Oregon
Oregon State researchers develop device for better delivery of gene therapy for lung disease
PORTLAND, Ore. – Drug delivery researchers at Oregon State University have developed a device with the potential to improve gene therapy for patients with inherited lung diseases such as cystic fibrosis.
In cell culture and mouse models, scientists in the OSU College of Pharmacy demonstrated a novel technique for the aerosolization of inhalable nanoparticles that can be used to carry messenger RNA, the technology underpinning COVID-19 vaccines, to patients’ lungs.
The findings are important because the current nebulization method for nanoparticles subjects them to shear stress, hindering their ability to encapsulate the genetic material and causing them to aggregate in certain areas of the lungs rather than spread out evenly, the researchers said.
The study led by Gaurav Sahay, a professor of pharmaceutical sciences, was published in ACS Nano.
Sahay’s lab studies lipid nanoparticles, or LNPs, as a gene delivery vehicle with a focus on cystic fibrosis, a progressive genetic disorder that results in persistent lung infection and affects 30,000 people in the U.S., with about 1,000 new cases identified every year.
One faulty gene – the cystic fibrosis transmembrane conductance regulator, or CFTR – causes the disease, which is characterized by lung dehydration and mucus buildup that blocks the airway.
Lipids are organic compounds containing fatty tails and are found in many natural oils and waxes, and nanoparticles are tiny pieces of material ranging in size from one- to 100-billionths of a meter. Messenger RNA delivers instructions to cells for making a particular protein.
With the coronavirus vaccines, the mRNA carried by the lipid nanoparticles instructs cells to make a harmless piece of the virus’ spike protein, which triggers an immune response from the body. As a therapy for cystic fibrosis, the genetic material would fix the flaw in patients’ CFTR gene.
“We utilized a novel microfluidic chip that helps in generation of plumes that carry nanoparticles and does not cause any shear stress,” Sahay said. “This device is based on the similar idea of an ink-jet cartridge that generates plumes to print words on paper.”
Four years ago, Sahay said, an Oregon-based startup called Rare Air Health Inc. contacted him about the prospect of using microfluidic technology for the aerosolization and delivery of lipid nanoparticles.
Microfluidics is the study of how fluids behave as they travel through or are confined in microminiaturized devices equipped with channels and chambers. Surface forces as opposed to volumetric forces dominate fluids at the microscale, meaning fluids act much differently there than what is observed in everyday life.
“When Rare Air came to me, I thought the device might work great for our purposes, and what followed were extensive studies that demonstrated the superiority of this device in generating aerosolized nanoparticles as compared to clinically used vibrating mesh nebulizers,” Sahay said. “The device does not let the nanoparticles aggregate and can deliver mRNA with higher precision than existing tech. The additional cool thing is that this device can be digitally controlled, and Rare Air is developing prototypes for human use.”
In addition to Sahay, the other Oregon State researchers on the study were Yulia Eygeris, Jeonghwan Kim, Antony Jozić and Elissa Bloom. Scientists from Funai Microfluidic Systems of Lexington, Kentucky, were also part of the collaboration.
“Funai focuses on inkjet tech and building these chips at scale; they worked closely to enable the device to be suitable for aerosolization,” said Sahay, who in addition to his role at OSU serves as an advisor and consultant to Rare Air. “This study demonstrates a marriage between new devices and formulation science that might hugely impact human health.”
Funding from the National Heart, Lung, and Blood Institute and Rare Air supported the study.
Entering the 2026 college football season, the Oregon Ducks are looking to not only win their first national championship in program history but also their second Big Ten title in the last three seasons.
When the Ducks joined the Big Ten in 2024, they kicked off their inaugural season in the conference in style, finishing the regular season undefeated at 13-0. This regular season was concluded with a thrilling 45-37 win over the Penn State Nittany Lions in the Big Ten championship game.
Eug 040522 Lanning 02 | USA TODAY Network via Reuters Connect
The Ohio State Buckeyes, however, got revenge for their loss to the Ducks at Autzen Stadium earlier in the regular season, beating Oregon 41-21 in the CFP Quarterfinal at the Rose Bowl. Entering the 2026 season, here’s a look at the Ducks’ chances of winning the Big Ten for the second time.
Oregon Ducks Big Ten Title Odds: Who’s The Biggest Threat?
According to the latest betting odds by FanDuel Sportsbook, the Ducks have +270 odds to win the Big Ten championship this season. The one team ahead of them is the Ohio State Buckeyes at +190, who, believe it or not, are in search of their first Big Ten title since 2020. The Buckeyes were upset by the Indiana Hoosiers 13-10 in the Big Ten championship last season.
Among the top teams in the Big Ten next season, Ohio State poses the biggest threat to the Ducks’ chances of not only winning a conference title but also the national championship. The Buckeyes and Ducks will face off in what could be the game of the year in Columbus on Nov. 7.
As exciting as this matchup will be for college football fans, it likely won’t be the only one between the Buckeyes and Ducks. Regardless of which team wins the Nov. 7 showdown in Columbus, the Buckeyes and Ducks could match up again in the Big Ten title game and in the CFP.
Other Teams That Pose a Threat to Oregon
While the Buckeyes are the main threat to the Ducks’ Big Ten title aspirations, other teams will be worth watching. One of those teams is the defending national champions, the Indiana Hoosiers.
Despite the key losses this offseason, which include Heisman Trophy-winning quarterback Fernando Mendoza, coach Curt Cignetti’s Hoosiers restocked talent with the addition of TCU Horned Frogs transfer quarterback Josh Hoover and Michigan State Spartans wide receiver Nick Marsh.
The only two losses that the Ducks suffered last season came against the Hoosiers. If the two face off in the Big Ten championship, Indiana looks to continue its dominance over the Ducks. The Hoosiers and Ducks don’t play each other during the regular season.
The USC Trojans, whom the Ducks will face at the Los Angeles Coliseum on Sept. 26, also look to knock off Oregon in what should be one of the top games of the first month of the college football season. Oregon coach Dan Lanning is undefeated 2-0 against USC’s Lincoln Riley and looks to extend the Ducks’ winning streak against the Trojans to five games.
Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
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The Oregon Lottery offers several draw games for those aiming to win big.
Here’s a look at July 14, 2026, results for each game:
Winning Mega Millions numbers from July 14 drawing
02-04-10-48-56, Mega Ball: 22
Check Mega Millions payouts and previous drawings here.
Winning Pick 4 numbers from July 14 drawing
1PM: 6-3-6-3
4PM: 7-0-0-9
7PM: 2-0-6-0
10PM: 2-5-1-5
Check Pick 4 payouts and previous drawings here.
Feeling lucky? Explore the latest lottery news & results
When are the Oregon Lottery drawings held?
- Powerball: 7:59 p.m. on Monday, Wednesday and Saturday.
- Mega Millions: 7:59 p.m. on Tuesday and Friday.
- Pick 4: 1 p.m., 4 p.m., 7 p.m. and 10 p.m. daily.
- Win for Life: 7:30 p.m. on Monday, Wednesday, and Saturday.
- Megabucks: 7:29 p.m. on Monday, Wednesday, and Saturday.
This results page was generated automatically using information from TinBu and a template written and reviewed by an Oregon editor. You can send feedback using this form.
DESCHUTES COUNTY, Ore. — Oregon State Police are asking for additional witnesses to come forward after a three-vehicle crash on Highway 20E in Deschutes County left two people seriously injured.
Troopers responded at 12:47 p.m. Friday, July 10, to the crash near milepost 41. A preliminary investigation found a westbound 2013 black Chevrolet Silverado pickup truck pulling a single-axle utility trailer attempted to pass a black Dodge 4500 towing a trailer. Police said an eastbound Hyundai Elantra tried to avoid a collision with the Chevrolet, lost control in the gravel on the eastbound shoulder, veered into the westbound lane and collided with the trailer pulled by the Dodge 4500.
The driver and passenger of the Hyundai were flown by air medic to a local hospital with serious injuries.
The crash affected traffic for about five hours. The driver of the Chevrolet was cited for careless driving and unsafe passing.
OSP is asking anyone who may have seen the Chevrolet driving westbound on Highway 20 at the moment of, or prior to, the collision to contact the OSP Northern Command Center dispatch at 800-442-0776 or *OSP (*677) from a mobile phone. Callers should reference case number SP26-255130.
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