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Heart attack damage reversed with injectable RNA therapy, study finds

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Heart attack damage reversed with injectable RNA therapy, study finds

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Scientists have developed a new therapy designed to repair cardiac damage after a heart attack.

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The study, led by researchers at Columbia University and published in the journal Nature Biomedical Engineering, explored a two-step strategy that uses skeletal muscle to produce a healing molecule that activates when it reaches an injured heart.

Unlike many organs, the adult human heart has a limited ability to repair itself after a heart attack, the researchers noted.

DIABETES BREAKTHROUGH APPROACH COULD PROTECT CELLS AND PREVENT DISEASE

“The heart is one of the organs with the least ability to regenerate,” said Ke Cheng, a professor of biomedical engineering at Columbia and the study’s lead author, in a press release.

Dead muscle is typically replaced by stiff scar tissue, often leading to heart failure. However, newborns’ hearts can spontaneously regenerate during a brief window of time.

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Scientists have developed a new therapy designed to repair cardiac damage after a heart attack. (iStock)

“The neonatal heart spontaneously produces more of this molecule after a heart attack,” Cheng said. “The adult can’t produce a sufficient amount, so we found a way to supplement this to the heart.”

“The whole idea is that we learn from nature.”

The secret to this treatment is a protein called ANP, which acts as a repair mechanism for the heart, according to the researchers. Normally, this protein is impossible to use as a drug because it dissolves in the blood within minutes, long before it can reach the heart.

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To solve this, researchers turned the body’s own skeletal muscles into a sort of factory to produce ANP, using a specialized RNA injection to give the arm or leg muscles a set of instructions.

These instructions tell the muscle to produce a “sleeping” version of the repair protein. This inactive version safely travels through the bloodstream until it hits the heart, according to the release.

Dead muscle is typically replaced by stiff scar tissue, often leading to heart failure, the researchers noted. (iStock)

Once there, it meets a specific enzyme that acts like a key, “waking up” the protein so it can begin repairing exactly where it’s needed.

In preclinical trials involving both small and large animals, a single injection into the limb reduced scarring and significantly improved heart function.

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Because the researchers used self-amplifying RNA, which replicates once it’s inside the body, the treatment continued to produce the healing protein for at least four weeks.

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The therapy remained effective even when administered a week after the initial injury, providing hope for patients who do not receive immediate treatment, the researchers also found.

The treatment continued to produce the healing protein for at least four weeks. (iStock)

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“The patient doesn’t have to go to the hospital today and tomorrow,” Cheng said, noting that the method avoids the risks associated with injecting treatments directly into the heart muscle.

So far, the treatment has only been tested in animals, which poses a significant limitation to the study. Human hearts are much more complex, and clinical trials are needed to determine whether they react in the same way.

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Additionally, because the RNA remains active for several weeks, scientists need to ensure that producing this repair protein for an extended time doesn’t cause any unintended side effects in other parts of the body.

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LeAnn Rimes’ emotional reaction to jaw release therapy sparks widespread buzz

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LeAnn Rimes’ emotional reaction to jaw release therapy sparks widespread buzz

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Singer LeAnn Rimes has gone viral for her reaction while receiving jaw release therapy.

In a session with Garry Lineham, co-founder of Human Garage in California — a resource for self-healing practices — Rimes received an intra-oral massage, releasing the tension in her jaw. She seemed to instantly feel relief, sobbing on the table.

Jaw release therapy, which involves the massaging or stretching of muscles in the face, is popular for relieving TMJ pain, headaches and jaw clicking, according to experts.

LEANN RIMES BREAKS DOWN INTO TEARS WHILE UNDERGOING ‘DEEP JAW RELEASE’

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In an interview with Fox News Digital, Lineham shared that stress has an immense impact on human health, especially on muscle tension and pain.

“We hold emotions in our body,” he said. “Emotions cause a sympathetic response or a stress response in the body.”

“When you release the jaw, instantaneously you come out of that fight or flight mode,” Lineham said. (iStock)

“Stress is one thing that impacts every disease, whether it’s emotional or physical, whether it is genetic,” he went on. “Stress is the thing that makes genetics pop. If you take away stress, those genetic markers no longer express themselves.”

STUDY REVEAL WHY CHEWING GUM MIGHT ACTUALLY HELP WITH FOCUS AND STRESS RELIEF

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Clenching the jaw can create stress, which happens naturally with physical and emotional exertion, according to Lineham.

“If you clench your jaw and hold it there for three to five minutes … you’ll actually fire adrenaline and norepinephrine (hormones and neurotransmitters),” he said.

This sends a message to the body that you’re bracing for an “attack,” releasing hormones like stress, Lineham added.

“When you release the jaw, then instantaneously you come out of fight or flight mode.”

How jaw release works

Jaw release therapy targets the fascia, or the connective tissue that supports the body’s muscles, organs and joints. Stretching the fascia also allows the muscle to stretch, providing relief, Lineham said.

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“When you release the jaw, then instantaneously you come out of that fight or flight mode,” he said. “And if you’ve been there for a long time, like most people have, it instantaneously shocks the nervous system in a good way.”

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Dr. Justin Richer, oral and maxillofacial surgeon at Riverside Oral Surgery in New Jersey, shared the benefits and risks of jaw release treatment with Fox News Digital.

Jaw release therapy can help with facial pain and muscle tightness. (iStock)

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Certain muscles in the body, such as the shoulder or back, can tense up and “overreact to problems that are going on within them,” said the doctor, who did not treat Rimes.

“Jaw release is almost like a massage or similar technique, to put pressure on the muscles and let the tension that’s built up just kind of relax away,” he said. “It’s not something that a lot of people do.”

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The procedure is most beneficial for those with symptoms of TMJ, facial and muscle pain, and tightness, according to Richer.

Some physical therapists and massage therapists offer this treatment, but Richer recommends seeking help from an oral-facial pain specialist or surgeon who “really understands the anatomy of the jaw joint.”

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Dr. Richer recommends seeing an oral surgeon or specialist before seeking the procedure. (iStock)

“If it’s done properly, there’s very minimal risk,” he said. “What we get concerned about is undue manipulation of the joint, so either cracking or distorting or trying to forcefully move the joint . . . that can actually cause undue harm from an orthopedic perspective.”

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Despite the benefits, Richer stressed that this kind of therapy may be a temporary fix, as it could be treating only the symptoms of an underlying problem.

“Get a diagnosis first before you go ahead and start manipulating things,” he advised.

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Study reveals one simple eating habit that may help boost weight loss

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Study reveals one simple eating habit that may help boost weight loss

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Losing weight might be as simple as sticking to the meals you know, a new study found.

People who ate the same meals more often lost more weight during a 12-week weight-loss program, according to a new study published in Health Psychology.

“Maintaining a healthy diet in today’s food environment requires constant effort and self-control,” lead author Charlotte Hagerman of the Oregon Research Institute said in a statement. 

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“Creating routines around eating may reduce that burden and make healthy choices feel more automatic.”

Experts say maintaining muscle after 50 may require more protein than the minimum federal guideline. (iStock)

Hagerman and fellow researchers from Drexel University and the Oregon Research Institute analyzed food logs from 112 adults who were overweight or obese who tracked their meals in an app and weighed themselves daily, according to the study.

The researchers measured “routinized” eating in two main ways —how much participants’ daily calorie intake fluctuated and how often they repeated the same meals and snacks over time, according to the paper.

DOCTOR WARNS MANY AMERICANS EAT ‘FOOD-LIKE SUBSTANCES,’ NOT REAL FOOD

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Those whose diets included more repeated foods lost an average of 5.9% of their body weight compared to 4.3% for those whose eating patterns were more varied, according to a press release from the American Psychological Association.

A man shows how much weight he has lost by holding out the waist of his jeans, symbolizing his successful diet. (iStock)

People who kept their daily calorie intake more consistent also lost more weight, according to the researchers.

Liza Baker, a Vermont-based nutrition expert and founder of Simply: Health Coaching, said the findings line up with what she has seen firsthand in more than a decade of working with clients.

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“Removing the mental load of ‘What’s for breakfast, lunch or dinner?’ can make the wellness journey much more sustainable,” Baker told Fox News Digital.

A breakfast of oatmeal porridge with summer berries. (iStock)

She said repeat meals can reduce decision fatigue and make it easier for people to stick to healthier habits, especially when they are packing lunches, cooking at home and following a simple routine.

Baker said people do not necessarily have to repeat every meal to see benefits.

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“One can start by eating one meal that is repetitive, usually breakfast or lunch,” she said. “As results start to show, it’s then more conducive to increasing to two to three repetitive meals a day.”

At the same time, experts cautioned that the findings do not prove cause and effect. The study was observational, meaning it found an association between routine eating and greater weight loss but could not show that repetition alone caused the better results, according to the researchers.

Consistency — not variety — may be key when it comes to weight loss, researchers found. (iStock)

Baker also warned that repeat meal plans can backfire if they are not nutritionally balanced or if they trigger perfectionism.

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“Unless someone is well-versed in nutrition, setting up a repeat meal plan can quickly become a nutritional nightmare that leads to becoming deficient in one or more nutrients,” she said.

The study authors similarly noted that too little variety could come with trade-offs. Future research is needed to determine whether a more repetitive diet should be actively recommended as a weight-loss strategy, they said.

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Fox News Digital reached out to the study’s authors for comment.

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Prayer for Weight Loss Works: How Faith Can Help You Shed Weight Faster

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Prayer for Weight Loss Works: How Faith Can Help You Shed Weight Faster


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How Prayer for Weight Loss Can Help You Shed Pounds Faster




















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