Health
Jelly Roll’s wife says weight-loss drug sent her into ‘worst suicidal depression’
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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).
Bunnie XO, the wife of country singer Jelly Roll, is discussing how a weight-loss medication may have led to her experiencing a “dark” depression.
During an episode of her podcast “Dumb Blonde,” Bunnie, whose real name is Alyssa DeFord, revealed that she had been taking a new drug by Lilly called retatrutide (reta), which is currently in late-stage trials and not approved by the FDA.
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Bunnie, 45, confirmed that she received her dose from a “reputable wellness center” in Nashville, and felt sick within the first week. Within two weeks, she noticed she looked and felt slimmer. In the fourth week, she increased her dose by one unit, which is when she noticed the “mental numbness.”
“I literally got sent into the worst suicidal depression that I’ve had since 2020,” she said. “I’m talking like it scared me so bad. I didn’t think I was going to make it through the two weeks. Like I was praying to God.”
Bunnie XO, the wife of country singer Jelly Roll, is discussing how a weight-loss medication may have led to her experiencing a “dark” depression. (Christopher Polk/Penske Media via Getty Images)
The podcaster shared how she had “no emotion” and couldn’t listen to music that would typically “bring me joy.”
“You could see like my eyes were black,” she said. “I just drove in silence because I just couldn’t handle anything. It was either overstimulating or it was to the point where it just stole my joy. I had no joy, like nothing to live for. It was so dark.”
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After 20 days off the drug, Bunnie reported that her joy is “finally” returning, calling the experience a “battle.”
“My story is not what’s going to happen to you,” she shared with her listeners. “There’s so many people who are taking reta and love it and all that. But something happened with me.”
“My story is not what’s going to happen to you,” Bunnie XO shared with her listeners. “There’s so many people who are taking Reta and love it and all that. But something happened with me.” (Taylor Hill/WireImage)
Indiana-based drug-maker Lilly confirmed in a statement to Fox News Digital that retatrutide is an “investigational molecule that is legally available only to participants in Lilly’s clinical trials.”
“No one should consider taking anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial,” the spokesperson wrote. “This was not a Lilly product, and the company continues to warn the public about the potential dangers of fake medicines.”
“This was not a Lilly product and the company continues to warn the public about the potential dangers of fake medicines.”
Fox News senior medical analyst Dr. Marc Siegel reacted in an interview with Fox News Digital, warning that retatrutide should not be taken while it has still not received FDA approval unless it is part of a clinical trial.
“This drug is new — known as a triple agonist (GLP-1, GIP and glucagon receptor agonist),” he said. “[It] has been linked potentially to depression and suicidal thoughts, as have the GLP-1 drugs, where some studies have shown increased psychiatric risks, so there is a potential link here.”
What is retatrutide?
The drug has received the nickname “GLP-3” because it targets the three hormones, which experts suggest could lead to more substantial weight loss.
Lilly announced results from its phase 3 trial TRIUMPH-4 in December, which tested retatrutide’s effect on weight loss and other health conditions.
“GLP-3s” are positioned to “approach bariatric surgery level outcomes,” although it doesn’t come without risks, one expert said. (iStock)
Participants with obesity and knee arthritis who took a 12-mg dose of retatrutide saw an average weight loss of 71.8 lbs (28.7%) at 68 weeks.
“We believe retatrutide could become an important option for patients with significant weight loss needs and certain complications, including knee osteoarthritis,” a Lilly spokesperson said in a statement to Fox News Digital.
Seven additional phase 3 trials for retatrutide are expected to wrap up in 2026. The drug could see FDA approval in 2027, according to GoodRx.
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Despite limited data availability on the drug, the medication could also be applied to treat other conditions like type 2 diabetes, kidney disease, cardiovascular risk reduction and metabolic dysfunction, according to GoodRx and other experts.
Siegel confirmed that retatrutide’s side effects can be similar to other GLP-1s, including gastrointestinal symptoms and other rare reactions like pancreatitis, gallstones and heart arrhythmia.
Retatrutide could lead to more substantial weight loss for some patients, according to experts. (iStock)
Philip Rabito, M.D., a specialist in endocrinology, weight loss and wellness in New York City, shared in a previous interview with Fox News Digital that this new class of weight-loss drugs is positioned to “approach bariatric surgery level outcomes” — although it doesn’t come without risks.
“The novel glucagon‑agonist component introduces less‑understood long‑term safety considerations, so it is imperative that patients are followed closely by healthcare professionals experienced with this class of medicines, with cautious, stepwise use, despite the impressive efficacy,” he cautioned.
The mental health connection
The potential link between mental health symptoms and weight-loss drugs is most likely due to the impact on the brain’s reward system, according to Siegel.
“Dopamine, serotonin and norepinephrine affect mood and appetite, reduce cravings and can have a positive effect on mood, but also can be negative,” he said. “Somewhat unpredictable.”
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Dr. Peter Balazs, a hormone and weight-loss specialist in New York and New Jersey, noted that any presentation of significant depressive symptoms, particularly those including “psychotic features and suicidal ideation,” requires a full clinical evaluation.
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“It is essential to understand the patient’s complete medical and psychiatric history, including other medical conditions, precise weight change dynamics, concomitant medications and psychosocial stressors,” he said. “Major depressive episodes are multifactorial — attributing them to a single agent without this context is premature.”
Patients should be screened for mental health complications before taking weight-loss medication, experts suggest. (iStock)
Any individual experiencing these symptoms should “seek immediate professional help,” Balazs said.
“We are still learning about the psychiatric effects of these medications, even the ones that have already been approved,” he added.
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Bunnie’s age would typically place her in the perimenopausal stage, which can include “significant fluctuations” in reproductive hormones like estrogen, Balazs noted.
“Estrogen has well-documented neuroprotective and mood-stabilizing effects,” he said. “Its decline can render the brain more vulnerable to stress and dysregulation, potentially precipitating or exacerbating depressive episodes.”
Hormonal changes can impact mood when on a GLP-1 drug, according to experts. (iStock)
Obesity can also cause hormone shifts and inflammation that can interfere with normal brain function, sometimes affecting mood and emotional balance, the expert noted.
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Balazs stressed that experts should be “vigilant” in monitoring symptoms of people taking these medications.
“Until a protocol is established, patients outside clinical trials should not inject these medications,” he cautioned. “Dose and dose-related responses can change the whole experience.”
Health
Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health
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The key to feeling better in a fast, overstimulated world might be surprisingly simple: Live a little more like your grandparents.
A growing social media trend, dubbed “nonnamaxxing,” draws inspiration from the slower, more intentional rhythms associated with an Italian grandmother.
The lifestyle is often linked to activities like preparing home-cooked meals, spending time outdoors and making meaningful connections.
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“Nonnamaxxing is a 2026 trend that embraces the slower, more intentional lifestyle of an Italian grandmother (a Nonna). Think cooking from scratch, long family meals, daily walks, gardening and less screen time,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.
Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)
Stepping away from screens and toward real-world interaction can have measurable benefits, according to California-based psychotherapist Laurie Singer.
“We know that interacting with others in person, rather than spending time on screens, significantly improves mental health,” she told Fox News Digital, adding that social media often fuels comparison and lowers self-esteem.
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Living more like previous generations isn’t purely driven by nostalgia. Cooking meals from scratch, for example, has been linked to better nutrition and more mindful eating patterns.
Adopting traditional mealtime habits can improve diet quality and support both physical and mental health, especially when meals are shared regularly with others, Palinski-Wade noted.
One longevity expert stresses that staying healthy isn’t just about food — it’s also about joy and community. (iStock)
There’s also a psychological benefit to slowing down and focusing on one task at a time. Anxiety often stems from unfinished or avoided tasks, Singer noted, and engaging in hands-on activities can counteract that.
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“Nonnamaxxing encourages us to be present around a task, like gardening, baking or knitting, or just taking a mindful walk, that delivers something ‘real,’” she said.
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Palinski-Wade cautions against turning the trend into another source of pressure, noting that a traditional “nonna” lifestyle often assumes a different pace of life.
The key, she said, is adapting the mindset, not replicating it perfectly.
Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)
The goal is to reintroduce small, intentional moments that make you feel better.
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That might mean prioritizing a few shared meals each week, taking a walk without your phone or setting aside time for a simple hobby, the expert recommended.
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Singer added, “Having a positive place to escape to, through whatever activities speak to us and make us happy, isn’t generational – it’s human.”
Health
Loneliness may be silently eroding your memory, new research reveals
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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.
Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.
Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.
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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.
Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)
“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.
The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.
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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.
Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)
Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.
About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.
DEMENTIA RISK SIGNALS COULD LIE IN SIMPLE BLOOD PRESSURE READINGS, SAY RESEARCHERS
Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.
The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.
Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)
Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.
“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.
“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.
By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)
He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.
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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.
Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.
“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)
Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.
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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”
Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.
Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)
She said staying socially and mentally engaged is crucial for overall brain health.
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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”
The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.
Fox News Digital reached out to the researchers for comment.
Health
Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day
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