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Universal Antivenom May Grow Out of Man Who Let Snakes Bite Him Hundreds of Times

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Universal Antivenom May Grow Out of Man Who Let Snakes Bite Him Hundreds of Times

The video is just under two and a half minutes long. A slim man with close-cropped hair walks into a room, pulls a long black mamba — whose venom can kill within an hour — from a crate and allows it to bite his left arm. Immediately after, he lets a taipan from Papua New Guinea bite his right arm. “Thanks for watching,” he calmly tells the camera, his left arm bleeding, and then exits.

Over nearly 18 years, the man, Tim Friede, 57, injected himself with carefully calibrated, escalating doses of venom to build his immunity to 16 deadly snake species. He also allowed the snakes — mostly one at a time, but sometimes two, as in the video — to sink their sharp fangs into him about 200 times.

This bit of daredevilry (one name for it) may now help to solve a dire global health problem. More than 600 species of venomous snakes roam the earth, biting as many as 2.7 million people, killing about 120,000 people and maiming 400,000 others — numbers thought to be vast underestimates.

In Mr. Friede’s blood, scientists say they have identified antibodies that are capable of neutralizing the venom of multiple snake species, a step toward creating a universal antivenom, they reported on Friday in the journal Cell.

“I’m really proud that I can do something in life for humanity, to make a difference for people that are 8,000 miles away, that I’m never going to meet, never going to talk to, never going to see, probably,” said Mr. Friede, who lives in Two Rivers, Wis., where venomous snakes are not much of a threat.

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While deforestation, human sprawl and climate change have heightened the danger from snake attacks in recent years, research on antivenom has not kept pace with demand.

“This is a bigger problem than the first world realizes,” said Jacob Glanville, founder and chief executive of Centivax, a company that aims to produce broad-spectrum vaccines, and lead author on the study.

Dr. Glanville and his colleagues found that two powerful antibodies from Mr. Freide’s blood, when combined with a drug that blocks neurotoxins, protected mice from the venom of 19 deadly snake species of a large family found in different geographical regions.

This is an extraordinary feat, according to experts not involved in the work. Most antivenoms can counter the venom from just one or a few related snake species from one region.

The study suggests that cocktails of antitoxins may successfully prevent deaths and injuries from all snake families, said Nicholas Casewell, a researcher at the Liverpool School of Tropical Medicine in England.

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“The principles of this study can definitely be applied to other snakes,” he said.

Mr. Friede’s first snake encounter, a harmless bite by a garter snake at age 5, started a lifelong fascination. “If I only knew back then what was going to happen,” he recalled, laughing uproariously.

But he didn’t begin dabbling with snakes in earnest until he was married with children and working in construction. He began experimenting with scorpions around the year 2000, but quickly switched to snakes. At one point, his basement lab housed 60 venomous snakes.

His experiments nearly ended soon after they began. On Sept. 12, 2001, crazed by the terrorist attack of the previous day and by the death of a friend a few days earlier, he let himself be bitten by two cobras. They were his first bites by live snakes, and he had not built up enough immunity. He was fine after the first bite, but after the second, he felt cold, his eyes started to droop and he couldn’t talk. He blacked out and woke up from a coma in a hospital four days later.

His wife was furious, but he was angrier with himself. He vowed to become more methodical in his work, carefully measuring out doses of venom and timing his bites.

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“I’d work all day, come home, play with the kids and the family, and go downstairs and do my stuff all night long, wake up and do it again,” he said.

There were other mishaps — accidental bites, anaphylactic shocks, hives, blackouts. Mr. Friede describes himself as a nondegree scientist, but “there’s no college in the world that can teach you how to do it,” he said. “I was doing it on my own as best I could.”

Two teams of scientists sampled Mr. Friede’s blood over the years, but neither project led anywhere. By the time he met Dr. Glanville, in 2017, he was nearly ready to give up.

Dr. Glanville had been pursuing what scientists call broadly acting antibodies as the basis for universal vaccines against viruses. He grew up in a Maya village in the Guatemala highlands, and became intrigued by the possibility of using the same approach for universal antivenom.

At first, he said, he had a “humble” goal of finding someone like a clumsy snake researcher who had been bitten a couple of times. But then he came across news articles about Mr. Friede.

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“I’ve been waiting for this call for a long time,” Dr. Glanville recalls Mr. Friede as saying.

In collaboration with Peter Kwong, an immunologist at Columbia University, Dr. Glanville isolated broadly acting antibodies from Mr. Friede’s blood and created the combination treatment.

The researchers tested antibodies from Mr. Friede’s blood against venom from 19 snake species. One broadly neutralizing antibody they identified protected mice from six of the species. Adding a small molecule called varespladib and a second antibody fully protected mice against 13 snake species, and provided a partial defense against the remaining six.

Cobras and mambas produce toxins that paralyze neurons. Venom from snakes in the viper family rips up tissues, causing victims to bleed to death. Each snake species within those families produces a distinct blend of dozens of toxins, and the venom even within a species can vary by region, age, diet and season.

But antivenom is made much the same way it was 130 years ago when it was first produced. A small amount of venom is pumped into a horse, camel or sheep, and the antibodies produced in response are harvested. The antibodies tend to be specific to the type of venom injected, and do little to ease symptoms from other types of snakes.

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Many antivenoms, in fact, may pose more serious problems than venom itself, because the proteins from the mammal may trigger a deadly allergic shock.

Scientists are pursuing treatments that would avoid this side effect. Cocktails of small molecule drugs and monoclonal antibodies — artificially made copies of powerful human antibodies — against the most important toxin families may be able to neutralize the venom of many species, Dr. Casewell said.

The researchers next plan to test the treatment in Australia in any dogs that are brought into veterinary clinics for snakebites. They are also hoping to identify another component, perhaps also from Mr. Friede’s blood, that would extend full protection to all 19 snake species that were subjects of the research.

Mr. Friede himself is done now, however. His last bite was in November 2018, from a water cobra. He was divorced — his wife and children had moved out. “Well, that’s it, enough is enough,” he recalled thinking.

He misses the snakes, he said, but not the painful bites. “I’ll probably get back into it in the future,” he said. “But for right now, I’m happy where things are at.”

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Forest Service completed prescribed burns on 127,000 acres during shutdown, despite reduced workforce

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Forest Service completed prescribed burns on 127,000 acres during shutdown, despite reduced workforce

During the government shutdown, the U.S. Forest Service completed prescribed burns on more than 127,000 acres, Forest Service Chief Tom Schultz announced in an internal memo welcoming back furloughed employees. During the same time frame in 2023 and 2024, the Forest Service completed a comparable amount of work, indicating the agency managed to take advantage of prime weather for burns even with a reduced workforce.

“Despite the disruption, we accomplished a great deal together,” the memo, first reported by the Hotshot Wake Up and verified by The Times, said. “We advanced timber sales that strengthen local economies, kept recreation sites open and safe for public enjoyment, and carried out critical wildfire response and active management work.”

By comparison, the Forest Service completed about 200,000 acres of prescribed burns in 2023 from Oct. 1 through Nov. 12 — the same span as the 2025 shutdown — and in 2024, it burned roughly 90,000 acres during that time frame, according to a Forest Service database that tracks hazardous fuel treatment work.

The latest contingency plan for the Forest Service — the largest federal firefighting entity in the country — called for continuing essential work during a shutdown, including responding to and suppressing wildfires.

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The plan also involves furloughing roughly 30% of the service’s workforce, including those who oversee forest-use permit processing and public recreation, as well as researchers studying forest health and the timber market. Yet fuel treatment work, such as prescribed burning and mechanically thinning forests, is conducted by many of the same personnel responsible for putting out fires — the part of the workforce that avoided the furloughs.

That was important, given that significant fire activity across the West in 2024 inhibited the Forest Service from reducing wildfire risk on as many acres. So, this year, the Forest Service has been playing catch-up.

However, Grassroots Wildland Firefighters, a nonprofit representing current and former federal firefighters, found in October that Forest Service fuel management work in 2025 was down by 38% compared with recent years. The organization said that downturn was largely due to staff and resource cuts championed by President Trump’s cost-cutting team at the start of his second administration.

The Forest Service did not immediately respond to a request for comment.

California Gov. Gavin Newsom has challenged the federal government to match state investments in wildfire risk reduction work, and in July even sent the White House a draft executive order that Newsom said would accomplish exactly that.

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In 2021, the state and U.S. Forest Service agreed to ramp up their yearly fuel treatment work in California to 500,000 acres each by 2025.

In 2023, the most recent year both state and federal data are available, the state reached 415,000 acres, and the Forest Service reached 311,000, according to a state dashboard. From 2021 to 2024, the state invested $4.3 billion to complete that work, whereas the Forest Service invested $3.1 billion.

This past weekend’s rain could mark an early start to prescribed-burn season in Southern California — home to a handful of national forests, including the Los Angeles and San Bernardino forests — as federal employees return to work until at least the end of January, when the agreed-upon funding is set to expire.

“I’m profoundly grateful to welcome our furloughed employees back as the government reopens,” Schultz said in the memo. “I look forward to getting the entire team back together to continue and build upon the work that we’ve begun this new fiscal year.”

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CDC warns of dramatic rise in dangerous drug-resistant bacteria. How you can protect yourself

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CDC warns of dramatic rise in dangerous drug-resistant bacteria. How you can protect yourself

Infection rates are soaring in the United States due to a menacing bacteria that are resistant “to some of the strongest antibiotics available,” prompting infectious-disease experts to warn about the difficulty of responding to the surge.

The Centers for Disease Control and Prevention warned in a report this week that between 2019 and 2023, bacterial infections caused by a “super bug” bacteria dubbed NDM-producing carbapenem-resistant Enterobacterales (NDM-CRE) surged by more than 460% in the U.S.

The NDM-CRE is a type of bacteria with a special gene that can break down powerful antibiotics rendering most drug treatments ineffective, said Shruti Gohil, associate professor of infectious diseases at UC Irvine School of Medicine.

“This makes these ‘superbug’ bacteria very hard to treat because they’re resistant to some of the strongest antibiotics we have,” Gohil said.

The CDC’s findings, originally published in a 2022 report, noted that there were approximately 12,700 infections and 1,100 deaths in the U.S. in 2020 due to this drug-resistant bacteria.

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The public health agency did not determine the exact reason for the surge; however, there is an association involving the use of antibiotics to treat COVID-19 patients in the beginning of the pandemic, said Neha Nanda, medical director of antimicrobial stewardship with USC’s Keck Medicine.

Public health officials warn that NDM-CRE has not historically been common in the U.S., so healthcare providers might not suspect it when treating patients with bacteria-related infections.

The rise of the bacteria also “threatens to increase NDM-CRE-related infections and deaths,” according to the CDC.

This is the second report the CDC released that highlighted a rise in bacteria-related cases, the most recent was published in June and focused on cases in New York City between 2019 and 2024.

Available treatment for NDM-CRE?

Experts say people with NDM-CRE bacteria won’t have any symptoms unless they develop an infection. Once they develop an infection, the symptoms will vary. NDM-CRE can cause such ailments as pneumonia, bloodstream infections, urinary tract infections and wound infections.

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Some symptoms can include fever, chills with cough, shortness of breath if the bacteria infect the lung, and pain or blood when urinating if the bladder/kidneys are infected.

Since the bacteria are resistant to most antibiotics, treatment options are severely limited, leading to slower recovery and higher risk of serious complications or death, Gohil said.

Another reason health officials are concerned is because the bacteria can spread to others and survive on contaminated surfaces.

Doctors can test for NDM-CRE, but most people do not need to be tested unless they are at higher risk for having it, according to experts.

Those at risk are people who have been “in a hospital (especially in another country), had repeated antibiotics, hospital stays, or invasive medical procedures, or if you’re sick and been in contact with someone known to have NDM-CRE,” Gohil said.

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Testing for the bacteria is also difficult because many hospitals and clinics do not have the tools to rapidly detect it in patients even when the patient is not sick.

How to protect yourself against NDM-CRE

NDM-CRE is caused by overuse of powerful antibiotics.

“I think this may be an opportunity for us to change the narrative where all patients typically want antibiotics,” Nanda said.

Nanda advises patients who are being prescribed with antibiotics to ask their healthcare provider:

  • Why they’re getting prescribed the antibiotics? Why is it necessary?
  • Ask about your options. Make sure you’ve exhausted all other treatments options before going straight to antibiotics.

“If you need it, you need it, but then be judicious about it,” she said.

Because NDM-CRE infections happen to people who are very sick, patients in hospitals or in long-term care, experts recommend that patients, healthcare staff and visitors in these settings wash their hands and avoid contact with dirty surfaces.

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Trump says research links Tylenol and autism; scientists say their paper is being misinterpreted

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Trump says research links Tylenol and autism; scientists say their paper is being misinterpreted

During this week’s White House press conference in which President Trump named the over-the-counter drug Tylenol as a possible cause of rising autism rates, he did not mince words, urging pregnant women to “fight like hell” not to take it.

But outside those remarks in the Roosevelt Room — during which Trump himself acknowledged “I’m not so careful with what I say” — the discussion on the common fever and pain reliever’s role during pregnancy is a lot more nuanced.

What the research on Tylenol use during pregnancy actually says

Physicians, researchers on the very studies cited in support of Trump’s position and even other members of the president’s administration are largely united on a few key facts: untreated fevers in pregnancy pose real risks to the fetus, acetaminophen (Tylenol’s active ingredient) remains the safest medication to treat them and any pregnant person seeking advice on the issue should consult their doctor.

“All that we should be asking of the medical profession [is] to actually weigh the risks and benefits for the women, with the women, and be cautious about chronic use of pain medications,” said Dr. Beate Ritz, a UCLA professor of epidemiology who co-authored a paper published last month that the White House cited as evidence for the link between Tylenol and autism.

Ritz said it has been misinterpreted.

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The conclusion of the paper, which reviewed existing studies on the topic, was that the association between acetaminophen use in pregnancy and later diagnoses of neurodevelopmental disorders in kids was strong enough to merit doctors’ consideration when determining how to treat fever or pain in pregnancy. The group did not determine a causal relationship between the drug and autism, or suggest barring the drug altogether, she said.

“Looking at all of these studies, yes, there is a risk,” Ritz said. “It’s not very big, but it’s there, but the risk increases are more seen in regular users of Tylenol. This is not a woman who has a fever and takes three Tylenols.”

“There is always a weighing of the risks and the benefits, and fever in women is no good either. … Not having to take any pain medications when you are in severe pain or in chronic pain is also very cruel,” she said. “We all should have an interest in helping out here, making the right decisions without blaming the victim and putting it all on the individual woman.”

Her co-author, University of Massachusetts epidemiologist Ann Bauer, has made similar statements.

“What we recommend is judicious use — the lowest effective dose [for] the shortest duration of time under medical guidance and supervision, tailored to the individual,” Bauer told the news outlet Politico.

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The administration’s confusing recommendations

Ultimately, that’s what the administration is recommending as well.

The letter that U.S. Food and Drug Administrator Dr. Marty Makary sent to physicians this week made clear that “a causal relationship” between autism and acetaminophen “has not been established and there are contrary studies in the scientific literature.”

It went on to recommend that clinicians consider limiting their use of acetaminophen for routine low-grade fevers during pregnancy, while noting that medical advice “should also be balanced with the fact that acetaminophen is the safest over-the-counter alternative in pregnancy among all analgesics and antipyretics.” (An analgesic is a pain reliever; an antipyretic reduces fever.)

Untreated fevers during pregnancy are associated with higher rates of birth defects, particularly those of the heart, brain and spinal cord; premature birth; low birth weight; neurodevelopmental disorders including autism; and fetal death, said Dr. E. Nicole Teal, an assistant professor of maternal-fetal medicine at UC San Diego.

“The FDA’s letter, while significantly more nuanced than the president’s comments on the issue, still gives too much weight to findings from poorly designed studies,” she said.

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She said she will continue to prescribe acetaminophen to pregnant patients who need to treat fevers or severe pain, as it has the fewest known risks in pregnancy.

Are there other pain-relief and fever-reducing drugs that can be used during pregnancy?

Nonsteroidal anti-inflammatory drugs like ibuprofen (often sold as Advil) or naproxen (often sold as Aleve) are linked to problems with blood vessel and kidney development, as well as oligohydramnios, a condition in which there isn’t enough amniotic fluid to support a healthy pregnancy. Aspirin raises the risk of bleeding complications, and narcotics — which can relieve pain but not fever — pose addiction risks for the mother and infant alike, Teal said.

She referred to a statement from the American College of Obstetricians and Gynecologists noting that two decades of research on the question had failed to find a causal relationship between acetaminophen and autism.

“Acetaminophen is one of the few options available to pregnant patients to treat pain and fever, which can be harmful to pregnant people when left untreated,” American College of Obstetricians and Gynecologists president Dr. Steven J. Fleischman said in the statement.

The group also noted that reviews in 2015 and 2017 from the FDA and the Society for Maternal-Fetal Medicine respectively found no risks associated with appropriate usage of the drug in pregnancy.

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How to navigate government communications around Tylenol use

Nonetheless, the mixed messaging from the Trump administration about Tylenol seems likely to continue.

The Department of Health and Human Services this week reposted a 2017 tweet from the Tylenol brand’s account that said, “We actually don’t recommend using any of our products while pregnant.”

A spokesperson for Kenvue, the company that owns Tylenol, said the post was taken out of context and incomplete.

“Consistent with regulations, our label states clearly ‘if pregnant or breast-feeding, ask a health professional before use,’ ” Melissa Witt said in an email. “We do not make recommendations on taking any medications in pregnancy because that is the job of a healthcare provider.”

Vice President JD Vance offered similar guidance this week.

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“My guidance to pregnant women would be very simple, which is follow your doctor. Right?” Vance said in an interview with the outlet NewsNation after Trump’s press conference. “Talk to your doctor about these things.”

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