Science
Opinion: We’re retracting two papers from Stanford’s outgoing president. That’s part of how science should work
As the movie “Oppenheimer” has shown to millions, scientists disagree, have fragile egos, experience office politics and have problems in their personal lives. And they do something else that all humans do — make mistakes. That’s because science is a process, not a set of fixed facts. It doesn’t fall out of the sky fully formed. It’s messy and iterative.
On Thursday, Science issued retractions of two research papers it published from the outgoing president of Stanford University, Marc Tessier-Lavigne, who officially leaves his post Sept. 1. As editor in chief of Science, I hope that this move will help illustrate the importance of transparency in our field, especially around the fallible humanity of its scientists, their work and the publishing system that disseminates it.
Prior to publication, research papers have traditionally been seen only by the authors of the paper, the journal editor who handles the paper, and the authors’ peers who advise the journal on whether the work is of sufficient interest and reliability to be published. Only when the results are published are they pored over by many other experts.
If problems are spotted, they are sometimes shared and discussed online at websites such as PubPeer, on social media or by email among editors and authors. The now widespread online dissemination of “preprints,” which are unpublished versions of the paper, means that a broader group will see the results ahead of time on sites like bioRxiv. But even then, lots of mistakes still don’t get caught until after publication.
Then comes the challenge of how to react to identified mistakes. In an ideal world, the authors would engage collaboratively with journals and those who have raised concerns on determining how to adjust the scientific record to account for these problems, and journals would post updates quickly. This rarely happens, and that needs to change.
In the case of Tessier-Lavigne, scientists on PubPeer raised concerns in 2015 about papers he had co-authored in Science and Cell several years earlier. Images in the papers appeared to have been altered inappropriately prior to publication. Tessier-Lavigne contacted the journals to post corrections. Cell decided that they were not significant enough to warrant a correction. Science approved the corrections, but because of human error they were never posted to its website (our current staff was unable to nail down why that lapse occurred).
Theo Baker, an enterprising student journalist at Stanford, took interest in this and started writing extremely detailed stories about the specifics of this case, along with new concerns about the papers. That ignited a firestorm in Palo Alto. Because it involved the president of Stanford, the national media followed Baker into the story.
In keeping with what usually happens when high-profile institutions face uncomfortable matters, Stanford’s board of trustees commissioned an investigation by independent experts. Their report concluded that Tessier-Lavigne did not have direct knowledge of the errors, but that he did not catch or make enough effort to correct them and that “there may have been opportunities to improve” his lab’s oversight and management. He resigned after the release of the review.
Much has been written about why incidents like this happen, but the main reason is that securing a paper in prestigious journals such as Science, Cell or Nature can be so significant to the careers of the authors and their research that errors often either get overlooked or, in a subset of those cases, are carried out intentionally. This fact creates a high burden of responsibility for all involved. Journals, authors, institutions and funding organizations would all be best served if errors were corrected quickly and without a lot of drama over who is at fault.
Unfortunately, that seldom happens. Authors often contest corrections, even to the point of hiring attorneys to threaten legal action. While Tessier-Lavigne and other authors requested the retractions Science published, one author disagreed that the papers should be retracted. Institutions are afraid of legal action and running afoul of onerous requirements from funders over how to adjudicate these matters. And journals do not have the ability to carry out our own investigations, so we depend on other entities, which are bogged down by legal and public relations bureaucracies.
Journals are often the first to be criticized for the sluggishness and ineffectiveness of this process. We are an obvious, perhaps even easy target, as it is ultimately our decision to publish and then correct or retract papers. Some of the criticism is warranted. Journals have their own bureaucracies that we all need to manage better. More importantly, journals are often timid about explaining the details of errors in the scientific record for fear of further eroding public confidence in their practices and, more broadly, of wearing away public trust in science.
That needs to change. It’s time for everyone involved in recording the progress of science to start talking about its woes as well as its glories in plain language, without delays and before scandal forces the conversation. For all the triumphs of the scientific process, mistakes are part of it too. Whether they are allowed to erode trust is up to us.
Holden Thorp has been editor in chief of the Science family of journals since 2019.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight
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