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California case suggests Tamiflu may save cats infected with H5N1 bird flu

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California case suggests Tamiflu may save cats infected with H5N1 bird flu

Since the avian flu arrived en force in California’s dairy industry in 2024, not only has it sickened cows, it has killed hundreds of domestic cats. Some pet cats that live on dairy farms were infected with the H5N1 virus by drinking raw milk. Both pets and feral barn cats got sick after eating raw pet food that harbored the virus. Still others got it by eating infected wild birds, rats or mice, or from contact with dairy workers’ contaminated clothes or boots.

But a new published case suggests that death may be averted if infected cats are treated early with antiviral medications, such as Tamiflu, or oseltamivir. Once treated, these animals may carry antibodies to the virus that makes them resistant to reinfection, at least temporarily.

The discovery was made by Jake Gomez, a veterinarian who treats small animals, such as cats and dogs, as well as large ones, including dairy cows, from his clinic, Cross Street Small Animal Veterinary Hospital, in Tulare.

Last fall, Gomez worked with a team of scientists from the University of Maryland and University of Texas who were in the Central Valley collecting blood samples from outdoor cats at dairy farms, looking to see if they could find antibodies to the H5N1 flu.

Cats are exquisitely sensitive to H5N1; one of the telltale signs that a dairy herd is infected is the presence of dead barn cats.

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On Oct. 31, a cat owner brought in an indoor/outdoor cat to Gomez’ clinic that was ADR — a technical veterinarian acronym that stands for “ain’t doing right.”

The cat was up-to-date on all its vaccinations and the owner reported no known exposure to toxic chemicals.

Gomez offered to do blood work and urinalysis to probe more deeply what was going on, but the owner declined. So, Gomez sent them home with an antibiotic and an appetite stimulant. Two days later, the cat died.

It turned out the family had had another cat die just a few days earlier, Gomez said, recalling the visit.

Also during that time, Gomez was treating infected dairy herds around Tulare. Thousands of cows were falling sick from the virus. The family with the sick cats, he learned, lived less than a mile from an infected dairy, and the cat owner worked delivering hay to local dairies, spending time on infected farms.

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“Considering how quickly it moved from one cat to the next, it occurred to me it might be H5N1,” he said.

Gomez said he reached out to the U.S. Department of Agriculture and the California Department of Food and Agriculture to see if they would test the dead animals for the virus. The agencies, he said, gave him the runaround and he couldn’t get anyone to answer his calls — which he said was perplexing, considering the rapid response when he alerted them to infected cattle.

“If I called to tell them a dairy herd had it, within 24 hours a SWAT team from the USDA and state would be swarming the farm,” he said. But for a cat? Crickets.

On Nov. 6 and 7, the family returned with two more sick cats.

Gomez said he still didn’t know what they had, but had a suspicion they could be infected with H5N1. So, he treated them with the antiviral oseltamivir, known also as Tamiflu, and they recovered.

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In March this year, blood samples collected from the two cats showed high levels of antibodies to H5N1 — suggesting the cats had been exposed.

The case was published in the journal One Health.

Kristen Coleman, an airborne infectious disease researcher at the University of Maryland School of Public Health, and an author on the paper, said the findings suggest that cats may be effectively treated and that antiviral medications could help prevent further spread of the virus among cats living in the same home and the humans who care for them.

She said there have been no known transmissions from cats to humans in this outbreak, but there have in the past — in 2005, Thai zookeepers were infected by tigers that had the virus, and in 2016, New York veterinarians at an animal shelter got it from tending to sick cats.

But Jane Sykes, a professor of medicine and epidemiology at UC Davis School of Veterinary Medicine, said she’s not convinced the cats in this case actually had H5N1 — and urged people to read the study with care and caution.

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“It’s possible that the positive antibody test results were unrelated to the reasons why those two cats died,” she said. “The virus wasn’t detected in any of the four cats, so infection was not proven.”

And whether the cats recovered because they were treated with Tamiflu, or whether the medication was incidental and they’d have recovered on their own — from another virus, infection or ailment — isn’t clear.

In addition, she said, no one has researched the effects of Tamiflu on cats. And while these two cats appeared to tolerate the drug, that doesn’t mean other cats will.

“Cats metabolize some of the anti-infective compounds very differently than other animals, including people, and they’re quite susceptible to bad side effects of many of these drugs,” she said. “We have to be really careful when we start just using random antiviral drugs that haven’t been studied for safety in cats, because they are so likely to get bad side effects.”

Having said that, she said if she were faced with a similar situation, a high certainty that a cat had been exposed, whether from drinking raw milk or eating raw food that had been infected, she would consider prescribing the medication. But she’d caution her client that it was experimental, and the animal could die from the drug.

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She said there are numerous labs across the country that will test blood and urine for the virus.

Sykes urged people not to feed raw food or milk to their pets.

She said she’s seeing more raw food products for pets “and people want them, and they don’t understand the harms and the fact that some of these are contaminated for a long period of time with influenza viruses, like H5N1.”

Neither freezing nor smoking meat kills the virus.

“It’s astonishing how big this industry is getting,” Sykes said. “It’s crazy.”

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One label, many risks: how grouping Asian Americans hides deadly cancer patterns

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One label, many risks: how grouping Asian Americans hides deadly cancer patterns

California researchers are leading a nationwide effort to find out why some Asian American communities have high rates of certain cancers.

It comes as health experts see rising rates of lung cancer among Asian American women who have never smoked and increasing rates of early-onset breast cancer.

“Asian Americans are actually the first racial and ethnic group for whom cancer is the leading cause of death,” said Scarlett Gomez, a cancer epidemiologist at UC San Francisco and a lead on the project.

UCSF joins researchers from UC Irvine, UC Davis, Cedars-Sinai and Temple University in launching a $12.5 million National Cancer Institute-funded study called the ASPIRE Cohort, that will follow 20,000 Asian Americans over time. Researchers say it’s the first large-scale longitudinal cancer study focused on Asian Americans.

Lung cancer incidence has declined across much of the United States as smoking rates have fallen. However, researchers have observed a slight increase among Asian Americans, despite relatively low smoking rates, particularly among women. More than half of Asian American women diagnosed with lung cancer are nonsmokers, they say.

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Many existing studies of lung cancer risk among nonsmokers have been conducted in Asia, where exposure patterns can differ significantly from those in the United States, said Iona Cheng, a molecular epidemiologist at UCSF and also a lead on the project.

Researchers know that outdoor air pollution, secondhand smoke and cooking oil fumes can contribute to lung cancer risk. But it’s not clear if these explain disease patterns among Asian Americans in the United States.

Rising rates of breast cancer among Asian American women are also driving the push.

“Early onset breast cancer” — diagnosed before age 50 — “is going up the fastest among Asian Americans,” Gomez said. Recent data show rates among Asian Americans, Native Hawaiians and Pacific Islanders are approaching those of non-Hispanic white women, she said. Cancer experts don’t know why.

One of the central goals of the ASPIRE study is to move beyond treating Asian Americans as a single category. The term can include people with roots in dozens of countries from Sri Lanka to China’s border with Russia to Pacific islands, with completely different exposure patterns and cuisines.

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“When we separate and look at all the distinct Asian ethnicities, we see a wide variation,” Cheng said.

Filipino women have a higher incidence of thyroid cancer, and stomach cancer has been more common among some Korean and Japanese people. Combining all Asian Americans into one category can make those differences impossible to detect.

The study also seeks to address longstanding gaps in representation. Although Asian Americans make up nearly 8% of the U.S. population, they have historically received little research funding.

Existing cancer studies have also often included too few Asian Americans to draw meaningful conclusions about specific ethnic groups, researchers said. Salma Shariff-Marco, a social and behavioral scientist at UCSF and also a lead on the projects, aid that has made it hard to show the need for more targeted research. The ASPIRE cohort, she said, is designed to show the variation by including a broader range of ethnic groups and more contemporary exposures than previous work.

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Scientists probe cosmic visitor from deep space, come up empty in search for alien life

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Scientists probe cosmic visitor from deep space, come up empty in search for alien life

Last summer, a NASA-funded asteroid impact warning system detected a mysterious object speeding through the solar system.

Scientists determined the object had entered the solar system from deep space, making it the third known object to have come from another star system.

NASA called it Comet 3I/ATLAS and said it didn’t pose a threat. But its discovery in July led to wild speculation that the object was a piece of extraterrestrial technology — maybe even an alien spacecraft.

The SETI Institute, a nonprofit that explores the origins of life and searches for extraterrestrial intelligence, said this week that a team of scientists had used a radio telescope to try to detect signals that could indicate extraterrestrial life on the comet.

But they found none.

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“While observations strongly indicate that 3I/ATLAS is a natural object, interstellar visitors are also compelling technosignature targets because an artificial object — however unlikely — could represent detectable extraterrestrial technology and potentially provide the first evidence of life beyond Earth,” the institute said in a news release.

SETI scientists said they used the Allen Telescope Array at the Hat Creek Radio Observatory in Northern California to scan the object for seven hours, covering a spectrum of 1 to 9 gigahertz.

“This broad range allows scientists to search for narrowband radio signals, which are not produced in nature and would be evidence of technology,” the news release said.

The institute said the team identified nearly 74 million narrowband signals, but ultimately traced them back to technology on the Earth’s surface or orbiting satellites.

“The results from 3I/ATLAS show how realistic it is to detect a signal with the technology we have today,” said Valeria Garcia Lopez, one of scientists on the SETI team. “That is why it is important to keep searching for technosignatures, even from objects we might not expect to have signals.”

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The institute said the researchers also can learn more about the natural properties of interstellar objects as they travel through our solar system.

“As more interstellar objects are discovered, each offers a new opportunity to probe the cosmos for technosignatures, advancing our understanding of both natural and possible technological phenomena beyond our Solar System,” the SETI statement said.

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Emergency room visits during heat waves available to the public in ‘near-real time’ in L.A. County

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Emergency room visits during heat waves available to the public in ‘near-real time’ in L.A. County

For the first time, Los Angeles County residents can see how many people are ending up in emergency rooms, their bodies pushed past the limit, during heat waves.

The county Department of Public Health says its new Heat-Related Illness and Mortality Dashboard will provide heat illness counts in “near real time,” which means weekly. That might seem like a lag, but until now the data were only provided upon request and in ad hoc reports.

Heat is the leading cause of weather-related death in the United States and heat waves are only getting more frequent and intense as the climate changes.

Public health experts called the tracker a meaningful step toward assessing how well county programs are addressing heat risks.

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“It’s showing the county’s commitment to reducing the burden of heat on people’s health,” said David Eisenman, director of UCLA’s Center for Public Health and Disasters. “As the county puts more resources into that, this is a metric that allows the public to judge the effectiveness of the work.”

“There’s a handful of other places that also do this, but they’re all relatively new,” said Bharat Venkat, director of the UCLA Heat Lab, noting as examples Imperial and Riverside counties in California, Harris County in Texas and Maricopa County in Arizona. “It is very much welcome.”

The tracker takes heat illness data from patient complaints and doctor diagnoses provided by a countywide monitoring project that was previously available only to public health officials. The website says that what it provides is an undercount. The records often fail to count people when heat exacerbates more obvious health problems.

“Heat piggybacks off of preexisting health conditions,” Venkat said. “Say you go to the ER and you’re experiencing an intense psychotic episode, or a heart attack or a stroke. It’s very likely that the doctor is going to diagnose that as a psychotic episode, heart attack or stroke, and less likely that they’ll note that heat is contributing to that.”

Heat-related deaths are counted from death certificates, which present similar issues for undercounting. Those numbers will be reported monthly on the dashboard.

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L.A. County has a recently approved heat action plan that aims to educate the public and reduce indoor and outdoor temperatures with strategies such as opting for shade and air conditioning.

The new tracker breaks down daily heat-related emergency room visits and deaths by age group, geography, and race and ethnicity.

It shows that people over 65 are more vulnerable to heat illness. For Black residents, heat is disproportionately fatal. And people in the San Fernando, San Gabriel, and Antelope valleys see the most heat-related emergency room visits.

Kelly Turner, a professor of urban planning at UCLA, stressed that heat sickness tracks closely with social inequality and is preventable.

“A heat death or heat illness is dependent on who you are and what assets you have,” Turner said. “If you have air conditioning or not, if you work outside or you don’t, all of those factors factor in.”

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She noted that there is more risk in the San Fernando and San Gabriel valleys because of the combination of hotter days and more people who are unprotected. “When you map those two things on top of each other, you get a hot spot of vulnerability,” she said.

California already has a tool called CalHeatScore that uses historical hospital records and temperatures to forecast risk for different ZIP Codes in the state during heat events.

Public health officials hope to use the new dashboard to target messaging and public outreach when extreme heat strikes.

“If we’re having an extended heat event we can show that, ‘Hey, we’re having heat impacts’ as they’re happening,” said Dr. Nicole Quick, chief science officer at the L.A. County Department of Public Health.

Venkat said he would like to see the tool become more robust, in line with Maricopa County’s dashboard, widely viewed as the current gold standard for heat illness and mortality tracking. He said the Arizona county, which includes Phoenix, dives deeper into health records and conditions surrounding hospitalizations and deaths to better reflect the role of heat.

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“They do scene investigations and send someone out to take notes about where the body was found,” Venkat said. “What was going on? Did they have air conditioning? Were they outside? Did they have access to water? What medications were they taking? All those things provide important context.”

Eisenman said he would like to see the county train physicians on recording heat-related illness, as it has been “clear for a long time” that doctors don’t make the diagnosis enough.

“It would have to be more than just a handout or a few slides. You’d really have to have each institution make some effort to change physicians’ behaviors,” Eisenman said. He added that it probably hasn’t been done because of the costs involved.

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