Science
11% of high school seniors report using delta-8 THC, advertised as 'legal' form of cannabis
A molecular lookalike of the intoxicating compound found in marijuana has become popular among teens in the United States, especially in areas where marijuana use is illegal, a new study shows.
More than 11% of high school seniors who took part in a national survey last spring said they had used delta-8 THC, a psychoactive compound typically derived from hemp, in the last year.
That figure surprised researchers at USC and the University of Michigan, who published their findings this week in the Journal of the American Medical Assn.
Products containing delta-8 “have really only been on the market since 2018,” said study leader Alyssa Harlow, a USC epidemiologist and faculty member of the school’s Institute for Addiction Science.
Gummies, vapes and other products containing delta-8 are available online and in gas stations and convenience stores. They are often marketed as a federally legal substitute for marijuana — and often without solid measures for age verification.
“We don’t know enough about these drugs, but we see that they are already extremely accessible to teens,” said Dr. Nora Volkow, director of the National Institute on Drug Abuse, which helped fund the research. “Cannabis use in general has been associated with negative impacts on the adolescent brain.”
Delta-8 looks much like delta-9 THC — the more common molecule in cannabis that makes people feel high — but has a slightly different structure, with a double bond located between a different set of carbon atoms. Although both are naturally found in cannabis, delta-8 is less abundant.
In a 2021 survey, delta-8 users reported it to have less intense effects than delta-9, on average. But the Food and Drug Administration has warned consumers that it has not evaluated the safety of delta-8 products. Chemicals used to convert cannabinoids found in hemp into delta-8 may include harmful contaminants, the agency cautioned.
Products containing delta-8 exploded in popularity after the 2018 passage of an agricultural bill that eased federal restrictions on hemp and created a legal loophole for the compound.
The Agriculture Improvement Act allowed for the broader production of hemp, “which is cannabis that has only a very small amount of delta-9 THC,” said Ziva Cooper, director of the UCLA Center for Cannabis and Cannabinoids. That opened the door for people to extract chemical compounds from hemp, such as CBD, and convert them into other substances that can produce intoxicating effects, she said.
The result was that “delta-8 THC now seems to be legal, because it’s not specifically banned,” Cooper said. However, another federal law restricts a broader category of compounds that includes delta-8, she said, making things “very, very confusing.”
Some states have restricted or banned delta-8. But as of November, the National Cannabis Industry Assn. described it as “de facto legal” in nearly half of states.
The new findings on teen use of delta-8 come from the annual Monitoring the Future survey, a NIDA-funded project that asks U.S. adolescents about drug and alcohol use.
Some were using delta-8 fairly frequently: Among high school seniors who said they had used it in the previous year, more than a third said they had done so 10 or more times during that period.
It’s unclear if delta-8 affects teens differently than other forms of THC, but “even if it’s the same as other forms, we’re not in favor of 13-, 14- and 15-year-olds using cannabis,” said Dr. Wilson M. Compton, NIDA’s deputy director.
For teens, “we’d be concerned about its impact on learning and memory and day-to-day brain function,” Compton said. “There are also concerns about its use being associated with development of psychiatric illness, particularly psychotic disorders in those that are using cannabis particularly earlier in life,” he added.
Harlow and her colleagues found that in states where marijuana use is illegal for adults, 14% of high school seniors said they had used delta-8 in the last year. However, in states where marijuana was legal for adults, 8% of high school seniors said they used delta-8 in the previous year.
There was no clear difference based on state policies when it came to marijuana use, with more than 30% of the seniors overall saying they had used the drug in the last year. Among teens who reported using delta-8, nearly 91% said they had used marijuana as well.
The survey also revealed that teen use of delta-8 was more common in states where the psychoactive compound was not regulated.
“The alarm bells go off for me that these products are being marketed with claims of being a completely legal substitute for marijuana and they seem to be proliferating in areas where there’s really no regulation,” Harlow said. That lack of oversight can mean no required testing for potential contaminants, she said.
“We don’t necessarily know what is in the product that you are using — and you don’t know either,” Cooper said. “People are not making sure that there’s quality control or that there’s accurate labeling. … That in itself should make people who are thinking about experimenting pause.”
Other researchers have warned in the American Journal of Emergency Medicine that because of the lack of federal regulation, “products may be packaged in brightly-colored containers featuring cartoon characters, sweet or fruity flavors and candy-themed images that may be attractive to young children.”
In California, industrial hemp products may not legally contain more than a 0.3% concentration of THC — including delta-8 THC — nor can they include versions of the cannabinoid created through chemical synthesis, according to the state’s Department of Public Health. Harlow said that for delta-8, “most of the products that we’re seeing on the market are illegal in California.”
But “there is widespread flouting” of the state rules and “enforcement is practically nonexistent,” said Dale Gieringer, director of California NORML, an advocacy group focused on the rights of cannabis consumers. The result is “an enormous amount of delta-8 available by internet and convenience stores.”
Last year marked the first time the Monitoring the Future survey included a delta-8 question, which was posed to more than 2,000 high school seniors. In the coming years, researchers plan to query younger teens as well.
Compton said the numbers show that in a typical high school classroom, a handful of teens are likely using delta-8. In light of that, he said, “it’s incumbent on us to expand our research to understand the health impacts.”
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
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