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Experiencing low back pain? Clinical trial at Brown Health could help.

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Experiencing low back pain? Clinical trial at Brown Health could help.



The injection could be “revolutionary” for treating degenerative disc disease, said the trial’s principal investigator

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A clinical trial at Brown University Health to treat chronic low back pain with a one-time, non-surgical injection treatment is seeking to enroll patients in Rhode Island.

The trial is testing whether a single injection of rexlemestrocel-L, an experimental stem cell therapy derived from healthy adult donors, combined with hyaluronic acid, a gel-like substance found in the body’s joints, and delivered directly into the damaged disc, can provide prolonged relief for low back pain.

Low back pain, or degenerative disc disease, can affect quality of life, disrupt daily activities, commission people out of work and have an impact on a person’s mood, said Alexios Carayannopoulos, chief of physical medicine and rehabilitation at Rhode Island Hospital, Newport Hospital and Brown Health Medical Group and the principal investigator in the trial.

The treatment Carayannopoulos is investigating involves an injection without the need for an incision or hardware. While other treatments, such as anti-inflammatory pills, physical therapy or steroid injections, assuage the pain, they don’t treat the underlying issues with the damaged disc. The trial’s injection aims to do more than numb pain: it seeks to change the environment inside the disc, reducing inflammation and potentially slowing or stabilizing disc degeneration, according to Carayannopoulos.

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Earlier clinical trials of the injection with over 400 patients “found substantial pain improvements” lasting up to two to three years, according to Carayannopoulos. They also showed signs that the injection slowed disc height loss.

Carayannopoulos reckons the treatment could be “revolutionary” for managing chronic low back pain.

“We have struggled through many years trying to figure out the holy grail for treating back pain,” Carayannopoulos said.

There are surgical options and non-surgical options for treating low back pain. In most cases, the non-surgical options are sought first, but some patients still get unnecessary surgeries, according to Carayannopoulos.

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The new treatment could also cut back on the use of opioids, which for some patients can be addictive to the point of overdose. More than half of opioid prescriptions are for low back pain, according to Carayannopoulos.

“If we can identify a treatment that has long-term promise, then we can sort of have a paradigm shift in the way we organize and treat a cohort of patients with degenerative disc pain, which is one of the common contributors to low back pain,” Carayannopoulos said.

Carayannopoulos did not have data on how many people suffer from low back pain in Rhode Island, but based on the number of spine centers in the state and anecdotal evidence, he reckons there is a significant number of people with the condition.

“Part of that comes from some of the legacy of blue-collar work that’s being done, industry stuff, line work that’s still being done, some jewelry business. But the type of stuff that we see is often degenerate, meaning it’s happened over time,” he said.

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The trial is funded by Mesoblast, an Australia-based medicine company specializing in inflammatory diseases. It is designed for adults 18 years and older who have experienced chronic low back pain for at least six months, have been diagnosed with degenerative disc disease and have not found relief from other treatment options.

The trial is recruiting participants at Rhode Island Hospital and Newport Hospital. They will not be charged for participating and will be reimbursed for time and travel, according to Brown Health. To inquire about the trial, call 401-793-9177 or fill out a pre-screening information form online.

The trial is in its third phase, where researchers and clinicians are comparing results with a larger group of patients. It will be followed by a fourth phase, which will seek FDA approval to monitor long-term effectiveness and safety.



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Rhode Island

Health professionals warn Rhode Islanders to watch out for Lone star ticks

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Health professionals warn Rhode Islanders to watch out for Lone star ticks


Health professionals are warning Rhode Islanders to look out for a fast-moving threat in the brush this summer: the Lone star tick.

NBC 10’s Martha Konstandinidis went out to see the increase in ticks firsthand and has some simple steps to protect your family.



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Rhode Island House passes bill allowing water cremation and human composting

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Rhode Island House passes bill allowing water cremation and human composting


The Rhode Island House has passed a Bill that offers a rare alternative when considering end-of-life options: water cremation and human composting.

These processes are actually considered better for the environment.

Instead of being rooted in flames during cremation, remains are placed in water and no greenhouse gases are released.

Tom Harries, CEO of Earth Funeral – Green Funeral Home, explains the natural organic reduction also known as human composting, process while standing in front of an actual vessel in the warehouse during a tour at their new location, which will open in Elkridge. Eventually it will house 126 vessels. Jeffrey F. Bill/Baltimore Sun)

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Last year NBC 10 was able to get a first-hand look into how it works.

The John F. Tierney Funeral Home in Connecticut became one of the first in Southern New England to offer water cremation or “Aquamation” for humans.

Remains are placed into a machine, and water begins to circulate, leaving bone material behind.

Human composting uses fertile soil to break down remains.

Lawmakers on both sides spoke before the vote.

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It passed 47-17.

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It now heads to the Senate.



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On Your Dime: Rhode Island mayors traveling across the country on public funds

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On Your Dime: Rhode Island mayors traveling across the country on public funds


Rhode Island mayors are spending taxpayer dollars on out-of-state travel, attending conferences, summits, and networking events across the country while away from the cities they were elected to lead.

Public records obtained by the NBC 10 I-Team shows the mayors of Providence, Pawtucket, and Central Falls used public funds for out-of-state travel between March 2025 and March 2026. The mayors of Cranston, East Providence, and North Providence traveled out of state during that period but reported spending no taxpayer money on those trips.

Pawtucket Mayor Don Grebien spent $5,061.60 tied to 20 days of out-of-state travel, including $2,676.39 in city funds.

Grebien’s trips included the AGRIP Conference with the Rhode Island Interlocal Trust, Rhode Island Day in Washington, a Business Leaders Day conference hosted by U.S. Sen. Jack Reed, a Veterans Honor Flight, and a medical mission to Cape Verde with Project Health.

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Pawtucket Mayor Don Grebien spoke about his travel. (WJAR)

“I try to use the least amount of city dollars, use some campaign, and then put some of the private as well,” Grebien said. “I do understand the perception, and that’s why I’m very, very careful.”

Asked how much time at conferences is spent working versus networking, Grebien said, “It’s probably honestly 60-40, 60% work and 40% off time by the time you get everything going.”

Several Rhode Island mayors attended Rhode Island Day in Washington alongside the state’s congressional delegation, despite lawmakers regularly returning to Rhode Island.

Grebien defended the trips as an opportunity to meet federal officials and pursue funding opportunities for the city.

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“We are able on those days to go down and meet with department heads, so we have a lot of grants that we are in front of — HUD, the National Park Service — so it gives us that opportunity while we are there to do that,” he said.

{p}Pawtucket Mayor Don Grebien spent $5,061.60 tied to 20 days of out-of-state travel, including $2,676.39 in city funds. (WJAR){/p}

Pawtucket Mayor Don Grebien spent $5,061.60 tied to 20 days of out-of-state travel, including $2,676.39 in city funds. (WJAR)

Providence Mayor Brett Smiley spent more than 30 days out of state during the one-year period, according to records.

“Most of my travel is with the U.S. Conference of Mayors, which is hugely valuable,” Smiley said.

Invoices show Smiley attended five conferences or summits across the country, more than any other Rhode Island mayor.

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Those trips included the U.S. Conference of Mayors Summer Annual Meeting in Tampa, Florida; the U.S. Conference of Mayors Fall Leadership Meeting in Oklahoma less than three months later; the North American Mayors Summit Against Antisemitism in New Orleans; the International LGBTQ+ Leaders Conference in Washington; and the U.S. Conference of Mayors Winter Annual Meeting.

Records also show Smiley traveled to Israel with the Rhode Island Jewish Alliance and took a personal trip to Portugal.

Rhode Island mayors are spending taxpayer dollars on out-of-state travel, attending conferences, summits, and networking events across the country while away from the cities they were elected to lead.

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The city spent $1,793.75 on conference registration fees for two of Smiley’s trips.

While Smiley was in Providence during the Brown University shooting, he had been traveling the week before. When asked what would happen if a trip coincided with a city emergency, Smiley said he remains accessible.

“My travel is almost entirely domestic, and I have ready access to get home quickly,” Smiley said. “I was not prevented from doing my job at any point last year or this year either.”

The investigation found Central Falls Mayor Maria Rivera spent the most taxpayer money on travel during the period reviewed.

Rivera spent $3,302.23 on 17 days of out-of-state travel. That total included $717 from the police department budget for a joint trip with the city’s police chief.

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Rivera traveled to Washington for the Yale Mayor’s College and CEO Caucus and Rhode Island Day, to Atlanta for the Purpose-Built Communities Conference, to Puerto Rico for the Northeast Leadership Conference hosted by the Boys & Girls Club of Rhode Island, and to Chicago for meetings with the U.S. Conference of Mayors and police chiefs.

Rivera said the trips are necessary to build relationships and secure funding opportunities for Central Falls.

“Not every community has a $22 million budget, right? A lot of these communities have more funding,” Rivera said.

Central Falls City Hall. (WJAR)

Central Falls City Hall. (WJAR)

Rivera pointed to a connection she made during a trip to Chicago that later resulted in funding for the city.

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“This was a relationship I built when I went on one of these trips and I was able to get $25,000 for our summer food service program for this year,” she said.

When asked why she does not personally pay for conference travel, Rivera said the costs are difficult to cover privately.

“I wish I could pay for these trips out of my pocket, but it’s really hard,” Rivera said. “I am very careful. We get requests all the time. I don’t go to all these trips.”

Rivera was also the only mayor interviewed who said she canceled travel plans because of a city emergency, including a February 2026 trip to Washington that coincided with a blizzard.

Cranston City Hall (WJAR File Photo){p}{/p}
Cranston City Hall (WJAR File Photo)

Cranston Mayor Ken Hopkins spent six days out of state attending two national conferences but reported spending no city funds on the travel.

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Those conferences included the Community Leaders of America CLA|FCL South Carolina Spring National Conference in April 2025 and the CLA|FCL South Dakota Fall National Conference in October 2025. Attendance for both trips was paid for by the conference organization.

East Providence Mayor Bob DaSilva spent 12 days out of the city on two international trips, also without spending city funds.

DaSilva’s office says he traveled to Cabo Verde in July 2025 with several state and local leaders to celebrate the country’s 50th anniversary of independence. He also traveled to Sao Miguel in the Azores in June 2025 for the “Sister Cities Summit,” which was paid for by FLAD, the Luso-American Development Foundation.

North Providence Mayor Charles Lombardi spent 26 days out of state on five personal trips or vacations and one charitable honor flight, according to records reviewed by the I-Team.

The town said no city or campaign funds were used for Lombardi’s travel.

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