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Weight-loss drugs’ impact on cancer risk revealed in new study

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Weight-loss drugs’ impact on cancer risk revealed in new study

Weight-loss medications and bariatric surgery have both been found effective at helping people shed excess pounds — and now a new study explores their link to obesity-related cancer (ORC) risk.

Obesity is a known risk factor for certain types of cancers, and has also been shown to impact cancer survival.

Obesity-related cancers include multiple myeloma, meningioma, adenocarcinoma of esophagus; stomach, colorectal, liver or bile duct, gallbladder, pancreas, uterus, ovary, renal-cell kidney, thyroid, and postmenopausal breast cancer, according to the Centers for Disease Control and Prevention (CDC).

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Researchers at Clalit Health Services in Tel Aviv, Israel, conducted an observational study of the medical records of 6,356 participants aged 24 and older who had obesity and diabetes, with no history of obesity-related cancer.

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Between 2010 and 2018, half of the participants took GLP-1 receptor agonists (GLP-1 RAs) — injectable medications for obesity and type 2 diabetes — with at least six drug purchases within 12 months. The other half underwent bariatric metabolic surgery (BMS).

Obesity is a known risk factor for certain types of cancers, and has also been shown to impact cancer survival. (iStock)

Overall, the study determined that “the direct effect of GLP1-RAs compared to BMS on the risk for ORC beyond their effects on weight-loss is estimated as 41% relative risk reduction.”

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The findings were published in the journal eClinicalMedicine.

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“The results point at the existence of additional pathways beyond weight loss in which GLP-1RAs contribute to the decreased risk of obesity-related cancer,” lead study author Yael Wolff Sagy, PhD, head of research at Clalit Health Services, told Fox News Digital.

How do GLP-1 RAs affect cancer risk?

Niketa Patel, professor of molecular medicine with the USF Health Morsani College of Medicine in Tampa, Florida, noted that obesity is associated with chronic inflammation.

“GLP1-RAs are shown to reduce inflammation and thus decrease the risk of developing ORC,” she told Fox News Digital. (Patel was not involved in the study.)

“The anti-inflammatory properties of these medications address a known risk factor for various cancers.”

“Bottom line: Obesity can cause certain cancers, and treatment of obesity with GLP1-RA reduces the risk of only obesity-related cancers.”

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Dr. Britta Reierson, MD, medical director of knownwell, a provider of metabolic health services, said there are several ways in which GLP-1 RAs could have cancer mitigation properties. 

“First, the anti-inflammatory properties of these medications address a known risk factor for various cancers,” the Minnesota-based doctor, who also was not part of the research, told Fox News Digital. 

Overall, the study determined that “the direct effect of GLP1-RAs compared to BMS on the risk for ORC beyond their effects on weight-loss is estimated as 41% relative risk reduction.” (iStock)

“Second, the metabolic regulation and improvement in metabolic health from these medications, including lowering blood glucose levels and decreasing insulin resistance, can reduce cancer risk.”

Emerging evidence also suggests that GLP-1 RAs may have direct anti-tumor effects, Reierson noted — “potentially through modulation of immune responses and epigenetic changes (changes that occur to gene expression and are passed down to future generations).”

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Research suggests that GLP-1 medications help reduce inflammation not just through weight loss, but also in other organs of the body, such as the heart, according to Dr. Susan Savery, MD, a board-certified obesity medicine and primary care physician with PlushCare, a virtual health platform offering primary care, therapy and weight management services.

“Over time, chronic inflammation can be a risk factor for cancer development, as it may damage cell DNA,” San Francisco-based Savery, who was not involved in the study, told Fox News Digital. 

“The metabolic regulation and improvement in metabolic health from these medications, including lowering blood glucose levels and decreasing insulin resistance, can reduce cancer risk.” (iStock)

“Our fat cells (adipose tissue) naturally produce inflammatory cells, and GLP-1 medications, similar to bariatric surgery, help reduce this inflammation by decreasing the amount of adipose tissue through weight loss.” 

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Potential limitations

The study did have some limitations, the researchers acknowledged.

“First, it is an observational study. It means that our comparison groups (persons who had surgery versus those who received GLP1-RAs) may still have some residual differences, despite our methodological efforts,” Sagy told Fox News Digital.

“However, only this type of real-life observational study can provide the long follow-up period that is necessary to evaluate the risk of developing cancer, which often has very long latency periods.”

Another limitation is that the primary drug included in the study was liraglutide (Saxenda, Victoza), with smaller numbers of people taking exenatide (Byetta) and dulaglutide (Trulicity).

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While GLP-1 RAs are “wonderful tools” that can support people on weight-loss journeys, Savery pointed out that maintaining a healthy lifestyle through nutritious eating and regular physical activity is “the foundation for cancer prevention and better overall health.” (iStock)

“It will be important to evaluate the comparative effectiveness of the newer GLP1-RA drugs, which are expected to have a larger effect,” Sagy said.

“Although the direction of the results is promising, we should wait and see if and how clinical guidelines will consider it.”

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Reierson agreed that much more research is needed before GLP-1 RAs could ever be considered as cancer prevention options. 

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“Larger, randomized, controlled trials are necessary to confirm the observed effects and better understand the underlying mechanisms,” she said. 

“It will also be important to investigate the impact of GLP-1 RAs on different types of cancer and assess the long-term safety and potential side effects of using GLP-1 RAs as a cancer therapy.” (American Cancer Society/Getty Images)

“It will also be important to investigate the impact of GLP-1 RAs on different types of cancer and assess the long-term safety and potential side effects of using GLP-1 RAs as a cancer therapy.”

Savery agrees that it’s likely too early to predict FDA approval for cancer therapy, but noted that “weight reduction plays an important role in cancer prevention, and GLP-1s seem to offer an additional benefit through inflammation reduction.”

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While GLP-1 RAs are “wonderful tools” that can support people on weight-loss journeys, Savery pointed out that maintaining a healthy lifestyle through nutritious eating and regular physical activity is “the foundation for cancer prevention and better overall health.”

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Common nighttime noise exposure may trigger heart problems, study suggests

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Common nighttime noise exposure may trigger heart problems, study suggests

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Living near heavy traffic could negatively impact your heart health.

A European study, published in the journal Environmental Research, found that exposure to nighttime road traffic noise is linked to changes in the blood, leading to worsened cholesterol and cardiovascular risks.

The researchers considered data from the U.K. Biobank, Rotterdam Study, and Northern Finland Birth Cohort 1966, including more than 272,000 adults over the age of 30, according to a press release.

Nighttime road noise exposure was estimated at all participants’ homes based on national noise maps. Researchers also took blood samples to measure the participants’ metabolic biomarkers for disease, then mapped the link between nightly noise levels and existence of biomarkers.

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Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers. (iStock)

The study found that people exposed to louder noise at night — especially sounds above 55 decibels — showed changes in 48 different substances in their blood. Twenty of these associations “remained robust” throughout all cohorts.

Exposure to loud noise was associated with increased concentrations of cholesterol-related biomarkers, especially LDL “bad” cholesterol, IDL (intermediate-density lipoprotein) and unsaturated fatty acids.

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As noise levels increased, starting at around 50 decibels, cholesterol markers rose steadily, the release stated.

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The authors concluded that this study “provides evidence that nighttime road traffic noise exposure from 50 dB upward is associated with alterations in blood cholesterol and lipid profiles in adults.”

Researchers noted a link between traffic noise and cardiometabolic disease. (iStock)

Study co-author Yiyan He, doctoral researcher at the University of Oulu in Finland, noted that in this type of research, small effect sizes are expected, and environmental exposures such as traffic noise are “typically modest.”

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“Despite this, we observed statistically robust and consistent associations across many biomarkers, especially those related to LDL and IDL lipoproteins,” she told Fox News Digital.

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“We also identified a clear exposure-response pattern starting at around 50 dB, suggesting that metabolic changes become more evident as noise levels increase.”

This aligns with public health guidance, as the World Health Organization recommends lower nighttime noise limits at around 40 to 45 dB, Yiyan He added.

“This finding may clarify the association between traffic noise and cardiometabolic diseases,” the researchers wrote. (iStock)

“The 55 dB level is often used as an interim benchmark associated with substantial noise annoyance and sleep disturbance,” she said. “In our study, we observed associations not only at 55 dB, but also indications of effects emerging at around 50 dB.”

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The strength and consistency of the cholesterol-related associations were surprising, as these changes are usually “subtle.”

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“Instead, we found consistent associations across multiple large European cohorts, which strengthens confidence that the findings may reflect real biological patterns,” Yiyan He went on. “We were also interested to see that effects were minimal below ~50 dB, suggesting a possible threshold-like pattern.”

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The researcher noted that these findings were consistent across genders, education levels and obesity status.

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The study was restricted to White Europeans, which posed a limitation. There was also a lack of information on the fasting status in the UK Biobank.

Changes in cholesterol levels were more severe than researchers expected. (iStock)

“Fasting can influence levels of certain metabolites, particularly fatty acids,” Yiyan He said. “However, based on UK Biobank documentation, fewer than 10% of participants were fasting for at least eight hours, and our main findings focused on cholesterol-related biomarkers, which are generally less sensitive to short-term fasting.”

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The researchers also lacked information on bedroom location, indoor noise exposure and time spent at home.

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“These factors may introduce non-differential exposure misclassification,” Yiyan He said. “Additionally, noise exposure estimates were based on participants’ temporary residential addresses at the time of blood sampling, without considering the duration of residence.”

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“Many of these limitations would tend to bias results toward the null, so the consistent associations we observed remain noteworthy.”

Experts recommend taking measures to limit traffic noise at night. (iStock)

Based on this latest research, Yiyan He noted that nighttime noise is a “health-relevant exposure,” not just “an annoyance.”

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“Our findings suggest that nighttime traffic noise may subtly but consistently affect metabolic health,” she said. “While the changes in cholesterol and lipid levels for any one individual are small, traffic noise affects a very large number of people, which means the potential public health impact could be substantial.”

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The researcher recommends taking measures like improving sound insulation, using noise-reducing strategies and placing bedrooms on the quieter side of the home when possible.

“Because sleep is a key pathway linking noise to health, protecting the nighttime sleep environment is especially important,” she added.

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism

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The Best Time To Drink Coffee for Weight Loss and a Faster Metabolism


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The Best Time To Drink Coffee for Weight Loss and Fat Burn | Woman’s World




















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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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‘SuperAgers’ stay mentally sharp well past 80, as scientists reveal the reason

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→ Some 80-year-olds still have razor-sharp brains — and now scientists know why

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SuperAger Ralph Rehbock sits with his wife in his home.  (Shane Collins, Northwestern University)

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