The Portland Trail Blazers, when healthy, don’t match up well with the Denver Nuggets.

On Monday, the Blazers lost 146-117 at Denver while playing without Robert Williams III and Jerami Grant. Both are questionable for Wednesday night’s rematch.

Scoot Henderson (ankle) and Deandre Ayton (calf) are out.

Should all four miss the game, the Blazers would have virtually zero chance to win.

Denver destroyed the Blazers in virtually every statistical category on Monday. Losing Ayton and Henderson dramatically impacts the team’s ability to score in the paint, where the Nuggets held an 88-46 advantage in the first game.

The Blazers’ best shot to win would be to get hot from three-point range. Anfernee Simons, Deni Avdija and Shaedon Sharpe have the ability to do so, but it’s unlikely all three will get going enough on the same night to give Denver much trouble.

Prediction: The Nuggets could take the Blazers lightly, resulting in a relatively close game, if they put forth a better overall effort than they did on Monday.

But it would be reasonable for the Blazers to be cautious and not play Grant or Williams, with this being the final game before the All-Star break.

If just one sits out, along with Henderson and Ayton, the Blazers will absolutely leave Denver with another loss.

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PORTLAND TRAIL BLAZERS AT DENVER NUGGETS

What: Trail Blazers (23-31) at Nuggets (35-19), 6 p.m., Wednesday.

Where: Ball Arena, Denver.

Radio: Rip City Radio (KPOJ 620 AM).

TV channel: KATU (Antenna: 2.2 in Portland. Xfinity: 302 and 1170. DirecTV: 688-1. KUNP (Antenna: 47.1. Xfinity: 16, 302, 1170. DirecTV: 47. Spectrum: 184).

How to Watch: Rip City TV Network. If you don’t have cable, you can still watch this game live for FREE with the help of an HDTV antenna on your local ABC affiliate (Charge 2.2 in Portland). These antennas are very easy to install and cost around $20. You can purchase one at your local Bi-Mart or Fred Meyer, or buy one online at Walmart or from Amazon and have it shipped quickly to your home. Here are some instructions on how to set up an HDTV antenna on your television or other display. You can find out more about which channel Rip City TV Network is on in your area by using the channel finder here.

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ODDS (Oregon Lottery/DraftKings)

Moneyline: POR +295 | DEN -375

Spread: POR +8.5 | Over/Under: 233

INJURIES

Blazers: Robert Williams III (right knee soreness), Jerami Grant (right knee soreness) and Kris Murray (left quad contusion) are questionable. Deandre Ayton (left calf strain), Scoot Henderson (right ankle sprain) and Matisse Thybulle (right ankle sprain) are out.

Nuggets: Jamal Murray (left knee inflammation) and Aaron Gordon (right calf injury management) are probable. Michael Porter Jr. (left hamstring tightness) is questionable. Russell Westbrook (left hamstring strain), Peyton Watson (right knee sprain). Vlatko Cancar and (left knee surgery), DaRon Holmes (right Achilles tendon repair) are out.

NEXT UP

All-Star break. The Blazers host the Los Angeles Lakers at 7 p.m. Feb. 20.

— Aaron Fentress | afentress@Oregonian.com | @AaronJFentress (Twitter), @AaronJFentress (Instagram), @AaronFentress (Facebook)