Health
Kids who get less sleep face greater risk of future drug, alcohol use, study finds
A good night’s sleep has many proven benefits — potentially including a healthier future for kids.
New research from Penn State University analyzed how childhood sleep patterns could be linked to future substance use.
Researchers at the university found that adolescents who went to bed later and slept fewer hours during their childhood were more likely to have consumed alcohol or marijuana by the age of 15.
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The study, published in the journal Annals of Epidemiology, looked at data of 1,514 children from 20 cities across the U.S., focusing on sleep duration and bedtime in different developmental stages.
Recent research found that teens were 45% more likely to try alcohol by the age of 15 if they had a later bedtime at age 9. (iStock)
Parents involved in the Future of Families and Child Wellbeing Study, from where the data was obtained, recorded their children’s bedtimes at ages 3, 5 and 9, as well as sleep duration at 5 and 9.
The results showed that teens were 45% more likely to try alcohol by age 15 if they had a later bedtime at age 9.
Bedtime at age 5, however, wasn’t associated with future alcohol use, nor was sleep duration at either age.
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Meanwhile, a later bedtime at age 5 was associated with a 26% increased likelihood of marijuana use by age 15.
Sleeping an hour less at age 9 led to a 19% increased chance of trying marijuana during adolescence.
A later bedtime at age 5 was associated with a 26% increased likelihood of marijuana use by age 15. (iStock)
15-year-olds also reported their bedtime, sleep duration and substance use, which revealed that those with a later bedtime had a 39% increased chance of drinking alcohol and a 34% chance of trying marijuana.
“By ensuring that children get adequate and high-quality sleep, we may protect long-term health and encourage positive health behaviors later in life.”
Adolescents who slept one hour less increased their odds of trying alcohol by 28%, but there was no association with marijuana.
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In a statement sent to Fox News Digital, study co-author David A. Reichenberger, PhD — a researcher in the Department of Biobehavioral Health at Penn State — noted that the study only included participants who had complete data, “so that we could assess the effects across time within the same set of kids.”
“Overall, the implications of our results suggest that sleep may play a crucial role in whether children engage in substance use as teens,” he said.
The researchers suggested that going to bed later could impact school-aged children’s ability to sleep well. (iStock)
“By ensuring that children get adequate and high-quality sleep, we may protect long-term health and encourage positive health behaviors later in life,” the researcher added.
Dr. Wendy Troxel, a senior behavioral and social scientist at RAND Corporation in Park City, Utah, shared with Fox News Digital how this study adds to growing evidence that sleep problems may lead to “risky health behaviors” later in life.
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“These findings are consistent with my work conducted with my RAND colleagues, showing that poor sleep health in adolescence longitudinally predicts increases in alcohol and marijuana use in early adulthood,” she said.
“Overall, the implications of our results suggest that sleep may play a crucial role in whether children engage in substance use as teens,” a researcher said. (iStock)
“Importantly, this new data suggests that sleep problems even earlier in life can predict substance use during adolescence — a critical inflection point for the onset and exacerbation of drug and other alcohol use.”
Sleep problems may increase the likelihood of substance use due to affected decision-making, impulse control and emotion regulation skills, according to Troxel.
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“Collectively, these findings point to the importance of addressing sleep problems using multi-level strategies, including family-based programs and public policies, such as later school start times, to promote sleep health in childhood and adolescence,” she said.
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There may be a “promising new strategy” in combating aggressive forms of prostate cancer, according to a new study.
Researchers at Flinders University and the University of South Australia investigated how the novel drug, CDKI-73, has the potential to tackle drug-resistant prostate cancer.
This drug reportedly “defies conventional therapies,” as noted in the study findings, which were published in the British Journal of Cancer.
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Prostate cancer is the second-leading cause of cancer death in American men, following lung cancer, according to the American Cancer Society (ACS).
In 2024, around 299,010 new cases will be diagnosed and more than 35,000 men will die from the disease, per the ACS.
Prostate cancer is the second-leading cause of cancer death in American men, following lung cancer, according to the American Cancer Society. (iStock)
The disease “frequently evolves into aggressive forms that do not respond to standard hormone therapies,” according to Flinders University.
The researchers, including professors Luke Selth and Shudong Wang, targeted cyclin-dependent kinase 9 (CDK9) – a protein responsible for the growth and survival of prostate cancer cells.
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Selth, of Flinders University, confirmed in a press release that the CDKI-73 inhibitor has shown to be effective in blocking prostate cancer growth in models and tumor samples.
“Our research demonstrates that CDKI-73 potently blocks the growth of prostate cancer, even aggressive subtypes of the disease that are resistant to current treatments,” he said.
The drug being orally available may help “facilitate its use as a new treatment,” one of the researchers said. (iStock)
“Importantly, CDKI-73 targets cancer cells specifically without harming normal cells.”
In an email sent to Fox News Digital, Selth said the drug is orally available as a tablet, which could help “facilitate its use as a new treatment.”
“We still need to do a lot more work to fully understand the potential of CDK9 inhibitors and to deliver a new treatment for patients.”
Selth said he considers the study results a “significant step forward in understanding the role of CDK9 in aggressive prostate cancer.”
“Having said that, we still need to do a lot more work to fully understand the potential of CDK9 inhibitors and to deliver a new treatment for patients,” he added.
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Wang, who developed CDKI-73, said in the release that the drug is a “promising candidate for treating solid tumors, such as prostate cancer.”
“Our proof-of-principle study is an important step toward future clinical trials, and these findings will inform future studies on the use and efficacy of CDKI-73 as a prostate cancer treatment,” he went on.
One of the researchers called the drug a “promising candidate for treating solid tumors, such as prostate cancer.” (iStock)
CDKI-73 is currently being investigated in phase 2 clinical trials in patients with relapsed and therapy-resistant acute myeloid leukemia (AML), a type of blood cancer that affects the bone marrow and blood cells, according to Flinders University.
While the research is an “important step forward,” Wang said, the research team plans to complete more trials to assess the efficacy and safety of the drug before it is given to patients.
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Selth encouraged all men over the age of 50 — and those over 40 who have a family history of prostate cancer — to talk to their providers about getting screened during regular check-ups.
Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, was not involved in the study, but commented on the drug’s potential.
The new drug “shows promise in treating advanced or aggressive prostate cancer,” a doctor told Fox News Digital. (iStock)
“We know that CDK 9 is an enzyme associated with prostate cancer growth,” he told Fox News Digital.
“In this new study, an inhibitor of CDK 9 (CDKI-73) was found to inhibit growth and lead to death in human prostate cancer cells in the laboratory, and also in animals and models.”
“The drug has not been used yet in human subjects and clinical trials may be the next step,” Siegel went on. “It shows promise in treating advanced or aggressive prostate cancer.”
Fox News Digital reached out to oncologists for comment on the experimental drug.
For people with psoriasis and rheumatoid arthritis (RA), finding comprehensive treatment that works can be a lifelong battle. Medications are often expensive and hard to access, appointments with specialists can take months to secure, and lifestyle factors that may contribute to the diseases tend to be left out of the clinician-patient conversation entirely.
Ohio-based healthcare company AndHealth believes it doesn’t have to be that way — and is inviting patients with the conditions to help prove it. Through its innovative study, called Project IMPACT, the company aims to demonstrate that addressing underlying causes (like nutrition, stress, or sleep) alongside conventional treatments (like biologic medications) has the potential to stop the progression of or even reverse autoimmune conditions including psoriasis and RA.
“Insurance doesn’t reimburse for a lot of time spent talking to patients about how they can participate in their own care and how they can incorporate lifestyle changes, even though the science is there,” says Dr. Myles Spar, AndHealth’s National Medical Director who’s certified in both internal and integrative medicine.
But Project IMPACT’s model is different. It’s whole-person specialty care approach views patients in the full context of their lives—including any social, physical, or financial barriers they face to care—and connects them with coordinated, culturally competent primary and specialty care.
More specifically, Project IMPACT patients first meet with a provider virtually for about an hour. Soon after, they receive a personalized care plan developed by experts that may include specialists, a dietitian, a pharmacist, and a health coach. Depending on their health status, goals, and readiness for change, patients may also receive medications, lab testing, meal delivery, supplements, and wearable health tracking devices — all at no cost to them.
Unlike a clinical trial, where subjects are blindly given either an intervention or a placebo, this study is observational, meaning everyone receives the support they want in the way they want it. “We’re analyzing the whole availability of those treatment paths, not testing each path,” Spar says. “So signing up for the study doesn’t mean you’re signing up to do steps A, B, and C—you’re signing up to have A, B, and C as options, and then choose your own path.”
For example, those who want to work with a health coach may learn about what lifestyle changes—be it reducing sugar intake or adding in an after-dinner walk each day—can make the biggest difference in their symptoms. Then, they can call on their coach via an app for support in implementing those new habits along the way.
“The number of touchpoints that we have with patients per week is extraordinary because even me, I’m not gonna bug my doctor with a little thing,” Spar says. “But if it’s a health coach who says, ‘I want you to bug me,’ patients are more likely to say, ’I did my two-minute meditation today’ or ‘I bought running shoes’ or ‘I noticed that I was able to not snack while I was watching the news.’ So they see the coach as a real buddy.”
Ultimately, the company is betting that, when patients are equipped with the right tools, team, and knowledge, they can help improve a condition that they’re often made to believe will only get worse.
“When you’re diagnosed with a condition that you didn’t pick, one that took control away from you throughout your life, and that makes your life more limited, to suddenly be told, ‘But there is something you can do to get some control back,’ that’s hugely empowering,” Spar says.
That was the case for Phyllis, a 60-year-old in Mansfield, Ohio whose RA had prevented her from doing what she loved, whether it was dropping by relatives’ homes to play cards or visiting a venue to dance two-step. “I lost interest in wanting to socialize with my friends and family because I just hurt most of the time,” she says. Outside of church, she says, “I literally stayed in bed all day.”
But through Project IMPACT, Phyllis worked with a physician who seemed “to truly care” and a health coach who helped her eat more fruits and vegetables and limit her sugar intake. Within weeks and even days, “I had more energy and less pain,” she says. “I felt rejuvenated.”
She also felt like she mattered. When Phyllis told her care team she didn’t have enough gas in the car to get to the clinic for lab work, for example, they swooped in to help. “Traditional healthcare, if you can’t make it there, then you reschedule. And if you don’t reschedule, who cares?” she says. “With this team, if you can’t make it, they try to figure out why. Once they figure out why, then they try to figure out how to fix it. And once they figure out how to fix it, they fix it.”
Interested in participating? Project IMPACT is currently enrolling adults 21 and older in Ohio and Indiana who are taking specialty medications (or have been advised by a physician to start one) for psoriasis or RA. For more information or to see if you qualify, visit andhealth.com/impact or email impact@andhealth.com.
“The exciting part,” Spar says, “is … you’re helping to move this field forward, and you’re helping to add to the data that this whole-person specialty care approach works.”
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