Science
Researchers discover thousands of nanoplastic bits in bottles of drinking water
It seems anywhere scientists look for plastic, they find it: from the ice in Antarctica, to the first bowel movement produced by newborn babies.
Now, researchers are finding that the amount of microscopic plastics floating in bottled drinking water is far greater than initially believed.
Using sophisticated imaging technology, scientists at Columbia University’s Lamont-Doherty laboratory examined water samples from three popular brands (they won’t say which ones) and found hundreds of thousands of bits of plastic per liter of water.
Ninety percent of those plastics were small enough to qualify as nanoplastics: microscopic flecks so small that they can be absorbed into human cells and tissue, as well as cross the blood-brain barrier.
The research, which was published Monday in the journal Proceedings of the National Academy of Sciences, raises new concerns about the potentially harmful health effects — and prevalence — of nanoplastics. The researchers found that the quantity of such particles was 10 to 100 times greater than previously estimated.
“For a long time before this study, I actually thought that what was inside bottled water [in terms of] nanoplastics was just a few hundred PET particles,” said Naixin Qian, a Columbia chemistry graduate student and the study’s lead author. “It turns out to be much more than that.” PET, or polyethylene terephthalate, is a type of clear plastic that is commonly used for single-use water bottles.
Microplastics — particles that range from 1 micrometer to 5 milimeters in size — have been documented in bottled and tap water for several years. But the identification of nanoplastics — particles that measure just billionths of a meter — is raising alarms.
The incredibly small size of nanoparticles allows them to behave differently than larger pieces of matter, said Beizhan Yan, a Columbia environmental chemist and a co-author of the study.
Pollutants and pathogens can be carried on the surface of a particle, and the smaller a particle gets, the larger its surface area-to-volume ratio becomes.
As a result, Yan said, “even if they’re not that toxic at a larger particle size, when they become smaller they become toxic, because they can interfere in the cells, in the tissues, inside of the organelles.”
Research on the effects of plastic on human health is still in its infancy. It’s only been recently that scientists have identified the presence of plastics in people’s bodies and organs.
But research on other animals suggests a strong, negative influence on health. In laboratory studies of fish and rodents, microplastics were shown to interfere with development, reproductive ability and health, gut health, hormone levels, immune responses, the heart and more.
Study authors used a new type of microscope that can image the vibration of molecules to analyze the nanoparticles against a library of seven common plastics. They were unsurprised to find tiny bits of PET, as that’s what the bottles were made of. However, the amount of PET was dwarfed by the amount of polyamides, a form of nylon used in the reverse osmosis filters that water is run through before bottling.
Other plastics confirmed in the water in microscopic quantities include polystyrene, polyvinyl chloride and polymethyl methacrylate, also known as plexiglass. But only 10% of the nanoparticles analyzed could be classified as one of those seven known plastics, the researchers found. The origin of the rest is unknown.
During the past several years, researchers have identified microplastics from the deepest oceanic waters to the snowy tops of the planet’s highest mountains. They’ve found it in human blood, lung tissue and in the brain, and in organisms ranging from worms and zooplankton to whales and polar bears.
In some cases, the particles are ingested with food and water. In other cases, they are inhaled — scientists have found them in outdoor and indoor air, as well as in clouds — or absorbed through the skin.
The laundering of synthetic clothing and the breaking down of automobile tires are two of the largest sources of airborne plastics.
“As people, we are in environments where plastic is everywhere,” Yan said.
There’s also evidence that these small particles bioaccumulate, or grow more concentrated as they move up the food chain from one organism to the next.
Though the Columbia study didn’t analyze samples of tap water, previous studies looking at microplastics have found much lower concentrations of those particles in tap water than in bottled water.
Food packaging is also a known source of plastic contamination in food. On Jan. 4, Consumer Reports released the results of its investigation into plastic chemicals in common processed foods widely available in the U.S.
Plastic chemicals and nanoplastics “are part of the same problem, but they’re two totally different animals,” said James E. Rogers, a microbiologist who is acting director of product safety at Consumer Reports. “One is a chemical and one is a physical piece, even if it is micro-sized.”
Of the 85 food products tested, 84 had traces of phthalates, the most common type of chemical used to make plastic more durable. Nearly 80% of the foods contained bisphenols, another industrial chemical.
Both phthalates and bisphenols are known endocrine disruptors, meaning they interfere with the body’s hormonal systems. Exposure to these chemicals over time is associated with higher risks of diabetes, obesity, cancers and fertility problems, Rogers said.
“You may not be able to get to zero exposure, but at least you can reduce your risk by reducing your exposure,” Rogers said. “Cut out the fast food. Eat less processed foods. Eat less fatty food.”
Now that they’ve grossed us out about bottled water, the Columbia team are looking at how else they can use stimulated Raman scattering microscopy to seek out nanoplastics in other areas of life.
One project looks at the nanoplastics in exhaust and wastewater from commercial and residential washers and dryers. A pair of British adventurers currently trekking across Antarctica are collecting samples of snow for the team to analyze. The Columbia team is also collaborating with other research institutions to measure nanoplastics in human tissues and try to understand their effects on health.
And a group at the University of Waterloo, in Canada, are using artificial intelligence to help sort through the plastic bits they find in wastewater — providing a novel, and potentially more powerful and accurate, way of identifying different and often difficult to identify varieties of plastic in water samples.
“It’s an example of using AI for good,” said Wayne Parker, a professor of civil and environmental engineering at the school.
Methods like AI, or the technology used by the Columbia team to identify micro- and nanoplastics, will enable researchers to better identify “and assess the risks of these of these particles” in the environment and in ourselves, Parker said.
Science
What’s in a Name? For These Snails, Legal Protection
The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.
Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.
Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.
The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.
A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.
Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.
Science
Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order
new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order
By Meg Felling and Carl Zimmer
April 20, 2026
Science
Contributor: Focus on the real causes of the shortage in hormone treatments
For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.
Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.
In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.
Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.
Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.
The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.
Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.
Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.
Meanwhile, there are a few strategies to cope.
- Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
- Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
- Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
- Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.
Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.
Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.
Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book “When in Menopause: A User’s Manual & Citizen’s Guide.” Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”
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