San Francisco


Sometimes life requires an easy hang, without the need for reservations and dressing up, and preferably with food that’s easy to rally folks behind. The newish Hamburguesa Bar is just such a place, opening in December 2025 and serving a tight food menu of smash and tavern burgers (made with beef ground in-house), along with hand-cut duck fat fries, poutine, and Caesar salad. The best part? Nothing here costs more than $20. Seriously, this spot has so much going for it, including solid cocktails and boozy shakes. It’s become a homing beacon for post-work hangs, judging by a recent weekday crowd.

Hamburguesa Bar’s drinks are the epitome of unfussy: Cocktail standards, four beers on tap, two choices of wine (red or white), boozy and non-boozy shakes, plus 21 beers by the can or bottle. Standards on the cocktail menu are just that, a list of drinks you’ve heard before — such as an Old Fashioned, daiquiri, gin or vodka martini, or Harvey Wallbanger — with no special tinctures or fat-washed liquors to speak of (that we know of, at least). I’m typically split on whether boozy shakes are ever worth it, but the Fruity Pebbles option ($14) makes a convincing case, mixed with a just-right amount of vodka and some cereal bits. (I’ll leave the more adventurous Cinnamon Toast shake made with Fireball to others with more positive experiences with that liquor.)

Downtown and SoMa has a reputation for restaurants closing early, but Hamburguesa Bar keeps later hours, closing at midnight from Monday through Saturday (closed Sundays). It’s also open for lunch at noon during those days, with the exception of Saturdays when it opens at 5 p.m.



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Iran conflict disrupts flights out of SFO

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Iran conflict disrupts flights out of SFO


SAN FRANCISCO (KRON) — Attacks on Iran by U.S. and Israeli forces have disrupted air travel across the Middle East, leading to thousands of flight cancellations and delays worldwide. The instability has reached the Bay Area, where international flights at San Francisco International Airport have been canceled or grounded. The travel disruptions followed retaliatory strikes […]



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Hundreds Rally in San Francisco Against U.S.-Israel Strikes on Iran | KQED

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Hundreds Rally in San Francisco Against U.S.-Israel Strikes on Iran | KQED


She acknowledged that Iranian Americans hold a range of political views, including some who support U.S. intervention, but said she believes the future of Iran should be determined by its people.

“The Iranian people in Iran can decide the future of their country,” she said. “War, I don’t think, is going to help.”

Speaking to the crowd, Mortazavi challenged what she described as a narrative that Iranians broadly support U.S. and Israeli military action.

“They want you to believe that every Iranian … is cheering on the United States and Israel,” she said. “That is unequivocally false.”

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She urged attendees to continue organizing beyond the rally and announced plans for additional demonstrations.

A demonstrator holds an Iranian flag as protesters gather outside the San Francisco Federal Building during a “Hands Off Iran” rally Feb. 28, 2026, in San Francisco. The demonstration called for an end to U.S. involvement in the strikes on Iran. (Gustavo Hernandez/KQED)

Dina Saadeh, an organizer with the Palestinian Youth Movement, said multiple groups mobilized quickly in response to the strikes.

“I’m angered today,” Saadeh told KQED. “People here don’t want to see our country engaged in more endless war.”

Saadeh described the protest as part of a broader effort to oppose sanctions, military escalation and what she called U.S. imperialism. She said participants were calling on elected officials to redirect public funds toward domestic needs.

“People want money for jobs and education, not for war and occupation,” she said.

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KQED’s María Fernanda Bernal contributed to this story.



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