Health
Men going bald turn to 'new Botox' for hair loss treatment
The cure for baldness has long been a scientific enigma.
Yet advanced treatment options and hair-loss clinics have continued to emerge — and researchers are making progress on finding fixes for balding.
UCLA scientists recently alerted a “breakthrough” discovery involving a molecule named PP405 that can “waken long-slumbering but undamaged” hair follicles, according to a press release.
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In a 2023 clinical trial, researchers found that applying PP405 as a topical medicine to the scalp at bedtime showed “statistically significant” results.
They believe this treatment will produce “full ‘terminal’ hair rather than the peach fuzz variety.”
PP405 is now in Phase 2 clinical trials for men and women with androgenetic alopecia, according to a researcher. (iStock)
William Lowry, Ph.D., a co-researcher at UCLA Broad Stem Cell Research Center, told Fox News Digital that although this research is promising, “cure is a strong word.”
“There are only two FDA-approved treatments for androgenetic alopecia (AGA, or pattern baldness): minoxidil and finasteride,” he said in an interview.
“They are both limited in efficacy and improve hair in only a portion of patients who take them.”
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Other treatment options include supplements, red light therapy, platelet-rich plasma injections and hair transplantation, Lowry said, although these have not undergone “definitive clinical trials and can be expensive, time-consuming and limited in efficacy.”
He added, “None of these are curative, meaning none of them permanently restore all hair lost due to AGA.”
Some treatment options for hair loss are “limited in efficacy,” said a co-researcher (not pictured) at UCLA Broad Stem Cell Research Center in LA. (iStock)
Lowry and his fellow researchers have discovered that hair follicle stem cells have a “distinct metabolism from other cells in the follicle.”
He said, “We found that promoting this metabolism can accelerate stem cell activation, which makes new hairs grow. We subsequently developed drugs that can drive this effect in various models of hair loss that reflect the multifactorial drivers of androgenetic alopecia in patients.”
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PP405 has become the leading candidate for hair-loss treatment as part of this new class of drugs.
“We are excited about the opportunity to bring a novel treatment option to patients with hair loss based on strong science and rigorous clinical trials,” he said.
“Additionally, because the mechanism of action we discovered is distinct from previous approaches, it can potentially be used in combination with other therapies.”
“This novel class of drugs drove the formation of Pelage Pharmaceuticals, a regenerative medicine biotech developing new treatments for hair loss, with PP405 being the lead candidate.” (iStock)
Brendan Camp, M.D., a Manhattan-based dermatologist, told Fox News Digital in an interview that hair loss is a condition that “affects many and can have a negative impact on people’s psychosocial health.”
So identifying a potential new hair-loss treatment is an “exciting step for patients and providers in the management of what can otherwise be a difficult condition to treat.”
‘New Botox’
Camp agreed there is an “unmet need” for hair-loss treatment and that there’s growing interest in providing solutions and offering hair restoration services more widely.
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As cosmetic injections such as Botox and fillers have continued to be popular anti-aging and beauty treatments, hair-loss and restoration med spas are similarly surfacing nationwide.
The clinics offer a variety of services for men and women given the availability of modern options.
Early intervention when to balding is “key,” said one expert. (iStock)
Dr. Amy Spizuoco, DO, of True Dermatology in New York, dubbed balding treatments in this capacity the “new Botox.”
“With advances in treatments like minoxidil, finasteride, PRP (platelet-rich plasma) therapy, hair transplants and the latest stem cell research, hair restoration has become more accessible and effective,” she told Fox News Digital.
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“And much like Botox is used preventatively, younger people are tackling hair loss at the first signs rather than waiting until it’s severe.”
Camp added that while there are many hair-loss treatment options available, the response will look different for each person.
Medications such as minoxidil, finasteride and dutasteride can “slow down the process and even grow hair back,” one expert said, while procedures such as PRP, low-level laser therapy and hair transplants are also effective. (iStock)
“When looking for a treatment, stick to those with a well-established body of evidence and data to support their use, such as minoxidil, finasteride and spironolactone (in the case of female-pattern hair loss),” he advised.
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And be sure to get “the advice of a board-certified dermatologist when at-home treatments are not effective,” he also said.
These treatments are “typically used indefinitely” and should be tested for three to four months before being ruled out as effective or not, the dermatologist added.
Spizuoco said that while hair loss is common, early intervention with the right treatment plan can “significantly slow it down or possibly reverse it.”
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As measles cases continue to spread throughout the U.S. — with 12 states reporting official outbreaks, according to the latest CDC data — concern is growing among high-risk groups.
Children under the age of 5 are most vulnerable to measles, health experts confirm.
The CDC recommends that children receive two doses of the MMR (measles-mumps-rubella) vaccine, starting with the first dose at 12 to 15 months of age, and a second dose at 4 through 6 years of age.
MEASLES OUTBREAKS EMERGE ACROSS US: SEE WHICH STATES HAVE REPORTED CASES
That means children under 5 may not have full protection.
As measles cases continue to spread throughout the U.S. — with 12 states reporting official outbreaks, according to the latest CDC data — concern is growing among high-risk groups. (iStock)
Allison Croucher, DO, a pediatrician and doctor of osteopathic medicine with Duly Health and Care in Illinois, said she frequently gets questions from concerned parents looking to protect their children from the highly contagious virus.
Chroucher shared some of the most common inquiries she receives, along with her responses.
1. Should I be worried about measles where I live or where I’m traveling to?
Measles cases have been reported in 20 states so far (according to the CDC): Alaska, Arkansas, California, Colorado, Florida, Georgia, Hawaii, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Missouri, Montana, New Jersey, New Mexico, New York City, New York State, Ohio, Oklahoma, Pennsylvania, Rhode Island, Tennessee, Texas, Vermont, Virginia and Washington.
Children under the age of 5 are most vulnerable to measles, health experts confirm. (iStock)
Even if you do not live in one of those areas, keep a close eye on local health alerts, since the disease is rapidly evolving.
Your state’s Department of Health website, which should end in “.gov,” is a great place to start. If you plan on traveling to an area with reported cases, be sure to seek guidance from your doctor beforehand.
2. How do I know if my child is fully vaccinated?
A child is considered fully vaccinated for measles if they have received two doses of the measles, mumps and rubella (MMR) vaccine at least four weeks apart.
The first dose is typically given to children between 12 and 15 months old, followed by the second at four to six years.
In the early stages, symptoms to watch out for include fever, cough, runny nose, and red, irritated eyes. (iStock)
3. Can my infant get the vaccine early?
In certain cases, yes. Infants who are high-risk or traveling to areas with active cases may be eligible to get the MMR vaccine between six months and 12 months of age. This depends on individual circumstances, so it’s important to talk with your pediatrician.
Keep in mind that an early dose doesn’t count on the regular vaccination schedule — your child will still need two additional doses after their first birthday.
ANOTHER STATE CONFIRMS MEASLES CASE WITH INFECTED CHILD ITS FIRST OF YEAR
4. What if my infant is too young to get the MMR vaccine?
If your infant is too young for the vaccine, it’s important to take extra precautions to limit their exposure to others who are or might be ill. Don’t be afraid to decline travel or gatherings — you have every right to protect your child’s health.
5. How early can my child get their second MMR vaccine?
For children over one year, the second MMR dose can be given as early as four weeks after the first. Once they’ve received both doses, children are considered fully vaccinated and don’t require any additional doses.
“One to three of every 1,000 children infected with measles will die due to complications from the disease.”
6. We have been around other people who recently traveled. What symptoms should we watch for?
In the early stages, symptoms to watch out for include fever, cough, runny nose, and red, irritated eyes.
These symptoms usually appear seven to 14 days after initial exposure.
7. My child is showing signs of a cold. Could this be early-stage measles?
It’s not always easy to tell, since measles shares symptoms with many other illnesses. One key differentiator is that children with measles typically display very high fevers, around 104°F. They also tend to be very fussy.
Around the second or third day of symptoms, many patients develop small, bluish-white spots on their inner cheeks, referred to as Koplik spots — though not every child will develop these spots. The telltale red rash typically develops three to five days into the illness.
A child is considered fully vaccinated for measles if they have received two doses of the measles, mumps and rubella (MMR) vaccine at least four weeks apart. (Jan Sonnenmair/Getty Images)
8. What does the measles rash look like?
This rash typically starts three to five days after the initial symptoms. It begins as small spots on the face near the hairline, then spreads downwards and can cover the entire body.
9. Why is measles dangerous?
Measles can have many complications, ranging from mild to severe. About one in 10 people will develop ear infections or diarrhea.
About one in five unvaccinated children with measles will require hospitalization. Up to one in 20 children will contract pneumonia, which is the most common cause of death from the disease.
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About one in 1,000 children will develop encephalitis, or inflammation and swelling of the brain. This can lead to seizures, lifelong disability or even death. In all, one to three of every 1,000 children infected with measles will die due to complications from the disease.
10. Why aren’t some people getting their kids the MMR vaccine?
There is a growing amount of misinformation and disinformation circulating about vaccines, which has led some parents to delay or skip them altogether.
The MMR vaccine has been safely administered to millions of people and has an excellent safety record — and research has repeatedly debunked the myth that the vaccine is linked to autism.
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11. What should I do if I think my child might have the measles?
Don’t wait — contact your doctor right away. They can guide you through the next steps.
The above questions and answers were provided by Allison Croucher, DO, a pediatrician and doctor of osteopathic medicine with Duly Health and Care in Illinois.
A federal prosecutor in Washington has contacted The New England Journal of Medicine, considered the world’s most prestigious medical journal, with questions that suggested without evidence that it was biased against certain views and influenced by external pressures.
Dr. Eric Rubin, the editor in chief of N.E.J.M., described the letter as “vaguely threatening” in an interview with The New York Times.
At least three other journals have received similar letters from Edward Martin Jr., a Republican activist serving as interim U.S. attorney in Washington. Mr. Martin has been criticized for using his office to target opponents of the administration.
His letters accused the publications of being “partisans in various scientific debates” and asked a series of accusatory questions about bias and the selection of research articles.
Do they accept submissions from scientists with “competing viewpoints”? What do they do if the authors whose work they published “may have misled their readers”? Are they transparent about influence from “supporters, funders, advertisers and others”?
News of the letter to N.E.J.M. was reported earlier by STAT, a health news outlet.
Mr. Martin also asked about the role of the National Institutes of Health, which funds some of the research the journals publish, and the agency’s role “in the development of submitted articles.”
Amanda Shanor, a First Amendment expert at the University of Pennsylvania, said the information published in reputable medical journals like N.E.J.M. is broadly protected by the Constitution.
In most cases, journals have the same robust rights that apply to newspapers — the strongest the Constitution provides, she added.
“There is no basis to say that anything other than the most stringent First Amendment protections apply to medical journals,” she said. “It appears aimed at creating a type of fear and chill that will have effects on people’s expression — that’s a constitutional concern.”
It’s unclear how many journals have received these letters or the criteria that Mr. Martin used to decide which publications to target. The U.S. attorney’s office in Washington did not respond to a request for comment.
“Our job is to evaluate science and evaluate it in an unbiased fashion,” Dr. Rubin said. “That’s what we do and I think we do it well. The questions seem to suggest that there’s some bias in what we do — that’s where the vaguely threatening part comes in.”
Jeremy Berg, the former editor in chief of the journal Science, said he thought the letters were designed to “intimidate journals to bend over backward” to publish papers that align with the administration’s beliefs — on climate change and vaccines, for example — even if the quality of the research is poor.
Robert F. Kennedy Jr., the nation’s health secretary, singled out N.E.J.M in an interview with the “Dr. Hyman Show” podcast last year as an example of a medical journal that has participated in “lying to the public” and “retracting the real science.”
Andrew Nixon, a spokesman for the Health and Human Services Department, declined to comment on whether Mr. Kennedy had any involvement with the letters.
In the interview, Mr. Kennedy said he would seek to prosecute medical journals under federal anti-corruption laws.
“I’m going to litigate against you under the racketeering laws, under the general tort laws,” he said. “I’m going to find a way to sue you unless you come up with a plan right now to show how you’re going to start publishing real science.”
Dr. Jay Bhattacharya, the new director of N.I.H., has vigorously criticized the leadership of scientific journals. Recently he co-founded a new journal as an alternative to traditional scientific publishing. It has published contrarian views on Covid.
Other prominent journals said they had not received the letter. On Friday, The Lancet, which is based in Britain, published a scathing editorial in solidarity, calling the letters “an obvious ruse to strike fear into journals and impinge on their right to independent editorial oversight.”
“Science and medicine in the U.S.A. are being violently dismembered while the world watches,” the editorial said.
One of Mr. Martin’s letters was sent to the journal Chest, a low-profile publication that publishes highly technical studies on topics like lung cancer and pneumonia. The New York Times reported last week that at least two other publishers had received nearly identically worded letters.
They declined to speak publicly for fear of retribution from the Trump administration.
Dr. Rubin said he, too, was worried about political backlash. Scientific journals rely on public funds in several indirect ways — for example, universities often use federal grants to pay for subscriptions.
“Are we concerned? Of course we are,” he said. “But we want to do the right thing.”
Mr. Martin gave the journals until May 2 to respond to his questions. N.E.J.M. has already responded to Mr. Martin with a statement that pushes back against his characterization of the journal.
“We use rigorous peer review and editorial processes to ensure the objectivity and reliability of the research we publish,” the statement read. “We support the editorial independence of medical journals and their First Amendment rights to free expression.”
This is not the N.E.J.M’s first brush with a Trump administration.
In 2020, the journal published an editorial condemning the president’s response to the pandemic — the first time the journal had supported or condemned a political candidate in its 208-year history.
Dr. Rubin said he doubted Mr. Martin’s letter was related to the editorial. The journal Chest didn’t write about Trump’s first term yet received a letter, he noted.
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