Health
A large study finds that ivermectin does not reduce risk of Covid-19 hospitalization.
The anti-parasitic drug ivermectin, which has surged in reputation in its place therapy for Covid-19 regardless of a scarcity of robust analysis to again it up, confirmed no signal of assuaging the illness, based on outcomes of a big scientific trial revealed on Wednesday.
The research, which in contrast greater than 1,300 individuals contaminated with the coronavirus in Brazil who obtained both ivermectin or a placebo, successfully dominated out the drug as a therapy for Covid, the research’s authors mentioned.
The researchers shared a abstract of those ends in August throughout a web based presentation hosted by the Nationwide Institutes of Well being, however the full information set had not been revealed till now, in The New England Journal of Drugs.
“Now that individuals can dive into the main points and the info, hopefully that can steer the vast majority of docs away from ivermectin in direction of different therapies,” Dr. David Boulware, an infectious-disease knowledgeable on the College of Minnesota, mentioned.
For many years, ivermectin has been extensively used to deal with parasitic infections. Early within the pandemic, when researchers have been making an attempt hundreds of outdated medicine in opposition to Covid-19, laboratory experiments on cells recommended that ivermectin would possibly block the coronavirus — although at a lot larger concentrations than can be secure for human use.
Some small research recommended potential advantages in people, however subsequent evaluation discovered the research to be flawed and the advantages illusory. The scientific trial whose information was revealed on Wednesday was a lot bigger and extra rigorous.
Researchers in Brazil offered the drug to 679 sufferers over the course of three days between March and August 2021 in a double-blinded therapy, which means that neither the sufferers nor the medical employees knew whether or not any specific affected person was receiving a Covid therapy drug or a placebo.
The outcomes have been clear: Taking ivermectin didn’t cut back a Covid affected person’s threat of ending up within the hospital.
The researchers zeroed in on totally different teams of volunteers to see in the event that they skilled advantages that others didn’t. For instance, it may need been potential that ivermectin labored provided that taken early in an an infection. However volunteers who took ivermectin within the first three days after a optimistic coronavirus check turned out to have worse outcomes than did these within the placebo group.
There are different giant randomized trials of ivermectin, with hundreds of volunteers, which are nonetheless in progress and have but to share their outcomes. The Nationwide Middle for Advancing Translational Sciences, which is a part of the N.I.H., has been working one intently watched trial of ivermectin and several other different medicine for Covid sufferers for greater than a yr, with no outcomes launched but.
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Health
Many families take patients off life support too soon after traumatic brain injuries: study
Many patients who died after traumatic brain injuries may have survived and recovered if their families had waited to take them off life support, a new study found.
Researchers from Massachusetts General Hospital, Harvard Medical School and other universities analyzed “potential clinical outcomes” for patients with traumatic brain injury (TBI) who were removed from life support, according to a press release.
The study included 1,392 patients who were treated in 18 trauma centers across the U.S. over a 7½-year period.
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Using a mathematical model, the researchers compared patients for whom life support was withdrawn to similar patients who were kept on life support.
Among the group for whom life support was not withdrawn, more than 40% recovered at least some independence, according to a press release.
The researchers also discovered that the notion of remaining in a vegetative state was an “unlikely outcome” six months after injury.
When designing the study, the team didn’t know what to expect, according to study author Yelena Bodien, PhD, of the Department of Neurology’s Center for neurotechnology and neurorecovery at Massachusetts General Hospital.
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“Our anecdotal experience was that some families are told their loved ones had no chance for recovery, they would never walk, talk, work or have a meaningful relationship again — yet they chose not to discontinue life support and their loved one made a remarkable recovery,” she told Fox News Digital.
“On the other hand, clinicians are under a lot of pressure to make early prognoses and do not want to commit someone to a life that would never be acceptable to them, so it could be that those patients who died after life support was withdrawn would have had very significant impairments otherwise.”
“I think there are two stories here,” said Bodien.
“One is that some patients with traumatic brain injury who died because life support was withdrawn may have recovered, but the other is that many would have died even if life support was continued.”
A patient’s prognosis after severe traumatic brain injury is highly uncertain, she noted. “Sometimes patients with the most devastating injuries survive and make meaningful recoveries.”
“Families can advocate for delaying a decision to discontinue life support if this is aligned with what they believe their loved one would want.”
The problem, Bodien said, is that health care providers lack the tools required to determine which patients with devastating injuries will recover, to what extent they will recover — and how long that will take.
‘Very important’ study
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the research but said it was a “very important” study.
“Previous research shows a high-level recovery from mild TBI and a significant recovery percentage even with moderate to severe injury,” Siegel told Fox News Digital.
HEAD INJURY ASSOCIATED WITH DOUBLED MORTALITY RATE, 30-YEAR STUDY REVEALS
“After head trauma, the brain may swell, and the use of mannitol and steroids and even sometimes surgery — where the top of the skull is removed — can be used to decrease pressure on the brain and increase chance of a full recovery,” he continued.
Rehabilitation is also crucial, Siegel added.
“All of these tools should be given a chance to work in most cases.”
Based on the study findings, Bodien recommended that clinicians should be “very cautious” with “irreversible decisions” like withdrawing life support in the days following traumatic brain injury.
“Families should also be aware of our results so that they can advocate for delaying a decision to discontinue life support if this is aligned with what they believe their loved one would want,” she added.
Limitations of the research
There were some limitations to the study, Bodien said.
“The sample size of the study was small, which made it difficult to find an adequate number of participants who did not have life support discontinued and were clinically similar, or ‘matched,’ to those who had life support discontinued,” she told Fox News Digital.
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Among the participants who did not have life support discontinued, the researchers were not able to follow all of them for a six-month period.
Another limitation is that the researchers used clinical variables that were available on the day of, or the day after, hospitalization — but sometimes decisions to discontinue life support are made several days later.
“There are many considerations that may lead to a decision to discontinue life support after traumatic brain injury that we were unable to factor into our analyses,” she continued.
“For example, personal beliefs, religion and advanced directives could all affect decision-making but were not captured in our study.”
Bodien also noted that the Harvard study was focused on traumatic brain injury and cannot be generalized to other injuries and illnesses.
For more Health articles, visit www.foxnews.com/health.
Health
7 important health stories you might have missed this week: Catch up here
Every day of the week, Fox News Digital publishes a range of health pieces to keep you up-to-date on the most important wellness news.
We cover cutting-edge medical research, breakthrough medications, mental health challenges, personal medical dramas and more.
In case you missed them, here are a few of our biggest health stories from this week.
CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER
You can see a full list of recent health pieces at http://www.foxnews/health.
1. Hunger could be tied to sleep, expert says
If you’re feeling hungrier than usual lately, your sleep routine could be the culprit. A nutritional biologist offers tips for regulating sleep and curbing unhealthy cravings. Click here to get the story.
2. Health agencies issue bird flu update: ‘Alert, not alarmed’
The CDC and WebMD teamed up this week to deliver an hour-long update on Thursday about the current bird flu outbreak. Fox News Digital breaks down the most important points. Click here to get the story.
3. Melanoma patients share their stories
For Skin Cancer Awareness Month, two melanoma patients are speaking up about their symptoms, treatment and prevention tips to help others avoid the potentially deadly disease. Click here to get the story.
4. Report reveals staggering discrepancy in health care costs
Patients with private health insurance could be charged up to 300% more than those with Medicare, a new report reveals. Doctors explain the reasons for the sticker shock. Click here to get the story.
5. Pastor shares important message about depression
A Dallas pastor who fought his own depression battle shares how he overcame the disease – and why it’s so important for those in church leadership to seek help when they need it. Click here to get the story.
6. Nurse’s depression is cured through breakthrough tech
A Chicago nurse struggled with COVID-19-related PTSD and depression for years until electrical brain tapping therapy finally gave her a new lease on life. Click here to get the story.
7. Young vaper shares warning after nearly dying
A 22-year-old man in Nebraska required a double lung transplant due to vaping. Jackson Allard shares his story as a cautionary tale. “I had a 1% chance to live,” he said. Click here to get the story.
For more Health articles, visit www.foxnews.com/health.
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