Health
Ketamine dangers in spotlight after arrests made in actor Matthew Perry’s death
Recent arrests made in actor Matthew Perry’s death have cast new light on the dangers of ketamine abuse.
Perry’s Oct. 28th death — which initially appeared to be a drowning in a hot tub at his California home — was later attributed to the “acute effects of ketamine,” as ruled by the Los Angeles County Department of Medical Examiner.
Several people are now charged in connection with the 54-year-old actor’s overdose death — including Perry’s assistant, Kenneth Iwamasa, who allegedly administered excessive amounts of ketamine — as well as multiple physicians and dealers, who are said to have provided the drug.
MAIL-ORDER KETAMINE INJECTIONS CAN BE ‘EXTREMELY DANGEROUS,’ WARNS DR. MARC SIEGEL
On the day of Perry’s death, the “Friends” star received three ketamine injections, according to information in the assistant’s plea agreement.
Here’s a deeper dive into ketamine and the issues around it.
What is ketamine?
Intended for use as an anesthetic to be handled by medical doctors and veterinarians, ketamine is also used illegally as a recreational drug.
The Alcohol and Drug Foundation (ADF) describes ketamine as a “dissociative drug,” which means it causes people to feel “separated or detached” from their bodies or physical surroundings.
For some, it can cause hallucinations and alter people’s thoughts and emotions, according to the ADF.
“Ketamine is in the PCP (phencyclidine) family,” Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, told Fox News Digital.
(PCP is a dissociative, mind-altering drug that may lead to hallucinations.)
MARIJUANA USE AMONG PREGNANT WOMEN IS LINKED TO LOW BIRTH WEIGHT, STUDY FINDS
The off-label use of ketamine has “skyrocketed” in recent years, “despite limited data supporting the safety and efficacy of that practice,” according to a report from Yale School of Medicine.
The drug is usually sold as a colorless, odorless liquid or as a white or off-white powder, according to the National Drug Intelligence Center (NDIC) website.
When used in a powder or liquid form, it is often mixed with beverages or smoked with marijuana or tobacco.
The powder form can also be snorted or pressed into tablets.
As a liquid, ketamine can be injected, the NDIC states.
Ketamine approved for depression in health care setting
In 2019, the U.S. Food and Drug Administration (FDA) approved ketamine in a nasal spray format (Spravato, or S-ketamine) for treatment-resistant depression and suicidal ideation.
It is intended to be used in combination with antidepressant pills only under the supervision of a medical professional.
“S-ketamine is regulated very tightly,” the Yale report stated. “It has to be delivered intranasally, in a certified health care setting under the supervision of a health care professional, and patients must remain in the facility for two hours after dosing.”
Ketamine is more commonly used for treatment of severe depression and for pain management, according to Siegel.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
Dr. Justin Gerstner, psychiatrist and chief medical officer at Ellie Mental Health in Minnesota, uses ketamine therapy in his own practice, saying the response from clients has been “great,” as Fox News Digital previously reported.
Ketamine therapy eliminates the need for patients to take medication every day, according to the doctor.
Gerstner’s practice usually administers ketamine to clients via IV injection in two- to three-hour sessions, partnered with psychotherapy before and after treatment, he said. While ketamine can work as a “really powerful anti-depressant and anti-suicidal drug,” it is “not the right answer for everybody or everything,” he previously told Fox News Digital.
When does ketamine become deadly?
There are risks and limitations involved, Gerstner warned — including the potential for ketamine to be abused.
There isn’t too much regulation surrounding how ketamine treatments are administered, Gerstner noted, since the drug was previously approved for anesthetic use.
For more Health articles, visit www.foxnews/health
“The field is wide open, and it’s a little bit like the Wild West,” he said. “This is a really powerful medication and the way that it’s used can vary quite drastically.”
At high doses, the drug can cause adverse health issues that affect cardiovascular, respiratory and neurologic function, which can be fatal, said the American Addiction Centers website.
“Common causes of overdose death include excess sedation, respiratory failure, low blood pressure, cardiac arrhythmia, coma and seizures.”
Some of the risks include elevated blood pressure, difficulty breathing, amnesia, seizures, addiction, problems with judgment and coordination, and a lower urinary tract irritation called ulcerative cystitis, according to the same source.
“Common causes of overdose death include excess sedation, respiratory failure, low blood pressure, cardiac arrhythmia, coma and seizures,” said Siegel.
In Perry’s case, the report stated that given the high levels of ketamine found in his blood, “the main lethal effects” from the ketamine included “cardiovascular overstimulation and respiratory depression.”
Angelica Stabile of Fox News Digital contributed reporting.
Health
Words and game of Scrabble keep married couple in wedded bliss for decades
A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.
They’re still playing in tournaments built around the game decades after they began doing so.
Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.
WATCHING GAME SHOWS LIKE ‘JEOPARDY!’ AND ‘WHEEL OF FORTUNE’ CAN BOOST COGNITIVE HEALTH, SAY EXPERTS
They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.
But it was a “special match” in 2000 that brought the couple together — and has kept them together now.
Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.
They have been taking part in the UK Open Scrabble Championship in Reading this week.
“The more words you know, the more ammunition you’ve got.”
“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.
7 HEALTHY LIFESTYLE CHANGES THAT COULD HELP REDUCE RISK OF DEPRESSION, SAYS STUDY: ‘ENORMOUS BENEFITS’
“But it is a Scrabble vocabulary — not necessarily everyday English.”
Added Helen Harding, “The more words you know, the more ammunition you’ve got.”
The couple said they were “vague acquaintances” for about five years after they first met.
Then they got together after a special match in Swindon.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
They maintained a long-distance relationship before they got married in 2004.
The couple even brought their Scrabble board to their wedding.
It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”
For more Health articles, visit www.foxnews.com/health
They each took up the hobby early in life well before they met each other.
The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported.
Health
Deep sleep can keep two big health problems at bay, new studies suggest
It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.
Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.
The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.
ANOTHER REASON TO GET MORE SLEEP AND THIS ONE MIGHT SURPRISE YOU
Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.
Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”
The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists.
The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.
But the scientists indicated that what drives the system was unclear until now, according to the study.
Is all sleep created equal? The researchers wanted to find out.
To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.
TRUMP’S DAYLIGHT SAVING PLAN AND SLEEP: WHAT YOU MUST KNOW
They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.
The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.
Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.”
She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”
‘I CAN’T SLEEP BECAUSE OF RACING THOUGHTS AT NIGHT — HOW CAN I STOP THEM?’: ASK A DOCTOR
Hauglund said she wanted to understand whether all sleep is created equal.
To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.
“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice.
Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.
The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.
Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.
Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”
For more Health articles, visit www.foxnews.com/health
Meanwhile, a lack of sleep may be doing more damage than just making people groggy.
It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.
Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post.
“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.
Health
How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss
Sign Up
Create a free account to access exclusive content, play games, solve puzzles, test your pop-culture knowledge and receive special offers.
Already have an account? Login
Use left and right arrow keys to navigate between menu items.
Use escape to exit the menu.
-
Politics1 week ago
New Orleans attacker had 'remote detonator' for explosives in French Quarter, Biden says
-
Politics1 week ago
Carter's judicial picks reshaped the federal bench across the country
-
Politics1 week ago
Who Are the Recipients of the Presidential Medal of Freedom?
-
Health6 days ago
Ozempic ‘microdosing’ is the new weight-loss trend: Should you try it?
-
World1 week ago
South Korea extends Boeing 737-800 inspections as Jeju Air wreckage lifted
-
Technology3 days ago
Meta is highlighting a splintering global approach to online speech
-
World1 week ago
Weather warnings as freezing temperatures hit United Kingdom
-
News1 week ago
Seeking to heal the country, Jimmy Carter pardoned men who evaded the Vietnam War draft