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Midlife exercise may help lower Alzheimer's risk

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Midlife exercise may help lower Alzheimer's risk

An increase in physical activity between the ages of 45 and 65 could help prevent Alzheimer’s disease, while inactivity may be detrimental to brain health. This is the main conclusion of a scientific paper published in Alzheimer’s & Dementia, which highlights the need to promote physical activity among middle-aged adults. The study is the result of a collaboration between the Barcelona Institute for Global Health (ISGlobal), a center promoted by the “la Caixa” Foundation, and the Barcelonaβeta Brain Research Center (BBRC), a research centre of the Pasqual Maragall Foundation.

It is estimated that 13% of Alzheimer’s disease cases worldwide can be attributed to physical inactivity. In fact, the World Health Organization (WHO) recommends 150 to 300 minutes of moderate activity per week or 75 to 150 minutes of vigorous activity per week. While extensive research has shown that exercise reduces the risk of Alzheimer’s disease by improving cardiovascular and mental health, recent studies suggest that physical activity may have a direct impact on the development of brain pathology associated with the disease.

The study, led by Eider Arenaza-Urquijo, researcher at ISGlobal, included 337 participants from the ALFA+ longitudinal cohort, part of the ALFA study (ALzheimer’s and FAmilies) at the BBRC, supported by the “la Caixa” Foundation.

We conducted a four-year follow-up of middle-aged residents of Catalonia with a family history of Alzheimer’s disease.”

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Müge Akıncı, doctoral researcher at ISGlobal and the BBRC at the time of the study and first author of the paper

“We used physical activity questionnaires to assess changes in activity over a four-year period and neuroimaging tests to analyse the effects of exercise on brain structure and function,” she adds. Participants were classified as adherent (meeting WHO recommendations), non-adherent (doing less than the recommended amount of physical activity), and sedentary (doing zero minutes of physical activity per week).

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Benefits of physical activity on brain mechanisms

Beta-amyloid (Aβ) is a protein that can impair neural communication when it accumulates in the brain and is considered the first pathological event in Alzheimer’s disease. Participants who increased their physical activity to meet WHO-recommended levels showed less beta-amyloid accumulation than those who remained sedentary or reduced their physical activity. Moreover, this effect appeared to be dose-dependent; the greater the increase in activity, the greater the reduction in amyloid burden.

Non-sedentary participants also showed a greater cortical thickness in brain regions associated with Alzheimer’s disease. Cortical thickness in the medial temporal area is crucial for memory, so its thinning or atrophy (loss of volume) is an early sign of neurodegeneration.

“Even those who did less physical activity than recommended had greater cortical thickness than sedentary people, suggesting that any amount of exercise, no matter how minimal, has health benefits,” explains Müge Akıncı.

More exercise as a prevention strategy

The research team looked at both the increase in physical activity and the adherence to WHO recommendations. They observed that the benefits of physical activity appear to be related to increasing activity over time, rather than reaching a specific activity threshold.

“These findings reinforce the importance of promoting physical activity in middle age as a public health strategy for Alzheimer’s prevention,” emphasises Eider Arenaza-Urquijo, ISGlobal researcher and lead investigator of the study. “Interventions aimed at promoting increased physical activity could be key to reducing the incidence of the disease in the future,” she concludes.

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Source:

Barcelona Institute for Global Health (ISGlobal)

Journal reference:

Akinci, M., et al. (2025). Physical activity changes during midlife link to brain integrity and amyloid burden. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. doi.org/10.1002/alz.70007.

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From Lifespan to ‘Health-span’: Use the New Year to Focus on Both Health and Fitness

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From Lifespan to ‘Health-span’: Use the New Year to Focus on Both Health and Fitness

Fitness encompasses cardiovascular endurance, strength training, and mobility/flexibility. These are non-negotiables for continuing to live throughout your later years with your independence and ability to move and socialize still intact.

Instead of thinking simply about living longer, let’s use the start of a new year to focus on getting healthier, so we live better. More than any other time each year, the New Year is a popular time to focus on a “fresh start.” Temporal landmarks like New Year’s Day, Mondays, birthdays and the change of seasons are standard starting lines for many of us when we have a goal to work toward and bad habits to break.

Science Says Fitness Matters (Even More than Weight)

A recent study published in the British Journal of Medicine, Cardiorespiratory Fitness, BMI, and Mortality: A Systematic Review and Meta-Analysis, shows that, regardless of body weight (obese, overweight or normal), fitness matters more for all-cause mortality. They measured the weight, BMI and fitness of six groups: normal weight-fit; normal weight-unfit; overweight-fit; overweight-unfit; obese-fit; and obese-unfit.

The analyses revealed that individuals classified as fit, regardless of their BMI, did not have a statistically significantly higher risk of cardiovascular disease or all-cause mortality compared to normal weight-fit people. At the same time, all unfit groups across different BMI categories exhibited a two- to threefold higher risk of cardiovascular disease and all-cause mortality compared to their regular weight-fit counterparts.

About Body Mass Index (BMI)

Now, you may be saying, “But BMI is flawed!” Sure. BMI is not the best indicator for distinguishing normal weight, overweight and obesity because it is simply a height-to-weight ratio that does not account for differences in body fat/muscle composition, age, sex or other factors. Before you discredit this entire study because of the BMI issue, remember that it measured fitness levels among people of different sizes. Some had more muscle and were considered fit in the overweight/obese group, while others were deemed unfit in the normal weight group. Still, BMI helps place people of differing sizes (height and weight groups) and focuses on measuring each group’s fitness. In the end, fitness matters more than BMI, so the goal is to exercise, get in shape, build muscle and lose fat.

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Set Your Training Goals to Be Long-Term

It is fine to have short-term, specific training goals, such as strength gains and endurance times, or weight gain or weight loss. However, start this year with a 10-year fitness focus, as what you do in your 40s-50s will determine how you live in your 60s-70s. Always think 10 years ahead, no matter what your age, because what you gain today and maintain tomorrow is needed to continue to live independently for a few more generations in your family’s lineage. You can focus on longevity and optimal performance for your fitness and health goals at the same time by maintaining a consistent activity level and healthful nutrition, sleep and recovery.

Try This Goal: Make Annual Physical and Blood Screening Appointments

If you have not been to a doctor in a while, set an appointment in January, and get into the habit of annual health and wellness screenings. Treat annual physicals with the doctor as opportunities to PR (personal record) common blood work results, such as cholesterol, triglycerides, blood sugar, body weight and blood pressure. These are just the basics to help you assess how to adjust your sleep, nutrition, physical activity and stress management. These meetings are also quite satisfying when you achieve solid results that show health and wellness.

Don’t Give Up

While a large portion of us (nearly half of Americans) will create a New Year’s resolution, only about 9%-10% will achieve their goals. After a stressful holiday season, we are typically burned out in January. This may not be the best time to start a lifestyle change, complete with quitting bad habits (over-eating, smoking, drinking) and starting new healthy habits (gym membership, diet, etc.).

Instead, use the first few weeks of January to focus on stress mitigation and recovery. This should include building easy habits of walking every day, stretching, taking deep breaths and simply not overeating. This is a great way to move into a new fitness focus. Then, when feeling back to normal, focus a little harder, with more intensity, duration of training, and specificity to your fitness and health goals.

There are many ways to expand your “health-span.” Check out these options and get consistent with any or all of them:

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Final Advice

If you want to get started on a focused health and wellness goal of being able to do physical activities, stay social and be independent, start with the basics of walking and stretching daily for a month. The following month, add calisthenics such as squats, lunges, push-ups and the plank pose. The following month, add weights such as dumbbells or kettlebells, or suspension trainers such as the TRX.

This steady progression helps you ease into fitness habits gently and adds a new component each month to keep it interesting. To achieve results with lifelong wellness goals, you need to keep endurance, strength and mobility/flexibility as primary focuses. Stability, durability, balance, speed and agility can also be developed once you have built the foundation. This is the beauty of long-term goals. Focus on doing something each day, being disciplined about eating and drinking healthfully, and learning stress-mitigation techniques such as breathing to take into your next decade on this planet.  

There are dozens of these types of articles at the Military.com Fitness Section. Check them out for ideas on specific ways to train. 

Want to Learn More About Military Life?

Whether you’re thinking of joining the military, looking for fitness and basic training tips, or keeping up with military life and benefits, Military.com has you covered. Subscribe to Military.com to have military news, updates and resources delivered directly to your inbox.

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Exercise ‘snacks’ can keep your fitness on track when time is tight – try these 3 today

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Exercise ‘snacks’ can keep your fitness on track when time is tight – try these 3 today

December is great for many things – socialising, scoffing, falling out with relatives – but sticking to a training schedule is not one of them.

Heading out the door on Christmas morning for a two-hour long run is likely to put anyone on the naughty list, while it takes a dedicated runner indeed to spend part of the festive period running loops of the track.

What the mere mortal needs is exercise “snacks”. These can be enjoyed/endured alongside the carb-based variety and snuck in to even the busiest Christmas schedule.

A review in Sports Medicine and Health Research confirmed that regular, short bursts of physical activity throughout the day improved cardiovascular respiratory fitness, increased fat oxidation and polished off blood sugar levels after eating.

Vigorous intermittent exercises, such as sprints, were good for building muscle strength. Meanwhile, 10-minute resistance training sessions were found to be particularly beneficial to older people. The researchers concluded that exercise snacks could be a viable alternative to longer, less frequent sessions.

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Cram in vigorous bouts of stair climbing for muscle strength, or one or two sub-10 minute morsels for muscle growth as an efficient alternative to meatier long sessions. Here’s some inspo below…


3 exercise snacks to gorge on

Try these simple workouts for results on the quick

For upper-body

Press-ups: 3 x 20 with a 30-sec rest between (b/w) reps

Bench dips: 3 x 15 with a 30-sec rest b/w reps

For lower-body

Bodyweight squats: 3 x 20 with 20-sec rest b/w reps

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Wall sit: 2 x 90 secs with 1-min rest b/w reps

For cardio fitness

Burpees: 3 x 20 with 30-sec rest b/w reps

Skipping: 4mins consisting of 1min normal, 1min high knees, 1min normal, 1min high knees

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Study shows the antioxidants in this tea improve exercise recovery

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Study shows the antioxidants in this tea improve exercise recovery

I love many different herbal teas just as much as I enjoy a good old-fashioned British cup of PG tips, Earl Grey, or Glengettie — a Welsh favorite from the rolling valleys where I was born. In an interesting study, researchers explored whether drinking green or matcha tea can improve sports performance and exercise recovery, and the results might have you reaching for a vibrant green drink. If you want to get straight to the results, the short answer is that drinking green and matcha tea can support hydration, body fat control, and exercise recovery. Still, it definitely won’t be a game-changer when it comes to your performance in the gym, on the court, or on the field.

Hydrating with tea

In a study published in Nutrition and Food Technology, researchers reviewed existing studies of athletes and active adults that focused solely on drinking tea — no pills or extracts. They revealed that green or matcha tea can help hydrate the body when consumed in normal amounts. Tea counts toward your daily water intake.

Antioxidants and recovery

The research highlighted how the widely-studied antioxidants in green and matcha tea can improve exercise recovery and help protect your cells from the stress associated with intense exercise. That said, the research shows that drinking tea won’t lead to faster or better strength gains, so it’s no silver bullet for helping you achieve your fitness goals. However, they also concluded that low-caffeine green tea could even improve sleep quality, which I would argue could potentially help you power through that workout if you’re getting better sleep the night before.

Linked to lower body fat

Interestingly, the study authors also concluded that drinking around two or three cups of green or matcha tea per day was associated with slightly lower body fat and improved body composition and fat burning. While the effects weren’t overly significant, they were noted in the research. Cup of tea, anyone?

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