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Ivermectin Does Not Reduce Risk of Covid Hospitalization, Large Study Finds

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Ivermectin Does Not Reduce Risk of Covid Hospitalization, Large Study Finds

The anti-parasitic drug ivermectin, which has surged in reputation instead remedy for Covid-19 regardless of an absence of robust analysis to again it up, confirmed no signal of assuaging the illness, in keeping with outcomes of a giant medical trial printed on Wednesday.

The research, which in contrast greater than 1,300 folks contaminated with the coronavirus in Brazil who acquired both ivermectin or a placebo, successfully dominated out the drug as a remedy for Covid, the research’s authors stated.

“There’s actually no signal of any profit,” stated Dr. David Boulware, an infectious-disease knowledgeable on the College of Minnesota.

The researchers shared a abstract of those leads to August throughout a web-based presentation hosted by the Nationwide Institutes of Well being, however the full information set had not been printed till now in The New England Journal of Drugs.

“Now that folks can dive into the main points and the information, hopefully that can steer the vast majority of medical doctors away from ivermectin in direction of different therapies,” Dr. Boulware stated.

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For many years, ivermectin has been extensively used to deal with parasitic infections. Early within the pandemic, when researchers have been making an attempt hundreds of previous medication in opposition to Covid-19, laboratory experiments on cells recommended that ivermectin may block the coronavirus.

On the time, skeptics identified that the experiments labored because of excessive concentrations of the drug — far past protected ranges for folks. Nonetheless, some medical doctors started prescribing ivermectin for Covid-19, regardless of a warning from the Meals and Drug Administration that it was not authorized for such use.

All over the world, researchers carried out small medical trials to see if the drug handled the illness. In December 2020, Andrew Hill, a virologist on the College of Liverpool in England, reviewed the outcomes of 23 trials and concluded that ivermectin appeared to considerably decrease the danger of loss of life from Covid-19.

If bigger trials confirmed these findings, Dr. Hill stated in a presentation on the time, “this actually goes to be a transformative remedy.”

Ivermectin’s reputation continued to climb within the pandemic’s second 12 months. The podcaster Joe Rogan promoted it repeatedly on his exhibits. In a single week in August, U.S. insurance coverage firms spent $2.4 million paying for ivermectin remedies

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However not lengthy after Dr. Hill printed his overview final summer season, stories surfaced that lots of the research he included within the evaluation have been flawed and, in a minimum of one case, alleged to be fraudulent. Dr. Hill retracted his unique research and began a brand new one, which he printed in January.

On their second overview, Dr. Hill and his colleagues centered on the research least more likely to be biased. In that stricter survey, ivermectin’s profit vanished.

Nonetheless, even the most effective research on ivermectin and Covid have been small, with just a few hundred volunteers at most. Small research may be susceptible to statistical flukes that counsel constructive results the place none really exist. However bigger research on ivermectin have been underway on the time, and people promised to be extra rigorous.

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In Brazil, researchers arrange a medical trial often known as TOGETHER in June 2020 to check Covid sufferers with various extensively used medication, together with ivermectin. The remedies have been double-blinded, which means that neither the sufferers nor their medical employees knew whether or not they acquired a Covid remedy drug or a placebo.

In a single spherical of the trial, the researchers discovered promising proof that an antidepressant drug known as fluvoxamine decreased the necessity for hospitalization by one-third. The researchers printed their leads to October in The Lancet International Well being.

In a brand new research printed on Wednesday, the TOGETHER crew reported on its ivermectin information. Between March and August 2021, the researchers supplied the drug to 679 sufferers over the course of three days.

The outcomes have been clear: Taking ivermectin didn’t scale back a Covid affected person’s threat of ending up within the hospital.

The researchers zeroed in on completely different teams of volunteers to see in the event that they skilled advantages that others didn’t. For instance, it is likely to be attainable that ivermectin solely labored if taken early in an an infection. However volunteers who took ivermectin within the first three days after a constructive coronavirus check turned out to have worse outcomes than did these within the placebo group.

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Dr. Hill was impressed with the outcomes. “They’ve run a high-quality, placebo-controlled trial,” he stated. He additionally expressed impatience with the New England Journal of Drugs for taking months to publish the outcomes: “I don’t perceive the delay with this trial from NEJM.”

Julia Morins, a spokeswoman for the journal, declined to touch upon the delay. “We don’t touch upon the editorial course of, because it’s confidential,” she stated in an e mail.

Dr. Hill has run his evaluation of ivermectin research once more, this time together with the brand new information from the TOGETHER trial. All informed, his evaluation included greater than 5,000 folks. And as soon as extra, he noticed no profit from ivermectin.

Nonetheless, there are a number of ongoing randomized trials of ivermectin, with hundreds of volunteers, which have but to share their outcomes. The Nationwide Heart for Advancing Translational Sciences, which is a part of the N.I.H., has for greater than a 12 months been working one carefully watched trial of ivermectin and several other different medication for Covid sufferers. However it has but to launch outcomes.

Dr. Sarah Dunsmore, a program director within the medical improvements division at NCATS, stated that researchers have been analyzing the primary batch of outcomes on ivermectin and would launch them in two to 3 months.

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Dr. Boulware doubted that the extra trials would come to a unique conclusion, because the TOGETHER trial was so giant and punctiliously designed. “Not often would you look forward to finding one thing completely different,” he stated.

Dr. Paul Sax, an infectious-disease knowledgeable at Brigham and Ladies’s Hospital in Boston who was not concerned within the TOGETHER trial, shared Dr. Boulware’s view.

“I welcome the outcomes of the opposite medical trials and can view them with an open thoughts, however in some unspecified time in the future it is going to change into a waste of assets to proceed learning an unpromising strategy,” he stated.

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.

The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.

The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.

Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.

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The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.

After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.

As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.

Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.

The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.

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Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.

Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.

The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.

Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.

While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.

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Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.

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Political stress: Can you stay engaged without sacrificing your mental health?

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Political stress: Can you stay engaged without sacrificing your mental health?

It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.

“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”

Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.

Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.

The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.

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That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.

In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.

“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”

Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).

The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.

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For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.

Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.

“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.

Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.

There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.

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“Politics is many forms of stress all rolled into one,” Ford said.

Weinschenk observed this firsthand the day after the election.

“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”

That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.

Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.

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“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”

Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.

“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”

On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”

“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.

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Genessa Krasnow has been seeing a lot of that since the election.

The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.

“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.

“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”

That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.

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“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.

Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.

“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”

Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.

“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.

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The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”

“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

President-elect Donald Trump joined Elon Musk in Texas and watched the launch from a nearby location on Tuesday. While the Starship’s giant booster stage was unable to repeat a “chopsticks” landing, the vehicle’s upper stage successfully splashed down in the Indian Ocean.

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