Health
Experimental drug helps patients lose nearly a quarter of body weight in early trials
NEWYou can now listen to Fox News articles!
An experimental weight-loss medication was shown to help people lose nearly 25% of their body weight in early-stage 1a/2b trials.
The drug, amycretin — developed by Novo Nordisk — works by replicating two hunger hormones — amylin, which regulates appetite and creates a feeling of fullness, and glucagon-like peptide 1 (GLP-1), the same hormone that is used in Ozempic and Wegovy to suppress appetite and boost insulin secretion.
“Amycretin is the first treatment to harness the two distinct biological pathways stimulated by amylin and GLP-1 in a single molecule,” Martin Holst Lange, executive vice president and head of development at Novo Nordisk, previously said in a statement sent to Fox News Digital.
GRANDFATHER’S SIMPLE CHANGES REVERSED PRE-DIABETES DIAGNOSIS THAT LEFT HIM ‘PETRIFIED’
In the study, which included 125 overweight or obese adults, participants who received weekly injections of amycretin lost more weight than those who took a placebo, according to a press release from Novo Nordisk.
Those who got the highest doses (up to 60 mg) lost up to 24.3% pounds after 36 weeks, compared to just 1.1% for the placebo group, per the release.
An experimental weight-loss medication was shown to help people lose nearly 25% of their body weight in early-stage 1a/2b trials. (iStock)
A previous phase 1 trial of the oral (pill) version of amycretin also showed that treatment was “safe and tolerable,” with an “observed reduction in body weight” compared to placebo, the company stated.
Taking the pill once a day led to around 10% weight loss, and those who doubled the dose lost 13%.
YOUR DNA COULD BE STOPPING YOU FROM LOSING WEIGHT, NEW STUDY SUGGESTS
Another benefit the researchers highlighted is that people taking amycretin did not appear to hit a “weight-loss plateau,” continuing to shed pounds as long as they took it.
“The lack of weight loss plateauing indicates the possibility of achieving further weight reductions with extended treatment,” Agnes Gasoirek, a senior clinical pharmacology specialist at Novo Nordisk, wrote in the phase 1 study findings.
Novo Nordisk presented the latest findings at the American Diabetes Association in Chicago on June 22. ((Photo by LISELOTTE SABROE/Scanpix Denmark/AFP via Getty Images))
Novo Nordisk presented the latest findings at the American Diabetes Association in Chicago on June 22; they were also published in the medical journal Lancet.
“We are pleased with the promising results of amycretin and the feedback from regulatory authorities and are excited to advance both subcutaneous and oral versions of this molecule into phase 3 development for weight management,” said Martin Holst Lange, executive vice president for Development at Novo Nordisk, in the release.
“Amycretin is the first treatment to harness the two distinct biological pathways stimulated by amylin and GLP-1 in a single molecule.”
“These results reflect our robust pipeline in obesity, [and] our focus on progressing scientific innovation and expanding the range of options available to patients and healthcare professionals.”
The most common side effects of amycretin, similar to other GLP-1s, were gastrointestinal symptoms — primarily nausea, vomiting and decreased appetite.
Adverse events were “mild to moderate” in severity, according to researchers. More frequent doses resulted in greater side effects.
It’s important to monitor these side effects closely, experts advise, as GI issues are common among patients with obesity.
“Obesity is a chronic, multifactorial disease that requires a comprehensive, long-term approach,” a doctor said. (iStock)
“While the initial weight-loss outcomes are indeed encouraging, further studies are needed to ensure that the therapeutic benefits consistently outweigh the potential risks, especially with long-term administration,” Dr. Christine Ren-Fielding, director and chief of bariatric surgery at the NYU Langone Weight Management Program, previously told Fox News Digital.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
While GLP-1-based drugs — including this new experimental pill — may show promising results, Ren-Fielding, who was not involved in the study, emphasized that they’re “not a cure-all for obesity.”
“Obesity is a chronic, multifactorial disease that requires a comprehensive, long-term approach,” she said at the time.
For more Health articles, visit www.foxnews.com/health
“Pharmacological treatments can play a significant role in managing the condition, but they are often most effective when combined with other interventions.”
Next, Novo Nordisk plans to prepare for phase 3 trials of the medication, in both oral and injectable forms, for the management of obesity.
Health
New ways to prevent flu revealed in ‘accidental’ lab breakthrough, study finds
NEWYou can now listen to Fox News articles!
An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
5 THINGS YOU NEED TO KNOW BEFORE GETTING YOUR FLU SHOT, ACCORDING TO DOCTORS
Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
HOW LONG YOU’RE CONTAGIOUS WITH THE FLU — AND WHEN IT’S SAFE TO GO OUT
The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
RESEARCHERS LOCKED FLU PATIENTS IN A HOTEL WITH HEALTHY ADULTS — NO ONE GOT SICK
The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
CLICK HERE FOR MORE HEALTH STORIES
This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
Health
One extra serving of processed meat a day linked to higher cancer risk
NEWYou can now listen to Fox News articles!
Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
FREQUENT HEARTBURN MAY BE A WARNING SIGN OF A MORE DANGEROUS CONDITION, DOCTOR SAYS
The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
BACTERIA IN YOUR MOUTH MAY TRAVEL TO THE GUT AND TRIGGER STOMACH CANCER, RESEARCH FINDS
After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
CLICK HERE FOR MORE HEALTH STORIES
These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
Health
The Surprising Hormone That Could Make Menopause Weight Loss Easier
Use left and right arrow keys to navigate between menu items.
Use escape to exit the menu.
Sign Up
Create a free account to access exclusive content, play games, solve puzzles, test your pop-culture knowledge and receive special offers.
Already have an account? Login
-
Washington17 seconds agoSteelers Sign TE Darnell Washington to Four-Year Extension
-
Wisconsin3 minutes agoWisconsin DNR reminding ATV and UTV drivers that more wardens will be out this weekend
-
West Virginia8 minutes agoRoot’s walk-off hit sends Keyser past PikeView, 4-3 – WV MetroNews
-
Wyoming15 minutes ago
Take Back Wyoming fundraiser
-
Crypto18 minutes agoRobert Kiyosaki Asks How Government Taking 40% of Your Money Still Ends up Trillions in Debt
-
Finance23 minutes agoHouston budget amendment would give financial assistance to help those impacted by a trash fee
-
Fitness30 minutes agoHow Jeremy Clarkson Reset His Health and Fitness at 66 – Walking, Pilates and Trying ‘Not to Die’
-
Movie Reviews38 minutes ago
Movie Review: Paul Rudd and Nick Jonas hit the right notes in ‘Power Ballad’