Health
Single dose of 'magic mushrooms' provides 5 years of depression relief, researchers find
NEWYou can now listen to Fox News articles!
Psilocybin, the main psychoactive ingredient in magic mushrooms, could alleviate depression for at least five years after just one dose, according to a new study.
The research, presented June 18 at the Psychedelic Science 2025 conference in Denver, followed up with patients who had been diagnosed with clinical depression — also known as major depressive disorder (MDD) — and had participated in a previous psilocybin treatment study in 2020.
“Most people who participated in our trial reported improvements in depression symptom intensity or in the ways in which they experienced depression in their life, lasting up to five years after the trial,” study co-author Alan Davis, director of the Center for Psychedelic Drug Research and Education at The Ohio State University, told Fox News Digital.
PSYCHEDELICS AS POTENTIAL MENTAL HEALTH TREATMENT ARE EXPLORED BY TRUMP ADMINISTRATION
Doug Drysdale, CEO of the Canadian pharmaceutical company Cybin in Toronto, Ontario, told Fox News Digital that the outcome speaks to the “exciting” potential of psilocybin and other psychedelic-based treatments in treating MDD and other mental health conditions.
“The results of the study are certainly very encouraging,” said Drysdale, who was not involved in the study.
A worker holds dried psychedelic mushrooms. The results of the new study are “certainly very encouraging,” said one pharmaceutical company executive. (James MacDonald/Bloomberg via Getty Images)
Earlier studies pointed toward the possibility of psilocybin as a potential antidepressant, prompting researchers to conduct the first-ever randomized clinical trial.
The initial 2020 trial, published in JAMA Psychiatry, included 24 patients with major depressive disorder. Half received psilocybin at the beginning of the trial, and the other half received the treatment eight weeks later.
Each patient also underwent 11 hours of psychotherapy.
WHAT IS KETAMINE THERAPY? MORMON REALITY STARS TOUT CONTROVERSIAL TREATMENT
One month after treatment, 17 patients reported experiencing symptom relief. Fourteen of those reported full remission from depression, according to the published study.
“The effectiveness of psilocybin therapy after a single or only a few administrations represents another substantial advantage over commonly used antidepressants that require daily administration,” the researchers wrote.
Patients appeared to respond much faster to psychedelics than to traditional antidepressants, the researchers stated. (James MacDonald/Bloomberg via Getty Images)
The new study aimed to explore the longer-term effects of this treatment on 21 of the original trial participants.
Sixty-seven percent reported being in remission from depression five years after treatment, and they also had less anxiety and easier daily functioning.
“The study doesn’t account for naturalistic changes that could have affected their depression in the five years since the main trial.”
For those whose depression came back, many still reported lasting benefits in their attitudes, perspectives and ability to pursue things that were meaningful to them, Davis told Fox News Digital.
“Certainly, more controlled and rigorous study is required, but at least anecdotally, these findings are very interesting, and I am cautiously optimistic about the potential for extended efficacy provided by these types of treatments,” Drysdale added.
Sixty-seven percent of participants reported being in remission from depression five years after treatment, and they also had less anxiety and easier daily functioning. (JASON CONNOLLY/AFP via Getty Images)
Other factors may have also played a role in the participants’ long-term mental health benefits, such as psychotherapy sessions or other antidepressants, experts agreed.
“The study doesn’t account for naturalistic changes that could have affected their depression in the five years since the main trial, and the sample is not representative of the population of people suffering with depression,” Davis told Fox News Digital.
PARKINSON’S PATIENTS WHO TAKE ‘MAGIC MUSHROOMS’ SEE KEY BENEFITS, STUDY FINDS
Psilocybin has also been explored as a potential treatment for post-partum depression (PPD), which affects as many as one in seven new mothers.
A 2022 study outlined the potential role of psychedelics in PPD cases, finding that psilocybin has been shown to catalyze a sense of “reconnection” in new mothers.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“This effect in PPD, by fostering a sense of ‘reconnection’ for the mother, may allow for improved mood and maternal sensitivity toward the infant, which can positively impact maternal role gratification and the mother-infant relationship,” the researchers stated.
In February, Cleveland Clinic reported on an upcoming study that explores single-dosing psilocybin as a way to treat PPD.
Psilocybin has been explored as a potential treatment for post-partum depression (PPD), which affects as many as one in seven new mothers. (iStock)
The trial, now in its second phase, focuses on RE104, a proprietary drug similar to psilocybin.
Study participants will undergo multiple physical and mental health tests.
Potential risks and limitations
Ryan Moss, chief science officer at Filament Health, a clinical-stage natural psychedelic drug development company in Canada, has emphasized the importance of administering psychedelics in a safe setting when treating mental health conditions.
For more Health articles, visit www.foxnews.com/health
“Psychedelic experiences can sometimes feature anxiety, hallucinations and paranoia,” Moss previously told Fox News Digital.
Experts recommend that therapeutic use of psychedelics should be carefully managed by medical experts.
“Some patients using traditional psychedelics have reported experiencing adverse cardiovascular events during clinical trials.”
To mitigate these risks, Moss recommended clinical trial participants receive thorough preparation and monitoring by trained professionals during sessions.
Other factors may have also played a role in the participants’ long-term mental health benefits, noted an expert (not pictured), such as psychotherapy sessions or other antidepressants. (iStock)
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and Fox News’ senior medical analyst, previously interviewed two of the country’s top researchers on psychedelics: Dr. Rachel Yehuda, founder and director of the Center for Psychedelic Psychotherapy and Trauma Research at Mt. Sinai in New York, and Dr. Charles Marmar, director of the PTSD research program at NYU Langone.
“They agree there is therapeutic potential if very carefully studied under very strict medical guidance, but there is a huge downside in terms of unregulated recreational uses,” Siegel told Fox News Digital at the time.
“Both doctors see likely therapeutic value to psychedelics if carefully managed by medical experts,” Siegel added.
Melissa Rudy and Angelica Stabile, both of Fox News Digital, contributed reporting.
Health
Brain Health Challenge: Doctor Appointments for Your Mind and Body
Congratulations, you’ve reached the final day of the Brain Health Challenge! Today, we’re asking you to do a few things that might feel a bit out of left field — like getting your blood pressure checked.
No, it isn’t as fun as playing Pips, but experts say it’s one of the most important things you can do for your brain. That’s because heart health and brain health are intrinsically linked.
High blood pressure, in particular, can damage brain cells, and it’s a significant risk factor for stroke and dementia. When blood pressure is too high, it places stress on the walls of arteries in the brain. Over time, that added stress can cause the blood vessel walls to thicken, obstructing blood flow. In other cases, the increased pressure causes the artery walls to thin and leak blood into the brain.
These changes to the blood vessels can sometimes cause a large stroke to occur. More commonly, the damage leads to micro-strokes and micro-hemorrhages, which cause fewer immediate problems and often go unnoticed. But if someone has hypertension for years or decades, these injuries can build up, and the person may start to experience cognitive impairment.
High blood pressure “is known as a silent killer for lots of reasons,” said Dr. Shyam Prabhakaran, the chair of neurology at the University of Chicago. “It doesn’t cause you any symptoms until it does.”
Because the damage accumulates over many years, experts say that managing blood pressure in midlife matters most for brain health. Hypertension can be addressed with medication or lifestyle changes, as directed by your doctor. But the first thing you need to do is know your numbers. If your blood pressure comes back higher than 120/80, it’s important to take it seriously, Dr. Prabhakaran said.
While you’re at it, there are a few other aspects of your physical health that you should check on.
Your eyes and ears are two of them. Hearing and vision loss have both been shown to increase the risk of dementia. Experts think that with less sensory information coming in to stimulate the brain, the regions that process hearing and vision can start to atrophy. What’s more, people with sensory loss often withdraw or are left out of social interactions, further depriving them of cognitive stimulation.
Oral health can also affect your brain health. Research has found a connection between regular flossing and reduced odds of having a stroke. That may be because good oral health can help to reduce inflammation in the body. The bacteria that cause gum disease have also been tied to an increased risk of Alzheimer’s.
And have you gotten your shingles vaccine? There is mounting evidence that it’s a powerful weapon for protecting against dementia. One study found that it lowered people’s odds of developing the condition by as much as 20 percent.
To wrap up this challenge, we want you to schedule a few medical appointments that benefit your brain, as well as your body.
After five days of feeding, exercising and challenging your brain, you are well on your way to better cognitive health. Thanks for joining me this week, and keep up the good habits!
Health
Health experts react as Andrew Huberman backs Trump admin’s new food pyramid
NEWYou can now listen to Fox News articles!
The Trump administration has taken a new approach to the food pyramid.
The Department of Health and Human Services (HHS) announced new guidelines on Wednesday with an updated, inverted pyramid. The top of the pyramid, which is now the wider part of the structure, is built on meat, fats, fruits and vegetables, while whole grains are at the narrow bottom.
This follows HHS Secretary Robert F. Kennedy Jr.’s mission to “Make America Healthy Again” (MAHA), aimed at addressing chronic disease, childhood illnesses and ultraprocessed foods.
DOCTORS WARN SOME POPULAR FOODS AND DRINKS COULD BE SECRETLY SABOTAGING MEN’S TESTOSTERONE LEVELS
“The new guidelines recognize that whole, nutrient-dense food is the most effective path to better health and lower health care costs,” Kennedy said during a press briefing in Washington, D.C.
“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines. We are ending the war on saturated fats.”
The Trump administration announces the 2025-2030 Dietary Guidelines for Americans, putting “real food” back at the center of health. (realfood.gov)
The HHS secretary rallied against refined carbohydrates, food additives and added sugar, highlighting the health risks associated with sugar-sweetened beverages.
Kennedy’s main message to Americans was to “eat real food.”
TRUMP ADMIN’S NEW NUTRITION GUIDELINES TARGET ULTRA-PROCESSED FOODS, EASE UP ON RED MEAT AND SATURATED FATS
The announcement triggered reactions from top health and wellness voices, including Stanford neuroscientist Dr. Andrew Huberman, host of the “Huberman Lab” podcast.
In a post on X, Huberman shared the White House’s graphic of the new pyramid, praising the decisions that were made.
“Oatmeal (and I think that’s rice and sourdough) made the cut!” he commented. “In all seriousness, assuming overall calories are kept in check and people exercise & get sun(day)light, this looks spot on.”
He added, “Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great.”
CLICK HERE FOR MORE HEALTH STORIES
Huberman said in a thread on the same post that Americans “don’t have to eat all the foods” shown in the diagram.
“You won’t see me drinking milk or eating shrimp,” he said. “Nothing against shrimp, I just don’t like the taste. Aversion to crustaceans.”
“Maybe up the veggies a bit, add low-sugar fermented foods like sauerkraut & this is great,” Huberman commented on X. (Chance Yeh/Getty Images for HubSpot; iStock)
The new guidelines received praise from other major health figures, including former FDA commissioner Dr. David Kessler.
“There should be broad agreement that eating more whole foods and reducing highly processed carbohydrates is a major advance in how we approach diet and health,” Kessler told The Associated Press.
“Protein and healthy fats are essential, and were wrongly discouraged in prior dietary guidelines.”
Dr. Bobby Mukkamala, president of the American Medical Association, shared in a statement that these guidelines “affirm that food is medicine and offer clear direction patients and physicians can use to improve health.”
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
“The American Medical Association applauds the Administration’s new Dietary Guidelines for spotlighting the highly processed foods, sugar-sweetened beverages and excess sodium that fuel heart disease, diabetes, obesity and other chronic illnesses,” Mukkamala wrote.
The American Medical Association applauded the HHS for its updated nutrition guidelines. (iStock)
But not all feedback was positive.
Some people expressed concern about prioritizing red meat and dairy, while calling for the limitation of saturated fat.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
Neal Barnard, president of the Physicians Committee for Responsible Medicine, shared in a reaction to STAT that while the guidelines “do have one or two good points, emphasizing fruits and vegetables and limiting alcohol,” the guidelines are “for the most part a strong reflection of industry influence.”
Christopher Gardner, a nutrition expert at Stanford University, also spoke out against the new guidelines, as reported by NPR.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
“I’m very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that’s something to prioritize. It does go against decades and decades of evidence and research,” said Gardner, who was a member of the Dietary Guidelines Advisory Committee.
Fox News Digital’s Rachel Wolf, as well as Alexandria Hoff of Fox News, contributed reporting.
Health
Matt Damon’s Gluten-Free Diet Helped Him Lose 18 Pounds
Use left and right arrow keys to navigate between menu items.
Use escape to exit the menu.
Sign Up
Create a free account to access exclusive content, play games, solve puzzles, test your pop-culture knowledge and receive special offers.
Already have an account? Login
-
Detroit, MI5 days ago2 hospitalized after shooting on Lodge Freeway in Detroit
-
Technology3 days agoPower bank feature creep is out of control
-
Dallas, TX4 days agoDefensive coordinator candidates who could improve Cowboys’ brutal secondary in 2026
-
Health5 days agoViral New Year reset routine is helping people adopt healthier habits
-
Nebraska2 days agoOregon State LB transfer Dexter Foster commits to Nebraska
-
Iowa2 days agoPat McAfee praises Audi Crooks, plays hype song for Iowa State star
-
Nebraska2 days agoNebraska-based pizza chain Godfather’s Pizza is set to open a new location in Queen Creek
-
Entertainment2 days agoSpotify digs in on podcasts with new Hollywood studios