Health
Greater weight loss promised by higher-dose Wegovy shot, now approved by FDA
Novo Nordisk to slash Wegovy, Ozempic list prices
Board certified rheumatologist Dr. Mahsa Tehrani discusses Novo Nordisk’s decision to dramatically cut the U.S. list prices for its popular diabetes and weight-loss drugs Ozempic and Wegovy on ‘America Reports.’
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The U.S. Food and Drug Administration announced on Thursday its approval of a new, higher-dose Wegovy (semaglutide) injection.
The 7.2 mg dosage, called Wegovy HD, is intended for weight loss and long-term weight loss maintenance for adult patients. It is triple the previous maximum dose of 2.4 mg.
This marks the fourth approval in the FDA’s National Priority Voucher pilot program, which “seeks to expedite approval of applications that address critical national health priorities,” according to FDA Commissioner Dr. Martin Makary.
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“The new FDA is moving with unprecedented efficiency on products that advance national priorities,” he said in a press release. “Today’s approval is another demonstration of what the FDA can accomplish when we try bold new things.”
The U.S. Food and Drug Administration announced on Thursday its approval of a new, higher-dose Wegovy (semaglutide) injection. (Michael Siluk/UCG/Universal Images Group via Getty Images)
The higher-dose GLP-1 is indicated to “reduce excess body weight and maintain weight reduction long-term in adults with obesity, or overweight with at least one weight-related condition,” per the FDA’s statement.
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“The approval of a new higher dose will provide adult patients with an additional therapeutic option, offering the potential for greater weight loss,” the agency stated.
The FDA’s approval, granted to drugmaker Novo Nordisk, was supported by clinical data that found higher doses resulted in additional average weight reduction compared to previous dosing.
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Higher-dose patients with both obesity and type 2 diabetes saw similar lowering of blood sugar compared to the lower dose, the agency noted.
The safety profile is consistent with the known side effects of semaglutide, which commonly include gastrointestinal reactions like nausea, vomiting, diarrhea, constipation and abdominal pain.
Wegovy HD (7.2 mg) is triple the dosage compared to the previous maximum dose of 2.4 mg. (Steve Christo – Corbis/Corbis via Getty Images)
Skin sensitivity, pain or burning occurred more frequently with higher doses of Wegovy, but generally resolved on their own or with dose reduction, the FDA reported. The agency is investigating these adverse effects.
The FDA warned that Wegovy should not be used by patients with a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer) or who have multiple endocrine neoplasia syndrome type 2 (a rare inherited genetic disorder that causes tumors to develop in certain hormone-producing glands). All patients should see a doctor for guidance on proper use.
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Jamey Millar, executive vice president of U.S. operations for Novo Nordisk, commented on this approval in a press release.
“We are excited to bring Wegovy HD injection to adults with obesity who are looking for powerful weight loss, as no other weight-loss medicine has been studied to show superiority to Wegovy HD,” he said.
Millar also noted that Wegovy has been shown to reduce the risk of events such as stroke, heart attack or cardiovascular death in those who also have known heart disease.
A weight-loss expert warned that Wegovy HD should be used only for obesity management. (iStock)
Dr. Peter Balazs, a hormone and weight-loss specialist practicing in New York and New Jersey, reflected on results of the STEP UP clinical trial, on which the drug’s approval was based.
Patients taking the higher dose experienced an average weight loss of 20.7% compared to about 16% on the standard dose, the doctor noted. About one-third lost 25% or more of their body weight.
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“For patients who start on 2.4 mg and then hit a frustrating plateau, or for those with a very high baseline BMI who may need a stronger metabolic push, this creates a legitimate, evidence-based escalation path rather than forcing an early switch to another drug class,” Balazs, who was not involved in the study, told Fox News Digital.
“That said, I think this is an interesting approval, but I do not expect it to dramatically reshape the GLP-1 landscape,” he went on. “It gives Novo Nordisk an opportunity to remain competitive on efficacy while it continues developing next-generation therapies.”
“This creates a legitimate, evidence-based escalation path.”
“Other drugs have already shown greater efficacy in prior studies, and the broader GLP-1 space is likely to see much more significant change as new molecules enter the market.”
Balazs called the higher dosage a “major jump,” noting that the incidences of stomach- and skin-related side effects at this higher dose are “meaningful.”
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“This approval is for obesity management, not diabetes treatment,” the expert emphasized. “For patients with type 2 diabetes, currently approved semaglutide dosing remains lower unless the primary treatment goal is weight loss under the obesity indication.”
Fox News Digital reached out to the FDA for comment.
Health
Tick bite ER visits hit highest seasonal level in years as doctors warn of disease surge
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Tick bite-related ER visits are at their highest seasonal levels since 2017 across most U.S. regions, raising concerns about increased Lyme disease and other tick-borne illnesses.
That’s according to recent data from the Centers for Disease Control and Prevention’s Tick Bite Tracker, which monitors weekly emergency department visits associated with tick bites across the country.
For every 100,000 ER visits, approximately 71 were related to tick bites in April 2026, compared to a historical seasonal average of roughly 30 per 100,000.
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Some of the highest rates of tick-based ER visits were among children younger than 10 years and adults between 70 and 79 years.
A close-up shows a parasitic mite in motion on a human fingertip, highlighting the potential for disease transmission such as encephalitis. (iStock)
“Over the past three decades, the geographic range of the blacklegged tick has expanded significantly, and with it, the risk of Lyme disease and other Ixodes-transmitted infections,” Dr. Steven Goldberg, a family medicine physician who practices urgent care and family medicine at UofLHealth in Louisville, Kentucky, told Fox News Digital.
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“The Ohio River Valley region is one of the most striking examples — Lyme disease cases in Ohio have increased roughly 10-fold over the past decade, likely driven by the convergence of Northeastern and Upper Midwestern tick populations meeting in that corridor.”
States like Virginia and West Virginia, as well as areas south of the traditional endemic zone, are reporting increasing tick abundance and disease cases, the doctor noted.
“Over the past three decades, the geographic range of the blacklegged tick has expanded significantly.”
“The lone star tick is also expanding its range northward beyond its traditional stronghold in the Southeast, which means diseases like ehrlichiosis and alpha-gal syndrome are appearing in regions where clinicians may not yet be thinking about them,” he warned.
Some climate studies predict that the blacklegged tick’s suitable habitat could expand by over 200% by the end of the century, Goldberg noted, including into Canada and across the central and southern U.S.
What’s driving the spike?
“Warmer, wetter conditions allow ticks to survive in habitats that previously would have been too cold,” said Dr. Suraj Saggar, chief of infectious disease at Holy Name Medical Center in Teaneck, New Jersey. “Milder winters also extend the lifespan of both ticks and the animals they feed on, accelerating tick reproduction and shortening their life cycles.”
Areas that historically experienced longer, colder winters or significant snow cover are now more hospitable to ticks, the doctor noted.
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“As temperatures rise and precipitation patterns change, ticks are able to spread northward and thrive in new ecosystems,” he said.
Another contributing factor is increased land development and human expansion into wooded and grassy areas, as well as reforestation of formerly agricultural land.
“As temperatures rise and precipitation patterns change, ticks are able to spread northward and thrive in new ecosystems,” an expert said. (iStock)
“The recovery and expansion of white-tailed deer populations — critical hosts for adult blacklegged ticks — has been a major driver,” Goldberg added. “Deer density is positively associated with Lyme disease incidence. Small mammal communities, particularly white-footed mice that serve as key reservoir hosts for Borrelia burgdorferi, also play a central role.”
Tick-borne diseases
Tick bites are known to transmit numerous illnesses, the most widespread of which is Lyme disease, a bacterial infection.
“Lyme disease cases alone have increased roughly two- to threefold over the past 20 years,” Saggar said. Approximately 476,000 Americans are diagnosed and treated for Lyme disease each year, per CDC surveillance data.
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Also common are anaplasmosis and ehrlichiosis, two different types of bacterial infections, according to the doctor. Tick bites can also cause babesiosis, a malaria-like parasitic disease that infects and destroys red blood cells.
“Another growing concern is alpha-gal syndrome, a condition in which a (lone star) tick bite triggers a serious allergic reaction to red meat,” Saggar said. “In rare cases, people have died from anaphylactic reactions linked to alpha-gal syndrome following a tick bite.”
Some common symptoms of tick-borne illness include fever, chills, fatigue, headaches, muscle aches and joint pain. (iStock)
Ticks can also transmit viruses, including the Powassan virus, which can cause severe neurologic injury.
“Powassan virus disease is arguably the most concerning emerging tick-borne infection,” said Goldberg, who is also chief medical officer at HealthTrack. “It’s transmitted by the same blacklegged tick that carries Lyme disease, but unlike Lyme, it can be transmitted within minutes of tick attachment.”
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Powassan can cause severe encephalitis with a roughly 10% to 15% fatality rate, and more than half of survivors have lasting neurological deficits, Goldberg noted.
In the Rocky Mountain states, the Rocky Mountain wood tick (Dermacentor andersoni) transmits Rocky Mountain spotted fever and Colorado tick fever.
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“In the Southeast and South-Central U.S., the lone star tick (Amblyomma americanum) drives a different set of concerns: ehrlichiosis, tularemia, and two emerging viral threats — Heartland virus and Bourbon virus,” said Goldberg.
Symptoms to watch for
Some common symptoms of tick-borne illness include fever, chills, fatigue, headaches, muscle aches and joint pain, according to Saggar.
Another sign is the classic “bull’s-eye” rash associated with Lyme disease, known medically as “erythema migrans.”
“If you think you have been bitten by a tick, you should seek medical attention if you develop symptoms after a known tick bite or after spending time in tick-prone areas, especially during the spring, summer and fall.” (iStock)
“Because testing can sometimes be falsely negative early in the disease process, doctors may treat patients based on symptoms and exposure history rather than waiting for laboratory confirmation,” Saggar noted.
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“If you think you have been bitten by a tick, you should seek medical attention if you develop symptoms after a known tick bite or after spending time in tick-prone areas, especially during the spring, summer and fall.”
Preventing tick bites
As there are no vaccines currently available for any tick-borne disease in the U.S., prevention is the most effective strategy.
Goldberg shared the following recommended prevention strategies.
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- Use EPA-approved repellents, including DEET, picaridin, IR3535 or oil of lemon eucalyptus on exposed skin. Treat clothing and gear with permethrin (a synthetic insecticide and repellent) or purchase pre-treated clothing.
- Wear light-colored clothing (to spot ticks more easily), long sleeves and long pants tucked into socks when in wooded or grassy areas.
- After spending time outdoors, check your entire body, paying special attention to the scalp, behind the ears, armpits, groin and behind the knees, the doctor advised. It’s also recommended to shower within two hours of coming indoors.
- Tumble-dry clothing on high heat for at least 10 minutes to kill any ticks on clothing.
- Remove ticks promptly and properly. Using fine-tipped tweezers, grasp the tick as close to the skin as possible, and pull upward with steady, even pressure. Clean the bite area afterward.
Approximately 476,000 Americans are diagnosed and treated for Lyme disease each year, per CDC data.
“The longer a tick is attached, the higher the risk of disease transmission — for Lyme disease, transmission generally requires at least 36 hours of attachment,” Goldberg said. “The Powassan virus can be transmitted much more quickly.”
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How Author Mary Kay Andrews, 71, Lost 65 Lbs. Microdosing GLP-1 Meds
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Health
What to know about thyroid cancer prognosis following Pam Bondi’s diagnosis
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Former Attorney General Pam Bondi was diagnosed with thyroid cancer shortly after leaving the Department of Justice last month, according to a report.
Bondi, 60, who left her role at the Justice Department in early April, underwent treatment and is recovering, a source stated.
The thyroid is a gland located in the neck. It makes hormones that are then secreted into the blood, which help the body “use energy, stay warm and keep the brain, heart, muscles and other organs working as they should,” according to the American Thyroid Association.
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Thyroid cancer is relatively uncommon compared to other cancers. Even so, as of 2023, more than one million people in the U.S. are living with the disease.
The National Cancer Institute (NCI) predicts that there will be an estimated 45,260 new cases in 2026.
Former Attorney General Pam Bondi was diagnosed with thyroid cancer shortly after leaving the Department of Justice last month. (Alex Wong/Getty Images)
Risk factors and symptoms
While more common in women, thyroid cancer can affect both sexes. Those with a family history may be more likely to develop it, as well as those between the ages of 25 and 65. Exposure to radiation is also a risk factor, according to the National Cancer Institute.
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Signs of thyroid cancer may include lumps or swelling in the neck, trouble breathing, trouble swallowing, hoarseness and pain when swallowing, per the above source. Anyone experiencing these symptoms should seek medical attention.
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If thyroid cancer is suspected, a doctor can diagnose it in several ways. A laryngoscopy is a procedure where the doctor checks the voice box with a mirror or laryngoscope — a thin, tube-like instrument with a light and lens, per NCI.
Signs of thyroid cancer may include lumps or swelling in the neck and trouble breathing. (iStock)
Blood hormone studies – where a blood sample is checked to measure hormone levels – can also reveal indicators of thyroid cancer. Ultrasounds and CAT scans are then used to check for tumors in the body.
Treatment options
Surgery, radiation, chemotherapy and hormone therapy are the main ways doctors treat thyroid cancer. A new type of therapy, immunotherapy, is being tested in clinical trials.
“Surgery is the primary therapy, followed by regular surveillance and thyroid hormone replacement,” Dr. Marc Siegel, Fox News senior medical analyst, told Fox News Digital.
Bondi, 60, who left her role at the Justice Department in early April, underwent treatment and is recovering, according to a source. (Roberto Schmidt/AFP via Getty Images)
If the thyroid must be completely removed, patients will take hormones to replace the gland’s natural function.
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“Radioactive iodine is added in extensive or more aggressive cases,” Siegel said, but noted that it is “usually not needed.”
The thyroid gland is located in the neck. It makes hormones that are then secreted into the blood, which help the body use energy. (iStock)
Survival rates
The prognosis for thyroid cancer is generally positive and depends heavily on how the cancer responds to treatment, according to NCI.
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Some types are much milder and slower-growing than others. Doctors will also consider the stage of the cancer’s progression.
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The best-case scenario is when a surgeon can completely remove the tumor during surgery. Doctors will also factor in whether this is a brand-new diagnosis or if the cancer has returned after previous treatment.
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