Health
Pennsylvania mom seeks ‘perfect match’ bone marrow donor to cure daughter’s rare disorder: ‘Crucial need’
A 10-year-old girl in Pennsylvania is in dire need of a bone marrow transplant — and her mother is on a mission to find the perfect match.
Lani Walter suffers from a disease called DOCK8 deficiency (dedicator of cytokinesis 8 deficiency), an immunodeficiency syndrome that can cause recurrent, life-threatening infections.
DOCK8 is very rare, with only 250 people worldwide currently diagnosed, statistics show. The only cure for DOCK8 is a bone marrow transplant — also known as a hematopoietic stem cell transplant (HSCT).
YOUNG GIRL SURVIVES CANCER THANKS TO LITTLE SISTER’S LIFESAVING DONATION: ‘A PERFECT MATCH’
Ashleigh Walter, a kindergarten teacher, is pleading for people to join the bone marrow/blood stem cell registry to help her daughter find a donor by summer.
“Time is of the essence,” she told Fox News Digital.
Search for answers
Walter’s daughter was diagnosed with DOCK8 when she was 7½ years old, the culmination of a long series of symptoms and illnesses.
Lani Walter, 10, is in dire need of a bone marrow transplant — and her mother is on a desperate mission to find the perfect match. (Ashleigh Walter)
“Lani’s health issues started at just a couple of months old,” Walter told Fox News Digital during an interview. “As a baby, she had full-body eczema from head to toe and continuous ear infections.”
At 11 months old, she was diagnosed with severe allergies to eggs, milk, peanuts, tree nuts and many other foods. She’s also experienced continuous skin infections and staph infections.
In Jan. 2021, the family was invited to a clinic at the Children’s Hospital of Philadelphia (CHOP), where Walter’s daughter was able to see specialists from immunology, allergy and dermatology together in one appointment.
NEW JERSEY WOMAN RECOVERING AFTER RECEIVING SUCCESSFUL PIG KIDNEY TRANSPLANT
“They all came together to try and figure out what might be going on,” Walter said. “Each of the specialties ran their own special bloodwork to see what was going on with Lani.”
The results showed some abnormalities in the immune system, and doctors recommended doing genetic testing.
Lani Walter, pictured, has suffered from health issues since birth. She was diagnosed with a DOCK8 deficiency when she was 7 years old. The only known cure is a bone marrow transplant. (Ashleigh Walter)
A few months later, the family received the news that Walter’s daughter has two variants of the DOCK8 gene.
“If you have issues on both sides of the gene, that’s when you present with the disorder,” Walter said. “Testing showed that both my husband and I are recessive carriers to the DOCK8 variant, which we passed down to Lani.”
She added, “So that was when we found out that all of the health issues Lani has experienced throughout her entire life were not unrelated.”
“All of the health issues Lani has experienced throughout her entire life were not unrelated.”
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in Lani Walter’s care but commented on the condition.
“DOCK 8 is a rare immune condition where the bone marrow doesn’t make enough immune cells and the immune cells that are made have trouble penetrating into dense tissue, like skin,” he told Fox News Digital.
After the diagnosis, Walter’s daughter was invited to visit the National Institute of Health in Maryland, where researchers are studying DOCK8 deficiency.
Lani Walter, left, is pictured with her mother, older sister and father. If she does not find a 100% perfect bone marrow match, her mom, Ashleigh Walter, who is a 50% match, will donate. (Ashleigh Walter)
“We go there about every six months to see how Lani is doing, and what they recommend as she gets older,” Walter said.
The symptoms of DOCK8 deficiency tend to get more severe as the child grows into late adolescence and early adulthood, doctors have said.
Some of the biggest concerns are respiratory difficulties and a higher risk of various cancers, along with the ongoing risk of infections.
FOUR TEXAS RESIDENTS FOREVER CONNECTED BY TWO KIDNEY DONATIONS IN DIFFERENT CITIES: ‘SUPERBLY TIMED’
To help manage her condition, Walter’s daughter has been getting weekly intravenous immune globulin (IVIG) infusions, which add human antibodies to help fight off infections.
She also takes daily antibiotics to help prevent pneumonia, uses an inhaler to help her respiratory system and takes other medications to treat different illnesses she experiences as a result of her DOCK8 deficiency.
Lani Walter’s hobbies include swimming, crafting, bike-riding, and spending time with her friends and pets. (Ashleigh Walter)
“That’s probably one of the least favorite parts of her day, when I tell her that she needs to take her medicine,” Walter said.
Since the only cure for her condition is a bone marrow transplant, “her doctors recommend that Lani has [the] transplant to help cure the DOCK8 before she gets older.”
What to know about bone marrow transplants
Dr. Brett Osborn, a Florida neurologist and longevity expert at Senolytix, described HSCT as a “transformative reset button” for patients suffering from DOCK8 deficiency.
Osborn is not involved in Lani Walter’s care.
“Imagine your immune system as a computer plagued by a virus,” he told Fox News Digital.
“HSCT can mean a dramatic shift toward immunologic normalcy, providing a new lease on life.”
“HSCT removes the compromised ‘software’ and installs new, functional cells. For individuals with DOCK8 deficiency — who typically face frequent infections, severe allergies and increased cancer risk — HSCT can mean a dramatic shift toward immunologic normalcy, providing a new lease on life.”
Siegel also emphasized the procedure’s importance, calling it a “crucial life-saving procedure.”
Dr. Marc Siegel, left, and Dr. Brett Osborn, right, both weighed in on the importance of a diverse bone marrow registry. (Dr. Marc Siegel/Dr. Brett Osborn)
The average wait for a transplant is about three months, according to Siegel.
“They are very expensive — about $190,000,” he said. “Insurance generally covers the procedure, but not the cost of finding a donor.”
There is around a 25% chance that a sibling will be a match. In Lani Walter’s case, her 14-year-old sister was not a match.
PENNSYLVANIA MOTHER AND SON BOTH BORN WITH RARE GENETIC DISEASE: ‘CLOSER BECAUSE OF THIS’
“The overall chance of finding a match in the world is 1/3 to 2/3,” Siegel said.
The National Marrow Donor Program (NMDP) maintains a registry of people who are willing to donate. The Walter family found a 90% match on the registry, but the optimal situation would be to find a 100% match.
“There’s much less risk with the bone marrow transplant if you can find that perfect match,” Walter told Fox News Digital.
‘Time is of the essence’
Lani Walter’s doctors recommend that she receives the donation before she starts middle school. Next year, she will start fifth grade.
“Ideally, we would do it before Lani sees significant issues with other organs in her body,” said Ashleigh Walter.
“Joining the bone marrow registry could be your most profound gift.”
If the family does not find a perfect match, Walter said she will donate to her daughter, as parents are always half-matches.
“Obviously, we would still love for her to be able to find a full match on the donor registry, which is much less of a risk,” she said. “But if that’s not possible, we can move forward with a half match.”
Lani Walter’s doctors are recommending she receive the bone marrow donation before she starts middle school. Next year, she will start fifth grade. (Ashleigh Walter)
With partial matches, there is a higher risk of “graft versus host disease,” which is a complication that occurs when donor bone marrow or stem cells attack the recipient.
“It can cause different issues throughout the body, similar to an organ transplant rejection,” Walter said.
If her daughter receives a successful bone marrow transplant, Walter said — she will be cured of DOCK8.
PENNSYLVANIA PARENTS HONOR THEIR DAUGHTER WHO DIED OF A RARE GENETIC DISEASE: ‘SWEETEST GIRL IN THE WORLD’
“She won’t have an immune deficiency anymore,” she said. “She’ll adopt the immune system of the donor, and we won’t have to worry about any of those increased risks at all.”
Walter is hopeful that her daughter — whom she describes as “a little kid at heart” — will soon be healthy and able to return to the activities she loves, including swimming.
If her daughter receives a successful bone marrow transplant, Ashleigh Walter said, she will be cured of DOCK8. Walter is hopeful that her daughter will soon be healthy and able to return to the activities she loves (Ashleigh Walter)
“Lani has been on a swim team since kindergarten, and this will be her first summer not doing it,” Walter said.
She also enjoys bike-riding, crafting, and spending time with her friends and pets.
A call to register
There are millions of potential donors on the bone marrow registry — with more than 300,000 Americans joining just last year — but Walter noted that the likelihood of someone finding a perfect match is very low.
“The more people who join the registry, the more likely that a perfect match will be there for you,” she said.
THE GIRL WHO CAN’T SMILE: HOW A RARE DISORDER BECAME A YOUNG WOMAN’S ‘GREATEST GIFT’
As a neurosurgical trauma surgeon, Osborn of Florida said he can attest to the dire need for blood and bone marrow donors.
“There is a critical shortage of both,” he said. “In emergency and surgical settings, the availability of blood products can be the difference between life and death.”
People can join the bone marrow registry by visiting the NMDP’s website to order a test kit. “It’s a really simple cheek swab kit that they’ll send to your house and then you send it back,” Walter said. (iStock)
It’s “vital” to have diversity in the bone marrow registry, Osborn noted.
“A closely matched donor reduces complications and improves outcomes,” he said.
“This emphasizes why everyone should consider joining the registry. We can all manufacture these potentially life-saving blood products, and by donating, we fulfill a crucial societal need.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
While some have the misconception that donation is difficult, Osborn said that’s not the case.
“Donating bone marrow is a low-risk, outpatient procedure associated with only minor discomfort. It’s a great way to pay it forward.”
“In emergency and surgical settings, the availability of blood products can be the difference between life and death.”
People can join the bone marrow registry by visiting the NMDP’s website to order a test kit.
“It’s a really simple cheek swab kit that they’ll send to your house and then you send it back,” Walter said. “You don’t have to pay any money for anything.”
“The more people that join, the more people who can find their perfect match.”
“For conditions like DOCK8 deficiency, a bone marrow transplant can offer a chance at a healthier life,” Osborn added.
“Joining the bone marrow registry could be your most profound gift, potentially saving a life with your healthy cells.”
For more Health articles, visit www.foxnews.com/health.
NEWYou can now listen to Fox News articles!
Americans are popping more supplements – and fewer multivitamins – than ever before, a new study found.
Research published in JAMA Network Open, led by researchers at Memorial Sloan Kettering Cancer Center in New York and the Harvard T.H. Chan School of Public Health in Boston, looked at 25 years of U.S. dietary supplement use data from 1999 to 2023.
This included more than 63,000 adults over the age of 20 who reported their supplement usage.
AGING COULD SLOW DOWN WITH ONE COMMON DAILY HABIT: ‘LIVE LONGER AND BETTER’
When tracking patterns over time, the analysis revealed that overall supplement use increased from 51% of U.S. adults to 60%. The largest rise – from 62% to 78% – was identified in adults 65 and older.
Supplement use was found to be more common in women, people with a higher income or education, and those with insurance.
Supplement use was found to be more common in women, people with a higher income or education, and those with insurance. (iStock)
During the same period, multivitamin use decreased from 35% to 31%, while intake of vitamins and minerals outside of multivitamins increased.
Some of the largest increases in intake were seen in vitamin D, zinc, magnesium, vitamin B12 and turmeric. Other emerging supplements include ashwagandha, elderberry, collagen, hyaluronic acid, probiotics and prebiotics, according to the research.
‘WILD WEST’ PEPTIDE CRAZE SURGES BEYOND GLP-1S AS FDA FACES PRESSURE TO EASE ACCESS
The later post-pandemic period saw an influx of immune support-based products, like zinc and vitamin D (outside of multivitamins).
The rise in supplement use aligns with the longevity movement, as more people seek products tailored to specific health goals, such as immune support, inflammation, gut health, skin health and joint health.
The study only shows that people are taking more supplements, but does not prove that they’re effective for these uses, the researchers noted.
Those on a GLP-1 medication should factor in a multivitamin to counteract the risk of nutrient gaps or deficiencies, an expert recommended. (iStock)
In an interview with Fox News Digital, Los Angeles-based registered dietitian nutritionist Ilana Muhlstein gave her take on the emerging supplement movement.
“I love that people are getting more educated and more intentional – I just wish they were being advised by more doctors and dietitians and less by ‘wellness influencers’ who are likely not doing the due diligence on the quality and efficacy of the supplements they’re promoting,” she said.
CLICK HERE FOR MORE HEALTH STORIES
Muhlstein expressed concern that all-in-one-multivitamin use has “slipped,” despite the rise in GLP-1 weight-loss medications.
“A multivitamin is where I think people should start as the foundation to help bridge nutrient gaps, especially for people on a GLP-1 who are eating about 15% to 30% less, and therefore likely consuming 15% to 30% less vitamins and minerals,” she said. “I recommend that everyone on a GLP-1 medication [should] take a multivitamin daily.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
A daily probiotic, magnesium and vitamin D3 are also “smart for many of us,” the nutritionist added. She also recommends elderberry as an effective supplement for boosting the immune system when fighting a cold.
A nutrition expert cautioned against taking supplements that have not gone through third-party testing for safety and quality. (iStock)
Collagen has also been shown to benefit the skin and joints, which Muhlstein said is “worth considering as we get older.”
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
“My real concern is the unregulated market,” she cautioned. “I can’t tell you how many calls I’ve received over the years of people pitching me new supplements … because the margins are high and the market is huge.”
“That’s why I’m extremely picky about what I take and what I recommend to my family and clients.”
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
Muhlstein warned against taking a supplement that hasn’t gone through third-party testing for safety and quality.
“The best ones go further and test for pesticides, arsenic and heavy metals, especially for protein powders,” she said. “If a product has many ingredients, I like to see that they do testing on each individual ingredient.”
Bipartisan push to invest in US national parks
Bret Baier moderates a discussion with Representatives Bruce Westerman (R-AR) and Jared Huffman (D-CA) about the ‘America the Beautiful’ initiative. This bipartisan effort seeks to modernize national parks ahead of America’s 250th anniversary, investing $1.9 billion annually. They emphasize national parks as common ground, beloved by all Americans, and crucial for our shared heritage.
NEWYou can now listen to Fox News articles!
As the United States celebrates its 250th anniversary, many Americans are taking extra notice of all the things the country has to offer.
One such case is our access to vast wilderness. Today, the nation’s national parks are bustling tourist attractions, but they may also serve as vital resources for public health, experts say.
The most immediate health boost comes from physical movement.
HIKERS FACE URGENT GRAND CANYON HEAT WARNING AFTER TEEN’S DEATH ON POPULAR TRAIL
Guidelines from the Centers for Disease Control and Prevention show that regular physical activity is crucial for reducing obesity, improving sleep quality and lowering the risk of chronic illnesses.
The nation’s public lands include parks, trails and open spaces that encourage outdoor recreation and physical activity.
Beyond physical fitness, national parks contribute to documented mental health benefits. (iStock)
A review by the Community Preventive Services Task Force (CPSTF) found that implementing park, trail and greenway infrastructure directly increases physical activity across communities.
AMERICA’S LIFESPAN HAS DOUBLED SINCE 1776 — EXPERTS REVEAL WHAT CHANGED
When people walk, hike or bike through national parks, they are actively lowering their blood pressure, boosting immune function and reducing overall mortality, data shows.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
Beyond physical fitness, national parks may contribute to documented mental health benefits.
Previous research has demonstrated that direct exposure to nature significantly reduces physiological stress, lowers heart rates and decreases levels of stress hormones, like cortisol.
Engaging in educational activities and lifelong learning preserves brain function, improves memory and helps stave off age-related cognitive decline, research shows. (iStock)
This research also shows that natural environments boost attention span, combat mental fatigue and improve cognitive performance.
CLICK HERE FOR MORE HEALTH STORIES
Parks also act as natural venues for mindfulness and social connection.
Research shows that practicing mindfulness in quiet outdoor spaces lowers stress and mitigates feelings of loneliness and social isolation.
Research highlights that practicing mindfulness in quiet outdoor spaces lowers stress and mitigates feelings of loneliness and social isolation. (iStock)
Additionally, because parks protect cultural and historical resources, they can inspire lifelong learning.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
According to the data, engaging in educational activities and lifelong learning preserves brain function, improves memory and helps stave off age-related cognitive decline.
The National Park Service was established in 1916 to conserve the nation’s natural and historic resources for future generations, according to the organization.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
Today, that mission has expanded, as parks are recognized not only for their scenic and cultural value, but also the opportunities they provide for recreation and physical activity.
Screwworm outbreak threat to US livestock, prompts USDA action
Agriculture Secretary Brooke Rollins discusses USDA’s response to the New World Screwworm outbreak in Texas and New Mexico, assuring safe food supply on ‘The Bottom Line.’ VI LONG DEK: Agriculture Secretary Brooke Rollins addresses the alarming resurgence of New World Screwworm in Texas and New Mexico, emphasizing USDA’s aggressive containment efforts. She confirms the food supply remains safe while highlighting the administration’s focus on domestic fertilizer production, investing billions in new plants and infrastructure projects. Rollins celebrates 250 years of American agriculture and its vital role in national security.
NEWYou can now listen to Fox News articles!
Doctors thought a 60-year-old man had metastatic brain cancer after scans revealed multiple tumors – but further testing revealed a shocking diagnosis.
The Spanish man, who was not named, was found to have a parasitic tapeworm larvae lodged in his brain — a case of neurocysticercosis, a parasitic infection of the central nervous system caused by the pork tapeworm (Taenia solium).
The patient, a lifelong resident of Castellón, Spain, had not traveled to any regions where the disease is endemic, according to the case report published in the CDC journal Emerging Infectious Diseases.
DEADLY ‘FOX TAPEWORM’ LINKED TO LETHAL DISEASE DETECTED IN WEST COAST WILDLIFE
The man had initially come to the hospital after suffering two weeks of progressive headaches and mild behavioral changes.
Radiologic findings from a study of autochthonous neurocysticercosis brain lesions mimicking metastatic disease. (Emerging Infectious Diseases)
CT scans showed multiple abnormal spots that looked like tumors that had spread from cancer elsewhere in the body, leading doctors to suspect advanced brain cancer.
However, whole-body scans, a colonoscopy and specialized imaging failed to identify cancer anywhere in the patient’s body, the case report stated.
NEUROLOGISTS REVEAL THE TOP 3 FOODS TO AVOID TO PROTECT YOUR BRAIN AND NERVOUS SYSTEM
When doctors performed a more detailed MRI, they discovered several fluid-filled cysts in the brain, some of which contained the head of a tapeworm. A blood test confirmed the diagnosis of neurocysticercosis.
The man was treated with a combination of albendazole and praziquantel (two antiparasitic medications), as well as corticosteroids to reduce inflammation. He successfully recovered with no complications, according to the case report.
CT scans (not pictured) showed multiple abnormal spots that looked like tumors that had spread from cancer elsewhere in the body, leading doctors to suspect advanced brain cancer. (iStock)
The authors suggested that the patient may have gotten the infection after accidentally ingesting microscopic tapeworm eggs years earlier.
The exposure may have occurred while working a construction job with migrant coworkers from regions where neurocysticercosis is endemic.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
People can catch the pork tapeworm in two different ways. Eating undercooked infected pork usually leads to an intestinal tapeworm, but accidentally swallowing the parasite’s eggs — typically through food or water contaminated with feces — can send the larvae into the bloodstream, where they may form cysts in the brain and other organs. This can cause the disease the patient in the case report acquired.
A photomicrograph shows histopathologic features in a brain tissue specimen from a case of neurocysticercosis caused by the pork tapeworm Taenia solium. The image documents pathological changes associated with this parasitic infection. (Smith Collection/Gado/Getty Images)
As this was just a single case, the source of transmission could not be proven, the researchers acknowledged, and the findings cannot be generalized to a wider population. The report shows that there is a possibility of local transmission in non-endemic settings, but cannot establish how often this occurs.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
In the United States, less than 2% of neurocysticercosis cases are considered domestically acquired, according to the case report.
A prior systematic review identified only 18 confirmed locally acquired cases in Western Europe between 1990 and 2011.
The authors suggested that the patient may have gotten the infection after accidentally ingesting microscopic tapeworm eggs years earlier. (Associated Press)
In some cases, NCC can cause serious symptoms, including seizures, stroke, neurological deficits and cognitive decline.
CLICK HERE FOR MORE HEALTH STORIES
“Our case emphasizes that the absence of travel history should not preclude NCC from the differential diagnosis of multiple ring-enhancing brain lesions, even in regions where metastatic cancer is statistically much more likely,” the researchers concluded in the case study.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
Detecting the worms earlier could have prevented “unnecessary invasive oncologic procedures and led to prompt, targeted antiparasitic therapy,” they added.
Fox News Digital reached out to the researchers for comment.
-
Colorado7 minutes agoWhere to watch Miami Marlins vs Colorado Rockies: TV channel, start time, streaming for July 1
-
Connecticut10 minutes agoLamont signs law in Norwich to stop pay to contractors violating wages
-
Delaware15 minutes agoDelaware has gotten these 15 verbal commitments from football recruits
-
Florida22 minutes agoKids with autism are prone to drowning. Florida is trying to prevent that
-
Georgia25 minutes agoBradenton man wanted for murder is found hiding in Georgia
-
Hawaii30 minutes agoFew state bills this year face potential veto – West Hawaii Today
-
Illinois40 minutes agoWest Suburban hospital sends permanent layoff notices to about 500 furloughed employees
-
Indiana45 minutes agoExtreme heat peaks before holiday weekend storms | July 1, 2026
