Science
New Drug Slashed Deaths Among Patients With Severe Covid, Maker Claims
An experimental drug halved the demise charge amongst critically sick Covid sufferers who have been receiving supplemental oxygen and have been at excessive threat for critical lung illness and demise, the drug’s developer introduced on Monday.
There’s a urgent want for brand spanking new remedies for critically sick sufferers. Medicine like Paxlovid, made by Pfizer, are aimed primarily at sufferers who’ve gentle or average illness. Different remedies administered to hospitalized sufferers in critical situation have proven restricted effectiveness.
The brand new drug, sabizabulin, decreased deaths amongst hospitalized Covid-19 sufferers so drastically in a scientific trial that impartial security screens really helpful stopping it early, officers at Veru Inc., the drug’s maker, mentioned. The trial was halted on Friday.
The outcomes of that trial haven’t been reviewed by outdoors consultants or revealed in a medical journal. Veru introduced the findings at an early-morning information convention. The corporate’s inventory soared in buying and selling Monday following the announcement.
About half of the 52 trial individuals given a placebo or dummy capsule together with common care died inside 60 days, an indicator of how very sick they have been. However the demise charge was 20 % among the many 98 individuals who acquired sabizabulin, who have been simply as sick. The drug was given as soon as a day for as much as 21 days.
“Sabizabulin is the primary drug to reveal a clinically and statistically significant discount in deaths in hospitalized sufferers,” Dr. Mitchell Steiner, chief govt of Veru, mentioned. “This represents a giant step ahead.”
Most Covid restrictions have been lifted in the US after declining case numbers, however instances, hospitalizations and deaths around the globe proceed to be excessive, Dr. Steiner added. New variants are sure to emerge, and surges will comply with.
Near one million Individuals have died of Covid, and there are nonetheless 570 fatalities day by day on common.
The drug was granted so-called fast-track standing by the Meals and Drug Administration in January, Dr. Steiner mentioned. The designation is meant to immediate sooner growth and evaluate of latest remedies that deal with unmet medical wants and goal critical or life-threatening circumstances.
Dr. Steiner mentioned the corporate plans to fulfill with the company later this month and might be making use of for emergency-use authorization for sabizabulin. An F.D.A. spokeswoman declined to remark, saying the company didn’t verify, deny or touch upon pending purposes.
No security issues associated to the drug have been recognized in the middle of the scientific trial, firm officers mentioned.
“Regardless of it being two and a half years into the battle, we’re nonetheless working onerous to get extremely efficient medication into the combo to deal with this particular inhabitants of sufferers, and this can be a pretty dramatic enchancment in 60-day mortality,” mentioned Dr. Michael Gordon, one of many trial investigators and chief medical officer at HonorHealth Analysis and Innovation Institute in Scottsdale, Ariz.
However Dr. Gordon leavened his optimism with warning, saying he was desirous to see extra detailed analyses. Further information have been nonetheless being analyzed on Monday, together with the proportion of handled sufferers with out respiratory failure, the variety of days they spent in intensive care, the size of their hospital keep and the way lengthy they have been on mechanical air flow.
“No drug works for everyone,” Dr. Gordon mentioned. “The profit that was seen is mortality — who resides and who’s dying — not who’s getting off oxygen, although I anticipate we’ll see enchancment in different parameters, too.”
Sufferers on each arms of the multicenter trial acquired all commonplace care and therapy. The individuals have been in the US, Brazil, Argentina, Mexico, Colombia and Bulgaria, they usually had been contaminated with each the Delta and Omicron variants. The drug is efficient whatever the variant sort, Dr. Gordon and firm officers mentioned.
Sabizabulin was given in a 9-milligram dose in a capsule that was taken as soon as a day. It doesn’t require refrigeration, and the capsule will be given by mouth or opened up in order that the contents will be added to a feeding tube.
The drug is meant just for hospitalized sufferers at this level, so making it accessible to sufferers in the US might be less complicated than making it accessible to outpatients, which requires distributing it to pharmacies and educating normal docs about its use.
Sabizabulin works by disrupting the transport of the coronavirus by microtubules in cells. “It disrupts these ‘highways’ and breaks them down, so the virus can’t get from Level A to Level B,” Dr. Steiner mentioned.
The disruption additionally interferes with the motion of the physique’s personal cytokines, which works to tamp down irritation, he added.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight
President-elect Donald Trump joined Elon Musk in Texas and watched the launch from a nearby location on Tuesday. While the Starship’s giant booster stage was unable to repeat a “chopsticks” landing, the vehicle’s upper stage successfully splashed down in the Indian Ocean.
-
Business7 days ago
Column: Molly White's message for journalists going freelance — be ready for the pitfalls
-
Science4 days ago
Trump nominates Dr. Oz to head Medicare and Medicaid and help take on 'illness industrial complex'
-
Politics6 days ago
Trump taps FCC member Brendan Carr to lead agency: 'Warrior for Free Speech'
-
Technology5 days ago
Inside Elon Musk’s messy breakup with OpenAI
-
Lifestyle6 days ago
Some in the U.S. farm industry are alarmed by Trump's embrace of RFK Jr. and tariffs
-
World6 days ago
Protesters in Slovakia rally against Robert Fico’s populist government
-
News6 days ago
They disagree about a lot, but these singers figure out how to stay in harmony
-
News6 days ago
Gaetz-gate: Navigating the President-elect's most baffling Cabinet pick