Health
Fish oil supplements linked to greater first-time heart attack risk in study: ‘Not universally good or bad'
Taking fish oil supplements could raise the risk of heart attack and stroke, a new study suggests.
Among healthy people, regular use of fish oil was found to make them more susceptible to developing heart disease and stroke for the first time, the study found.
Among those who had existing heart disease, however, fish oil consumption was shown to slow the progression of cardiovascular disease and reduce the risk of mortality.
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Researchers analyzed nearly 12 years of data for more than 415,000 participants from the UK Biobank study; the participants ranged in age from 40 to 69.
“Regular use of fish oil supplements might be a risk factor for atrial fibrillation and stroke among the general population, but could be beneficial for progression of cardiovascular disease from atrial fibrillation to major adverse cardiovascular events, and from atrial fibrillation to death,” the researchers wrote in the study, which was published in The BMJ (British Medical Journal).
Taking fish oil supplements could raise the risk of heart attack and stroke among certain people, a new study suggests. (iStock)
“Further studies are needed to determine the precise mechanisms for the development and prognosis of cardiovascular disease events with regular use of fish oil supplements.”
Study highlights ‘uncertainty,’ cardiologist says
Dr. Jim Liu, a cardiologist at The Ohio State University Wexner Medical Center, who was not involved in the study, pointed out that there has been conflicting data about whether or not fish oil or omega 3 fatty acids can help reduce the risk of cardiovascular disease.
“This is yet another study that reminds us there is still a lot that needs to be investigated when it comes to fish oil and heart disease.”
“This study appears to echo the same sentiment that there is still some uncertainty about their relation to heart health,” he told Fox News Digital.
“Similar to previous studies, I think this study indicates that fish oil is not necessarily universally good or bad for all.”
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Whether or not fish oil is beneficial or harmful depends on an individual’s specific underlying health conditions, he said — such as a history of heart attack or atrial fibrillation, and on other factors such as dosing and different formulations of the substance.
“Further studies are needed to determine the precise mechanisms for the development and prognosis of cardiovascular disease events with regular use of fish oil supplements,” the authors of a new study wrote. (iStock)
“Previous studies have shown that certain formulations of fish oil can help reduce cardiovascular events in people with elevated triglycerides and previous cardiovascular events,” Liu noted.
“Overall, this is yet another study that reminds us that there is still a lot that needs to be investigated when it comes to fish oil and heart disease.”
Dietitians weigh risks and benefits
Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina, who practices as The Lupus Dietitian, also was not involved in the study but offered insights.
“In this study, there was a slightly increased association between healthy people who took fish oil and developing atrial fibrillation and stroke, whereas for those people who took the fish oil after being diagnosed with cardiovascular disease, there was a slightly decreased association and risk of atrial fibrillation and stroke,” she told Fox News Digital.
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“Overall, I would say to take these results with a grain of salt, as it was a prospective study.”
A prospective study monitors what people self-report and their eventual health outcomes over time, she noted — versus a control study, where similar people are placed in two groups and one group takes the fish oil while the other does not.
“We don’t know about the population of healthy participants and why they decided to take fish oil,” Freirich said.
A registered dietitian recommended that most people get their omega 3s from food sources such as salmon, sardines, tuna, ground flaxseed, chia seeds, walnuts and almonds. (iStock)
“Perhaps they have a family history of heart disease, or other lifestyle features that are contributing to their risk of developing atrial fibrillation and stroke outside of the fish oil supplement.”
As a registered dietitian, Freirich said she recommends most people get their omega 3s from food sources such as salmon, sardines, tuna, ground flaxseed, chia seeds, walnuts and almonds.
“Making small changes to your diet over time can have big benefits in reducing your overall cardiovascular risk.”
“Many people do not get enough omega 3 fatty acids in their diet, and this can be a great way to consume healthy fats while also benefiting from protein and sources of fiber,” she said.
When preparing meals, replacing a serving of red meat with fatty fish can promote heart health by decreasing the intake of saturated fats and increasing the intake of omega 3s, according to Freirich.
“Always discuss your supplement use with your medical care providers, as some may be unnecessary or even increase your risk for poor health outcomes,” said one expert. (iStock)
“Making small changes to your diet over time can have big benefits in reducing your overall cardiovascular risk,” she advised.
“Always discuss your supplement use with your medical care providers, as some may be unnecessary or even increase your risk for poor health outcomes.”
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Michelle Routhenstein, a New York-based preventive cardiology dietitian at EntirelyNourished.com, agreed that prior research has indicated that taking high doses of fish oil supplements could potentially elevate the risk of atrial fibrillation — while regularly consuming fatty fish four to five times a week may lower that risk.
To determine the potential benefits of fish oil and the appropriate dosage, experts recommended consulting with a registered dietitian specializing in heart disease. (iStock)
“We need to recognize that when it comes to fish oil — and many other foods and supplements — more or a concentrated dose isn’t necessarily better,” Routhenstein, who was not involved in the study, told Fox News Digital.
“It is also important to note that not all fish oil supplements are created equal. Factors like dosage, quality and additional ingredients can influence cardiovascular health outcomes.”
To determine the potential benefits of fish oil and the appropriate dosage, Routhenstein recommended consulting with a registered dietitian specializing in heart disease.
Fox News Digital reached out to the study researchers for more detail, as well as several manufacturers of fish oil supplements requesting comment on the findings.
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A popular class of weight-loss drugs may prevent life-threatening cardiac complications by opening microscopic blood vessels that often remain blocked after a heart attack, according to a study published this week in Nature Communications.
The research, led by the University of Bristol and University College London, identified a biological brain-gut-heart signaling pathway.
This discovery appears to explain how GLP-1 drugs — which mimic glucagon-like peptide-1, a hormone that helps regulate blood sugar and appetite — protect heart tissue from a condition known as “no-reflow.”
“In nearly half of all heart attack patients, tiny blood vessels within the heart muscle remain narrowed, even after the main artery is cleared during emergency medical treatment,” Dr. Svetlana Mastitskaya, the study’s lead author and a senior lecturer at Bristol Medical School, said in a press release.
“This results in a complication known as ‘no-reflow,’ where blood is unable to reach certain parts of the heart tissue.”
In nearly half of all heart attack patients, tiny capillaries (blood vessels) remain narrowed even after the main blocked artery is cleared. (iStock)
This lack of blood flow increases the risk of heart failure and death within a year. GLP-1 medications could prevent this, according to the researchers.
How it works
When the GLP-1 hormone is released in the gut or administered as a drug, it sends a signal to the brain, which then sends a signal to the heart that switches on special potassium channels in tiny cells called pericytes.
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When these channels open, the pericytes relax, which allows the small blood vessels (capillaries) to widen and improve blood flow to the heart muscle, the researchers noted.
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The new study used animal models and cellular imaging to track how GLP-1 interacts with heart tissue. When the researchers removed the potassium channels, the drugs no longer protected the heart — confirming they play a key role.
The findings suggest that existing GLP-1 medications, already used for type 2 diabetes and obesity, could be repurposed as emergency treatments. (iStock)
The findings suggest that existing GLP-1 medications, already used for type 2 diabetes and obesity, could be repurposed as emergency treatments during or immediately after a heart attack to reduce tissue damage.
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The researchers noted several limitations, including that the study relied on animal models.
Clinical trials are necessary to determine whether the brain-gut-heart pathway operates with the same timing and efficacy in humans.
While the study highlights the drug’s immediate benefits during a heart attack, it des not establish whether long-term use of these drugs provides a pre-existing level of protection. (iStock)
Additionally, while the study highlights the drug’s immediate benefits during a heart attack, it does not establish whether long-term use of the medication provides a pre-existing level of protection.
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The research was primarily funded by the British Heart Foundation.
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Collagen supplements have exploded in popularity, touted as everything from an anti-aging miracle to a muscle recovery booster.
But a sweeping new review conducted by U.K. researchers suggests that while collagen may help improve skin elasticity and ease arthritis pain, it does little for athletic performance or wrinkle reduction.
Researchers from Anglia Ruskin University analyzed 16 systematic reviews and 113 randomized controlled trials involving nearly 8,000 participants worldwide, which they say is the most extensive evaluation of collagen’s health effects to date.
The review found consistent evidence that collagen supplementation improves skin elasticity and hydration over time and provides significant relief from osteoarthritis-related joint pain and stiffness, according to findings published in Aesthetic Surgery Journal Open Forum.
A large U.K. review found that collagen supplements may improve skin elasticity and hydration over time. (iStock)
The researchers, however, did not find meaningful improvements in post-exercise muscle recovery, soreness or tendon mechanical properties (strength, springiness and stretch resistance).
“Collagen is not a cure-all, but it does have credible benefits when used consistently over time, particularly for skin and osteoarthritis,” co-author Lee Smith, professor of public health at Anglia Ruskin University, said in a statement.
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“Our findings show clear benefits in key areas of healthy aging, while also dispelling some of the myths surrounding its use,” Smith added.
Collagen, the most abundant protein in the body, supports skin, bones, tendons, cartilage and connective tissue, according to experts. Natural collagen production begins to drop in early adulthood and declines more sharply with age.
The study found that collagen supplements may help reduce joint pain and stiffness in people with osteoarthritis. (iStock)
The review found that long-term collagen supplementation was linked to improved skin firmness and hydration, but did not help skin roughness — a proxy for visible wrinkles.
Benefits appear to accumulate gradually, suggesting that collagen should not be viewed as an “anti-wrinkle ‘quick fix,’ but as a foundational dermal support for individuals seeking holistic skin maintenance,” the researchers said.
“If we define anti-aging as a product or technique designed to prevent the appearance of getting older, then I believe our findings do support this claim for some parameters,” Smith told the BBC. “For example, an improvement in skin tone and moisture is associated with a more youthful-looking appearance.”
Collagen supplementation was linked to reduced pain and stiffness in people with osteoarthritis, with stronger benefits seen over longer periods of use, and showed modest improvements in muscle mass and tendon structure that may support healthy aging.
Collagen did not significantly improve skin roughness, a marker of visible wrinkles. (iStock)
However, it did not show meaningful results when used as a fast-acting sports performance supplement, and evidence for benefits related to cholesterol, blood sugar, blood pressure and oral health was mixed or inconclusive.
Dr. Daniel Ghiyam, a California-based physician and longevity specialist, said the findings align with what he sees in clinical practice.
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“Collagen is a targeted support tool, not a foundation of health or performance,” Ghiyam, who was not involved in the study, told Fox News Digital. “When marketed that way, it makes sense. When marketed as a cure-all, it doesn’t hold up to the data.”
The authors noted that while many previous collagen studies have received financial support from the supplement industry, the current review did not receive industry funding.
Experts say collagen supplements may offer modest benefits for skin hydration and joint comfort, but they are not a cure-all. (iStock)
The team called for more high-quality clinical trials examining long-term outcomes, optimal dosages and differences between collagen sources, such as marine, bovine and plant-based alternatives.
Among its limitations, the review could not determine whether certain forms of collagen work better than others or what the optimal regimen should be.
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While the review included randomized controlled trials, the quality of the studies varied, with newer research generally showing stronger results.
Experts say more data and studies are needed to build on the findings. They also noted that diet plays a crucial role in skin health.
Collagen supplements, often sold as powders or pills, may improve skin elasticity and ease joint pain, experts say. (iStock)
Dr. Erum Ilyas, a Pennsylvania-based dermatologist and chair of dermatology at Drexel University College of Medicine, noted that the review analyzed previously published meta-analyses rather than generating new primary data.
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“At this time, I have not seen sufficiently strong independent evidence to routinely recommend collagen supplements to my patients,” Ilyas, who was not involved in the review, told Fox News Digital.
“Although some studies show modest improvements in markers such as hydration and elasticity, there remains limited independent, biopsy-confirmed evidence demonstrating sustained increases in dermal collagen content,” she added.
Fox News Digital has reached out to the researchers for comment.
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