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Humans’ Wounds Heal Much More Slowly Than Other Mammals’

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Humans’ Wounds Heal Much More Slowly Than Other Mammals’

Watching wild baboons in Kenya, Akiko Matsumoto-Oda, an evolutionary biologist and primatologist at the University of the Ryukyus in Japan, had a front-row seat to the violence between these monkeys, especially the males.

“I was struck by how frequently they sustained injuries,” she said, “and, even more, by how rapidly they recovered — even from seemingly severe wounds.”

Compared with her own experiences with nicks and cuts, the baboons’ ability to heal seemed like a superpower.

In a study published on Wednesday in Proceedings of the Royal Society B, Dr. Matsumoto-Oda and her colleagues compared the healing rates of humans, chimpanzees, monkeys and mice. They found that human wounds took more than twice as long to heal as wounds of any of the other mammals. Our slow healing may be a result of an evolutionary trade-off we made long ago, when we shed fur in favor of naked, sweaty skin that keeps us cool.

When possible, the researchers wanted to study healing in a way that was less violent and more controlled than watching wild baboons.

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To measure human healing, they recruited 24 patients who were having skin tumors removed at the University of the Ryukyus Hospital. To gather data on chimpanzees, which are some of our closest animal relatives, researchers observed five captive chimps at the Kumamoto Sanctuary of the Kyoto University Wildlife Research Center, which houses animals formerly used in pharmaceutical research. The chimps’ wounds, like those of wild baboons, mostly came from tiffs between the animals.

The study’s other primate subjects, all kept at the Kenya Institute of Primate Research, included olive baboons, Sykes’ monkeys and vervet monkeys. Researchers anesthetized the monkeys, surgically wounded them and then monitored their recovery. “As a field researcher, I personally believe that invasive studies should be minimized as much as possible,” said Dr. Matsumoto-Oda, who noted that bite wounds on wild baboons are often similar in size to the surgical wounds in the study, but deeper.

Finally, to compare humans and primates with more distantly related mammals, researchers anesthetized and surgically wounded mice and rats.

Based on her field observations, Dr. Matsumoto-Oda was prepared to see humans healing more slowly than the other animals. The 24 people regrew skin at about a quarter of a millimeter per day, on average.

What surprised Dr. Matsumoto-Oda more was the consistency between the healing rates of the animal subjects, including chimpanzees. There was no significant difference in the speedy skin regrowth among different primates, which grew about 0.62 millimeters of new skin per day, or between primates and rodents. Humans were the clear outliers.

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Elaine Fuchs, a stem cell biologist at the Rockefeller University who studies skin growth and repair and was not involved in the new research, said the results were what she would have expected. That’s because skin healing depends on hair.

Each hair grows from a hair follicle, which also houses stem cells. Normally, those stem cells just make more hair. But when called upon, they can grow new skin instead. “When the epidermis is wounded, as in most kinds of scratches and scrapes, it’s really the hair-follicle stem cells that do the repair,” Dr. Fuchs said.

Furry animals are covered in follicles, which help quickly close up wounds in mice or monkeys. By comparison, “human skin has very puny hair follicles,” Dr. Fuchs said. And our ancestors lost many of those follicles, packing their skin with sweat glands instead. Sweat glands also have stem cells, but they’re much less efficient at repairing wounds, Dr. Fuchs said.

Why did we make that trade during evolution, giving up so much of our hair and its protective properties? The glands that make the watery, salty sweat that dampens our shirts on a hot day are called eccrine glands. Most furry mammals have them only in certain places, mainly the soles of their paws. But human ancestors went all-in on sweat — modern humans have millions of sweat glands all over our bodies, and they’re about 10 times denser than those of chimpanzees.

“We evolved to cool by sweating profusely,” said Daniel Lieberman, an evolutionary biologist at Harvard University. Our abundant sweat glands and lack of fur let our ancestors engage in physical activity in hot environments, Dr. Lieberman said, and cooled the machinery of our big brains.

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The benefits of trading hair for sweat must have outweighed the costs. Dr. Matsumoto-Oda and her co-authors speculate that social support among prehistoric humans might have helped wounded people stay alive, despite our slower healing. (Or maybe they had ways to treat wounds, like orangutans and chimps seem to.)

“The evolutionary disadvantage is that wound healing is slowed,” Dr. Fuchs said, but humans also gained evolutionary advantages by losing hair.

“They can put on a coat if they need to,” she added.

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Alzheimer’s scientists find key to halting brain decline before symptoms

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Alzheimer’s scientists find key to halting brain decline before symptoms

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Scientists may have found a way to stop Alzheimer’s damage before it starts — by “melting” the tiny protein clumps that are the early triggers of the disease.

Alzheimer’s has long been linked to harmful tau protein fibrils that build up in the brain and interfere with cognitive function, but researchers have now discovered soft, small clusters that appear first.

When those early clusters were dissolved, it prevented the toxic fibrils from forming, which could effectively block the disease, according to researchers from Tokyo Metropolitan University.

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Led by Professor Rei Kurita, the scientists used precise X-ray and fluorescence methods in a laboratory setting to find the microscopic “precursors,” which measured only tens of nanometers, according to a press release.

Because the tiny precursors were soft, the researchers were able to dissolve them. As a result, no tau fibrils were formed.

Scientists may have found a way to stop Alzheimer’s damage before it starts — by “melting” the tiny protein clumps that are the early triggers of the disease. (iStock)

These results suggest a shift in how scientists might develop Alzheimer’s disease treatments.

Rather than focusing on breaking apart the final fibril formations, new therapies could target the earlier, reversible precursor stage to prevent harmful structures from forming in the first place, according to the release.

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This strategy could eventually be applied to the research of neurodegenerative diseases like Parkinson’s.

The study did have some limitations, primarily that it involved in-vitro biochemical models and no humans or animals. It’s not known whether similar reversible clusters exist in human brain tissue.

Alzheimer’s has long been linked to harmful tau protein fibrils that build up in the brain and interfere with cognitive function. (iStock)

More research is needed to find out if breaking up these protein clusters is safe and could actually help treat the disease.

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Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the study but shared his reactions to the findings.

“There are three essential components structurally involved in the development of Alzheimer’s disease — beta amyloid proteins, tau proteins and neuroinflammation,” he told Fox News Digital.

“In the future, there will likely be triple therapy — anti-inflammation, anti-beta-amyloid and anti-tau.”

“There are already treatments on the market to target beta amyloid buildup, and now here’s a targeted therapy to dissolve and disrupt tau protein buildup before it forms the dreaded neurofibrillatory tangles.”

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Siegel believes this is “bound to be of clinical value” and will likely be better tolerated than other medications currently on the market.

“In the future, there will likely be triple therapy — anti-inflammation, anti-beta-amyloid and anti-tau,” he predicts.

“This is promising basic research that may turn out to deepen our understanding of the mechanisms underlying the disease, but it is preliminary,” an expert said. (iStock)

Courtney Kloske, Ph.D., director of scientific engagement for the Alzheimer’s Association in Chicago, also reacted to the study in an interview with Fox News Digital.

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“This manuscript focuses on altering the structure of tau, one of the hallmark brain proteins involved in Alzheimer’s, and on exploring approaches that could potentially slow or stop disease development,” said Kloske, who was also not involved in the study.

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“This is promising basic research that may turn out to deepen our understanding of the mechanisms underlying the disease, but it is preliminary, and additional studies are needed to determine how these findings can be translated into human studies.”

Fox News Digital reached out to the researchers for comment.

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I’m a Dietitian—Here’s the Best Snack for Weight Loss After 50

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I’m a Dietitian—Here’s the Best Snack for Weight Loss After 50


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Gut imbalance may be driving America’s food allergy epidemic, experts warn

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Gut imbalance may be driving America’s food allergy epidemic, experts warn

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With over 32 million Americans battling food allergies, health advocates and officials are looking for the root cause — which includes looking into microbiomes.

The Food Allergy Fund (FAF) hosted a forum on Monday in Washington, D.C., with HHS Secretary Robert F. Kennedy, FDA Chief Martin Makary and NIH Director Jay Bhattacharya.

In an interview with Fox News Digital, Makary shared how the function of microbiomes has evolved over time.

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The intestine hosts over a billion different types of bacteria, which normally live in balance, according to Makary.

The doctor added, “but when it’s altered by the modern-day diet and by antibiotics and other exposures … that disequilibrium can cause inflammation, it can cause health problems, and it may be implicated in food allergies.”

“Gut health is central to overall health,” said Makary, pictured at a Nov. 16 forum hosted by the Food Allergy Fund. (Ashley J. DiMella/Fox News Digital)

“Gut health is central to overall health,” Makary emphasized. Some beneficial microbes may be missing in modern populations due to dietary and environmental changes, which could play a role in the rise of food allergies, he added.

Researchers at Siolta Therapeutics are testing this theory. Their oral microbiome therapy, STMC-103H, has shown promising results in a Phase 2 trial involving 238 newborns with a family history of allergies.

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Early data suggests the therapy could reduce the risk of developing food allergies by 77%, indicating that improving gut bacteria early in life could prevent allergies before they start.

Final results are expected in early 2026.

Early data suggests the therapy could reduce the risk of developing food allergies by 77%, indicating that improving gut bacteria early in life could prevent allergies before they start. (iStock)

Ilana Golant, FAF founder and CEO, told Fox News Digital “food allergies may be the canary in the coal mine for a much larger health crisis tied to the microbiome.”

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FAF launched its Food Allergy Fund Microbiome Collective in New York City to further investigate how gut bacteria could help prevent or treat not only allergies, but also autoimmune and neurodegenerative diseases.

“Gut health is central to overall health.”

“Solving allergies could reveal how to prevent and treat a range of diseases — from autoimmune disorders to neurodegeneration — that impact millions of lives,” said Golant.

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Food allergies are widespread, affecting one in 10 adults and one in 13 children, according to FAF. Every three minutes, someone in the U.S. is treated in the emergency room for a severe allergic reaction.

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Peanut allergies are among the most prevalent food allergies in the U.S., with new research showing that early peanut introduction could significantly reduce childhood allergies.

Ilana Golant, FAF founder and CEO (left), chats with HHS Secretary Robert F. Kennedy Jr. in Washington, D.C., at the Food Allergy Fund Forum. (Ashley J. DiMella/Fox News Digital)

Secretary Kennedy observed at the FAF conference that food allergies — particularly involving peanuts — appear to be far more common among children today than when he was growing up.

“When I was a kid, I never met anyone with a peanut allergy,” Kennedy said. “I had 11 siblings and about 71 first cousins, and I didn’t know a single person in my schools or at any of the camps I went to who had one.”

“There may be many causes, or there may be just one — we don’t know yet.”

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One of his sons has severe anaphylactic allergies to peanuts, tree nuts and several other foods, he shared. 

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“By the time he was 2 years old, we’d been to the emergency room about 22 times,” Kennedy said.

“At first, I focused on how we were going to treat it and keep him safe. But my mind quickly went to the bigger question — why is this happening? I have five of my seven children with allergies,” he said.

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“There may be many causes, or there may be just one — we don’t know yet,” Kennedy continued. “But we’re going to study it. We’re going to break that omertà, end the taboo and find out what’s causing it.”

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