Science
Parental mental health — not medication — drives autism correlation, new study finds
A sweeping new review of prenatal antidepressant use underscores a finding that has surfaced repeatedly throughout the last decade: While parental depression is strongly linked to child neurodevelopmental disorders, taking antidepressants during pregnancy does not appear to significantly increase a child’s risk of autism.
In an analysis of 37 separate studies covering more than 25 million pregnancies, a research team from the University of Hong Kong found that children born to women who took antidepressants while pregnant were indeed more likely to later be diagnosed with autism or attention-deficit/hyperactivity disorder (ADHD).
But when the researchers took into account confounding factors such as a family history of neurodevelopmental disorders or mothers’ preexisting mental health conditions, the correlation disappeared.
The data showed that children born to women with a history of depression were more likely to be diagnosed with autism or ADHD, regardless of whether their mother took psychiatric medication. Children were also more likely to be diagnosed with autism and ADHD if their fathers took antidepressants during their gestation, even if their mothers did not — an association that suggests a genetic link, not a pharmacological one.
The results were published this month in the journal the Lancet.
“Our findings are consistent with current clinical guidelines, which generally support continuing antidepressant treatment during pregnancy when it is clinically indicated,” said Dr. Wing-Chung Chang, a psychiatry professor at the University of Hong Kong and the paper’s senior author. “Our findings do not provide strong evidence that prenatal antidepressant exposure causes neurodevelopmental disorders.”
The possibility that antidepressant use in pregnancy may play a role in neurodevelopmental conditions has been a source of anxiety for many expectant parents since at least 2015, when a much-publicized Canadian study observed that women who took certain antidepressants later in pregnancy were about twice as likely to have an autistic child than women who did not take the drugs.
Multiple studies since then have also identified a correlation between a woman’s use of antidepressants during pregnancy and her child’s later diagnosis of autism, and to a lesser extent, ADHD.
But ending the analysis there overlooks a crucial distinction, researchers say: the possibility that the association actually is between the neurodevelopmental disorders and depression, not the medication.
Autistic people of all ages are significantly more likely than their neurotypical peers to be diagnosed with mental health conditions such as depression or anxiety. Large-scale population studies have found that autistic adults are up to three times as likely to have depression compared with non-autistic people.
The reasons for mental health symptoms in autistic people are varied and complex, and the challenges of navigating a world designed for a different way of thinking may play an important role. But research has also identified multiple genetic profiles and biological pathways common to autism and mood disorders, and it’s likely that both conditions are at least partially the result of family genetics.
“The mental health of your family tree is in some way statistically associated with your risk of autism,” said Brian K. Lee, a professor of epidemiology and biostatistics at Drexel University.
Neither depression nor autism causes the other. Lee compared their frequent co-occurrence to the pairing of fiery red hair and pale, sunburn-prone skin: two highly heritable traits that can easily occur independently in a given individual, but that often travel together through family trees.
“What the literature has shown us so far is that while there does, at face value, appear to be an association of slightly increased risk of autism in mothers who take antidepressant medications, when you control for the underlying depressive disorder that risk goes away,” said Dr. Kathryn Erickson-Ridout, a senior psychiatrist for the Permanente Medical Group and research scientist with the Kaiser Permanente Division of Research. “This evidence shows us that most likely, the biological pathways that are disrupted in major depression are also important for autism.”
Erickson-Ridout compared the chilling effect of the 2015 Canadian study on psychiatric care for pregnant women with the anxiety around vaccines sparked by Andrew Wakefield’s since-retracted 1998 paper inaccurately linking autism to the mumps, measles and rubella shot.
The Canadian study did not contain major errors as Wakefield’s paper did, though some critics argued at the time that it didn’t sufficiently control for confounding factors such as maternal depression.
But its media coverage often failed to make clear both the low overall risk of autism — 1.2% of babies born to women who took selective serotonin reuptake inhibitors during their second or third trimester were later diagnosed with autism, compared with 0.7% of babies in the general population — or weigh the risk of antidepressant use against the risks of untreated depression.
Its effects persist today. Last year, the U.S. Food and Drug Administration convened a controversial panel on prenatal SSRI use. Nine of the panel’s 10 members were researchers, doctors or psychologists who have previously questioned the drugs’ safety or criticized antidepressant use in general. Among them was Anick Berard, an epidemiologist and lead author of the 2015 Canadian paper.
Suicide is the second-leading cause of maternal mortality in the U.S., with homicide being the first.
Any discussion of the risks of antidepressant medications has to be weighed against the potential harms of abruptly ceasing or refusing to treat a potentially life-threatening mental health condition, said Dr. Katie Unverferth, a reproductive psychiatrist and medical director of UCLA’s Maternal Mental Health Program.
“Pregnancy is such an anxious time at baseline — so many new things are happening, and your body’s changing, and you want to make sure you’re doing the right thing for yourself and your developing baby,” Unverferth said. “This study just provides additional reassuring data.”
Science
New Winged Robot Can Fly and Swim Like a Puffin
Scientists hoped for years to make a machine that could emulate the movements of diving birds, such as puffins, and offer an affordable, unobtrusive way to monitor fragile marine ecosystems. A team of researchers at M.I.T. has been able to create such a waterproof winged robot, according to a study published July 9 in the journal Science.
Science
Anger grows in Boyle Heights as warehouse fire leaves stench, flies and vermin in its wake
Nearly one month after a fire destroyed a massive cold-storage facility in Boyle Heights, the neighborhood has been overcome by the stomach-churning stench of rotting food.
As facility operator Lineage works to remove more than 85 million tons of weeks-old food from its 500,000-square-feet warehouse, the rancid odors have attracted throngs of rats and swarms of flies, as a foul-smelling brownish liquid pours from the seams of the building.
Now, with a heat wave descending over much of Southern California, residents worry the odor could get even worse and scores of residents have called air quality regulators to complain. At the same time, environmental groups are accusing Lineage representatives and emergency responders of downplaying the risks pose by chemicals released during the fire.
Boyle Heights, a neighborhood that has been subjected to decades of toxic pollution from rail yards and other industries, has again become the center of attention in another environmental disaster. Already, the official response to the Lineage fire has eroded trust in government agencies, residents say.
Remediation work continues at a Lineage facility in Boyle Heights, where residents and nearby businesses have complained of a rotting food odor for weeks.
(Allen J. Schaben / Los Angeles Times)
On Tuesday, Sen. Alex Padilla (D-Calif.) visited the gutted warehouse alongside L.A. Fire Chief Jaime Moore and representatives of the South Coast Air Quality Management District and a contingent of environmental organizations. Padilla, along with Sen. Adam Schiff (D-Calif.) and Rep. Jimmy Gomez (D-Los Angeles), wrote a letter to the U.S. Environmental Protection Agency, calling on the agency to return to the cleanup zone to monitor air and water quality.
“Given the materials present in the warehouse, we are concerned about the long-term health and environmental impacts from contaminated smoke and water runoff on communities surrounding the warehouse,” the letter read.
Joe Lyou, president of nonprofit Coalition for Clean Air, told Padilla that he has heard of people becoming sick in the weeks after the event.
“I think that pointed to a problem with the messaging while the event first happened,” Lyou said. “It wasn’t consistent [with] if you smell smoke, see ash to get out and protect yourself — make sure you’re not exposed to it. There were different messages coming from different people, and we need to fix that.”
“The whole community was completely overwhelmed … and concerned about the ammonia, concerned about burning plastic, concerned about all sorts of other [emissions] that are really hard, difficult, expensive to measure. But … we’ll just never know some of those things,” Lyou said.
Street vendor Lupe Gonzalez pushes her cart away from a gutted warehouse in Boyle Heights.
(Allen J. Schaben / Los Angeles Times)
Chief Moore has faced criticism for his decision to advise residents to shelter indoors rather than to evacuate during the blaze. That stood in sharp contrast with Orange County fire officials, who evacuated tens of thousands of residents near an overheating chemical tank in Garden Grove in May.
On Tuesday, Moore told Padilla that the two incidents were very different. Moore said he had discussed the dilemma with TJ McGovern, the interim fire chief for the Orange County Fire Authority.
“He says everybody got mad at him because he evacuated everybody and nothing blew up,” Moore told Padilla. “But everybody’s mad at you because of the shelter-in-place [order] and it smells.”
Moore said that “there was nothing in the air that was hazardous” and that firefighters “never had a threat of an explosion.”
However, environmental experts said 14,000 pounds of flammable anhydrous ammonia were stored in tanks and used as refrigerant at the Lineage warehouse and posed a significant risk of explosion until it was removed days into the fire.
Environmental and community groups said L.A. fire officials also repeatedly emphasized the risks from ammonia in their radio communications. On the first day of the fire, a group of firefighters was hit by a plume of ammonia gas, and fire command quickly organized medical help.
“The majority of my division got exposed to ammonia gas. We’ll need to get them assessed.”
On Tuesday, Moore said no amount of ammonia was detected.
“When [firefighters] opened those doors, there was what looked like a big vapor cloud that came out,” Moore said. “That was the cold air mixing with the hot air that caused a vapor. It wasn’t ammonia.”
But residents remain skeptical.
Padilla’s visit follows a notice of violation that the South Coast Air Quality Management District issued to Lineage. The notice of violation was issued on July 12, after the agency received more than 40 public complaints of rotten, sour, garbage-type odors in the area. Inspectors confirmed the odors with community members and traced them back to cleanup operations at the facility, according to the air quality agency.
Boyle Heights residents are calling on Gov. Gavin Newsom to declare a mandatory evacuation of their community, saying the fire and the toxic aftermath are continuing to pose health risks. Without an evacuation order, they said, insurance companies won’t help residents who want to relocate with rent or mortgage relief.
“For nearly a month, a cold-storage warehouse fire has poisoned the air over the Eastside and Los Angeles County and City officials have refused to issue a mandatory evacuation,” read a statement from the community group Protect LA Now. “That refusal forces victims to pay their own way out, and leaves those who can’t afford to leave trapped in gases and toxins that no agency will name.”
Joe Lyou, president of the Coalition for Clean Air, explains how smell is affecting his health while talking to the media near a fire-gutted Lineage facility Tuesday.
(Allen J. Schaben / Los Angeles Times)
Tensions have been building in the community since the fire broke out on June 17 and burned for days.
At a contentious town meeting last week, Los Angeles Mayor Karen Bass struggled to open the meeting over the loud boos and yelling of community members, actions that were repeated as other elected officials took the microphone. The crowd grew even louder when Lineage Chief Operating Officer Jeff Rivera took to the stage and was met with shouts of “Liar!”
Air quality has been a constant concern for the community since the incident began. Beyond the health hazards of breathing in smoke from a building fire, there was a brief, temporary scare when an ammonia line that helped keep the building refrigerated was compromised, though Lineage has said the chemical was not detected in the air. Additionally, 85 million pounds of food thawed, burned and spoiled inside, creating a terrible smell that emanated from the property.
Nora Saenz, a resident of Bell, said she believed local leaders when they said there was no threat. During the fire, she took her niece and nephew to a community event in La Mirada, which was downwind of the fire.
Now Saenz fears what they might’ve breathed in.
“The day of the fire, we were told that the air was safe to breathe,” she recalled. “To this day, I don’t know what I exposed my niece and my nephew to.”
Times staff writers Salvador Hernandez, Clara Harter and Seamus Bozeman contributed to this report.
Science
China Launches Reusable Rocket in Race With SpaceX
Video released by Chinese state media shows a state-owned aerospace company launching a rocket and recovering part of it on Friday. The successful launch of a reusable rocket was a major step for China toward challenging SpaceX’s satellite internet dominance.
-
Los Angeles, Ca54 minutes agoSouthern California hits hottest day of its extreme heat warning
-
Detroit, MI1 hour agoSteve Yzerman out as Detroit Red Wings GM, moves to senior advisor role
-
San Francisco, CA1 hour agoSupervisors urge California to expand S.F. speed-camera program
-
Dallas, TX2 hours agoFive teens injured after crashing carjacked vehicle during Dallas police chase
-
Miami, FL2 hours agoTokyo-style Neapolitan pizza is coming to Miami, led by legendary pizzaiolo chef Bun
-
Boston, MA2 hours agoSEE THE GOOD: Roxbury center reminds young adults ‘You got this’ – Boston News, Weather, Sports | WHDH 7News
-
Denver, CO2 hours ago
Five Points affordable housing building honors Dr. Justina Ford | Rocky Mountain PBS
-
Seattle, WA2 hours agoSeattle weather: Hot and sunny day Wednesday, highs in the 80s