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Common supplements and medications could cause liver damage, studies show

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Common supplements and medications could cause liver damage, studies show

As cases of drug-induced liver injury (DILI) are on the rise, experts are warning of the hidden dangers associated with some common medications and supplements.

Statistics show that DILI, also known as toxic hepatitis or hepatotoxicity — which is known to be a significant cause of acute liver failure — has been growing in Western countries since the 1960s.

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Around one-fifth of the total population who are prescribed medications will experience DILI, according to recent research published in the journal Toxicology Reports.

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Potential triggers of liver injury include herbal products, dietary supplements and medications, the study found.

Those with pre-existing liver conditions and nutritional deficiencies are at a higher risk, as are pregnant women.

As cases of drug-induced liver injury are on the rise, experts are warning of the hidden dangers associated with some common medications and supplements. (iStock)

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How drugs can harm the liver

One of the liver’s main functions is to break down substances taken orally, including supplements and medications, according to the American College of Gastroenterology (ACG).

For some people, the process of metabolizing these substances can be slower, increasing the risk of liver damage.

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Even medications that have been tested for safety and approved by the U.S. Food and Drug Administration (FDA) can potentially cause liver injury in rare cases, stated the ACG.

Common symptoms of liver disease include nausea, loss of appetite, abdominal pain, generalized itching, dark urine and jaundice, although some people may notice no signs, per the above source.

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Most common medications that cause DILI

The recent study in Toxicology Reports identified several drugs that are most likely to cause liver injury.

  • Paracetamol (acetaminophen), a common over-the-counter pain reliever
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used to treat headaches, fever and chronic inflammatory disorders
  • Aspirin, a common over-the-counter medication used as a fever-reducer, pain reliever and blood thinner
  • Nimesulide, an NSAID used to relieve pain and reduce fever
  • Methotrexate, an antimetabolite medication that is used to treat rheumatoid arthritis, lymphoma, leukemia and other cancers
  • Corticosteroids, which are used to treat conditions involving inflammation or overactive immune systems
  • Isoniazid, a first-line treatment for tuberculosis
  • Tetracyclines, a class of antibiotics that treat multiple types of bacterial infections
  • Halothane, which is used as a general anaesthetic during surgical procedures

Turmeric, a common spice added to foods, has been linked to potential liver toxicity. (iStock)

Supplements linked to liver damage

Medications aren’t the only agents that can cause drug-induced liver injuries.

Dr. Marc Siegel, Fox News senior medical analyst, spoke with Fox News Digital about the risks of herbal and dietary supplements (HDS) affecting the liver.

“The biggest problem with herbal supplements is that the amount you are taking of active chemicals isn’t strictly regulated, so you don’t know exactly what you are getting.”

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“The biggest problem with herbal supplements is that the amount you are taking of active chemicals isn’t strictly regulated, so you don’t know exactly what you are getting,” he said. 

“And since several of the supplements are metabolized through the liver, there is now an increasing incidence of liver toxicity in users.”

Garcinia cambogia, a popular weight-loss supplement, is among commonly used botanical products known for potential liver toxicity. (iStock)

Cases of DILI linked to herbal or dietary supplements have nearly tripled between 2004 and 2014, according to a 2024 study published in JAMA Network Open.

The researchers identified the following most commonly used botanical products known for potential liver toxicity.

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  • Turmeric, a common spice added to foods
  • Green tea
  • Ashwagandha, an herb used for stress and anxiety
  • Garcinia cambogia, a popular weight-loss supplement
  • Red yeast rice, which is said to help lower cholesterol levels
  • Black cohosh, a dietary supplement used to relieve menopause symptoms

It is estimated that at least 15.6 million U.S. adults have used at least one of these six botanical products within the past 30 days.

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“The most commonly implicated botanical products in the DILIN (Drug-Induced Liver Injury Network) include turmeric, kratom, green tea extract and Garcinia cambogia, with potentially severe and even fatal liver injury,” the study stated.

Drug-induced liver injury caused by HDS can be severe or even fatal, leading to death or liver transplantation, the researchers noted.

Toxic hepatitis or hepatotoxicity — which is known to be a significant cause of acute liver failure — has been growing in Western countries since the 1960s. (iStock)

Fox News’ Siegel also warned against the potential liver-related risks of some of these named supplements.

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“Turmeric is a natural anti-inflammatory and may be useful in small doses, but can be toxic in large doses,” he cautioned.

“Garcinia cambogia is very popular, especially as a weight-loss agent, but there is no real evidence that it actually works, and there is no reason to take it, especially with the new GLP-1 drugs.”

While red yeast rice has cholesterol-lowering statin-type properties, Siegel cautioned that the amount of active chemicals isn’t as strictly regulated as approved medications.

“Turmeric is a natural anti-inflammatory and may be useful in small doses, but can be toxic in large doses.”

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“I find it useful in some patients who are reluctant to start statins and are looking for a more natural alternative, but I must strictly monitor the amount taken and the effect on the liver,” he said.

Regarding green tea, Siegel noted that it does have antioxidant properties and can be useful to consume as a beverage (though it has a lot of caffeine) — “but there is no reason whatsoever to take more of it in an extract, where it can be toxic.”

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The FDA states on its website that it does regulate dietary supplement products and dietary ingredients, but under “a different set of regulations than those covering ‘conventional’ foods and drug products.”

Drug-induced liver injury caused by HDS can be severe or even fatal, leading to death or liver transplantation. (iStock)

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“Manufacturers and distributors of dietary supplements and dietary ingredients are prohibited from marketing products that are adulterated or misbranded,” the agency says. “That means that these firms are responsible for evaluating the safety and labeling of their products before marketing to ensure that they meet all the requirements of the Federal Food, Drug, and Cosmetic Act as amended by DSHEA and FDA regulations.”

For more Health articles, visit www.foxnews.com/health

Fox News Digital reached out to several researchers and the FDA regarding the rise in drug- and HSD-related liver injury.

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How long you’re contagious with the flu — and when it’s safe to go out

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How long you’re contagious with the flu — and when it’s safe to go out

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The U.S. is in the thick of flu season, with many states reporting “moderate to very high activity” of influenza-like illness, according to the CDC.

With influenza A (H3N2), or subclade K, making up a large portion of the circulating viruses, doctors emphasize the importance of getting the most recent flu vaccinations, staying at home while sick and washing hands frequently, among other prevention tactics.

If you’ve been exposed to or infected with influenza, here’s what to know about how long the virus is transmissible.

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“You are typically contagious with the flu for five to seven days after symptoms start,” Dr. Samantha Picking, the Massachusetts-based senior director of immunizations at Walgreens, told Fox News Digital.

“However, some groups remain contagious for longer periods. Young children and people with weakened immune systems can spread the virus for more than seven days, sometimes extending to two weeks or longer.”

The U.S. is in the thick of flu season, with many states reporting “moderate to very high activity” of influenza-like illness, per the CDC. (iStock)

It’s a myth that people can’t be contagious until they experience symptoms, according to Picking.

“The flu is most contagious during the first three to four days after symptoms appear,” she said. “However, you can begin spreading the virus a day before feeling ill and may remain contagious for up to a week or longer.”

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The incubation period — the time between exposure to the virus and when symptoms start — is typically two days, though it can range from one to four days, the pharmacist added. People with mild symptoms can still spread the flu. 

“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” a doctor told Fox News Digital. (iStock)

For anyone who is starting to feel sick or has been around someone who has the flu, Picking recommends limiting contact with others to avoid spreading the virus.

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“To be safe and prevent spreading the virus, stay home until you’re fever-free for at least 24 hours without using fever-reducing medicine,” Picking advised. “For most healthy adults, this typically corresponds to five to seven days after symptoms begin.”

People can take extra precautions, like masking, for a few days after returning to normal activities, she added.

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“However, use your best judgment and consult a healthcare professional if you’re unsure whether you’re well enough to leave the house,” she added. “If your other symptoms aren’t improving, or you generally still feel ill, it’s wise to stay home and practice good hand hygiene.”

Young children and people with weakened immune systems may be able to spread the virus to others for a longer time period, sometimes for up to 14 days, according to the pharmacist.

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“Stay home until you’re fever-free for at least 24 hours without using fever-reducing medicine.”

Picking noted that a cough can linger for weeks after other symptoms have abated. “While a lingering cough is not necessarily a sign that you’re still contagious, it’s considerate to mask up and practice good cough etiquette when around others,” she advised.

Some antiviral medications, when initiated early on, can shorten how long someone is contagious with the flu.

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“These medications work best when started within two days of seeing symptoms,” Picking noted. Anyone who is interested in antivirals should speak with a healthcare provider or pharmacist for personalized guidance. 

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Flu symptoms can include fever, chills, headache, fatigue, cough, sore throat and runny nose.

Subclade K has been detected as the culprit in rising global cases, causing more intense symptoms and higher risk of spread.

The flu is most contagious during the first three to four days after symptoms appear, a pharmacist said. (iStock)

“It’s becoming evident that this is a pretty severe variant of the flu,” Dr. Neil Maniar, professor of public health practice at Boston’s Northeastern University, previously told Fox News Digital. “Certainly, in other parts of the world where this variant has been prevalent, it’s caused some severe illness, and we’re seeing an aggressive flu season already.”

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“The vaccine still provides protection against serious illness resulting from the subclade K variant that seems to be going around,” he added.

Angelica Stabile contributed reporting.

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I Lost 31 Lbs on the Biblio Diet, Healed My Body and Found Joy—No Calorie Counting Required

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I Lost 31 Lbs on the Biblio Diet, Healed My Body and Found Joy—No Calorie Counting Required


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Meningitis cases rise in major Midwestern city, prompting public health alert

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Meningitis cases rise in major Midwestern city, prompting public health alert

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Chicago health officials are warning residents to be alert for symptoms of meningococcal disease after several recent infections were reported in adults across the city.

Seven cases of Neisseria meningitidis infections have been identified since mid-January, according to the Chicago Department of Public Health.

Two people have died as a result of the infection, the department said.

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Health officials have traced close contacts for all confirmed cases and provided preventive antibiotics to those who may have been exposed.

Meningococcal disease is caused by Neisseria meningitidis, a type of bacteria that can infect the bloodstream or the lining of the brain and spinal cord, according to Cleveland Clinic.

Chicago health officials are warning residents to watch for symptoms of meningococcal disease after seven infections were reported in the state. (iStock)

Transmission occurs through saliva and mucus during close or prolonged contact, such as sharing drinks, kissing, or being exposed to coughs and sneezes.

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While cases remain relatively rare, meningococcal disease continues to pose a serious public health risk nationwide. 

The Centers for Disease Control and Prevention reported 503 confirmed and probable cases in the U.S. in 2024, based on preliminary data.

Infection is passed from person to person through saliva and mucus, usually during prolonged close contact. (iStock)

Symptoms of meningococcal disease can include fever, headache, nausea and vomiting, diarrhea, sensitivity to light, a stiff neck, and a skin rash that may appear as dark spots or bruising, per Cleveland Clinic.

Other signs may include confusion, irritability, difficulty walking, joint or muscle pain, and loss of appetite.

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“Chicago sees up to 10 to 15 meningococcal infections each year, typically concentrated around the winter months,” the department noted.

The disease most often affects seniors as well as adolescents and young adults, Chicago health officials said.

Symptoms can range from fever and headache to vomiting, diarrhea, and a rash that appears dark or bruised, Cleveland Clinic noted. (iStock)

To reduce risk, state guidelines recommend getting the meningococcal vaccine beginning at ages 11 or 12, with a booster dose at 16.

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Meningococcal disease is treated with antibiotics, and doctors often begin immediate treatment if the illness is suspected because it can progress rapidly, Cleveland Clinic stated.

Patients with severe cases may also need additional treatments such as IV fluids, oxygen, blood pressure medications, or surgery to treat damaged tissue.

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Anyone who develops symptoms or believes they may have been exposed is urged to seek medical care promptly. Health experts stress that early treatment is critical.

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