Health
A common killer bug is endangering Americans: ‘Pandemic in plain sight’
Five years after the worldwide hyperfocus on COVID-19 began, some are concerned about the next pandemic — whether it could be caused by influenza, bird flu or another pathogen.
Too easily overlooked are non-influenza, non-COVID viruses and bacteria that are burgeoning and spreading unchecked — both in the U.S. and around the world. While they may not cause the next pandemic, they do cause a lot of illness and death.
One such bacteria is Streptococcus Group A, an old enemy that colonizes the throat and tonsils of close to 20% of U.S. children, according to Dr. Joshua Osowicki, team leader and senior research fellow at the Murdoch Children’s Research Institute in Melbourne, Australia.
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This problematic bacterial strain is easily treated with penicillin drugs when it causes a clinical infection, Osowicki told Fox News Digital in an on-camera interview. (See the video at the top of this article.)
But the problem, he said, is that because the bacteria may be harbored, the diagnosis isn’t always found early enough.
The Streptococcus Group A bacteria has been on the rise around the world, doctors warn. (iStock)
Scarlet fever and rheumatic fever/rheumatic heart disease can result from recurrent or untreated strep — and they are on the increase again in areas without adequate medical care, including parts of the U.S.
“Rheumatic heart disease is a chronic, non-infectious illness that occurs after untreated group-based streptococcal infections — and almost certainly after multiple untreated, group-based streptoococcus infections,” Osowicki said.
STREP THROAT INFECTIONS HAVE SPIKED ABOVE PRE-COVID HIGHS, SAYS REPORT: ‘WE’VE MISSED CASES’
His research reveals that the prevalence of a life-threatening invasive version of strep Group A — which can include deep-rooted skin infections, sepsis, meningitis and deadly pneumonia — is on the rise around the world.
The aggressive skin infections, which are associated with intravenous drug use, can lead to the need for repeated surgeries, along with antibiotics.
A life-threatening invasive version of strep Group A can include deep-rooted skin infections, sepsis, meningitis and deadly pneumonia. (iStock)
In the U.S., there have been more than double the annual incidents of invasive Group A strep in 10 states, affecting about 35 million Americans between 2013 and 2022, with 21,000 cases and about 2,000 deaths, according to Osowicki.
“In many ways, it’s a pandemic in plain sight,” he said of Group A strep, adding that close to a billion people likely experience symptomatic disease from the bacteria each year.
“It actually does its damage in severe, life-threatening cases before the patient receives antibiotics.”
The important thing with group A strep, according to the doctor, is that antibiotic resistance isn’t the primary issue.
“Group A strep is reliably killed by penicillin — and has been since 1941 when penicillin was introduced,” Osowicki noted.
Strep A colonizes the throat and tonsils of close to 20% of U.S. children, according to the researcher. (iStock)
“The point is that it actually does its damage in severe, life-threatening cases before the patient receives antibiotics. There’s this period where it is too hard to diagnose and treatment comes too late.”
In those cases, he said, the patients need ICUs, surgery and “the most intensive treatment we have to offer.”
Among patients over the age of 65 or so, a quarter of them will die with this form of the disease, according to Osowicki.
Need for a vaccine
There is not currently a vaccine for Group A strep.
While the more common form of strep throat and minor skin infections are “less scary,” Osowicki warned of the dangers of overlooking the more invasive version of the disease.
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“We look away sometimes from the life-threatening infections that we struggle to prevent, diagnose and treat, (until) these become the front-page sepsis cases that you see in the newspaper many weeks of the year,” he said.
“They’re headline-catching cases. They’re the cases like Rory Staunton in New York, whose tragic death (in 2012 from sepsis) really triggered the state census mandates across the U.S.”
There are up to 10 different group-based strep vaccines in development, ranging from entirely pre-clinical vaccines that have never seen a person to vaccines that have been tested in phase 1 trials. (iStock)
The need for an effective vaccine is clear — both for invasive strep and the more common variety. Osowicki and others in his group are working hard on developing them.
“The current thrust of my research is all vaccine-related,” he shared. “We do what are called human challenge trials, where we deliberately infect healthy adult volunteers with group A strep, painting it on their tonsils. And we do that in a very careful way, in an inpatient environment.”
The researchers also provide early antibiotic treatments and collect throat swabs, blood and saliva to study how the human-only pathogen works and to explore ways to stop it.
“The ultimate goal is that it becomes a really high-powered platform to establish the efficacy of vaccines,” said Osowicki.
There are many vaccine candidates in various stages of development, from the protein-adjuvant kind (like Shingrix or the Novavax COVID vaccine) to the MRNA platform and various other kinds, the researcher said.
“We’re working with every vaccine company that has a group-based streptococcal vaccine candidate in development,” he said.
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There are up to 10 different group-based strep vaccines in development, ranging from entirely pre-clinical vaccines that have never seen a person to vaccines that have been tested in phase 1 trials, Osowicki noted.
The goal, the researcher said, is to “create a vaccine that the world wants, that the world accepts, that the world says is safe, and that will help our children.”
He said he is concerned about vaccine skepticism, particularly after the COVID pandemic, which can keep people from trusting the emerging science.
Still, the researcher is excited about the future of the strep A vaccine and others, though he expects it could take at least five to 10 years before a worthy candidate reaches doctors’ offices.
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The new vaccine will be geared toward adults with skin infections, as well as the many millions of children who are at risk of both mild and severe disease.
The goal, Osowicki said, is to “create a vaccine that the world wants, that the world accepts, that the world says is safe, and that will help our children.”
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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
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Nearsightedness (myopia) is skyrocketing globally, with nearly half of the world’s population expected to be myopic by 2050, according to the World Health Organization.
Heavy use of smartphones and other devices is associated with an 80% higher risk of myopia when combined with excessive computer use, but a new study suggests that dim indoor lighting could also be a factor.
For years, scientists have been puzzled by the different ways myopia is triggered. In lab settings, it can be induced by blurring vision or using different lenses. Conversely, it can be slowed by something as simple as spending time outdoors, research suggests.
Nearsightedness occurs when the eyeball grows too long from front to back, according to the American Optometric Association (AOA). This physical elongation causes light to focus in front of the retina rather than directly on it, making distant objects appear blurry.
The study suggests that myopia isn’t caused by the digital devices themselves, but by the low-light environments where they are typically used. (iStock)
Researchers at the State University of New York (SUNY) College of Optometry identified a potential specific trigger for this growth. When someone looks at a phone or a book up close, the pupil naturally constricts.
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“In bright outdoor light, the pupil constricts to protect the eye while still allowing ample light to reach the retina,” Urusha Maharjan, a SUNY Optometry doctoral student who conducted the study, said in a press release.
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“When people focus on close objects indoors, such as phones, tablets or books, the pupil can also constrict — not because of brightness, but to sharpen the image,” she went on. “In dim lighting, this combination may significantly reduce retinal illumination.”
High-intensity natural light prevents myopia because it provides enough retinal stimulation to override the “stop growing” signal, even when pupils are constricted. (iStock)
The hypothesis suggests that when the retina is deprived of light during extended close-up work, it sends a signal for the eye to grow.
In a dim environment, the narrowed pupil allows so little light through that the retinal activity isn’t strong enough to signal the eye to stop growing, the researchers found.
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In contrast, being outdoors provides light levels much brighter than indoors. This ensures that even when the pupil narrows to focus on a nearby object, the retina still receives a strong signal, maintaining healthy eye development.
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The team noted some limitations of the study, including the small subject group and the inability to directly measure internal lens changes, as the bright backgrounds used to mimic the outdoors made pupils too small for standard equipment.
Researchers believe that increasing indoor brightness during close-up work could be a simple, testable way to slow the global nearsightedness epidemic. (iStock)
“This is not a final answer,” Jose-Manuel Alonso, MD, PhD, SUNY distinguished professor and senior author of the study, said in the release.
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“But the study offers a testable hypothesis that reframes how visual habits, lighting and eye focusing interact.”
The study was published in the journal Cell Reports.
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