Health
Diabetes patients now have access to first generic GLP-1 medication: ‘More accessible and affordable’
Ozempic, Wegovy and other GLP-1 medications have gained widespread popularity for weight loss and diabetes control in recent years — but the spike in demand has made it difficult for some people to get the drugs.
To help eliminate supply chain snafus, the first-ever generic GLP-1 — a duplicate of Victoza — launched on June 25.
Manufactured by Novo Nordisk and distributed and sold by Israel-based Teva Pharmaceuticals, Victoza is an injectable medication intended to treat type 2 diabetes. It has also been shown to promote weight loss in certain patients, according to Teva.
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While Ozempic and Wegovy contain semaglutide and Mounjaro has tirzepatide, Victoza has liraglutide as its active ingredient.
“By launching an authorized generic for Victoza (liraglutide injection 1.8mg), we are providing patients with type 2 diabetes another option for this important treatment,” said Ernie Richardsen, SVP, head of U.S. commercial generics at Teva, in a press release from the company.
The new authorized generic is the exact same medication as brand-name Victoza, but without the brand name on the label and sold at a lower price point, explained Alyssa Billingsley, PharmD, the senior director of Pharmacy Content at GoodRx in St. Louis, Missouri.
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Just as Wegovy is a higher-dose version of Ozempic to treat obesity, there is a higher-dose version of Victoza — sold under the brand name Saxenda — but a generic version is not yet available.
“This is a positive step forward to making GLP-1 agonist medications more accessible and affordable,” Billingsley told Fox News Digital via email.
This class of drugs has a growing list of beneficial applications beyond just treating type 2 diabetes, Billingsley noted, but their cost can be a barrier for many people to access them.
“In general, authorized generics are usually priced at a discount, potentially making them a more affordable option for some people,” she said.
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“However, some insurers may still prefer brand-name Victoza, even with a lower-cost authorized generic available.”
Patients should check with their insurance provider to confirm which options are covered and what they can expect to pay, Billingsley advised.
Dr. Brett Osborn, a Florida neurologist and longevity expert, agreed that the availability of the first generic GLP-1 is “great news.”
The generic’s lower price point is particularly beneficial for people who have chronic conditions like diabetes, Osborn noted — “where long-term medication use is necessary to prevent downrange effects like vascular disease, strokes and heart attacks, cancer, neurodegenerative diseases like Alzheimer’s, and obesity, the latter of which is also a ‘gateway disease,’” he said.
Differences between liraglutide and semaglutide
There are some differences between the generic version of Victoza and Ozempic and other GLP-1 agonists, doctors noted.
The new drug’s active ingredient is liraglutide instead of Ozempic’s semaglutide — and it is approved for use in both adults and children age 10 and older who have diabetes.
Semaglutides are not yet approved for children.
There are also dosing differences — while semaglutides like Ozempic are given once each week, liraglutide medications require daily dosing because they have a shorter half-life, the doctor said.
“Each medication has pros and cons,” Osborn said. “At base level, however, the molecules are similar and subserve identical bodily functions — appetite suppression and the promotion of insulin secretion from the pancreas.”
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The most common side effects of liraglutides include nausea, vomiting, diarrhea, decreased appetite, indigestion and constipation, according to the company’s release. Other, more serious side effects are possible.
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Patients who experience adverse or lingering side effects should see a health care provider.
Fox News Digital reached out to Teva Pharmaceuticals and Novo Nordisk for comment.
Health
Words and game of Scrabble keep married couple in wedded bliss for decades
A married couple who have long enjoyed the game of Scrabble both together and separately before they even met are never at a loss for words — and attribute their wedded bliss in part to their love of the nostalgic game.
They’re still playing in tournaments built around the game decades after they began doing so.
Graham Harding and his wife Helen Harding, both in their 60s, have been married for over 20 years.
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They met in the 1990s at Scrabble tournaments, as news agency SWNS reported.
But it was a “special match” in 2000 that brought the couple together — and has kept them together now.
Graham Harding is from the East Berkshire Scrabble Club, while his wife Helen is from the Leicester Scrabble Club in the U.K.
They have been taking part in the UK Open Scrabble Championship in Reading this week.
“The more words you know, the more ammunition you’ve got.”
“Scrabble is all about having a good vocabulary,” said Graham Harding, SWNS noted.
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“But it is a Scrabble vocabulary — not necessarily everyday English.”
Added Helen Harding, “The more words you know, the more ammunition you’ve got.”
The couple said they were “vague acquaintances” for about five years after they first met.
Then they got together after a special match in Swindon.
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They maintained a long-distance relationship before they got married in 2004.
The couple even brought their Scrabble board to their wedding.
It featured a message with Scrabble pieces that said, “Congratulations on your wedding day” — while their wedding cake said, in Scrabble letters, “Helen and Graham.”
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They each took up the hobby early in life well before they met each other.
The tournament that’s been taking place this week is the first since the COVID pandemic after a five-year break — and the couple has played some two dozen games in it as of Friday, SWNS reported.
Health
Deep sleep can keep two big health problems at bay, new studies suggest
It might be worth working a little bit harder to get that much-desired, but often elusive, good night’s sleep.
Deep sleep clears the mind of waste just as a “dishwasher” cleans dirty plates and glasses, just-published research suggests — and there’s more.
The findings also offer insights into how sleeping pills may disrupt the “brainwashing” system — potentially affecting cognitive function for people over the long run.
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Study senior author professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen said norepinephrine (a neurotransmitter and hormone) triggers blood vessels to contract — generating slow pulsations that create a rhythmic flow in the surrounding fluid to carry away waste, news agency SWNS noted.
Said Nedergaard, “It’s like turning on the dishwasher before you go to bed and waking up with a clean brain. . . . We’re essentially asking what drives this process and trying to define restorative sleep based on” this “glymphatic clearance.”
The brain has a built-in waste removal process – the glymphatic system – that circulates fluid in the brain and spinal cord to clear out waste, according to the scientists.
The process helps remove toxic proteins that form sticky plaques linked to neurological disorders, such as Alzheimer’s disease.
But the scientists indicated that what drives the system was unclear until now, according to the study.
Is all sleep created equal? The researchers wanted to find out.
To find clues, Nedergaard and her team looked into what happens in mice when their brains sleep, as SWNS reported of the study. The team focused on the relationship between norepinephrine and blood flow during deep sleep.
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They found that norepinephrine waves correlate to variations in brain blood volume — suggesting that norepinephrine triggers a rhythmic pulsation in the blood vessels. The researchers then compared the changes in blood volume to brain fluid flow.
The brain fluid flow fluctuates in correspondence to blood volume changes, suggesting the vessels act as pumps to propel the surrounding brain fluid to flush out waste.
Natalie Hauglund of the University of Copenhagen and the University of Oxford, the study’s lead author, said, “You can view norepinephrine as [the] conductor of an orchestra.”
She added, “There’s a harmony in the constriction and dilation of the arteries, which then drives the cerebrospinal fluid through the brain to remove the waste products.”
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Hauglund said she wanted to understand whether all sleep is created equal.
To find out, the research team administered zolpidem, a common drug to aid sleep, to mice.
“If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
They found that the norepinephrine waves during deep sleep were 50% lower in zolpidem-treated mice than in naturally sleeping mice.
Although the zolpidem-treated mice fell asleep more quickly — fluid transport into the brain dropped more than 30%, as SWNS reported.
The researchers say their findings, published in the journal Cell, suggest that the sleeping aid may disrupt the norepinephrine-driven waste clearance during sleep.
Hauglund said, “More and more people are using sleep medication, and it’s really important to know if that’s healthy sleep. If people aren’t getting the full benefits of sleep, they should be aware of that, so they can make informed decisions.”
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The research team said the findings likely apply to humans, who also have a glymphatic system, although it requires further testing.
Nedergaard added, “Now we know norepinephrine is driving the cleaning of the brain, we may figure out how to get people a long and restorative sleep.”
For more Health articles, visit www.foxnews.com/health
Meanwhile, a lack of sleep may be doing more damage than just making people groggy.
It could be sabotaging the brain’s ability to keep intrusive thoughts at bay.
Another new study, this one published in the Proceedings of the National Academy of Sciences, found that sleep deprivation weakens the brain’s defense against unwanted memories, allowing them to flood the mind, according to the New York Post.
“We show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep,” the scientists said.
Health
How Kathy Bates Lost 100 Lbs—Plus Her Tips for Sustainable Weight Loss
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