Health
High blood pressure and Alzheimer’s disease could go hand in hand, study finds
The risk of Alzheimer’s disease could escalate along with high blood pressure, according to a new study.
Published in the medical journal Neurology, the research found that people age 60 and older who have untreated high blood pressure may be more likely to develop the common dementia type.
Although the results don’t prove that untreated high blood pressure causes the disease, they do show an association, the American Academy of Neurology stated in a press release.
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Study author Matthew J. Lennon, M.D., PhD, of the University of New South Wales in Australia, wrote in a statement that high blood pressure is a “leading cause of stroke and cerebrovascular disease, and yet it can be controlled with medication, reducing a person’s risk of these diseases.”
The study found that people age 60 and older with untreated high blood pressure may have an increased risk of Alzheimer’s. (iStock)
While previous research has found that taking blood pressure medications can reduce dementia risk, according to Lennon, less is known about the condition’s impact on Alzheimer’s risk.
“Our meta-analysis looked at older people and found that not treating blood pressure may indeed increase a person’s risk,” he said.
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The researchers analyzed 31,250 people averaging 72 years old who were involved in studies measuring cognitive change and dementia diagnosis over time, the release stated.
After four years, 1,415 of those individuals developed Alzheimer’s disease.
A doctor points at potential evidence of Alzheimer’s disease spotted in a PET scan at Brigham And Women’s Hospital in Boston on March 30, 2023. (REUTERS/Brian Snyder/File photo)
People with untreated high blood pressure had a 36% increased risk of Alzheimer’s compared to those without the condition, the study found.
They had a 42% increased risk in comparison to those with high blood pressure who were taking blood pressure medication.
“This relationship is not altered by increasing age, which indicates that even those in their 70s and 80s are at significantly lower risk of AD if hypertension is treated,” Lennon told Fox News Digital in an email.
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“These results suggest that treating high blood pressure as a person ages continues to be a crucial factor in reducing their risk of Alzheimer’s disease,” he added.
The researchers also found that there were no significant risk differences in the effects of blood pressure or medication use across different sexes or racial groups.
“This is a very promising result, as it suggests that optimal care for one group will be similar for others,” Lennon noted.
“Treating high blood pressure as a person ages continues to be a crucial factor in reducing their risk of Alzheimer’s disease.”
Dr. Marc Siegel, a professor of medicine at NYU Langone Medical Center and Fox News senior medical analyst, reacted to these findings in a conversation with Fox News Digital.
Alzheimer’s involves “neuroinflammation and the formation of plaques, which interfere with neuronal communication,” noted Siegel, who was not involved in the study.
“We have long known that high blood pressure, high cholesterol and high glucose levels — as well as obesity, smoking and alcohol use — contribute to increased risk of heart attack, stroke and vascular dementia,” a doctor told Fox News Digital. (iStock)
Added the doctor, “High blood pressure may accelerate this development by interfering with oxygen and blood supply to the nerve cells of the brain in some areas — especially the frontal lobe, which is affected.
Dr. Elizabeth Landsverk, geriatric medicine physician and author in California, was not involved in the study but said she was not surprised by the findings.
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“We have long known that high blood pressure, high cholesterol and high glucose levels — as well as obesity, smoking and alcohol use — contribute to increased risk of heart attack, stroke and vascular dementia,” she told Fox News Digital.
“This new study also finds a decreased risk of Alzheimer’s disease (amyloid proteins deposing the brain) among those treated for hypertension.”
Potential study limitations
The researchers used data from 14 different longitudinal studies from around the world, Lennon noted, which means there may be some variability in the way they define dementia and high blood pressure.
“Most of the studies also did not report mortality data, and thus our analysis did not account for the competing risks of dementia and death,” the researcher told Fox News Digital.
“These results suggest that treating high blood pressure as a person ages continues to be a crucial factor in reducing their risk of Alzheimer’s disease,” a study researcher said. (iStock)
Factors like socioeconomic status, health literacy, access to medications, poorly managed medical conditions, and depression and other mental illnesses could also confound the association between hypertension status and dementia risk, Lennon added.
“Because the study is taken over a long period of time, any number of outside variables can alter the results, making it less reliable,” Landsverk noted.
Hypertension is extremely common, affecting two-thirds of those over age 65 and around 1.3 billion people worldwide, Lennon noted.
“In the vast majority of cases, it is clinically silent, causing no symptoms until you present with a heart attack, a stroke, or — as we now have shown — dementia,” Lennon said.
Hypertension is extremely common, affecting two-thirds of those over the age of 65 and around 1.3 billion people worldwide. (iStock)
Only 28% of those with high blood pressure have it under adequate control, he noted.
“While you might not feel the consequences of high blood pressure immediately, it is really important that you keep a close eye on it and bring it under control if you want to maximize your chance at a longer, happier, healthier life,” Lennon added.
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For those who are obese, Landsverk added, losing weight is the fastest way to decrease risk factors.
“In general, the healthiest approach is adopting a plant-based diet and exercising 30 minutes each day to reduce your risk of heart attack, stroke, dementia and now Alzheimer’s disease by as much as 40%,” she advised.
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Brain aging may accelerate after cancer treatment, study suggests
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Surviving cancer as a child or young adult may have a lasting impact on aging, new research suggests.
Researchers at the University of Rochester Medical Center looked at whether life-saving treatments, like chemotherapy and radiation, could speed up biological aging.
They also aimed to determine whether this age acceleration was linked to cognitive issues related to memory, focus and learning.
The team analyzed blood samples from a group of 1,400 long-term survivors treated at St. Jude Children’s Research Hospital, using epigenetic clocks — tools that estimate biological age by examining chemical tags on DNA.
Biological age is determined based on damage the cells accumulate over time, versus chronological age, which is measured by how long someone has been alive, according to scientists.
Biological age is determined based on the damage cells accumulate over time, according to scientists. (iStock)
“These well-established aging-related biomarkers have previously been associated with neurocognitive impairment and decline in older non-cancer populations, particularly in cognitive domains related to aging and dementia, such as memory, attention and executive function,” the study stated.
Most of the group consisted of acute lymphoblastic leukemia survivors, or Hodgkin lymphoma survivors. Participants were at least five years past their treatment, though some had survived for several decades.
They underwent neurocognitive testing to measure their attention span, memory and information processing speed.
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Chemotherapy was found to have the greatest impact on aging acceleration. The study suggests the treatment can alter DNA structure and cause cellular damage.
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“It’s no surprise to find out that young people with cancer who have chemo early in life are affected in terms of long-term aging,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.
Participants underwent neurocognitive testing to measure their attention span, memory and speed of information processing. (iStock)
Researchers also found that cellular aging was closely linked to cognitive performance, as survivors of a higher biological age had more difficulty with memory and attention.
“Chemo poisons and damages cellular function — hopefully the cancer cells more than normal cells, but there is a significant impact on normal cells as well,” said Siegel, who was not involved in the study.
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“There is also something called ‘chemo brain,’ which causes at least temporary difficulty with memory, concentration, word finding and brain fog,” the doctor added.
The research team hopes to use these findings to focus on intervention efforts, specifically by determining when accelerated aging begins.
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“Young cancer survivors have many more decades of life to live,” lead study author AnnaLynn Williams, PhD, said in a press release. “If these accelerated aging changes are occurring early on and setting them on a different trajectory, the goal is to intervene to not only increase their lifespan, but improve their quality of life.”
The team hopes this research will help in the development of early intervention tools that aim to prevent cognitive decline. (iStock)
There were some limitations to the study. The researchers could not adjust for chronic health conditions or education because they are directly impacted by treatment.
Additionally, the study only looked at the survivors at a single point of time, so it could not directly prove causation.
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The study was published in the journal Nature Communications.
Fox News Digital reached out to the researchers for comment.
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