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Early Parkinson’s could be detected decades before symptoms with simple blood test

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Early Parkinson’s could be detected decades before symptoms with simple blood test

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A new study from Chalmers University of Technology in Sweden, along with Oslo University Hospital in Norway, may have discovered a way to detect biomarkers of Parkinson’s disease in the blood up to decades earlier.

In the very early stages of the disease, the body goes through changes related to DNA repair and stress in cells. These changes leave detectable clues in the blood before major brain damage occurs, according to a press release for the study.

This could allow for early detection of Parkinson’s, when treatments might have a better chance of slowing or preventing serious damage.

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The processes of DNA repair and cellular stress response can occur for up to 20 years in Parkinson’s patients before motor symptoms fully develop, according to the researchers.

The team used machine learning to discover patterns linked to these processes, which were not found in healthy individuals or patients who were already diagnosed with Parkinson’s.

European researchers discovered a way to detect early Parkinson’s disease via a blood test. (iStock)

Annikka Polster, assistant professor at the Department of Life Sciences at Chalmers who led the study, suggested in a statement that the study has found an “important window of opportunity” in which the disease can be detected “before motor symptoms caused by nerve damage in the brain appear.”

“The fact that these patterns only show at an early stage and are no longer activated when the disease has progressed further also makes it interesting to focus on the mechanisms to find future treatments,” she added.

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Polster confirmed that the study highlighted biomarkers that “likely reflect some of the early biology of the disease,” which “paves the way for broad screening tests via blood samples: a cost-effective, easily accessible method.”

The findings were published in npj Parkinson’s Disease.

Blood tests for early Parkinson’s diagnosis could become more common, researchers predicted. (iStock)

The researchers plan to further develop tools to more easily detect these active mechanisms and understand how they work, according to the university.

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The team predicts that, within five years, blood tests for early Parkinson’s diagnoses could become more common within clinical practice. They are also optimistic about the development of new drugs to prevent or treat the disease.

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“If we can study the mechanisms as they happen, it could provide important keys to understanding how they can be stopped and which drugs might be effective,” Polster said. 

“This may involve new drugs, but also drug repurposing, where we can use drugs developed for diseases other than Parkinson’s because the same gene activities or mechanisms are active.”

More than 10 million people around the world are estimated to be living with Parkinson’s disease. (iStock)

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Study limitations  

The researchers acknowledged that the study had some limitations, including that the gene activity measured in the blood only partly matches what’s happening in the brain.

External factors, such as medication use, may have affected the results, they added.

Also, the study population may not represent all people, so findings may not apply broadly.

By the numbers

More than 10 million people around the world are estimated to be living with Parkinson’s disease, according to the Parkinson’s Foundation. About 90,000 people in the U.S. are diagnosed each year.

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Numbers are expected to continue rising because Parkinson’s is the second-most common neurodegenerative disease after Alzheimer’s.

While research is advancing, there is no cure for the disease, although medications are available to manage symptoms.

Common motor symptoms of Parkinson’s include tremors, slowed movement, muscle stiffness, balance and walking difficulties. (iStock)

Common motor symptoms include tremors, slowed movement, muscle stiffness, balance and walking difficulties, a shuffling gait and freezing episodes. 

Non-motor symptoms include loss of smell, sleep problems, constipation, fatigue, depression or anxiety, speech and swallowing changes, cognitive slowing and reduced facial expression, according to Parkinson’s Foundation and Mayo Clinic.

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Danish Anwer, a doctoral student at the Department of Life Sciences at Chalmers and the study’s first author, detailed in a statement how Parkinson’s affects the brain.

“By the time the motor symptoms of Parkinson’s disease appear, 50% to 80% of the relevant brain cells are often already damaged or gone,” he said. “The study is an important step toward facilitating early identification of the disease and counteracting its progression before it has gone this far.”

“By the time you have actual motor symptoms … a large majority of affected cells have been damaged and destroyed.”

Fox News senior medical analyst Dr. Marc Siegel agreed that Parkinson’s is a “very difficult disease” with an increasing global impact.

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“By the time you have actual motor symptoms affecting gait, tremor, etc., a large majority of affected cells have been damaged and destroyed,” he told Fox News Digital.

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Siegel called the new research “exciting,” suggesting that it “opens the door for earlier and more effective diagnosis and treatment.”

Fox News Digital reached out to the study authors for comment.

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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Intermittent fasting’s real benefit may come after you start eating again

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Intermittent fasting’s real benefit may come after you start eating again

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Research continues to uncover new details on how fasting may help extend life.

A new study published in the journal Nature Communications investigated how intermittent fasting can boost longevity in small worms often used in aging research.

Researchers from the University of Texas Southwestern Medical Center in Dallas compared worms that were fed normally to those that underwent a 24-hour fast in early adulthood and were then fed again, according to a press release.

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The scientists measured a variety of factors, including stored fat, gene activity related to fat metabolism and lifespan.

The results showed that the life-boosting benefit did not depend on the fasting itself but on the body’s behavior after eating again.

Experts say sustainability is key when choosing a long-term weight-loss strategy. (iStock)

Study lead Peter Douglas, associate professor of molecular biology and a member of the Hamon Center for Regenerative Science and Medicine at UT Southwestern, suggested that these discoveries “shift the focus toward a neglected side of the metabolic coin – the re-feeding phase.”

“Our data suggest that the health-promoting effects of intermittent fasting are not merely a product of the fast itself, but are dependent on how the metabolic machinery recalibrates during the subsequent transition back to a fed state,” he said.

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“Our findings bridge a gap between lipid metabolism and aging research,” he added. “By targeting aging, the single greatest risk factor for human disease, we move beyond treating isolated conditions toward a preventive model of medicine that enhances quality of life for all individuals.”

Lauri Wright, director of nutrition programs at the University of South Florida’s College of Public Health, called this a “high-quality” study that adds an “important nuance to how we think about fasting and longevity.”

Intermittent fasting typically involves limiting meals to an eight-hour daily window or fasting every other day. (iStock)

The benefits of the refeeding phase after fasting were “especially interesting,” Wright, who was not involved in the study, told Fox News Digital.

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“The researchers showed that longevity was linked to the body’s ability to turn off fat breakdown after fasting, allowing cells to restore energy balance,” she reiterated.

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“From a scientific standpoint, that’s a meaningful shift because it suggests fasting is not just about burning fat, but about metabolic flexibility.”

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Fasting may support longevity through triggering metabolic switching, enhancing cellular repair and stress resistance and improving markers like insulin sensitivity, research shows.

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Limitations and cautions

Although this study provides “important insight” on the power of refeeding, Wright noted that the findings should be approached with caution, as the study was done on worms and cannot always be translated to humans.

“Additionally, it explains how a process might work in a controlled lab condition rather than real-world eating behaviors,” she added as a limitation. “Finally, the study is short-term and doesn’t give us the long-term translation on lifespan outcomes.”

The review found intermittent fasting was barely more effective than doing nothing, according to the study authors. (iStock)

Wright cautioned that fasting is “not a magic solution for longevity, and how you eat overall matters more than when you eat.”

“I advise, first and foremost, to focus on diet quality, including a variety of fruits and vegetables, healthy fats and minimally processed foods,” she said.

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For those who are considering fasting, it’s better to stick with a moderate plan — like a 12- to 14-hour overnight fast — rather than going to extremes, Wright said. After fasting, she recommends focusing on well-balanced meals.

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Several groups of people should be cautioned against fasting, according to Wright, including those with diabetes who are on insulin or hypoglycemic medications, those who are pregnant or breastfeeding, anyone with a history of eating disorders and older adults at risk of malnutrition.

Anyone considering intermittent fasting should consult with a doctor before starting.

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