Health
Incurable, 'highly contagious' STD affects nearly 900 million people under age 50
The rise of sexually transmitted infections (STIs) continues to pose threats.
The prevalence of one uncurable STI in particular – genital herpes simplex virus (HSV) type 1 and 2 – is at a global high, according to a new study published in the BMJ Journals Sexually Transmitted Infections.
Approximately 846 million people between 15 and 49 years old (more than one in five) were living with a genital herpes infection as of 2020.
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The World Health Organization (WHO) confirmed that at least one person each second, amounting to 42 million people annually, is estimated to acquire the infection.
While HSV-2 is slowly declining, genital HSV-1 is increasing, although it does not cause as much burden, one expert said. (iStock)
The researchers at Weill Cornell Medicine, Qatar, noted that both types of HSV infections are lifelong and can cause symptomatic genital ulcer disease (GUC).
HSV-2 “almost always” causes sexually transmitted genital infection, the researchers said, while HSV-1 mainly causes oral infection, like cold sores, but can be sexually transmitted to cause a genital infection.
The infection can lead to painful genital sores and blisters that typically recur in random episodes throughout life. In 2020, more than 200 million people in the same age group suffered at least one painful symptomatic episode, data shows.
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Not every case of HSV is symptomatic, which makes transmission more likely.
The researchers concluded that the “high incidence and prevalence” of HSV worldwide requires new prevention and treatment measures, such as vaccines, to control the spread and reduce the disease burden.
Approximately 846 million people between 15 and 49 years old are living with a genital herpes infection as of 2020. (iStock)
Study co-author Laith Abu-Raddad, a health care policy and research professor at Weill Cornell Medical College in Qatar, emphasized the scale of HSV’s impact.
“Symptomatic genital herpes imposes a substantial global burden, affecting 200 million people annually and incurring significant economic costs, estimated at $35 billion per year due to health care expenditures and productivity loss,” he wrote in a statement to Fox News Digital.
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“Addressing this pressing health challenge requires a fundamental solution,” Abu-Raddad went on.
“Developing a vaccine capable of protecting against HSV-1 and HSV-2, the viruses responsible for genital herpes, represents a pivotal step toward controlling this infection on a global scale.”
Curing the incurable
There is currently no cure for HSV, although there are treatments to help manage symptoms.
The STI can also lead to more serious complications like neonatal herpes, which can be transmitted from a mother to her baby during childbirth.
HSV-2 accounts for 90% of symptomatic episodes and is linked to a significantly higher risk of contracting HIV, according to the WHO.
HSV can cause painful sores and blisters that can occur in periodic episodes, according to experts. (iStock)
Dr. Gabe Gaviola, senior medical director at Everlywell in New York — an at-home STD testing and treatment platform — shared his concern about increased exposure.
“HSV is highly contagious and often asymptomatic, which means many people may unknowingly transmit the virus,” Gaviola, who was not involved in the study, told Fox News Digital. “This makes prevention and early diagnosis more difficult.”
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“There’s also a persistent stigma associated with genital herpes, which may discourage individuals from seeking treatment or disclosing their herpes status to partners, leading to further spread.”
Gaviola reiterated how HSV infection can increase the risk of contracting other STIs due to the “sores and compromised skin barrier,” which makes it “even more crucial to seek proper testing and treatment.”
“New data in this study highlight just how widespread HSV-2 and HSV-1 are, with millions of new and existing cases each year,” one doctor said. (iStock)
“High prevalence rates, especially in individuals aged 15 to 49 years old, are driven by a lack of public awareness, prevention efforts, and access to testing and treatment,” he said.
For those experiencing symptoms, Gaviola recommends getting regular screenings and being open with sexual partners to reduce the spread.
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“Safer sex practices, including condom use and antiviral treatments for those who have HSV, can help reduce the transmission of HSV,” he added.
While HSV outbreaks can be controlled and potentially become less frequently or severely over time, flare-ups can occur during times of stress or illness, according to Gaviola.
Experts explain that the nature of HSV make it difficult to pinpoint a cure. (iStock)
HSV remains dormant in nerve cells after initial infection, which makes it “extremely difficult to completely eradicate from the body,” he said.
“It can reactivate at any time, often without warning,” he warned. “This dormancy also allows the virus to evade the immune system, which prevents the body from eliminating the infection.”
“It can reactivate at any time, often without warning.”
“While there are no cures yet, progress in vaccine development and antiviral therapies is promising,” he said.
“Public health measures to reduce transmission and improve treatment are critical in managing the global burden of HSV.”
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Anna Wald, M.D., professor of medicine, laboratory medicine and epidemiology at the University of Washington, noted that the nature of the herpes virus, much like chickenpox and shingles, makes the development of a cure difficult – although early, preclinical trials are underway.
According to Wald, there have also been some attempts to develop a preventative HSV vaccine that have failed. (iStock)
“[A] cure is likely to require gene therapy, which is a potentially risky approach for a non-lethal disease,” Wald, who was not involved in the research, told Fox News Digital. “So progress is slow as a result.”
There have also been some attempts to develop a prophylactic vaccine that have failed, according to the doctor.
“Testing vaccines for prevention is very expensive, but there are some new candidate vaccines that will hopefully be in trials in the next few years,” she shared.
“In my opinion, a preventative vaccine would be an optimal approach, but we don’t yet know how to make one that will work – and testing them is a lengthy and costly process.”
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Nearsightedness (myopia) is skyrocketing globally, with nearly half of the world’s population expected to be myopic by 2050, according to the World Health Organization.
Heavy use of smartphones and other devices is associated with an 80% higher risk of myopia when combined with excessive computer use, but a new study suggests that dim indoor lighting could also be a factor.
For years, scientists have been puzzled by the different ways myopia is triggered. In lab settings, it can be induced by blurring vision or using different lenses. Conversely, it can be slowed by something as simple as spending time outdoors, research suggests.
Nearsightedness occurs when the eyeball grows too long from front to back, according to the American Optometric Association (AOA). This physical elongation causes light to focus in front of the retina rather than directly on it, making distant objects appear blurry.
The study suggests that myopia isn’t caused by the digital devices themselves, but by the low-light environments where they are typically used. (iStock)
Researchers at the State University of New York (SUNY) College of Optometry identified a potential specific trigger for this growth. When someone looks at a phone or a book up close, the pupil naturally constricts.
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“In bright outdoor light, the pupil constricts to protect the eye while still allowing ample light to reach the retina,” Urusha Maharjan, a SUNY Optometry doctoral student who conducted the study, said in a press release.
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“When people focus on close objects indoors, such as phones, tablets or books, the pupil can also constrict — not because of brightness, but to sharpen the image,” she went on. “In dim lighting, this combination may significantly reduce retinal illumination.”
High-intensity natural light prevents myopia because it provides enough retinal stimulation to override the “stop growing” signal, even when pupils are constricted. (iStock)
The hypothesis suggests that when the retina is deprived of light during extended close-up work, it sends a signal for the eye to grow.
In a dim environment, the narrowed pupil allows so little light through that the retinal activity isn’t strong enough to signal the eye to stop growing, the researchers found.
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In contrast, being outdoors provides light levels much brighter than indoors. This ensures that even when the pupil narrows to focus on a nearby object, the retina still receives a strong signal, maintaining healthy eye development.
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The team noted some limitations of the study, including the small subject group and the inability to directly measure internal lens changes, as the bright backgrounds used to mimic the outdoors made pupils too small for standard equipment.
Researchers believe that increasing indoor brightness during close-up work could be a simple, testable way to slow the global nearsightedness epidemic. (iStock)
“This is not a final answer,” Jose-Manuel Alonso, MD, PhD, SUNY distinguished professor and senior author of the study, said in the release.
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“But the study offers a testable hypothesis that reframes how visual habits, lighting and eye focusing interact.”
The study was published in the journal Cell Reports.
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Older adults classified as “SuperAgers” generate at least twice as many neurons in the hippocampus than their typical aging peers, a new study has revealed.
These findings, released on Wednesday by the University of Illinois Chicago and Northwestern University, could help explain why SuperAgers have exceptional memory and cognitive resilience even well past 80 years old.
Northwestern has been studying SuperAgers for decades, defining them as “extraordinary individuals aged 80 and above whose memory performance rivals that of people three decades younger.” The researchers use special memory recall tests to make this determination.
In this study, they analyzed post-mortem brain tissue — nearly 356,000 individual cell nuclei — with a focus on the hippocampus, which is essential for forming new memories and supporting learning and spatial navigation.
They compared tissue from SuperAgers, typical older adults, older adults with early dementia/Alzheimer’s and younger healthy adults.
SuperAger Ralph Rehbock sits with his wife in his home. New findings from the University of Illinois Chicago and Northwestern University could help explain why SuperAgers have exceptional memory and cognitive resilience well past 80 years old. (Shane Collins, Northwestern University)
The researchers found that SuperAgers produced at least twice as many new neurons compared to “cognitively normal” older adults and those with Alzheimer’s pathology.
They also found that changes in certain brain support cells (astrocytes) and key memory cells (CA1 neurons) are linked to preserved cognitive ability, helping to keep the brain sharp with age.
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The SuperAgers also had different genetic activity patterns in their brains compared to those in Alzheimer’s disease.
“SuperAgers have more immature neurons and neuroblasts in the hippocampus, which is an indication of stronger neurogenesis when compared with other groups,” study co-author Changiz Geula, research professor of cell and developmental biology and neuroscience at Northwestern University Feinberg School of Medicine, told Fox News Digital.
Northwestern University study co-author Ivan Ayala examines a SuperAger brain sample on a slide. (Shane Collins, Northwestern University)
“The study also showed that specific cells in the hippocampus show unique gene expression profiles that relate to neuronal function and transmission and are associated with superior cognitive function.”
The findings were published in the journal Nature.
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“We’ve always said that SuperAgers show that the aging brain can be biologically active, adaptable and flexible, but we didn’t know why,” said co-author Tamar Gefen, associate professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and a neuropsychologist at Northwestern’s Mesulam Institute for Cognitive Neurology and Alzheimer’s Disease, in the release.
“This is biological proof that their brains are more plastic, and a real discovery that shows that neurogenesis of young neurons in the hippocampus may be a contributing factor.”
Dr. Tamar Gefen examines a slide of a SuperAger brain. (Shane Collins, Northwestern University)
Dr. Marc Siegel, Fox News senior medical analyst, commented that the study discovered signs of plasticity and regeneration in SuperAgers.
“It confirmed not only preservation of brain tissue in the hippocampus, which is crucial for memory and cognition, but also regeneration and increased development of brain cells in that area,” Siegel, who was not involved in the study, told Fox News Digital.
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“This is an important study because it may lead to certain cell gene treatments that could lead to more SuperAgers,” the doctor said. “It may also lead to more advanced testing to determine who will be a SuperAger and guide clinical treatment and management.”
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The study did have some limitations, primarily that the research relied on tissue samples taken at one specific point, instead of tracking changes over time.
Brain samples are fixed in blocks of wax so they can be stored and examined. (Shane Collins, Northwestern University)
Geula noted that studies using human brain tissue typically involve fewer cases than animal research, which can be a limitation. However, he emphasized that each case in this study was analyzed thoroughly.
“While these findings are not directly translatable to changes in everyday life and activities, they suggest that cognitive resilience is associated with greater integrity of many brain systems,” he told Fox News Digital. “This implies that attending to brain health is crucial for maintaining cognitive function in old age.”
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“Thus, maintaining good overall health by keeping systemic diseases in check, maintaining a healthy diet and exercise, and ensuring the elderly remain mentally active assume more importance.”
The study was funded by the National Institute on Aging, which is part of the National Institutes of Health.
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