Health
Study finds exposure to ‘forever’ chemicals in household products leads to liver cancer
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A brand new examine means that people with common publicity to artificial chemical substances present in on a regular basis family merchandise have a larger probability of creating liver most cancers.
Researchers from the Keck Faculty of Medication of the College of Southern California decided that people have 350% larger odds of creating the illness if they’re uncovered to man-made “perpetually” chemical substances. The examine, which was revealed in JHEP Studies earlier this week, is the primary to verify the correlation utilizing human samples.
“Endlessly” chemical substances is a time period utilized in reference to per- and polyfluoroalkyl substances (PFAS) present in client and industrial merchandise. The chemical substances break down slowly and embed themselves into human tissues, particularly the liver.
“This builds on the prevailing analysis, however takes it one step additional,” mentioned Jesse Goodrich, a postdoctoral scholar on the Keck Faculty of Medication. “Liver most cancers is likely one of the most severe endpoints in liver illness, and that is the primary examine in people to indicate that PFAS are related to this illness.”
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The staff was capable of make their dedication as a result of they got entry to human samples from the Multiethnic Cohort Research, a database of greater than 200,000 residents from Los Angeles and Hawaii. They narrowed their pattern measurement to 100 survey members and analyzed the blood and tissue samples of fifty with the illness and 50 with out most cancers.
“A part of the explanation there was few human research is since you want the best samples,” mentioned Keck Faculty of Medication professor Veronica Wendy Setiawan. “When you’re an environmental publicity, you want samples from properly earlier than a analysis as a result of it takes time for most cancers to develop.”
Researchers discovered that topics had been 4.5 occasions extra more likely to develop hepatocellular carcinoma, the most typical kind of liver most cancers, in the event that they had been within the high 10% of “perpetually” chemical publicity in comparison with these with decrease ranges of those chemical substances of their blood.
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PFAS was first found in human blood in the course of the Seventies, and by the Nineties was discovered within the blood samples of the overall inhabitants. Regardless of efforts by some U.S. producers to section out the utilization of those chemical substances, PFAS are long-lasting substances which are capable of break down into water provides. It’s believed that these chemical substances are current within the blood of greater than 98% of adults in the USA.
“We consider our work is offering vital insights into the long-term well being results that these chemical substances have on human well being, particularly with respect to how they will injury regular liver operate,” mentioned Dr. Leda Chatz, one of many examine’s researchers. “This examine fills an vital hole in our understanding of the true penalties of publicity to those chemical substances.”
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Health
One state leads country in human bird flu with nearly 40 confirmed cases
A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).
As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).
This represents more than half of the human cases in the country.
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The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.
The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.
The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.
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It is not yet known how the child was exposed to the virus and an investigation is ongoing.
“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release.
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“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.”
Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks.
“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.
Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.
“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.
“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”
As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).
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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.
Health
Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.
“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”
For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.
The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.
It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”
A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.
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