Science
Kratom regulations shelved in California amid battle between advocacy groups
A California bill that would have imposed regulations on kratom products was quietly shelved Thursday following a clash between advocacy groups focused on the burgeoning industry.
Kratom products are derived from the leaves of a tree that grows in Southeast Asia, where kratom has long been chewed and brewed into teas. As it has gained more popularity around the globe, greenish capsules, powders and extracts have popped up in vape and smoke shops in California.
Scientists are still learning about its complex effects, which can range from stimulant to sedative and stem from chemical compounds called alkaloids. The Food and Drug Administration has warned against using kratom for medical treatment and says it is “not appropriate for use as a dietary supplement.” Among the reported side effects have been seizures, vomiting and heart problems. Kratom has also been involved in a small share of overdose deaths, although most also involved other drugs, analyses have found.
A bill proposed by Assemblymember Matt Haney (D-San Francisco) would have required kratom products to be registered with the state, and to carry mandated labeling and warnings. It also would have prohibited sales to anyone under 21.
In addition, Assembly Bill 2365 would have banned products containing synthesized versions of kratom alkaloids. And it would have prohibited ones in which a specific chemical makes up more than 1% of its alkaloid content.
That chemical is 7-hydroxymitragynine, also known as 7-OH. It is typically found in the dried kratom leaf in very low concentrations, although a more common alkaloid in the plant — mitragynine — breaks down in the human body to create 7-OH as well.
Scientists have raised concerns about its effects: One study in the Journal of Medical Toxicology said 7-OH “is likely to be a major contributing factor to the addictive potential of kratom.” Another article published in Addiction Biology said 7-OH “should be considered a kratom constituent with high abuse potential.”
Kirsten Smith, an assistant professor in the Department of Psychiatry and Behavioral Sciences at Johns Hopkins University, said that because 7-OH appears naturally at very low levels in the kratom leaf, products with much higher levels of 7-OH are “easily identifiable as being manipulated and man-made.”
“It’s no longer the botanical as it’s been used in nature,” Smith said, adding that she didn’t consider synthesized 7-OH products to be kratom at all.
Kratom advocacy groups were split over the California bill. It was backed by the Global Kratom Coalition, whose executive director, Matthew Lowe, argued kratom products should have an alkaloid content similar to the natural plant that has long been used. The coalition was joined by law enforcement groups in backing AB 2365.
In the opposing camp were the American Kratom Assn., which has fought bans on kratom products throughout the country and backed other state regulations, and Holistic Alternative Recovery Trust, which wants 7-OH to be explored as an alternative to opioids for pain relief.
The American Kratom Assn. contended that the regulatory structure needed for the California bill would be so costly that few companies would be able to pay the needed fees. State officials estimated it could cost over $4 million annually to regulate kratom under the bill.
AB 2365 “is promoted by one company who will benefit from the onerous provisions … to the detriment of small and mid-sized kratom manufacturers,” said Mac Haddow, its senior fellow on public policy. He argued Botanic Tonics — a beverage company listed as a supporter of the Global Kratom Coalition — had enough market presence that for them, the registration fees would not be prohibitive.
The Holistic Alternative Recovery Trust argued for a higher limit on 7-OH, saying that California should avoid being so restrictive that the products would lose therapeutic benefits.
Lowe said that the level they were pushing for — 2% of dry weight rather than 1% of the alkaloid content — was vastly higher and would threaten consumer safety. As for concerns about fees, Lowe said the focus should be “how the provisions in the bill inform and protect consumers, rather than the cost on the industry.”
“The Global Kratom Coalition is not looking to support any single vendor. We’re looking to ensure that kratom products are safe,” Lowe said. He added that the bill envisioned a tiered system for fees related to annual sales in California, which would allow lower fees for smaller companies.
AB 2365 stalled in the state Senate’s appropriations committee as lawmakers culled hundreds of bills on the so-called suspense file. The process allows legislative leaders to quietly halt bills that would have significant costs or pose challenging political dynamics, averting the need for many lawmakers to have to weigh in.
Haney said that “Californians are not safer by leaving kratom entirely unregulated in our state,” calling it “a total free-for-all.” The lawmaker said he plans to reach out to the California Department of Public Health to weigh next steps and hopes the FDA will take action, rather than leaving the matter to states.
“I have no interest in benefiting any particular player” in the kratom industry, but chose to err on the side of less potency, to the chagrin of “people who want to sell much stronger versions of kratom,” Haney said. He said if discussions continue, he would like the Department of Public Health to help define what is “synthetic.”
The public health department, which would have handled product registration under the bill, said it has not conducted any scientific assessment of the safety risks of 7-OH in kratom products.
The Global Kratom Coalition spent $15,000 on lobbying related to the bill, according to financial disclosures available as of Thursday. It also contributed $5,500 in political donations to Haney, who introduced AB 2365, and $36,400 to Atty. Gen. Rob Bonta, who supported it, according to state records.
Botanic Tonics, in turn, reported spending $90,000 on lobbying during this legislative session, including $30,000 during a period it was advocating on AB 2365. The company said other expenses were for “advice and counsel on the regulatory and legislative landscape specific to California.”
Holistic Alternative Recovery Trust reported spending $18,000 on lobbying over AB 2365. The American Kratom Assn. said it had not hired a lobbyist until the end of July and would report its spending after that point.
And the bill also drew interest from the kratom company MIT45 Inc., which reported spending $60,000 on lobbying. A company leader did not immediately clarify its position on the bill.
The National Institute on Drug Abuse says that “much is still unknown about chemical compounds related to kratom,” its health impacts and possible therapeutic uses, complicating discussions among regulators in California and across the country.
The Global Kratom Coalition has funded research on kratom at the University of Florida college of pharmacy, where researcher Christopher McCurdy and others have raised concerns about “semi-synthetic, isolated” alkaloids. Lowe said his group provided $500,000 total this year. Advancing research on kratom is part of its mission and “ensures that regulations are led by the evolving science,” he said.
McCurdy said the coalition and “many independent kratom vendors” had helped fund research there, but “no one that donates has any influence on what studies we conduct” and “they all understand that we will publish our findings without their review or consent.”
Smith said she had done consulting for the Global Kratom Coalition in the past, but that her research was funded by NIDA, not the coalition or any other groups connected to the kratom industry.
“We are in such early, early days of research” on kratom, she said.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
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