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US man who got first pig heart transplant dies 2 months later

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US man who got first pig heart transplant dies 2 months later

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The primary particular person to obtain a coronary heart transplant from a pig has died, two months after the groundbreaking experiment, the Maryland hospital that carried out the surgical procedure introduced Wednesday.

David Bennett, 57, died Tuesday on the College of Maryland Medical Heart. Medical doctors didn’t give a precise explanation for loss of life, saying solely that his situation had begun deteriorating a number of days earlier.

MAN GETS GENETICALLY ALTERED PIG’S HEAT TRANSPLANT IN FIRST-OF-ITS-KIND PROCEDURE

Bennett’s son praised the hospital for providing the last-ditch experiment, saying the household hoped it could assist additional efforts to finish the organ scarcity.

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“We’re grateful for each revolutionary second, each loopy dream, each sleepless evening that went into this historic effort,” David Bennett Jr. stated in a press release launched by the College of Maryland College of Drugs. “We hope this story may be the start of hope and never the tip.”

Medical doctors for many years have sought to at some point use animal organs for life-saving transplants. Bennett, a handyman from Hagerstown, Maryland, was a candidate for this latest try solely as a result of he in any other case confronted sure loss of life — ineligible for a human coronary heart transplant, bedridden and on life help, and out of different choices.

FILE – On this photograph supplied by the College of Maryland College of Drugs, members of the surgical workforce present the pig coronary heart for transplant into affected person David Bennett in Baltimore on Friday, Jan. 7, 2022. Bennett, the primary particular person to obtain a coronary heart transplant from a pig died Tuesday, March 8, on the College of Maryland Medical Heart, two months after the groundbreaking experiment. His loss of life was introduced Wednesday.
(Mark Teske/College of Maryland College of Drugs through AP)

After the Jan. 7 operation, Bennett’s son advised The Related Press his father knew there was no assure it could work.

Prior makes an attempt at such transplants — or xenotransplantation — have failed largely as a result of sufferers’ our bodies quickly rejected the animal organ. This time, the Maryland surgeons used a coronary heart from a gene-edited pig: Scientists had modified the animal to take away pig genes that set off the hyper-fast rejection and add human genes to assist the physique settle for the organ.

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At first the pig coronary heart was functioning, and the Maryland hospital issued periodic updates that Bennett gave the impression to be slowly recovering. Final month, the hospital launched video of him watching the Tremendous Bowl from his hospital mattress whereas working together with his bodily therapist.

Bennett survived considerably longer with the gene-edited pig coronary heart than one of many final milestones in xenotransplantation — when Child Fae, a dying California toddler, lived 21 days with a baboon’s coronary heart in 1984.

“We’re devastated by the lack of Mr. Bennett. He proved to be a courageous and noble affected person who fought all the best way to the tip,” Dr. Bartley Griffith, who carried out the surgical procedure on the Baltimore hospital, stated in a press release.

PIG KIDNEY TRANSPLANT SUCCESSFULLY TESTED ON DECEASED WOMAN

The necessity for one more supply of organs is big. Greater than 41,000 transplants have been carried out within the U.S. final yr, a file — together with about 3,800 coronary heart transplants. However greater than 106,000 folks stay on the nationwide ready listing, hundreds die yearly earlier than getting an organ and hundreds extra by no means even get added to the listing, thought of an excessive amount of of a protracted shot.

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The Meals and Drug Administration had allowed the dramatic Maryland experiment underneath “compassionate use” guidelines for emergency conditions. Bennett’s medical doctors stated he had coronary heart failure and an irregular heartbeat, plus a historical past of not complying with medical directions. He was deemed ineligible for a human coronary heart transplant that requires strict use of immune-suppressing medicines, or the remaining various, an implanted coronary heart pump.

Medical doctors didn’t reveal the precise explanation for Bennett’s loss of life. Rejection, an infection and different issues are dangers for transplant recipients.

However from Bennett’s expertise, “now we have gained invaluable insights studying that the genetically modified pig coronary heart can operate nicely inside the human physique whereas the immune system is sufficiently suppressed,” stated Dr. Muhammad Mohiuddin, scientific director of the Maryland college’s animal-to-human transplant program.

One subsequent query is whether or not scientists have realized sufficient from Bennett’s expertise and another current experiments with gene-edited pig organs to steer the FDA to permit a medical trial — presumably with an organ akin to a kidney that isn’t instantly deadly if it fails.

Twice final fall, surgeons at New York College received permission from the households of deceased people to briefly connect a gene-edited pig kidney to blood vessels outdoors the physique and watch them work earlier than ending life help. And surgeons on the College of Alabama at Birmingham went a step additional, transplanting a pair of gene-edited pig kidneys right into a brain-dead man in a step-by-step rehearsal for an operation they hope to attempt in dwelling sufferers presumably later this yr.

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Pigs have lengthy been utilized in human medication, together with pig pores and skin grafts and implantation of pig coronary heart valves. However transplanting whole organs is rather more complicated than utilizing extremely processed tissue. The gene-edited pigs utilized in these experiments have been supplied by Revivicor, a subsidiary of United Therapeutics, certainly one of a number of biotech corporations within the working to develop appropriate pig organs for potential human transplant.

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’

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It’s long been known that no amount of alcohol is good for the body — and now new research spotlights the potential harm it can cause.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research (AACR).

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Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%).

TO REDUCE CANCER RISK, SKIP THE ALCOHOL, REPORT SUGGESTS

“Excessive levels of alcohol consumption increase the risk for six different types of cancer, including certain types of head and neck cancer, esophageal squamous cell carcinoma, and breast, colorectal, liver and stomach cancers,” said Rajarshi Sengupta, PhD, lead author of the AACR Cancer Progress Report 2024, in a statement sent to Fox News Digital.

More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research. (iStock)

“Further, research shows that alcohol intake at an early age can increase the risk of cancer later in life.”

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Based on these findings, limiting or eliminating alcohol can reduce the risk of developing alcohol-related cancers by 8% and the risk of all cancers by 4%, the report noted.

Addiction expert warns of risks

There has been a “roller coaster of information” about whether alcohol is harmful, according to addiction psychiatrist Dr. Adam Scioli of Caron Treatment Centers in Pennsylvania.

“There have even been reports for years that it could be beneficial for one’s health — but we know now that alcohol ingestion is one of the modifiable risk factors for cancer,” Scioli, who is not affiliated with AACR, told Fox News Digital.

‘DOES SMARTPHONE EXPOSURE CAUSE BRAIN CANCER?’: ASK A DOCTOR

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, according to Scioli. 

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The more someone drinks — both in volume and frequency — the higher the risk, he warned.

Doctor holding lung x-ray and woman smoking

Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%). (iStock)

“Alcohol is a toxin,” Scioli said. 

“We’ve long known that it impacts any number of organs, essentially starting with the brain and working its way down to the colorectal system.”

Is there a ‘safe’ amount?

Moderate alcohol use is defined as one drink or less in one day for women. 

For men, it is two drinks or fewer per day, according to the Centers for Disease Control and Prevention (CDC).

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“We’ve long known that alcohol impacts any number of organs, starting with the brain and working its way down to the colorectal system.”

“Drinking alcohol in moderation may increase your overall risks of death and chronic disease,” the agency stated on its website.

“Even low levels of alcohol use (less than one drink per day) can raise the risk of certain cancers.”

      

Scioli agreed, emphasizing that “we can definitely say there’s no added health benefit to ingestion of alcohol.”

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“The line between safety and danger is debatable, and is different for each person.”

While risk factors like tobacco use are widely known, public awareness about the link between alcohol and cancer is still low, according to Sengupta.

alcoholic beverages

Moderate alcohol use is defined as one drink or less in one day for women, and two drinks or fewer for men, per the CDC. (iStock)

Most Americans (51%) are not aware that alcohol increases cancer risk, per AACR data.

“It’s been flying under the radar for far too long — especially given the number of Americans who have met the criteria for alcohol use disorder, which is around 29 million Americans in 2023,” said Scioli.

What needs to change?

The good news, according to Scioli, is that with modifiable risk factors like alcohol, reducing the intake decreases the risk. 

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As the report stated, those who are successful in decreasing their drinking or abstaining below those moderate risk levels will see a risk reduction in overall cancers, he noted.

cancer patient looks out window

Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, an expert said. (iStock)

“We need to do a much better job of making the public aware of the risks inherent in drinking — particularly moderate to heavy drinking,” Scioli said. 

“And we need to make the public aware that there are mechanisms by which they can access help if they are unable to moderate their drinking or quit on their own.”

For more Health articles, visit www.foxnews.com/health

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To help raise awareness, Sengupta of the AACR called for public messaging campaigns, “such as cancer-specific warning labels displayed on alcoholic beverages.”

Along with that, she told Fox News Digital, “effective clinical strategies that reduce or eliminate alcohol consumption must be considered to reduce the burden of alcohol-related cancers.”

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight

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Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight


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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

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New schizophrenia drug gets FDA approval, taking novel approach to treating brain disorder

A new drug has been approved for the treatment of schizophrenia in adults.

On Thursday, the U.S. Food and Drug Administration (FDA) approved COBENFY (xanomeline and trospium chloride), an oral medication that is manufactured by Bristol Myers Squibb in New Jersey.

This marks the first new class of medications for the brain disorder in several decades, according to a press release.

5 MYTHS ABOUT SCHIZOPHRENIA, ACCORDING TO A MENTAL HEALTH EXPERT: ‘HUGE STIGMA’

COBENFY is expected to be available in the U.S. in late October, the company noted.

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A new drug has been approved for the treatment of schizophrenia in adults. (iStock)

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community, where after more than 30 years, there is now an entirely new pharmacological approach for schizophrenia — one that has the potential to change the treatment paradigm,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb, in the press release.

STUDY REVEALS HEAVY MARIJUANA USE IS LINKED TO SCHIZOPHRENIA

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors.

It often causes hallucinations, delusions, disordered speech and loss of touch with reality, Mayo Clinic states on its website.

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COBENFY

COBENFY (xanomeline and trospium chloride) is an oral medication that is manufactured by Bristol Myers Squibb in New Jersey. (Bristol Myers Squibb)

The disorder can also lead to lack of emotional expression, lack of motivation, cognitive dysfunction and social withdrawal.

Approximately 2.8 million people in the U.S. and 24 million people globally are living with schizophrenia.

AI-DISCOVERED DRUG SHOWS ‘ENORMOUS POTENTIAL’ TO TREAT SCHIZOPHRENIA: ‘REAL NEED FOR BETTER TREATMENT’

The disorder has traditionally been treated with antipsychotic medications, but around 40% of patients do not respond to treatments and 60% experience “inadequate improvement” in symptoms or “intolerable side effects,” studies have shown.

COBENFY

COBENFY is expected to be available in the U.S. in late October, the company noted. (Bristol Myers Squibb)

COBENFY works differently than the currently available schizophrenia medications.

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“Due to its heterogeneous nature, schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies,” said Rishi Kakar, MD, chief scientific officer and medical director at Segal Trials and investigator in the drug’s clinical trials, in the release. 

“Schizophrenia is not a one-size-fits-all condition, and people often find themselves in a cycle of discontinuing and switching therapies.”

“The approval of COBENFY is a transformative moment in the treatment of schizophrenia because, historically, medicines approved to treat schizophrenia have relied on the same primary pathways in the brain.”

“By leveraging a novel pathway, COBENFY offers a new option to manage this challenging condition.”

Bristol Myers Squibb

“Today’s landmark approval of our first-in-class treatment for schizophrenia marks an important milestone for the community,” said Chris Boerner, PhD, board chair and chief executive officer at Bristol Myers Squibb. (iStock)

Sam Clark, founder and CEO at Terran Biosciences — a biotech company that develops treatments and technologies for neurological and psychiatric diseases in New York City — commented on the new approval in a statement sent to Fox News Digital.

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“I am excited that the FDA has just approved [COBENFY] as a treatment for patients with schizophrenia, marking a big leap forward in the psychiatry space,” he said. 

      

“These patients live with a difficult disease, and this drug with a novel mechanism of action will surely make a significant impact,” Clark continued. 

“We look forward to seeing the renaissance continue as this approval paves the way for future breakthroughs and novel patient-focused therapeutics.”

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The approval follows three phases of clinical trials in which COBENFY was shown to result in a “statistically significant improvement in illness.”

schizophrenia split

Schizophrenia is a serious mental illness that affects a person’s thoughts, feelings and behaviors and often causes hallucinations and delusions. (iStock)

In terms of safety, the medication’s most common side effects during clinical trials were nausea, indigestion, vomiting, diarrhea, constipation, hypertension, abdominal pain, accelerated heart rate, dizziness and gastroesophageal reflux disease, the release stated.

Patients with certain existing medical conditions may experience other, more serious risks.

For more Health articles, visit www.foxnews.com/health

People should discuss potential complications with a doctor before starting the medication.

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Fox News Digital reached out to Bristol Myers Squibb and the Schizophrenia & Psychosis Action Alliance requesting comment.

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