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Universal Antivenom May Grow Out of Man Who Let Snakes Bite Him Hundreds of Times

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Universal Antivenom May Grow Out of Man Who Let Snakes Bite Him Hundreds of Times

The video is just under two and a half minutes long. A slim man with close-cropped hair walks into a room, pulls a long black mamba — whose venom can kill within an hour — from a crate and allows it to bite his left arm. Immediately after, he lets a taipan from Papua New Guinea bite his right arm. “Thanks for watching,” he calmly tells the camera, his left arm bleeding, and then exits.

Over nearly 18 years, the man, Tim Friede, 57, injected himself with carefully calibrated, escalating doses of venom to build his immunity to 16 deadly snake species. He also allowed the snakes — mostly one at a time, but sometimes two, as in the video — to sink their sharp fangs into him about 200 times.

This bit of daredevilry (one name for it) may now help to solve a dire global health problem. More than 600 species of venomous snakes roam the earth, biting as many as 2.7 million people, killing about 120,000 people and maiming 400,000 others — numbers thought to be vast underestimates.

In Mr. Friede’s blood, scientists say they have identified antibodies that are capable of neutralizing the venom of multiple snake species, a step toward creating a universal antivenom, they reported on Friday in the journal Cell.

“I’m really proud that I can do something in life for humanity, to make a difference for people that are 8,000 miles away, that I’m never going to meet, never going to talk to, never going to see, probably,” said Mr. Friede, who lives in Two Rivers, Wis., where venomous snakes are not much of a threat.

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While deforestation, human sprawl and climate change have heightened the danger from snake attacks in recent years, research on antivenom has not kept pace with demand.

“This is a bigger problem than the first world realizes,” said Jacob Glanville, founder and chief executive of Centivax, a company that aims to produce broad-spectrum vaccines, and lead author on the study.

Dr. Glanville and his colleagues found that two powerful antibodies from Mr. Freide’s blood, when combined with a drug that blocks neurotoxins, protected mice from the venom of 19 deadly snake species of a large family found in different geographical regions.

This is an extraordinary feat, according to experts not involved in the work. Most antivenoms can counter the venom from just one or a few related snake species from one region.

The study suggests that cocktails of antitoxins may successfully prevent deaths and injuries from all snake families, said Nicholas Casewell, a researcher at the Liverpool School of Tropical Medicine in England.

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“The principles of this study can definitely be applied to other snakes,” he said.

Mr. Friede’s first snake encounter, a harmless bite by a garter snake at age 5, started a lifelong fascination. “If I only knew back then what was going to happen,” he recalled, laughing uproariously.

But he didn’t begin dabbling with snakes in earnest until he was married with children and working in construction. He began experimenting with scorpions around the year 2000, but quickly switched to snakes. At one point, his basement lab housed 60 venomous snakes.

His experiments nearly ended soon after they began. On Sept. 12, 2001, crazed by the terrorist attack of the previous day and by the death of a friend a few days earlier, he let himself be bitten by two cobras. They were his first bites by live snakes, and he had not built up enough immunity. He was fine after the first bite, but after the second, he felt cold, his eyes started to droop and he couldn’t talk. He blacked out and woke up from a coma in a hospital four days later.

His wife was furious, but he was angrier with himself. He vowed to become more methodical in his work, carefully measuring out doses of venom and timing his bites.

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“I’d work all day, come home, play with the kids and the family, and go downstairs and do my stuff all night long, wake up and do it again,” he said.

There were other mishaps — accidental bites, anaphylactic shocks, hives, blackouts. Mr. Friede describes himself as a nondegree scientist, but “there’s no college in the world that can teach you how to do it,” he said. “I was doing it on my own as best I could.”

Two teams of scientists sampled Mr. Friede’s blood over the years, but neither project led anywhere. By the time he met Dr. Glanville, in 2017, he was nearly ready to give up.

Dr. Glanville had been pursuing what scientists call broadly acting antibodies as the basis for universal vaccines against viruses. He grew up in a Maya village in the Guatemala highlands, and became intrigued by the possibility of using the same approach for universal antivenom.

At first, he said, he had a “humble” goal of finding someone like a clumsy snake researcher who had been bitten a couple of times. But then he came across news articles about Mr. Friede.

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“I’ve been waiting for this call for a long time,” Dr. Glanville recalls Mr. Friede as saying.

In collaboration with Peter Kwong, an immunologist at Columbia University, Dr. Glanville isolated broadly acting antibodies from Mr. Friede’s blood and created the combination treatment.

The researchers tested antibodies from Mr. Friede’s blood against venom from 19 snake species. One broadly neutralizing antibody they identified protected mice from six of the species. Adding a small molecule called varespladib and a second antibody fully protected mice against 13 snake species, and provided a partial defense against the remaining six.

Cobras and mambas produce toxins that paralyze neurons. Venom from snakes in the viper family rips up tissues, causing victims to bleed to death. Each snake species within those families produces a distinct blend of dozens of toxins, and the venom even within a species can vary by region, age, diet and season.

But antivenom is made much the same way it was 130 years ago when it was first produced. A small amount of venom is pumped into a horse, camel or sheep, and the antibodies produced in response are harvested. The antibodies tend to be specific to the type of venom injected, and do little to ease symptoms from other types of snakes.

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Many antivenoms, in fact, may pose more serious problems than venom itself, because the proteins from the mammal may trigger a deadly allergic shock.

Scientists are pursuing treatments that would avoid this side effect. Cocktails of small molecule drugs and monoclonal antibodies — artificially made copies of powerful human antibodies — against the most important toxin families may be able to neutralize the venom of many species, Dr. Casewell said.

The researchers next plan to test the treatment in Australia in any dogs that are brought into veterinary clinics for snakebites. They are also hoping to identify another component, perhaps also from Mr. Friede’s blood, that would extend full protection to all 19 snake species that were subjects of the research.

Mr. Friede himself is done now, however. His last bite was in November 2018, from a water cobra. He was divorced — his wife and children had moved out. “Well, that’s it, enough is enough,” he recalled thinking.

He misses the snakes, he said, but not the painful bites. “I’ll probably get back into it in the future,” he said. “But for right now, I’m happy where things are at.”

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NASA Releases Photos of Far Side of the Moon From Artemis II Astronauts

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NASA Releases Photos of Far Side of the Moon From Artemis II Astronauts

New shades of brown and green in the rings of impact craters. Rugged terrain and long shadows along their rims. Earth rising over the moon’s horizon and the glow of lofted dust.

These are observations the Artemis II astronauts made during their lunar flyby on April 6. While passing by the far side of the moon, they saw parts never observed with human eyes before.

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The astronauts were able to catch a full view of the Mare Orientale, a dark, ringed 600-mile wide crater that straddles the near and the far sides of the moon. Human eyes had never seen the whole basin before. (The Apollo missions were timed so that the landings occurred as the crater was hidden in darkness.)

Everything to the left of the crater is the far side, the hemisphere we don’t get to see from Earth because the moon rotates on its axis at the same rate that it orbits around us.

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Astronauts looked at the dark smooth plains on its concentric impact rings, noting that there was more brown near the center of the multi-ring crater. To the naked eye, the basin looked like a plain or a plateau, but through the camera lens the Artemis II crew members were able to distinguish colors from shadows.

This is a close-up view of the Vavilov crater on the rim of the larger and older Hertzsprung crater. Astronauts looked at terrain changes: smooth inside the inner rings of the crater and rugged around the rim.

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Some 24 minutes into the flyby, the Artemis II crew began observing the South Pole-Aitken basin, seen in the photo below with the terminator line separating the sunlit side from the dark side.

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With an immense width of about 1,600 miles, it is the largest known impact crater in the solar system. These observations will help scientists find clues to the moon’s geological history.

The eastern edge of the South Pole-Aitken Basin.

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After Artemis II swung around the far side, the astronauts experienced a 53-minute solar eclipse.

They were able to observe the solar corona and get glimpses of a bright Venus, a reddish Mars far in the distance and a Saturn with hints of orange.

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The crew described the corona as similar to “baby hair” as the sun’s light intensified.

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Then, Earth came into view over the moon’s edge, an event described as Earthrise when humans first saw it in 1968.

Earthrise seen from the Orion spacecraft.

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Photos taken by Reid Wiseman, Victor Glover, Christina Koch and Jeremy Hansen from the Orion capsule on April 6 and provided by NASA. Time annotations are based on audio comments during NASA’s live transmission of the mission.

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Chicago Bears Pro Bowler Steve McMichael diagnosed with CTE a year after ALS death

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Chicago Bears Pro Bowler Steve McMichael diagnosed with CTE a year after ALS death

Hall of Fame defensive tackle Steve McMichael, a key member of the Super Bowl XX champion Chicago Bears, has been diagnosed posthumously with Stage 3 chronic traumatic encephalopathy, the Concussion & CTE Foundation said Tuesday.

McMichael died April 23, 2025, after a five-year battle with ALS, also known as Lou Gehrig’s disease. He was 67.

“By sharing Steve’s diagnosis, we want to raise awareness of the clear connection between CTE and ALS,” McMichael’s wife Misty said in a statement released by the Concussion & CTE Foundation.

“Too many NFL players are developing ALS during life and diagnosed with CTE after death. I donated Steve’s brain to inspire new research into the link between them.”

ALS — amyotrophic lateral sclerosis — is a neurological disorder that destroys motor neurons. CTE is a degenerative brain disease that has been found in people exposed to repetitive head trauma; it can be diagnosed only after death.

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McMichael’s CTE diagnosis was made by researchers at the Boston University CTE Center, which has found that several other former NFL players suffered from both ALS and CTE. According to the center’s director, neurologist Dr. Ann McKee, about 6% of people with CTE also have ALS.

“There is strong evidence linking repetitive brain trauma and ALS,” McKee said.

Michael kept up with the research, according to the Concussion & CTE Foundation, and pledged to donate his brain to be studied after his death.

“Steve McMichael was known for his strength, toughness, and larger-than-life presence,” said Dr. Chris Nowinski, co-founder and chief executive of the Concussion & CTE Foundation, “but his final act was to give a piece of himself back to the sports community so we might have a chance to save ourselves.”

McMichael spent 13 of his 15 NFL seasons in Chicago, earning Pro Bowl honors in 1986 and 1987. He set a Bears record playing in 191 consecutive games from 1981 to 1993 and is second on the team’s all-time sacks list with 92.5 (he had 95 total in his career).

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After football, McMichael spent several years as a professional wrestler with World Championship Wrestling.

Bedridden in the advanced stages of ALS, McMichael was inducted into the Pro Football Hall of Fame in a ceremony from his Homer Glen, Ill., home in 2024.

The Associated Press contributed to this report.

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Video: Artemis II Completes Historic Journey Around the Moon

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Video: Artemis II Completes Historic Journey Around the Moon

new video loaded: Artemis II Completes Historic Journey Around the Moon

transcript

transcript

Artemis II Completes Historic Journey Around the Moon

NASA’s Artemis II crew received a call from President Trump, who congratulated them for the successful lunar flyby.

“Today you’ve made history and made all America really proud, incredibly proud. Well, I look forward to seeing you in the Oval Office. And I’ll ask for your autograph, because I don’t really ask for autographs much, but you deserve that. You really are something. Everybody is talking about this.” “Orion has come back around the other side of the moon. And that little crescent that you see is Earth, over 252,000 miles away.” “And it is so great to hear from Earth again. To Asia, Africa and Oceania, we are looking back at you. “We are Earth bound and ready to bring you home.” “We’ve got to explore. We got to go further, to expand our knowledge, expand our horizons.” “I’m not ready to go home. I can’t believe that something this cramped of quarters, can fly by and still be fun every single minute.

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NASA’s Artemis II crew received a call from President Trump, who congratulated them for the successful lunar flyby.

By Nailah Morgan

April 7, 2026

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