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High-intensity exercise provides short boost to brain protein in PTSD sufferers

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High-intensity exercise provides short boost to brain protein in PTSD sufferers

A new study published in the Journal of Psychiatric Research has found that a single session of high intensity interval training can temporarily increase levels of brain-derived neurotrophic factor (BDNF), a brain protein important for memory and learning, in individuals with post-traumatic stress disorder (PTSD). However, the research also found that neither high intensity nor low intensity exercise led to sustained increases in BDNF over a period of nearly two weeks. These findings suggest that while intense exercise might offer a short-term biological boost, more research is needed to understand how exercise can best be used to support long-term brain health in people with PTSD.

PTSD is a mental health condition that can develop after a person experiences or witnesses a terrifying event. These events can include serious accidents, physical or sexual assault, war, natural disasters, or other life-threatening situations. People with PTSD can experience a range of distressing symptoms that significantly interfere with their daily lives. These symptoms can include re-experiencing the trauma through nightmares or flashbacks, avoiding reminders of the trauma, negative changes in mood and thinking, and feeling constantly on edge or hyperaroused. While effective treatments like therapy exist, many individuals with PTSD continue to struggle with their symptoms, highlighting the need for additional and complementary approaches to care.

Researchers are increasingly interested in biological factors that might contribute to PTSD and its treatment. One such factor is BDNF, a protein that acts like fertilizer for the brain, helping to support the survival, growth, and connection of brain cells. It plays a key role in brain plasticity, which is the brain’s ability to reorganize itself by forming new neural connections throughout life.

Studies have shown that individuals with PTSD often have lower levels of BDNF in their bloodstream compared to people without the condition. This reduced level of BDNF may play a role in some of the difficulties faced by individuals with PTSD, such as problems with processing and overcoming traumatic memories. For example, BDNF is thought to be involved in the brain’s ability to ‘extinguish’ fear memories – to learn that a previously feared situation is now safe. If BDNF levels are low, this process might be impaired, potentially contributing to the persistent fear and anxiety seen in PTSD.

Because of BDNF’s importance in brain health and its potential link to PTSD, researchers are eager to explore ways to increase BDNF levels in individuals with this condition, hoping to find new avenues for improving treatment and recovery. Given that physical exercise has been shown to boost BDNF in other populations, the researchers sought to determine whether exercise could be a way to raise BDNF levels and potentially alleviate PTSD symptoms.

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To conduct their research, the team recruited 40 adults who had been diagnosed with PTSD. Participants were carefully screened to ensure they met specific criteria, including having a confirmed diagnosis of PTSD according to established guidelines. Individuals with certain other serious mental health conditions like schizophrenia or bipolar disorder, those with current substance abuse issues, or those at immediate risk of suicide were excluded from the study. People who were already engaging in a significant amount of regular exercise were also not included, to ensure that the exercise interventions in the study would be the primary factor influencing any changes. Importantly, individuals who were taking psychiatric medications or undergoing psychotherapy were allowed to participate, as long as their medication doses and therapy type had been stable for at least two months prior to the study.

Once enrolled, participants underwent a thorough physical examination, including a fitness test to determine their individual exercise capacity and maximum heart rate. This personalized assessment was important to tailor the exercise programs to each person’s fitness level and to ensure safety. Participants were then randomly assigned to one of two exercise groups: high intensity interval training or low intensity training. The exercise period lasted for 12 days, with participants engaging in exercise sessions every other day, for a total of six sessions. Each session was 30 minutes long and consisted of a warm-up, 20 minutes of the assigned exercise type, and a cool-down period.

The high intensity interval training involved cycling on an exercise bike. During the high intensity intervals, participants were encouraged to cycle at a pace that elevated their heart rate to above 77% of their maximum heart rate. This high intensity period was followed by a recovery interval where they cycled at a lower intensity allowing their heart rate to drop below 77% of their maximum. Each high intensity interval training session included ten cycles of high intensity and recovery. The low intensity training was designed to be less strenuous. It consisted of a series of gentle movements and stability exercises inspired by yoga, but without the focus on breathing or mindfulness that is often part of yoga practice. The goal was to keep participants’ heart rates below 70% of their maximum during these sessions. Throughout all exercise sessions, participants wore heart rate monitors to ensure they were exercising at the correct intensity.

To measure BDNF levels, the researchers collected blood samples from participants on the first and last days of the exercise period. On each of these days, blood was drawn both before and immediately after the exercise session. These blood samples were carefully processed to measure the amount of BDNF in the serum, which is the liquid part of the blood. Because BDNF is also found in platelets, blood cells that help with clotting, the researchers also measured platelet counts in the participants’ blood and took these counts into account when analyzing the BDNF data, to get a more precise measure of BDNF levels. In addition to these biological measures, participants also completed a questionnaire each day to track their PTSD symptoms.

The study’s findings revealed that high intensity interval training did indeed lead to a short-term increase in BDNF levels. Immediately after a high intensity interval training session, participants in this group showed a significant rise in BDNF in their blood, both on the first and last days of the exercise period. This increase was observed even after accounting for platelet counts. In contrast, the low intensity training group did not experience a similar increase in BDNF levels after their exercise sessions.

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However, the researchers also found that neither type of exercise, high intensity or low intensity, resulted in a sustained increase in BDNF levels over the 12-day exercise period. When comparing BDNF levels from the beginning to the end of the study, there was no significant change in either exercise group.

Finally, while the study explored whether the short-term increase in BDNF was related to improvements in PTSD symptoms, no strong link was found. There was a slight suggestion that individuals who experienced a larger increase in BDNF after exercise might also report slightly greater day-to-day improvements in their symptoms, but this trend was not statistically strong.

The researchers concluded that high intensity interval training “might be a beneficial form of exercise for individuals with PTSD regarding serum BDNF levels,” but “further studies are needed to investigate whether transient and long-term BDNF increase contributes to a reduction of PTSD symptoms.”

In particular, future research could build upon these findings by examining larger groups of individuals with PTSD and specifically considering potential gender differences in the response to exercise. Longer-term studies are also needed to investigate whether regular high intensity interval training, or other forms of exercise, can lead to sustained increases in BDNF and, importantly, whether these increases translate into meaningful reductions in PTSD symptoms over time. Understanding how exercise affects BDNF in individuals with PTSD could pave the way for developing more effective and personalized exercise interventions to support their recovery and well-being.

The study, “Effects of high intensity interval training on serum brain-derived neurotrophic factor in individuals with PTSD,” was authored by Annabell Jäger, Anima Pieper, Kathlen Priebe, Rainer Hellweg, Kristina Meyer, Sarah Herrmann, Bernd Wolfarth, Maximilian Grummt, Andreas Ströhle, and Nikola Schoofs.

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I’m a running coach — I’ve just tested shoes actually designed for women’s feet, and they’re a total game changer

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I’m a running coach — I’ve just tested shoes actually designed for women’s feet, and they’re a total game changer

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QLVR ENDVR: Two minute review

Most running shoes feel familiar for a reason: the formula has barely changed in millennia. We have archaeological evidence of shoes being fastened with “shoelaces” as far back as around 3,500 BC, yet the basic lace-up running trainer remains the default.

QLVR (pronounced “clever”) set out to challenge that. Its debut shoe, the ENDVR, is a laceless “running slipper” built around a women-specific mechanical structure, with a slip-on Wing Fit system inspired by the way a bird’s wing opens and closes around movement.

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Mere minutes of daily vigorous exercise can cut your risk of 8 diseases | CNN

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Mere minutes of daily vigorous exercise can cut your risk of 8 diseases | CNN

Move more. Sit less. For many years, that’s been accepted guidance for people wanting to get healthier.

Now that message is getting refined, with a growing body of research suggesting that certain types of movements may be more beneficial than others when it comes to health benefits.

The intensity of your exercise may matter as well. A new study published in the European Heart Journal found that a small amount of vigorous activity may be linked to lower risk of eight different chronic diseases.

The findings raise questions about why intensity matters and how people can incorporate more intense exercise routines into everyday life. To better understand the study’s implications, I spoke with CNN wellness expert Dr. Leana Wen, an emergency physician and clinical associate professor at George Washington University. She previously served as Baltimore’s health commissioner.

Before beginning any new exercise program, consult your doctor. Stop immediately if you experience pain.

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CNN: What did this study examine about exercise and its relationship to chronic disease?

Dr. Leana Wen: This investigation looked at how the intensity of physical activity is related to the risk of developing a range of chronic diseases. Researchers analyzed data from two very large groups in the UK Biobank, which is a long-term health study in the United Kingdom that tracks medical and lifestyle information from hundreds of thousands of participants. One group included about 96,000 people who wore wrist activity trackers that objectively measured their movement, and the other included more than 375,000 people who self-reported their activity.

The researchers followed participants over an average of about nine years and examined the development of eight conditions: major cardiovascular events, atrial fibrillation, type 2 diabetes, immune-related inflammatory diseases, fatty liver disease, chronic respiratory disease, chronic kidney disease and dementia, as well as overall mortality.

The key finding was that the proportion of activity done at vigorous intensity mattered. People who had more than about 4% of their total activity classified as vigorous had substantially lower risks of developing these conditions compared with people who had no vigorous activity at all. The numbers were stunning, with the participants having the following results:


  • 63% lower risk of dementia,

  • 60% lower risk of type 2 diabetes,

  • 48% lower risk of fatty liver disease,

  • 44% lower risk of chronic respiratory disease,

  • 41% lower risk of chronic kidney disease,

  • 39% lower risk of immune-mediated inflammatory diseases,

  • 31% lower risk of major cardiovascular events,

  • 29% lower risk of atrial fibrillation, and

  • 46% lower risk of death from any cause.

These results are amazing. Imagine if someone invented a medication that could reduce the risks of all these diseases at once — it would be very popular! Crucially, even people who exercised a lot still benefited if the proportion of time they spent doing vigorous physical activity was increased. Conversely, people who were relatively inactive also benefited from adding just a little bit of higher-intensity exercise to their daily routines.

CNN: What counts as “vigorous” physical activity?

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Wen: Vigorous activity is generally defined as exercise that substantially raises your heart rate and breathing. A simple way to gauge it is the “talk test.” If you can speak comfortably in full sentences while exercising, you are likely in the low to moderate range. If you are so out of breath that you can only say a few words at a time, that is vigorous.

Running, cycling, lap swimming or climbing stairs quickly could count. But this also depends on people’s baseline fitness. For some individuals, taking longer strides with walking can be vigorous exercise. Others who are already fairly fit would need to do more. It’s also important to remember that vigorous activity doesn’t have to be in the context of a structured exercise plan. Short bursts of effort in daily life, such as rushing to catch a bus or carrying heavy groceries upstairs, can also qualify if they raise your heart rate and make you breathless.

CNN: Why might higher intensity exercise provide additional health benefits?

Wen: Higher intensity activity places greater demands on the body in a shorter period. This type of movement can improve cardiovascular fitness, increase insulin sensitivity and support metabolic health more efficiently than lower-intensity activity alone. Some studies have also linked vigorous activity with cognitive benefits.

Greater intensity may have distinct benefits across different organ systems. The researchers found that some conditions, such as immune-mediated inflammatory diseases, appeared to be more strongly linked to the intensity of activity than to the total amount. On the other hand, type 2 diabetes and kidney disease were influenced by both how much activity people did and how intense it was. Why this is the case is not yet known, but intensity appears to have a significant impact across diseases affecting multiple organs.

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CNN: How much vigorous activity do people need?

Wen: The threshold for people seeing a benefit appears to be relatively low. The researchers found that once people reached more than about 4% of their total activity as vigorous, their risk of developing chronic diseases dropped substantially.

To put that into practical terms, we are not talking about professional athletes dedicating their lives to hours of high-intensity training. Everyday people may see benefits from just doing a few minutes of vigorous effort daily.

CNN: How can people realistically incorporate vigorous activity into their daily routines?

Wen: One helpful way to think practically is that vigorous activity does not have to happen all at once. It can be accumulated in short bursts throughout the day.

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People can take the stairs instead of the elevator and do so at a faster pace than usual. When they are heading to work, they can add some speed walking. They can park farther away when grocery shopping and walk briskly while carrying groceries.

Structured exercise also can incorporate intervals where people alternate between moderate and more intense effort. If you’re swimming laps, you can warm up at a more leisurely pace, then do a few laps at a faster pace, then again at a leisurely pace and repeat. This suggestion applies to any other aerobic exercise: Aim for multiple intervals of at least 30 seconds to a minute each where your body is working hard enough that you feel noticeably out of breath.

CNN: What about someone who is older or has mobility issues?

Wen: Not everyone can or should engage in high-intensity activity in the same way. Vigorous activity is relative to that person’s baseline. For someone who is not used to exercise, even a short period of slightly faster walking or standing up repeatedly from a chair could be considered high intensity. And not everyone may be able to walk. In that case, some exercises from the chair can have aerobic benefits.

Individuals who have specific medical conditions should consult with their primary care clinicians before embarking on a new exercise routine. People with mobility issues also may benefit from working with a physical therapist who can help to tailor exercises appropriate to their specific situation.

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CNN: What is the key takeaway for people trying to improve their health?

Wen: To me, the main takeaway from this study is that it’s not only how much total exercise you get but also how hard you push yourself that matters. And you don’t have to have a lot of high-intensity exercise: Adding just a little has substantial health benefits across a wide range of chronic health conditions.

At the same time, exercise needs be practical. People should look for opportunities to safely increase intensity in ways that fit their daily lives. The most effective approach to physical activity is a balanced one: Exercise regularly, incorporate more challenging activities when you can and build habits that are sustainable over time.

Get inspired by a weekly roundup on living well, made simple. Sign up for CNN’s Life, But Better newsletter for information and tools designed to improve your well-being.

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‘Not what the fitness industry is trying to sell you’: this is the one simple move everyone really needs to be doing, according to an exercise scientist

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‘Not what the fitness industry is trying to sell you’: this is the one simple move everyone really needs to be doing, according to an exercise scientist

Ask any exercise scientist what they would prescribe to someone serious about staying strong into their 50s and beyond, and the answer is rarely what you’d hope for — and certainly not what the fitness industry is currently trying to sell you.

It isn’t long sessions on one of the best under-desk treadmills or a stationary bike like the Peloton, nor the kind of machine-based exercises that isolate muscles without ever teaching them to work together.

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