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Men face double dementia risk if they have a hidden genetic mutation

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Men face double dementia risk if they have a hidden genetic mutation

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A hidden genetic mutation could predict a man’s likelihood of developing dementia.

That’s according to an Australian study led by Monash and Curtin Universities, which analyzed the medical data of thousands of Australians and Americans.

Men who had a certain variant in the haemochromatosis (HFE) gene — which regulates iron levels in the body — were found to be at a higher risk of dementia, the researchers found.

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Previously healthy men over age 70 who have two copies of the variant, which is known as H63D, are at least twice — or up to four times — as likely to develop dementia. 

Having just one copy did not appear to elevate the risk.

A hidden genetic mutation could predict a man’s likelihood of developing dementia, according to a new study. (iStock)

One in 36 men carry two copies of the mutation; one in three have just a single copy.

“It is only men who have two copies of the variant that are at risk,” study co-author Professor John Olynyk from the Curtin Medical School told Fox News Digital. “Women are not affected by the abnormality – we do not know why that is at the current point in time.”

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The study, which was published in the journal Neurology, used data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, which gathered health and aging data for 19,114 healthy older adults.

Those who have the genetic variant can’t change it, but it’s possible that the “brain pathways” it affects could be treated, Olynyk noted.

“It is only men who have two copies of the variant that are at risk,” one of the researchers told Fox News Digital. Women are not affected. (iStock)

“The HFE gene is routinely tested for in most Western countries … when assessing people for haemochromatosis, a disorder that causes the body to absorb too much iron,” the doctor said. “Our findings suggest that perhaps this testing could be offered to men more broadly.”

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Despite the fact that the HFE gene is responsible for controlling iron levels, the team found no direct link between iron and dementia risk.

“Our findings suggest that perhaps this testing could be offered to men more broadly.”

“This points to other mechanisms at play, possibly involving the increased risk of brain injury from inflammation and cell damage in the body,” Olynyk added.

More research is needed to determine why the heightened risk wasn’t seen in women.

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“Understanding why men with the double H63D variant are at higher risk could pave the way for more personalized approaches to prevention and treatment,” added co-author Professor Paul Lacaze from Monash University in a press release.

The main limitation of the study, according to Olynyk, was that the study population was largely composed of Australians.

Previously healthy men over age 70 who have two copies of the variant, which is known as H63D, are at least twice — or up to four times — as likely to develop dementia. (Kurt “CyberGuy” Knutsson)

“Whether other populations exhibit the same effects is unclear,” he told Fox News Digital. “Our work should be repeated in different countries to assess this.”

“Further research will be undertaken to try and determine the likely mechanism by which this anomaly causes dementia and what more we can do to reduce the impact of it.”

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Beyond this specific mutation, many other genetic and environmental factors can contribute to dementia risk, Olynyk noted. 

“While genetic risk factors cannot be changed, the mechanisms by which these genetic abnormalities and environmental factors cause disease may well be modifiable to some extent, through adopting a healthy lifestyle and being proactive about maintaining an overall good state of health,” he said.

To reduce risk, the researchers recommend adopting a healthy lifestyle that includes exercising regularly, eating a nutritious diet, minimizing alcohol intake and remaining mentally active. (iStock)

To reduce risk, the researchers recommend adopting a healthy lifestyle that includes exercising regularly, eating a nutritious diet, minimizing alcohol intake, remaining mentally active, and seeing a doctor to address any medical problem known to increase the likelihood of dementia.

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The University of Melbourne, The Royal Children’s Hospital, Murdoch Children’s Research Institute and Fiona Stanley Hospital also contributed to the study.

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Doctor reveals what 30 days without alcohol does to the brain and body amid Dry January

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Doctor reveals what 30 days without alcohol does to the brain and body amid Dry January

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After a season of bingeing and drinking, your body may feel like it needs a break from the party.

Dry January — a modern trend that challenges people to abstain from drinking for the first month of the year — has become a popular way to “detox” from the holidays and start the new year on a healthy note.

Research has linked alcohol to a variety of health conditions, ranging from hangovers to higher cancer risk.

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In a recent podcast episode of “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health, shared how 30 days of not drinking alcohol can transform health.

Hyman, who is based in Massachusetts, called Dry January a “powerful way to see in real time how alcohol affects nearly every system of your body and how quickly those systems can recover.”

Dry January has become a popular way to “detox” from the holidays and start the new year on a healthy note. (iStock)

Alcohol’s toll on the brain and body

Hyman acknowledged that most people drink to feel happier and more comfortable in social situations. This effect is caused by the main ingredient in alcohol, called ethanol, which can also have toxic effects.

Instead of stimulating the brain, alcohol slows it down and loosens inhibitions. “You feel more relaxed, more social, more confident, maybe you feel a little euphoric,” Hyman said.

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Alcohol’s effect on the brain can also lead to poorer decisions and slower reflexes, the doctor cautioned.

Drinking alcohol can cause cognitive decline and brain fog, experts warn. (iStock)

Drinking also impacts the prefrontal cortex of the brain, which Hyman described as “the adult in the room,” responsible for judgment, planning and restraint. “It goes offline early in drinking, which explains why people feel freer or act impulsively when they drink,” he said.

Even moderate drinking can cause metabolic stress, inflammation, impaired detoxification and hormonal shifts, Hyman said, which can impact nearly every organ system in the body.

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Alcohol consumption has also been linked to an increased risk of cancer, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins.

It can also prevent the body from falling into REM sleep, which is the deep rest recovery period when the immune system cleans out the day’s toxins, according to Hyman.

Alcohol can impact deep rest and mental health, according to experts. (iStock)

Memory loss, cognitive decline, anxiety, sleep disruption, dementia and cardiovascular disease are all known risks of long-term alcohol use, as well as liver complications like fatty liver disease.

“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” Hyman said.

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The effects of 30 days with no alcohol

The first week after your last drink, the body begins to detoxify and reset, according to Hyman. Blood sugar and cortisol stress hormones level out, and the liver begins to process a “backlog of toxins.” The body also re-hydrates and re-energizes.

The first 30 days with no alcohol allows the body to balance itself out. (iStock)

The second week, the gut and brain will begin to re-balance, as hormones like serotonin and dopamine stabilize, gut inflammation drops and the microbiome begins to heal. Cravings for sugar and alcohol will wane and mental clarity returns, the doctor said.

Week three is marked by further decreases in inflammation, fatty liver and blood pressure. This can be noticeable in the skin, as puffiness and redness are reduced. Mood also begins to stabilize, with lower anxiety levels.

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In week four, the body experiences additional metabolic and immune benefits, Hyman shared, including more insulin sensitivity, which makes it easier to lose weight.

“You have a stronger immune response. You’re not getting sick as much. You have better deep sleep, balanced hormones, especially cortisol and testosterone,” he said. “And you see a big change in energy, confidence and focus.”

Abstaining from alcohol can help restore energy, according to experts. (iStock)

Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, said that Dry January isn’t a “detox,” but rather provides “feedback” from the body.

“It gives the body time to show people how it feels without alcohol. For many, that insight alone changes their relationship with drinking,” she said. “The biggest surprise isn’t what people give up, it’s how much better they feel.”

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The doctor confirmed that the first few days of not drinking may feel harder than expected, sometimes causing restlessness, cravings or disrupted sleep, but Dry January can ultimately change drinking habits for the remainder of the year.

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After a full year without alcohol, Chiang noted that health improvements are more profound. “We see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”

The risks of ‘all or nothing’

Some experts warn that adopting the Dry January trend could strengthen the urge to drink more in the other months, noting that some drinkers may find more success by slowly consuming fewer drinks per week.

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Thomas Stopka, Ph.D., an epidemiologist and professor in the public health and community medicine department at Tufts University School of Medicine in Massachusetts, shared in a Futurity report that for some people, “damp January” may be more suitable.

One expert warned that not all drinkers should quit “cold turkey,” as it could lead to severe withdrawals. (iStock)

“Dry January is well-intentioned, and it may work really well for the people who can stick to it, maybe even beyond January,” he said. “Other people may be more inclined to cut down on alcohol consumption rather than quit drinking completely for the month.”

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Stopka noted that successful harm-reduction approaches “aim to be judgment free.”

“Substance use disorder is a disease,” he said. “It takes time to treat the disease and to stay connected to the continuum of care — from prevention to treatment initiation to sustained therapy, whether through medication, self-help, or individual therapy or group support.”

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Those struggling with signs of alcohol use disorder should consult a medical professional for personalized guidance.

Fox News Digital reached out to several alcohol industry associations requesting comment.

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The Best Weight Loss Medications and Supplements in 2026

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