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Cancer is now leading cause of death among HIV-positive people, report says: ‘Of great concern’

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Cancer is now leading cause of death among HIV-positive people, report says: ‘Of great concern’

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Cancer is now the leading cause of death among those who are HIV positive.

The finding was announced in a report released last week from the American Cancer Society (ACS).

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Titled “Cancer Facts & Figures 2024,” the report noted that at least 10 cancers are associated with human immunodeficiency virus (HIV) infection, including non-Hodgkin lymphoma, Kaposi sarcoma, cervical cancer, liver cancer, anal cancer, lung cancer and Hodgkin lymphoma.

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HIV-infected people are also 10 times more likely to develop infection-related cancers compared to the general population, the report stated.

Cancer is now the leading cause of death among those who are HIV positive, as noterd in a new report from the American Cancer Society. (iStock)

The HIV/cancer link

People with HIV are seeing longer life expectancy due to improved antiretroviral drugs, noted Nicole B. Saphier, M.D., a New York-based Fox News medical contributor — but this has also led to a higher risk of developing certain cancers.

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“Decades ago, patients were dying from direct complications from HIV and cancers that developed because of a severely weakened immune system, such as lymphoma and Kaposi’s Sarcoma,” Saphier, who is also director of breast imaging at Memorial Sloan Kettering in Monmouth, New Jersey, told Fox News Digital.

“Now, rates of those particular cancers have declined. However, deaths from other cancers have begun to increase, specifically cancers associated with other viruses like HPV.”

People with HIV are more vulnerable to cancer due to a compromised immune system, Saphier said.

Nicole B. Saphier, M.D., shared her input about the link between HIV and cancer mortality. (Fox News)

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Azra Borogovac, M.D., a hematologist at City of Hope Orange County in Irvine, California, noted that certain viruses can increase the risk of different types of cancers.

“As a hematologist who treats patients with blood cancers, I’ve seen that HIV-infected people are at increased risk for both Hodgkin and non-Hodgkin lymphoma,” he told Fox News Digital. 

“In these individuals, lymphomas are typically more aggressive and are more likely to spread beyond the lymph nodes.” 

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While HIV does not directly cause cancer, it affects the immune system in such a way that the person may become more susceptible to other infections that can lead to cancer, said Borogovac.

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“When a virus invades the body, it can change the DNA of the cells in ways that make them more susceptible to becoming cancerous,” he told Fox News Digital.

However, the outlook for both HIV and lymphoma have improved greatly over the years due to advances in research and treatment, the doctor pointed out.

Key to curbing cancer rates

Preventive screenings and vaccinations are key to curbing cancer rates among those with HIV, experts agree.

“The shift in mortality patterns underscores the importance of comprehensive health care strategies addressing both HIV management and cancer prevention in this population, including HPV vaccination and cancer screening,” Saphier told Fox News Digital.

Experts recommend regular testing for HIV to prevent transmission. (iStock)

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Borogovac said the best way to stop cancer is to prevent it in the first place.

“That starts with taking preventative measures to protect yourself from viruses such as HIV,” he said.

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The virus spreads through bodily fluids, including blood, semen and breast milk. 

To prevent transmission, it is recommended that people use contraceptives during sex, limit the number of sexual partners, get tested for HIV and avoid the use of drug needles, according to the National Institutes of Health (NIH).

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“While there is currently no vaccine that can protect against HIV, there are medications that help prevent it, including PEP and PrEP,” said Borogovac.

“When a virus invades the body, it can change the DNA of the cells in ways that make them more susceptible to becoming cancerous.”

Overall, the impact of cancer on people who are HIV-positive is “of great concern,” the doctor said, noting that it reflects disparities in cancer care among at-risk groups.

“Many people with HIV face barriers to care — especially those who may not know they have HIV or do not have access to screenings and advanced treatments,” Borogovac said. 

Screening is critical to reducing risk, he noted, as individuals who are infected with HIV may not show physical symptoms for many years.

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The CDC recommends that anyone between the ages of 13 and 64 should get tested for HIV at least once as part of their routine health care.

Despite the challenges that remain, Borogovac pointed out that there has been much progress in the treatment for the virus since the early days of the HIV epidemic. 

“When a virus invades the body, it can change the DNA of the cells in ways that make them more susceptible to becoming cancerous,” an oncologist told Fox News Digital. (iStock)

“Today, FDA-approved antiretroviral therapy (ART) is recommended for everyone living with HIV,” he said, noting that these therapies prevent approximately two-thirds of cancer in individuals with HIV. 

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“These breakthrough medicines help patients keep HIV under control and prevent transmission to others,” Borogovac noted.

Fox News Digital reached out to the ACS requesting additional comment on the report’s findings.

For more Health articles, visit www.foxnews.com/health.

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Male fertility rates crash as doctors reveal health threats: ‘Something very wrong’

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Male fertility rates crash as doctors reveal health threats: ‘Something very wrong’

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Scientists and physicians agree that there’s been a general decline in male fertility — but they aren’t sure why.

Social media buzz has pointed to a few environmental exposures as potential factors, including cellphones and electric vehicles.

But the reality is “more complicated” than that, according to experts who recently spoke to National Geographic.

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Although it’s not clear whether the decline is at a stage where it should be considered a crisis, numbers show that overall fertility — demographically measured by the number of babies born compared to women of child-bearing age — has decreased.

Scientists and physicians agree that there’s been a general decline in male fertility. (iStock)

Dr. Alex Robles of the Columbia University Fertility Center in New York confirmed that clinical practitioners are “certainly seeing more couples where the male factor contributes to infertility.”

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“At least one-third of couples we evaluate have some male component,” he told Fox News Digital.

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A 2017 meta-analysis published in Oxford Journals: Human Reproduction Update found that sperm counts in Western countries have declined by almost 60% globally since 1973. The 2023 update confirmed these same results.

Urologists can track declining fertility in sperm quality, while demographic data uses the number of babies born compared to women of child-bearing age as a benchmark, according to National Geographic. (iStock)

Lead study author and epidemiologist Hagai Levine warned that this trend could lead to human extinction if it isn’t addressed.

“This is the canary in the coal mine,” Levine, public health physician at the Hebrew University-Hadassah Braun School of Public Health, told National Geographic. “It signifies that something is very wrong with our current environment, as lower sperm counts predict morbidity and mortality.”   

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These findings have been contradicted by other studies, however. A 2025 Cleveland Clinic analysis of studies from the last 53 years found sperm counts to be steady.

“There is no evidence to suggest that this decline is the cause of a precipitous decline in the ability to cause pregnancies,” primary study author Scott Lundy, a reproductive urologist at Cleveland Clinic, told National Geographic. “Most men, even with a modest decline in sperm counts, will still have no issues conceiving.”

Potential factors of decline

Multiple lifestyle factors can lead to a decline in male fertility, Robles noted, including obesity, smoking and diet, as well as environmental exposures and delayed parenthood.

National Geographic also reported that heavy drinking and marijuana use directly contribute to declining fertility and that quitting these habits, while also exercising and losing weight, can help.

Smoking of any kind can contribute to a decline in fertility, according to experts. (iStock)

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Systemic inflammation, infection and disease can also have a “big, profound effect on the current status of fertility,” Lundy told National Geographic. 

Those who are getting over a fever from an infection, like the flu or COVID, will have a “drastically lower” sperm count for three months, he said.

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Male infertility can also be a marker of overall health, according to Robles. “Poor semen parameters are associated with other medical conditions and may signal underlying metabolic, hormonal or environmental issues,” he told Fox News Digital.

Experts recommend seeing a doctor to discuss fertility concerns instead of relying on the internet. (iStock)

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Allan Pacey, deputy dean of the Faculty of Biology, Medicine and Health at the University of Manchester, told National Geographic that the decline could be caused by increased use of contraception, as well as men waiting longer to have children or choosing not to have them at all.

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Microplastics have also been raised on social media as a potential culprit, but the effects are unclear, according to experts.

There is some evidence of endocrine-disrupting chemicals — which are substances found in reusable plastics and some disposable products — altering male fertility, Lundy revealed to National Geographic.

Myths busted

Concerns have circulated on social media that keeping a cellphone in a front pocket could harm male fertility. While Lundy said such an effect is biologically possible, there is currently no scientific evidence supporting the claim.

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Another common myth is that infertility is mostly a women’s issue, Robles noted, but male factors contribute to about one-third to one-half of all cases.

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The claim that taking supplements can boost sperm counts is another common myth, he said, adding that it’s not backed by strong scientific evidence.

“Men should focus on factors that we know matter: maintaining a healthy weight, avoiding tobacco, limiting alcohol and managing chronic health conditions,” Robles advised. 

One common myth is that infertility is mostly a women’s issue, but male factors contribute to about one-third to one-half of all cases. (iStock)

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Experts recommend seeing a urologist to address fertility concerns. Robles said his approach begins with an evaluation, semen analysis, hormonal testing and medical history, while also exploring lifestyle factors.

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In addition to traditional treatment options, Robles said his fertility center also uses advanced tools that incorporate AI and robotics.

“Technologies like this are expanding options for patients who previously had very limited paths to biological parenthood,” he said.

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Goodbye, Late-Night Cravings! How To Curb Hunger and Make Weight Loss Easier

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Goodbye, Late-Night Cravings! How To Curb Hunger and Make Weight Loss Easier


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Lurking dementia risk exposed by breakthrough test 25 years before symptoms

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Lurking dementia risk exposed by breakthrough test 25 years before symptoms

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A new blood test could determine a woman’s dementia risk as early as 25 years before symptoms emerge.

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That’s according to new research from the University of California San Diego, which found that a specific biomarker protein associated with early pathological processes of Alzheimer’s disease was “strongly linked” to future dementia risk.

The researchers analyzed blood samples from 2,766 participants in the Women’s Health Initiative Memory Study in the late 1990s, according to the study’s press release. 

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The women ranged from 65 to 79 years of age and showed no signs of cognitive decline at the start of the study.

After tracking the participants for up to 25 years, the researchers concluded that the biomarker phosphorylated tau 217 (p-tau217) was “strongly associated” with future mild cognitive impairment and dementia. 

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A new blood test could determine a woman’s dementia risk as early as 25 years before symptoms emerge. (iStock)

Women who had higher levels of p-tau217 at the beginning of the study were “much more likely” to develop the disease. The findings were published today in JAMA Network Open.

“The key takeaway is that our study suggests it may be possible to detect risk of dementia two decades in advance using a simple blood test in older women,” first author Aladdin H. Shadyab, a UC San Diego associate professor of public health and medicine, told Fox News Digital. 

“These biomarkers may help us identify who is at greatest risk and develop strategies to delay or prevent dementia.”

“Our findings show that the blood biomarker p-tau217 could help identify individuals at higher risk for dementia long before symptoms begin,” he added.

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This long lead time could open the door to earlier prevention strategies and more targeted monitoring, rather than waiting until memory problems are already affecting daily life, according to Shadyab.

A specific biomarker protein associated with early pathological processes of Alzheimer’s disease was “strongly linked” to future dementia risk. (iStock)

“As the research advances, these biomarkers may help us identify who is at greatest risk and develop strategies to delay or prevent dementia,” he said.

This risk relationship wasn’t the same across the board, however. Women over 70 with higher p-tau217 levels had “poorer cognitive outcomes” compared to those under 70, as did those with the APOE ε4 gene, which is a known risk factor for Alzheimer’s disease.

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The study also found that p-tau217 was a stronger predictor of dementia in women who were randomly assigned to receive estrogen and progestin hormone therapy compared to those who received a placebo.

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“Blood-based biomarkers like p-tau217 are especially promising because they are far less invasive and potentially more accessible than brain imaging or spinal fluid tests,” said senior author Linda K. McEvoy, senior investigator at Kaiser Permanente Washington Health Research Institute and professor emeritus at the Herbert Wertheim School of Public Health, in the release. 

“Blood-based biomarkers like p-tau217 are especially promising because they are far less invasive and potentially more accessible than brain imaging or spinal fluid tests,” a researcher said. (iStock)

“This is important for accelerating research into the factors that affect the risk of dementia and for evaluating strategies that may reduce risk.”

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Blood tests for Alzheimer’s disease are still being studied and are not recommended for routine screening in people without symptoms, Shadyab noted. 

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More research is needed before this approach can be considered for clinical use prior to cognitive symptoms. 

Future studies should investigate how other factors — like genetics, hormone therapy and age-related medical conditions — might interact with plasma p-tau217, the researchers added.

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“The study examined only older women, so the findings may not necessarily apply to men or younger populations,” Shadyab noted. “We also examined overall dementia outcomes rather than specific subtypes such as Alzheimer’s disease.”

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