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Lilly weight loss drug Zepbound is now available

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Lilly weight loss drug Zepbound is now available


(CNN) — Indianapolis-based drugmaker Lilly announced Tuesday that its flagship weight loss medication, Zepbound, is now available for patient use.

Tirzepatide, its active ingredient, had been approved by the U.S. Food and Drug Administration as a treatment for type 2 diabetes called Mounjaro. Last month, the FDA approved it for use in chronic weight management, placing an official stamp of approval on a medicine widely prescribed off-label for weight loss.

Zepbound is intended for adults with obesity, or those who have a BMI higher than 30. It can also be prescribed for people who are overweight — with a BMI of 27 or higher — and who have weight-related medical problems, including hypertension, type 2 diabetes, obstructive sleep apnea or cardiovascular disease.

Tirzepatide works by mimicking two hormones, GLP-1 and GIP, which stimulate the release of insulin in the body. It reduces users’ appetites and slows the rate at which the stomach empties after a meal, helping them feel fuller. Semaglutide medications for weight loss, like Novo Nordisk’s Wegovy, focus on just targeting GLP-1.

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The medication will be available in six doses, ranging from 2.5 milligrams to 15 milligrams, through a prescription that can be filled at retail and mail-order pharmacies, Lilly said in a news release.

Like other weight loss drugs, Zepbound is an injection patients give themselves once a week. In the news release, Lilly recommends that the drug be used in combination with a reduced-calorie diet and increased physical activity.

However, Lilly warned that it should not be used alongside other similar weight loss medications such as Ozempic and Wegovy.

In clinical trials, Zepbound was found to yield more than 20% average weight loss at higher doses over 72 weeks, more than seen with other approved weight loss medications.

According to the FDA, Zepbound’s main side effects include gastrointestinal issues like nausea, vomiting, constipation and diarrhea.

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The drug’s label will also have warnings about the potential for inflammation of the pancreas, gallbladder problems, low blood sugar, acute kidney injury, diabetic retinopathy or damage to the retina in people with type 2 diabetes mellitus, and suicidal behavior or thinking.

Before insurance, Zepbound will cost about $1,060 per month, slightly higher than Mounjaro’s list price of $1,023.

However, it’s still unclear how broadly Zepbound will be covered. Medicare and Medicaid are prohibited from covering obesity medications. Lilly said it is releasing a savings card for people with commercial insurance to get Zepbound for $25 for a one- or three-month prescription if their plans cover it. For those whose plans don’t cover Zepbound, the savings card would lower the cost to $550 per month, or about half the list price.

Amid skyrocketing demand for weight loss drugs, many of the therapies have faced supply shortages. Mounjaro is still “in shortage” on the FDA’s drug shortages list, but all dose sizes are labeled as available.

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Indianapolis, IN

New Technology Can Change the Way You Hear Live Events  

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New Technology Can Change the Way You Hear Live Events  


An innovative technology company that enhances sound at live sporting events is looking to grow its operations in Indiana.   

Valtteri Salomaki, co-founder and CEO of EDGE Sound Research, says his company is building end-to-end audio infrastructure that allows users to control how they hear live events. The new technology, he says, lets users enjoy real-world experiences through heightened sound.  

Salomaki says the technology can be used at concerts, live sporting events, and at home. EDGE Sound Research works with sound from capture to reproduction. Salomaki calls it “a new way to create sound.”  

The new technology also allows the user to turn materials, like walls, couches, or seat cushions, into sound by manipulating vibrations. Once the hardware is attached to a material, the user can hear sound coming from it. Salomaki says this will allow event-goers to “feel what the performer feels.”

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Salomaki brought his idea to the Rally Innovation Conference pitch competition last year and walked away with a cash prize that allowed him to expand his research and development and create a new partnership with the Indiana Pacers. 

Initially, he was just looking to network and share how his product could impact the Indiana economy, but Salomaki says the Rally Innovation Conference was crucial to the growth of his business. Since then, he has been able to create new partnerships and is now focused on building out the commercial arm of his business in Indiana.  



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Indianapolis, IN

BLQ+ Pride Fest: A celebration of Indy's Black LGBTQ+ community

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BLQ+ Pride Fest: A celebration of Indy's Black LGBTQ+ community


INDIANAPOLIS — A celebration of Black LGBTQ+ pride was on full display on Monument Circle Saturday.

The BLQ+ Pride fest brought out hundreds of people as an opportunity to celebrate people of color who identify as LGBTQ+.

The celebration had vendors, queer health support organizations and entertainment.

WRTV

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According to the Human Rights campaign, over 80 percent of black LGBTQ+ youth say they have experienced homophobia or transphobia in the black community.

Organizers hope the event serves as a reminder to queer people of color that they have a community in the city of Indianapolis.

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“Black pride is important because black LGBTQ people need safe spaces to feel loved and celebrated in the State of Indiana,” President of Indiana Pride of Color Belinda Drake said.

The Human Rights campaign also says that racism is an issue in the LGBTQ+ community.

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Nearly 75 percent of black queer youth say they have experienced racism in the queer community.

Indiana Pride of Color is working to improve the quality of life for Indiana LGBTQ+ BIPOC communities.

Learn more about the Indiana Pride of Color organization, here.

WATCH | Organizations work to ‘break the stigma’ amid Mental Health Awareness Month

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Breaking the stigma of mental health during Mental Health Awareness Month





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Indianapolis, IN

BLQ+ Pride Summer Fest returns

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BLQ+ Pride Summer Fest returns


INDIANAPOLIS (WISH) — After a five-year hiatus, the BLQ+ Pride Summer Fest event was held on Monument Circle on Saturday.

The event featured several shopping, entertainment, and eating opportunities.

“They are doing testing, we have food vendors, we have alcohol for the adults, we have folks who are selling merchandise,” said Belinda Drake, president of Indiana Pride of Color. “We have the ice cone shop for the kiddos, too.”

The day is created to honor and celebrate Black, Queer joy in the city and state overall.

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One of the vendors who came out to sell items and celebrate alongside the community is Nakeya Harris, the owner of Meraki Mobile Boutique. Her shop carries women’s clothing items, with a specific focus on statement items with bright colors. She also carries jewelry and additional staples.

“I enjoy people expressing themselves and being free, so I wanted to be a part of that,” Harris said.

Local LifeJourney Church was also in attendance at the event. They aim to extend a safe space for worship to anyone interested.

“Today we are trying to reach out to communities of color and just say we have a welcoming space where people can come and be themselves

Though it is the first event of its kind since 2019, the Summer Fest is set to return to Monument Circle next year, and for many years to come.

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