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Major study reveals why COVID vaccine can trigger heart issues, especially in one group

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Major study reveals why COVID vaccine can trigger heart issues, especially in one group

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One of the most widely known risks linked to the COVID-19 vaccine is myocarditis, especially in young males — and now a new Stanford study has shed some light on why this rare effect can occur.

Myocarditis, which is inflammation of the heart, occurs in about one in 140,000 people who receive the first dose of the vaccine and one in 32,000 after the second dose, according to a Stanford press release. Among males 30 and younger, that rises to one in 16,750.

Symptoms of the condition include chest pain, shortness of breath, fever and palpitations, which can occur just one to three days after vaccination. Another marker is heightened levels of cardiac troponin, which indicates that the heart muscle has been damaged.

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In most cases, people who experience myocarditis recover quickly and restore full heart function, according to study author Joseph Wu, MD, PhD, the director of the Stanford Cardiovascular Institute and a professor of medicine and radiology.

One of the most widely known risks linked to the COVID-19 vaccine is myocarditis, especially in young males. (iStock)

“It’s not a heart attack in the traditional sense,” Wu told Fox News Digital. “There’s no blockage of blood vessels as found in most common heart attacks. When symptoms are mild and the inflammation hasn’t caused structural damage to the heart, we just observe these patients to make sure they recover.”

In rare cases, however, severe heart inflammation can lead to hospitalizations, critical illness or death, Wu noted.

Finding the cause

The new Stanford study — conducted in collaboration with The Ohio State University — aimed to determine the reasons for the myocarditis. The research team analyzed blood samples from vaccinated people, some with myocarditis and some without. 

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They found that those with myocarditis had two proteins in their blood, CXCL10 and IFN-gamma, which are released by immune cells. Those proteins then activate more inflammation.

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“We think these two are the major drivers of myocarditis,” said Wu. “Your body needs these cytokines to ward off viruses. It’s essential to immune response, but can become toxic in large amounts.”

In mouse and heart tissue models, high levels of these proteins led to signs of heart irritation, similar to mild myocarditis.

Prevention mechanism

“One of the most striking findings was how much we could reduce heart damage in our models by specifically blocking these two cytokines, without shutting down the entire (desired) immune response to the vaccine,” Wu told Fox News Digital, noting that a targeted, “fine‑tuning” immune approach might be enough to protect the heart.

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Myocarditis, which is inflammation of the heart, occurs in about one in 140,000 people who receive the first dose of the vaccine and one in 32,000 after the second dose. (iStock)

“This points to a possible future way to prevent or treat myocarditis in people who are at the highest risk, while keeping the benefits of vaccination,” he added.

The team also found that genistein, an estrogen-like natural compound found in soybeans, reduced inflammation in lab tests, but this has not yet been tested in humans.

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The findings were published in the journal Science Translational Medicine.

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“This is a very complex study,” Fox News senior medical analyst Dr. Marc Siegel told Fox News Digital. “Myocarditis is very rare, and the immune mechanism makes sense.”

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“Myocarditis is worse with COVID — much more common, and generally much more severe.” 

Wu agreed, adding that COVID infection is about 10 times more likely to cause myocarditis compared to mRNA-based vaccines.

‘Crucial tool’

The researchers emphasized that COVID-19 vaccines have been “heavily scrutinized” for safety and have been shown to have an “excellent safety record.”

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In rare cases, however, severe heart inflammation can lead to hospitalizations, critical illness or death. (iStock)

“mRNA vaccines remain a crucial tool against COVID‑19, and this research helps explain a rare side effect and suggests ways to make future vaccines even safer, rather than a reason to avoid vaccination,” Wu said.

“The overall benefits of COVID‑19 vaccination still clearly outweigh the small risk of myocarditis for nearly all groups.”

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The study did have some limitations, primarily the fact that most of the data came from experimental systems (mice and human cells in the lab), which cannot fully capture how myocarditis develops and resolves in real patients, according to Wu.

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“This points to a possible future way to prevent or treat myocarditis in people who are at the highest risk.”

“These findings do not change what people should do right now, because our work is still at the preclinical (mouse and human cells) stage,” he said. “Clinical studies will be needed to confirm whether targeted treatments are safe and effective.”

The researcher also added that myocarditis risk could rise with other types of vaccines.

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“Other vaccines can cause myocarditis and inflammatory problems, but the symptoms tend to be more diffuse,” he said in the release. “Plus, mRNA-based COVID-19 vaccines’ risks have received intense public scrutiny and media coverage. If you get chest pains from a COVID vaccine, you go to the hospital to get checked out, and if the serum troponin is positive, then you get diagnosed with myocarditis. If you get achy muscles or joints from a flu vaccine, you just blow it off.”

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The study was funded by the National Institutes of Health and the Gootter-Jensen Foundation.

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She Lost 101 Lbs by Flipping the Food Pyramid—Here’s How You Can Too

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She Lost 101 Lbs by Flipping the Food Pyramid—Here’s How You Can Too


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New Food Pyramid for Weight Loss Helped Her Drop 101 Pounds




















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Doctors expose ‘buffalo hump’ as potential sign of hidden health conditions

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Doctors expose ‘buffalo hump’ as potential sign of hidden health conditions

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A fatty bulge at the base of the neck — commonly known as a “buffalo hump” — isn’t always just a cosmetic concern, as experts say it can sometimes signal an underlying condition.

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As more Americans grapple with poor posture, obesity and chronic conditions requiring long-term medications, experts warn that these factors can contribute to the development of “buffalo humps.” 

There are a range of possible causes and treatments for the commonly misunderstood condition, Health.com recently reported.

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“A buffalo hump is a fullness at the base of the neck or upper back area,” Dr. Dahlia Rice, a Chicago-based plastic surgeon and founder of DMR Aesthetics, told Fox News Digital.

Posture can make a hump appear more pronounced, even if someone does not have much excess fat, Rice said. A forward head posture or rounding of the upper spine can contribute to this effect.

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Hormonal changes involving cortisol can lead to fat deposits in the neck and upper back, according to experts. (iStock)

“Depending on the pattern and timing, it could also signal an underlying medical issue,” the expert said.

The condition is often linked to weight, according to Dr. Rachel Mason, a Las Vegas-based plastic surgeon and founder of La Femme Plastic Surgery, though that is not always the case.

“In some cases, it can be associated with medical conditions like Cushing’s syndrome or long-term use of steroids,” she told Fox News Digital.

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“Depending on the pattern and timing, it could signal an underlying medical issue.”

Elevated levels of cortisol — the body’s primary stress hormone — can also lead to fat deposits in the neck and upper back, experts say. Certain medications, including some HIV treatments, may also play a role, according to Health.com.

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Experts emphasize the importance of distinguishing between a true buffalo hump and other conditions. The buffalo hump is often confused with a posture-related “dowager’s hump,” which is caused by spinal curvature rather than fat buildup.

“A true buffalo hump will feel soft and fatty,” Mason said. “Structural, posture-related issues require a completely different approach than fat reduction.”

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Maintaining a healthy weight and good posture may help reduce the risk of developing a buffalo hump, experts say. (iStock)

If the lump appears suddenly, continues to grow or is accompanied by other symptoms, medical evaluation is recommended, according to doctors.

“If it’s paired with fatigue, muscle weakness or changes in blood pressure, patients should seek medical evaluation,” Rice advised.

Mason added that symptoms such as easy bruising, hormonal changes or purple stretch marks could point to an endocrine disorder rather than a cosmetic issue.

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Treatment options depend largely on the underlying cause. In cases tied to posture, physical therapy and strengthening exercises may help. When medications are involved, doctors may adjust treatment.

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For patients with localized fat and no underlying condition, cosmetic procedures may be considered.

“Liposuction is often the effective option for contouring this area, as it directly removes excess fat and improves the profile of the upper back and neck,” Mason said, noting that more extensive cases may require surgical removal of dense tissue.

“Liposuction is often the effective option for contouring this area, as it directly removes excess fat and improves the profile of the upper back and neck,” an expert said. (iStock)

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Lifestyle changes — such as maintaining a healthy weight, improving posture and monitoring long-term medication use — may help to manage or reduce the condition, experts say.

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Although a buffalo hump itself is not usually dangerous, untreated underlying conditions can lead to more serious complications, including high blood pressure or sleep issues, according to Health.com.

“Identifying the cause early is important in ensuring the right treatment path is taken,” Mason said.

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What is butt microneedling? Behind the ‘desperate’ procedure Kelly Ripa tried

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What is butt microneedling? Behind the ‘desperate’ procedure Kelly Ripa tried

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Talk show host Kelly Ripa recently revealed she receives a niche procedure to enhance the appearance of her behind.

During a recent episode of her podcast, “Let’s Talk Off Camera,” the 55-year-old opened up about getting microneedling done “on my a– cheeks,” after her guest, actor Lukas Gage, shared that he had also undergone the treatment.

“I’m going to tell you something … just as old as before,” she said after Gage asked her whether she saw an improvement. “Desperate times call for desperate measures.”

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Dermatologist Dara Spearman, M.D., of Radiant Dermatology Associates in Indiana, described the cosmetic dermatologic procedure to Fox News Digital.

“Butt microneedling is where a device with very fine, sterile needles is used to create controlled micro-injuries in the skin of the buttocks,” she said.

Kelly Ripa, 55, admitted to microneedling her butt during a recent podcast episode. (Kelly Ripa/Instagram; iStock)

“This process stimulates the body’s natural wound healing response, which boosts collagen and elastin production over time.”

Microneedling is often used to improve skin texture concerns like acne scarring, stretch marks or uneven tone, especially in the rear end area, according to Spearman.

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The treatment can be performed in an office by a trained professional and is sometimes paired with topical serums to enhance results.

“While the concept may sound trendy, the underlying technology is the same as traditional microneedling used on the face and body,” Spearman said.

“Desperate times call for desperate measures,” said Ripa about the procedure she undergoes.  (Lorenzo Bevilaqua/Disney via Getty Images)

Microneedling the buttocks can lead to smoother, firmer and more even-looking skin after a series of treatments.

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An increase in collagen production over time can “subtly improve skin laxity,” Spearman said, with results building gradually over multiple sessions.

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“Consistency and realistic expectations are key,” the dermatologist said.

As with any procedure that disrupts the skin barrier, there are potential risks, according to Spearman, especially if it’s performed improperly or in a non-sterile environment.

Traditional microneedling is typically done on the face, experts say. (iStock)

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These potential side effects include irritation, infection and prolonged redness. In some cases, post-inflammatory hyperpigmentation can occur in patients with deeper skin tones.

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“There is also a risk of worsening acne or folliculitis if the area is not properly assessed beforehand,” Spearman said. “Overly aggressive treatments can lead to scarring rather than improvement, which is why technique and needle depth matter significantly.”

“It is not a quick fix, and multiple sessions are typically needed to achieve meaningful results,” the expert said. (iStock)

“It’s important that patients seek care from a qualified medical professional to minimize these risks.”

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Although this treatment is gaining viral popularity on social media, it should still be regarded as a medical procedure requiring proper training and safety standards, Spearman emphasized.

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“It is not a quick fix, and multiple sessions are typically needed to achieve meaningful results,” the dermatologist told Fox News Digital. “Patients should also be cautious about at-home devices for this area, as improper use can increase the risk of infection or skin damage.”

“A thorough consultation is essential to determine whether someone is a good candidate, especially if they have active skin conditions or a history of keloid (raised) scarring.”

Fox News Digital’s Lori A. Bashian contributed to this report.

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