Health
Blood pressure and dementia risk share surprising link, study suggests
Hypertension, or high blood pressure, is known to have a direct impact on heart attack and stroke risk — but a new study has revealed its surprising link to brain health.
In a large, randomized trial, researchers led by First Hospital of China Medical University discovered that “intensive blood pressure control” resulted in a 15% reduced dementia risk among participants and a 16% reduced risk of cognitive impairment.
The study included 33,995 people in rural China aged 40 or older who had “uncontrolled hypertension.”
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The participants were divided into two groups. One received “usual care,” while the other was assigned to “trained non-physician community healthcare providers” who prescribed “titrated antihypertensive medications.”
Hypertension, or high blood pressure, is known to have a direct impact on heart attack and stroke risk — but a new study has revealed its surprising link to brain health. (iStock)
For the latter group, the medications helped them achieve a systolic blood pressure goal of
“The primary outcome of all-cause dementia was significantly lower in the intervention group than in the usual care group,” the researchers wrote.
They were also less likely to experience “serious adverse events.”
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This was one of the first large-scale, randomized, controlled effectiveness trials to demonstrate a “significant reduction in all-cause dementia associated with lowering blood pressure,” the researchers concluded.
There were some limitations of the study, the article acknowledged, including the absence of baseline and follow-up cognitive assessments.
“The primary outcome of all-cause dementia was significantly lower in the intervention group than in the usual care group,” the researchers wrote. (iStock)
Dr. Bradley Serwer — an interventional cardiologist and chief medical officer at VitalSolution, an Ingenovis Health company that offers cardiovascular and anesthesiology services to hospitals — said this study presents an “intriguing approach” to addressing dementia in individuals with uncontrolled hypertension.
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“Unlike studies performed in the United States, this study employed non-physicians to significantly reduce blood pressure in rural China through a ‘cluster’ blinding method,” Ohio-based Serwer, who was not involved in the study, told Fox News Digital.
It would be beneficial to include baseline cognitive assessments of the patients and to identify the prevalence of Alzheimer’s dementia within the communities, one doctor noted. (iStock)
“While the study can be subject to scrutiny, it raises a pertinent question: How crucial is modification of cardiovascular risk factors in the development of dementia?”
The primary medications used in the study to lower blood pressure were calcium channel blockers and angiotensin receptor blockers, Serwer noted.
“These commonly prescribed medications have been independently associated with a reduced risk of dementia, irrespective of the magnitude of blood pressure reduction they achieve,” he said.
“This raises the possibility that the lower rates of dementia observed may be attributed to other beneficial effects of the medications rather than solely to blood pressure reduction.”
This was one of the first large-scale, randomized, controlled effectiveness trials to demonstrate a “significant reduction in all-cause dementia associated with lowering blood pressure,” the researchers said. (iStock)
To confirm the findings, Serwer said it would be beneficial to include baseline cognitive assessments of the patients and to identify the prevalence of Alzheimer’s dementia within the communities.
“The most significant takeaway from this study is the profound importance of addressing blood pressure, cholesterol, smoking and sedentary lifestyles,” the cardiologist said.
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“By prioritizing these factors, we not only aim to prevent heart attacks and strokes, but also strive to enhance overall quality of life.”
The study was supported by the National Key Research and Development Program of the Ministry of Science and Technology of China, Chinese Society of Cardiology Foundation, and the Science and Technology Program of Liaoning Province, China.
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Fox News Digital reached out to the researchers for comment.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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