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Study: Severe COVID raised risk of heart attack, stroke as much as having heart disease

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Study: Severe COVID raised risk of heart attack, stroke as much as having heart disease

People hospitalized for COVID-19 early in the pandemic suffered an increased risk of serious “cardiac events” such as heart attacks and strokes that was akin to people with a history of heart disease, a newly released study has found.

Researchers from USC, UCLA and the Cleveland Clinic analyzed more than 10,000 COVID cases tracked by the UK Biobank to examine how COVID affected the risk of heart attacks and other cardiac threats.

Their study, released Wednesday in the journal Arteriosclerosis, Thrombosis, and Vascular Biology, assessed outcomes for people sickened in the first year of the pandemic and followed for a period of nearly three years.

The findings underscore that among “people who don’t have any evidence of heart disease, having severe COVID put them at a significantly increased risk of heart attack, stroke and death,” said principal investigator Hooman Allayee, professor of population and public health sciences at USC’s Keck School of Medicine.

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Among the most striking findings: Being hospitalized for COVID in 2020 amplified the risk of heart attacks and other cardiac events so much that it ended up being comparable to people who had a history of heart disease but who hadn’t gotten COVID, the study found.

Although the analysis showed that the added risk was especially stark among people with severe cases, researchers stressed it was still apparent for patients who had gotten any form of COVID.

Such risks were roughly twice as high in people who had gotten COVID at all levels of severity, and four times as high for hospitalized cases, compared with people who hadn’t gotten COVID, the study found.

The study indicates that the increased risk “shows no apparent signs of attenuation up to nearly three years after SARS-CoV-2 infection and suggest that COVID-19 continues to pose a significant public health burden with lingering adverse cardiovascular risk,” they wrote.

Scientists also found that the risk differed by blood type: Being hospitalized for COVID ramped up the risks among people with blood types A, B or AB more than it did among people with type O blood.

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“Your genetics actually plays a role in this increased risk of developing future heart attacks and stroke,” said James Hilser, a Keck doctoral candidate in biochemistry and molecular medicine who helped write the paper.

Researchers said their findings could help shape how doctors try to head off such health problems in the future. Doctors routinely offer preventative treatment to patients with medical conditions such as cardiovascular disease or diabetes that put them at a higher risk of heart attack or stroke.

Allayee said that if someone walks into a doctor’s office and is newly diagnosed with diabetes, “it doesn’t matter what their cholesterol is … They get put on a lipid-lowering medication. They get put on a baby aspirin.”

But when physicians think about preventing heart attacks, “nobody is taking into consideration COVID — whether it’s severe or otherwise — in how to manage a patient,” Allayee said. In light of the findings, he said, “this is something that doctors should be discussing,” as should regulatory bodies for cardiac care.

The study, which was funded by the National Institutes of Health, had some limitations: It examined only COVID cases early in the pandemic before vaccines became available. (Another study published earlier this year, which also relied on the UK Biobank data, found that the incidence of heart attacks and strokes was generally lower after each dose of a COVID vaccine.)

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Researchers also cautioned that some COVID patients may have had undiagnosed heart disease when they were hospitalized, which would not be evident in the UK Biobank data.

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Want to understand CalRecycle's chemical recycling rules? You'll need to pay

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Want to understand CalRecycle's chemical recycling rules? You'll need to pay

Want to know what constitutes an acceptable form of recycling in California under CalRecycle’s new draft guidelines for the state’s landmark plastic waste law?

It’ll cost you roughly $187, and even then you may not find your answer.

The issue arose this week when CalRecycle held a Sacramento workshop on its proposed regulations to implement Senate Bill 54, the 2022 law designed to reduce California’s single-use plastic waste.

In the regulations’ latest iteration, the agency declared that it will only consider recycling technologies that follow standards issued by the International Organization for Standardization, or ISO, the Geneva-based group that sets standards for a variety of industries, including healthcare and transportation.

According to the draft regulations: “A facility’s use of a technology that is not a mechanical recycling technology … shall not be considered recycling unless the facility operates in a manner consistent with ISO 59014:2024.”

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To access ISO 59014:2024, one must purchase the report for about $187.

That’s not fair, said Nick Lapis, director of advocacy for Californians Against Waste. “Copies of those ISO standards should be publicly available,” he said.

Lapis and others also noted that the law, as written, expressly prohibits chemical and nonmechanical forms of recycling.

Officials at CalRecycle, also known as the California Department of Resources Recycling and Recovery, didn’t respond to the criticism or to questions from The Times.

ISO 59014:2024 turns out to be a 38-page report titled “Environmental management and circular economy — Sustainability and traceability of the recovery of secondary materials — Principles, requirements and guidance.”

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A copy of the report reviewed by The Times offered no specifics on recycling technologies, or information about the operation of a recycling plant.

The word “recycling” is only used five times in the “Annex,” a 13-page supplementary section of the report. And there it is mentioned only in the context of establishing definitions or examples of “organizations engaged in the recovery of secondary materials” or “collection system types.”

For instance, “Commercial waste and recycling companies” are listed as examples of a type of organization that collects waste. Other waste collectors, according to the report, include municipalities, retailers and reuse organizations such as nonprofit reuse operators.

“The draft calls on aligning facilities with this ISO standard,” said Monica Wilson, senior director of global programs at the Global Alliance for Incinerator Alternatives. “That ISO standard is not about recycling. It’s not about chemical recycling, it’s just not an appropriate comparison for us to be referring to.”

Lapis also found the report hard to decipher.

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“Maybe I should go back and look at it again, but it’d be helpful if you’re citing ISO standards … that you identify what parts” are being cited, he said.

Karen Kayfetz, chief of CalRecycle’s Product Stewardship branch, didn’t respond to questions or concerns about the inclusion of a report that is not freely available to the public to review.

During this week’s workshop, she said the agency’s use of the ISO standard “is not meant … to be a measure of whether you are recycling, but rather just one of multiple criteria that an entity needs to be measured against.”

She said the SB 54 statute requires that CalRecycle exclude recycling technologies that produce significant amounts of hazardous waste and tasks the agency with considering environmental and public health impacts of these technologies.

“The ISO standard for the operation of facilities does address some of the best practices that would help to ameliorate and measure those impacts. … It is meant to be one of multiple criteria that can be utilized as a measure and to help set a floor but not a ceiling,” she said.

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Anna Ferrera, a spokeswoman for the Wine Institute, which represents more than 1,000 wineries and affiliates across the state, was among those with no complaints about the proposed new regulations.

“We believe it incorporates common-sense changes that would reduce costs and ensure that products are appropriately recycled,” Ferrera said.

Tina Andolina, the chief of staff for state Sen. Ben Allen (D-Santa Monica), SB 54’s author, said the inclusion of the report and other items in the draft regulations suggests that CalRecycle is considering how to manage these polluting technologies — instead of forbidding them, as the law requires.

“The regulations unlawfully shift the standard from the production of hazardous waste as required by the statute to its management,” she said, reading from a letter Allen had written to the staff.

Anja Brandon, director of plastic policy at the Ocean Conservancy, added that along with not being freely available, the ISO standard “does not satisfy SB 54’s requirements to exclude the most hazardous technologies and to minimize the generation of hazardous waste and environmental, environmental justice and public health impacts.”

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SB 54, which was signed by Gov. Gavin Newsom in 2022, requires that by 2032, 100% of single-use packaging and plastic food ware produced or sold in the state must be recyclable or compostable, that 65% of it can be recycled, and that the total volume is reduced by 25%.

The law was written to address the mounting issue of plastic pollution in the environment and the growing number of studies showing the ubiquity of microplastic pollution in the human body — such as in the brain, blood, heart tissue, testicles, lungs and various other organs.

Last March, after nearly three years of negotiations among various corporate, environmental, waste, recycling and health stakeholders, CalRecycle drafted a set of finalized regulations designed to implement the single-use plastic producer responsibility program under SB 54.

But as the deadline for implementation approached, industries that would be affected by the regulations including plastic producers and packaging companies — represented by the California Chamber of Commerce and the Circular Action Alliance — began lobbying the governor, complaining that the regulations were poorly developed and might ultimately increase costs for California taxpayers.
Newsom allowed the regulations to expire and told CalRecycle that it needed to start the process over.

These new draft regulations are the agency’s latest attempt at issuing guidelines by which the law can be implemented.

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A new COVID subvariant spreads rapidly as Trump pivots away from vaccines

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A new COVID subvariant spreads rapidly as Trump pivots away from vaccines

A new, highly transmissible COVID subvariant has been detected in California — heightening the risk of a potential summer wave as recent moves by the Trump administration threaten to make vaccines harder to get, and more expensive, for many Americans, some health experts warn.

Health and Human Services Secretary Robert F. Kennedy Jr. announced this week that he was rescinding the federal government’s recommendation that pregnant women and healthy children get immunized against COVID, effective immediately.

Dr. Marty Makary, commissioner of the U.S. Food and Drug Administration, also said the agency will no longer routinely approve annually formulated COVID-19 vaccinations for healthy people under age 65.

“We simply don’t know whether a healthy 52-year-old woman with a normal BMI who has had COVID-19 three times and has received six previous doses of a COVID-19 vaccine will benefit from the seventh dose,” Makary, along with another FDA official, Dr. Vinay Prasad, wrote in the New England Journal of Medicine this month. “This policy will compel much-needed evidence generation.”

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However, some experts say mandating more extensive testing could delay vaccine access for many, as those efforts may not even be complete until after the end of the upcoming winter flu-and-COVID season.

“Pregnant women, infants and young children are at higher risk of hospitalization from COVID, and the safety of the COVID vaccine has been widely demonstrated,” Dr. Sean O’Leary, chair of the American Academy of Pediatrics’ Committee on Infectious Diseases, said in a statement.

The U.S. Centers for Disease Control and Prevention has said that, in general, getting an updated vaccine provides children and adults additional protection from COVID-related emergency room and urgent care visits.

The recent federal changes, according to some experts, could also prompt private insurance companies and government insurers to stop paying for COVID shots for wide segments of the population, including babies and children.

Absent a recommendation by federal officials, Americans could end up paying the entire cost of a vaccine, experts say. The out-of-pocket cost for a COVID vaccine at CVS, for instance, is $198.99.

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Although the emergency phase of the pandemic has long since passed, authorities note COVID remains a public health concern. A relatively new subvariant has been spreading in Europe and Asia, “particularly Hong Kong, Taiwan, other countries, Japan, etc.,” said Dr. Peter Chin-Hong, a UC San Francisco infectious diseases expert.

That subvariant, NB.1.8.1, was first documented in January and has since been detected in California, including in Los Angeles County and the San Francisco Bay Area. The World Health Organization designated it a “Variant Under Monitoring” last week.

NB.1.8.1 has grown exponentially worldwide in recent weeks. The Omicron subvariant represented 10.7% of genetically analyzed viral samples worldwide for the week ending April 27, WHO data show. That was up sharply from the week ending April 6, when the subvariant accounted for 2.5% of samples worldwide.

“While still low numbers, this is a significant rise,” the WHO said, adding that there was a “concurrent increase in cases and hospitalizations in some countries where NB.1.8.1 is widespread.”

NB.1.8.1 isn’t yet prevalent enough in the United States to be publicly tracked by the CDC. Another strain, LP.8.1, accounted for an estimated 73% of coronavirus specimens nationally for the two-week period ending Saturday.

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Data suggest NB.1.8.1 does not cause more severe illness, “but it is more transmissible, at least from what we’re seeing around the world and also from lab experiments,” said Dr. Yvonne Maldonado, an infectious-disease expert at Stanford University.

In Taiwan, a top health official told reporters that an NB.1.8.1-fueled outbreak was “continuing to rise rapidly, with a sustained increase in severe and fatal cases,” the Central News Agency reported, prompting a shortage of COVID testing kits. Health officials said a factor in Taiwan’s surge was the lack of a major COVID wave over the winter, and forecast that the island’s current spike may not peak for another four to six weeks.

NB.1.8.1 has seen increased prevalence in each of the three WHO regions that still consistently share genetic analysis of COVID samples — the Western Pacific (which includes East Asia, parts of Southeast Asia, and Australia); Europe; and the Americas.

The rate at which COVID tests are coming back positive in Los Angeles County has slightly increased over the past few weeks, although the overall positive rate remains low, at 3.5%, according to the county Department of Public Health. Coronavirus levels detected in the county’s wastewater have increased by 6% in the last three weeks, but also remain relatively low and are about one-eighth of the peak in the summer of last year.

Although California experienced a mild winter season — a first of the COVID era — that followed a powerful summer spike that was the strongest in years.

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Many experts and officials have touted available COVID vaccines as effective both in warding off infection and in lessening the severity of symptoms. However, the need for otherwise healthy individuals to roll up their sleeves has been a matter of debate.

In a video message Tuesday on X, Kennedy — a noted vaccine skeptic — said that he “couldn’t be more pleased to announce that, as of today, the COVID vaccine for healthy children and healthy pregnant women has been removed from the CDC recommended immunization schedule.”

Experts said they could not recall a time when a political appointee circumvented a well-established process of making vaccine recommendations, which typically involves panels of scientists advising the FDA and CDC.

“It’s kind of chilling,” Chin-Hong said. “It’s out of step with the system we’ve learned to trust and follow.”

In a statement to The Times, the L.A. County Department of Public Health urged Kennedy to listen to experts in the field — including from the CDC’s Advisory Committee on Immunization Practices, which is scheduled to meet next month — “before decreasing access to any vaccine.”

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As of Thursday, the CDC still had the long-standing vaccine recommendations on its website: Everyone ages 6 months and older should get the most recent COVID-19 vaccine, officially known as the 2024-25 version, which was introduced in September. The CDC also recommends seniors ages 65 and up get a second vaccine dose six months after their first.

In a statement, the California Department of Public Health said that it supports the current expansive recommendation for COVID vaccines, and that it “will continue to follow the federal conversation through this dynamic situation.”

“Staying up to date with COVID-19 vaccination can reduce the risk of disease, especially more severe cases that result in hospitalization or death,” the department added.

The Washington Post reported Wednesday that the CDC did not know of Kennedy’s directive until he posted it, and officials have been “scrambling to find out what it meant.”

Experts who spoke with The Times warned the practical effect of the edict — if it becomes official — could be far more costly vaccines for affected groups.

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“If vaccines are not recommended by the CDC, insurance companies would NOT be required to cover the cost,” the L.A. County Department of Public Health said in a statement.

As a result, the vaccines may be less accessible to healthier people who still want them — perhaps because they live or work with elderly or other higher-risk people, they’ve had severe COVID illness before, or they want to protect themselves against the latest subvariant, the agency said.

If the FDA withholds a license for an updated COVID vaccination for younger, healthier adults, this group “would not be able to receive it unless their provider chooses to give it ‘off label,’” the county said.

When asked whether healthy pregnant women and healthy children can still get vaccinated at its pharmacies, Walgreens said its teams operate “in full compliance with applicable laws.” CVS said its locations “follow federal guidance regarding vaccine administration and are monitoring any changes that the government may make regarding vaccine eligibility.”

Kaiser Permanente Southern California said it was aware of potential changes, but noted no new formal guidance has yet been issued. As a result, Kaiser is continuing to follow existing guidance, which recommends the shots for everyone.

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The L.A. County Department of Public Health said that as of Wednesday, “pregnant women and healthy children can get vaccinated for COVID-19,” according to existing recommendations from an advisory panel and the CDC.

Chin-Hong noted there were 150 pediatric deaths in the U.S. from COVID-19 in a recent one-year period. That’s in the same ballpark as the 231 pediatric flu deaths recorded this season, and federal health officials recommend everyone ages 6 months and older get an annual flu shot.

“Most people would agree that kids should be targeted for flu vaccines. It seems kind of weird to have COVID as an outlier in that respect,” Chin-Hong said.

In the video published this week, Makary said that “most countries in the world have stopped recommending the vaccine for children.”

Maldonado, however, said the U.S. doesn’t use other nations’ standards to dictate vaccine recommendations. The U.S., for instance, recommends other types of vaccines that have a lower prevalence than COVID that people want to get, Maldonado said, such as the meningococcal vaccine for children to guard against a serious bacterial disease that can infect the brain and spinal cord and cause death within hours.

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The effect of a recommendation also varies by country. Canada, for instance, recommends updated COVID vaccines for seniors and other people who meet certain criteria, such as if they’re pregnant or are a healthcare worker. But the country’s universal healthcare system still allows everyone ages 6 months and older to get an updated COVID vaccine.

Although it’s true that children overall are at lower risk of developing severe COVID illness, those under 6 months of age “have the same risk of complications as the 65-year-old-plus population in this country,” said Stanford’s Maldonado, who also serves on the CDC’s Advisory Committee on Immunization Practices.

Among children eligible for vaccination, COVID-associated hospitalization rates are highest for those ages 6 months to 4 years, according to the CDC.

“So are children going to be the highest risk group? No, they’re not. But would you want to protect your child from a disease that could potentially put them in the hospital and get them on a ventilator? Yes, I would say that I would want to make that choice for myself. And why not allow the parent to make that choice?” Maldonado said.

The CDC says COVID vaccination during pregnancy builds antibodies that can help protect the baby; studies have also shown that vaccinated moms who breastfeed have protective antibodies in their milk, which could help protect their babies.

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There have been an estimated 260,000 to 430,000 hospitalizations attributed to COVID since October, causing “an enormous burden on the healthcare system,” Dr. Fiona Havers, a medical epidemiologist with the CDC, said at a recent public meeting. There have also been an estimated 30,000 to 50,000 COVID-19 deaths over the same time period.

“It is a major cause of morbidity and mortality, particularly in older adults, but it does affect other people, particularly those with underlying conditions, in younger age groups.”

COVID is also a major cause of pediatric hospitalizations, even among otherwise healthy children, she said.

“If there’s a summer wave this year, we’ll be seeing it in children being hospitalized with COVID as well,” she said.

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'It's pretty bleak': A warming planet is poised to get even hotter, forecasters warn

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'It's pretty bleak': A warming planet is poised to get even hotter, forecasters warn

As hot, dry and disastrous as the last few years have been, it appears that the chaos caused by a warming planet is just getting started.

Though the hottest year in nearly two centuries was recorded only last year, the world will probably shatter that record yet again by 2029, according to a new report from the World Meteorological Organization, the climate and weather arm of the United Nations.

There is a very good chance that average warming over the next five years will be more than 2.7 degrees Fahrenheit, or 1.5 degrees Celsius, above preindustrial levels, the cap established by the Paris Agreement to ward off the worst consequences of climate change. There’s an even better chance that at least one of those years will be more than 2.7 degrees above the 1850 to 1900 average.

That means we can expect many more days when the weather feels freakish and far more natural disasters that cost people their homes, health or lives.

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“It’s pretty bleak,” said Mike Flannigan, a fire scientist at Thompson Rivers University in British Columbia. “My fear is that [the coming years] will be even warmer than they suggest, and the impacts will continue to catch us by surprise and be more severe than we expect across the world, including the American West.”

In the western U.S. states, including California, those effects most probably include drought, heat waves and longer fire seasons with more intense wildfires, climate scientists said.

“As the globe has warmed thus far, the western U.S. has warmed as well, but without increases in precipitation that compensate for the drought- and wildfire-promoting effects of warming,” UCLA professor Park Williams said.

Last year, Williams examined 1,200 years of geological records and found that the previous 25 years were probably
the driest quarter of a century since the year 800. He sees no reason why that trend won’t continue.

“Given that there is not even a whiff of a hint that our global greenhouse gas emissions are going to slow in the next few years, then it appears virtually certain that the globally averaged temperature will continue to set new records every few years or so, just as it’s done over the past four to five decades,” Williams said.

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The projections in the U.N. report are based on more than 200 forecasting models run by scientists at 14 research institutes around the globe, including two managed by the U.S. National Oceanic and Atmospheric Administration.

The report found an 80% chance that at least one year in the 2025 to 2029 period will surpass 2024 as the warmest year on record, and an 86% chance that at least one of those years will exceed the 2.7 degrees warming target.

It estimated a 70% likelihood that average warming over that period will be more than 2.7 degrees, though total warming averaged over 20 years — the Paris Agreement standard — will probably remain below that threshold.

“Unfortunately, this WMO report provides no sign of respite over the coming years, and this means that there will be a growing negative impact on our economies, our daily lives, our ecosystems and our planet,” Ko Barrett, deputy secretary-general of the World Meteorological Organization, said in a statement.

The consequences of warming will probably vary widely across the world, the report found: rapid thawing of Arctic sea ice, drier seasons in the Amazon, excess rain in places such as Alaska, northern Europe and the Sahel in north-central Africa.

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Hotter temperatures are more effective at evaporating water out of plants and soil, leading to droughts and failed crop seasons. At the same time, a warmer atmosphere holds more moisture, which increases the chance of flood-inducing downpours and hurricanes.

Episodes of climate “whiplash” — rapid swings between wet-to-dry and dry-to-wet conditions — are also growing more frequent and intense because of rising global temperatures.

The devastating Palisades and Eaton wildfires in January erupted after such a period. Unusually heavy rains in 2023 led to an explosion of new vegetation, which dried out and turned into kindling during an exceptionally dry 2024.

The same week that the fires began, government agencies in the U.S. and around the world confirmed that 2024 was the planet’s hottest year since recordkeeping began in 1880. It was the 11th consecutive year the record had been set.

The U.S. will likely head into this period of climate chaos with a drastically reduced ability to forecast disasters and head off their worst consequences.

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Rounds of firings have reduced staffing at NOAA, including in the agency’s National Weather Service. The Trump administration has proposed a $1.5-billion cut to NOAA’s budget in 2026, a 25% reduction from the previous year’s spending.

Those budget cuts are part of a wider turn away from climate mitigation efforts.

The U.S. already had a messy relationship with the Paris Agreement. It withdrew from the international accord just days before President Trump lost his reelection bid in November 2020. The U.S. rejoined when Joe Biden entered the White House in January 2021, but pulled out again when Trump began his second term in January.

Trump has gone even further to roll back U.S. climate science this time.

The phrases “climate crisis,” “clean energy” and “climate science” are among the prohibited terms that federal funding recipients and employees must reportedly strike from websites, reports, regulations and other communications.

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In April, the administration dismissed more than 400 scientists and other experts who started writing the latest National Climate Assessment report, a congressionally mandated assessment of the latest climate change science and mitigation progress.

Meanwhile, the warming trend continues. And there’s no withdrawing from the planetary consequences.

“It’s scary. It really is,” Flannigan said. “A lot of people are ignoring this, or [saying] ‘it won’t be in my backyard.’ But it’s going to be in just about everyone’s backyard soon.”

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