ST. LOUIS — Tamin Lipsey knew he had to step up for Iowa State with All-America forward Joshua Jefferson sitting on the bench, his sprained left ankle still encased in a boot, as the Cyclones played Kentucky on Sunday for a spot in the Sweet 16.

Lipsey, who grew up in the shadows of the Iowa State campus in Ames, answered with the finest game of his four-year career.

The senior guard poured in a career-high 26 points, tied a career high with 10 assists, and led a suffocating defense that shut down the Wildcats in the second half, allowing the second-seeded Cyclones to pull away for an 82-63 victory in the NCAA Tournament.

“All the guys knew we had to step up in different ways,” Lipsey said, “however that presented to us.”

Lipsey didn’t do it alone, of course — he needed someone scoring to pile up all those assists. Milan Momcilovic scored 20 points and Nate Heise, getting the start in Jefferson’s place, added 12 to help the Cyclones (29-7) advance to a Midwest Region semifinal against either third-seeded Virginia or No. 6 seed Tennessee on Friday night in Chicago.

It will be the eighth Sweet 16 trip for the Cyclones and the third under T.J. Otzelberger, though the question now is whether they will be whole for it. Jefferson, their second-leading scorer and top rebounder, is scheduled to have an MRI exam on Monday.

“We’ll see how that goes and take it from there,” Otzelberger said.

Kentucky (22-14) jumped to a 20-9 lead in the opening minutes Sunday before Iowa State fought back to take a 31-30 halftime lead.

The Wildcats were still within 46-40 with 13½ minutes to play when the Cyclones forced three of the Wildcats’ 20 turnovers in quick succession. They converted all three into baskets at the other end, part of a decisive 13-1 run, which not only allowed Iowa State to seize control but also seemed to finally deflate Kentucky.

The Wildcats had been buzzing after a buzzer-beater from Otega Oweh forced overtime in a first-round victory over Santa Clara.

“We had a tough time finding baskets and more importantly we had a real tough time getting a stop,” Kentucky coach Mark Pope said. “They shot 50 percent in the second half from 3, and they played really well. You’re not going to win games when you give up 51 in the second half, and there’s a lot of reasons that happened.”

Oweh followed up his 35-point performance against the Broncos with 18 against the Cyclones, playing most of the second half in foul trouble. Denzel Aberdeen led the Wildcats with 20 points, though the pair of guards didn’t get a whole lot more help.

“We didn’t play fully hard for the full 40 minutes,” Aberdeen said, “and we had to do a better job.”

For two teams that can score in bunches, there was little elegance for much of their first matchup since the 2012 NCAA tourney, when the Wildcats beat Iowa State in the second round on their way to winning the national championship.

The Cyclones missed their first 11 tries from beyond the 3-point arc. Kentucky had 12 turnovers in the first half.

“We got a little disoriented,” Pope said, “and that’s what Iowa State does. They increased their pressure and we turned it over 12 times in the first half, and kind of contributed to our own demise.”

Iowa State eventually began driving to the basket and picking up fouls, and generated offense from the free-throw line until its shots started to fall. That began just before the break, and Heise’s buzzer-beating 3 gave the Cyclones a 31-30 advantage.

They went on to outscore Kentucky 51-33 after halftime to coast into the semifinals of the Midwest Region.

“We knew we had to be at our best. I’m proud of our guys,” Otzelberger said. “Felt like the game didn’t start the way we’d like but on defense, our pressure as the game wore on paid dividends for us. We generated turnovers and scored off our defense.”

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Iowa State and Virginia have split four previous meetings, though the Cavaliers won the most recent matchup and the only one in the NCAA Tournament. The Cavaliers cruised 84-71 in the Sweet 16 on March 25, 2016, before losing to Syracuse in the Elite Eight.

The Cyclones beat Tennessee during the 1969 season but they’ve lost the last two to the Volunteers, the first during a tournament in December 1977 and the most recent on January 27, 2018, during the Big 12-SEC Challenge.

Kentucky basketball will be back in action on Sunday in the Round of 32 against Iowa State thanks to the heroics of guard Otega Oweh.

Oweh hit the game-tying buzzer-beater against Santa Clara in the first round, sending the game to overtime. The Wildcats ultimately won 89-84.

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The back-to-back Second Team All-SEC selection comes from an athletic family. His brother, Odafe Oweh, plays in the NFL, recently signing a free agent deal with the Washington Commanders. Oweh played college football at Penn State, and he was a first-round pick in 2021.

He previously played for the Baltimore Ravens and Los Angeles Chargers, earning All-Rookie Team honors in 2021.

The younger Oweh led Kentucky to the Sweet 16 last season, and thanks to his clutch shot on Friday, UK is playing for a shot at a return trip to the tournament’s second weekend.

This article originally appeared on College Sports Wire: Who is Otega Oweh’s brother who plays in NFL?

• Kentucky basketball will face Iowa State in the NCAA Tournament second round after both teams earned victories Friday in St. Louis.
• Iowa State dominated Tennessee State after UK escaped Santa Clara in overtime, but Cyclones star Joshua Jefferson left the game with an injury.
• Who has the edge with a Sweet 16 berth on the line? Here’s our prediction.

ST. LOUIS — Kentucky basketball survived. And advanced.

Thanks to its 89-84 overtime victory over Santa Clara on Friday, UK sealed a spot in the second round of the NCAA Tournament.

But the challenge for coach Mark Pope and the Wildcats is about to get considerably tougher.

The next opponent for seventh-seeded Kentucky (22-13) is the No. 2 seed in the Midwest Region, Iowa State. The Cyclones had far less drama in their first-round matchup than the Cats. Iowa State trounced Tennesseee State, 108-74, in the game immediately following UK/Santa Clara at the Enterprise Center.

The Cyclones are one of the country’s best teams. They enter Sunday’s matchup 28-7 in 2025-26. ISU went 12-6 in the Big 12 during the regular season. Its conference tournament ended in agonizing fashion, however, falling at the buzzer to Arizona in the semifinals.

The winner of Sunday’s game between UK and ISU will clinch a spot in the Sweet 16. And pack their bags for Chicago, where the Midwest Region’s Sweet 16 and Elite Eight games will be contested next week at the United Center.

Watch Kentucky vs. Iowa State on Fubo (free trial)

Here’s what to know about Kentucky’s second-round battle against Iowa State:

The Cyclones began the 2025-26 campaign 16-0. Not only was that the program’s best-ever start to a season, but it doubled as the longest win streak in school history. Iowa State also notched 25 wins prior to the postseason for only the third time in the program’s annals.

But if the Cyclones are to set a single-season school standard for wins, they’ll need to win out. The current record holder is the 1999-2000 club, which had 32 wins. To reach 33, Iowa State must win the national championship.

In just five seasons at the helm, T.J. Otzelberger has carved out plenty of space for himself in Iowa State’s record book.

He enters today with an overall record of 123-52. That’s the most wins for any ISU coach in the first five seasons of a tenure. Otzelberger was the quickest in program history to 100 victories, needing only 145 games. He also holds the Cylcones’ mark for wins over Associated Press top-25 foes (30).

His overall winning percentage (.714), conference winning percentage (.587) and home winning percentage (.874) also are No. 1 among Iowa State coaches. And Otzelberger’s six NCAA Tournament wins are two more than any other coaches the Cyclones have had.

He’s fourth on the school’s all-time wins list, trailing Johnny Orr (218), Louis Menze (166) and Glen Anderson (142).

It’s a safe bet that if Otzelberger stays in Ames, Iowa, long enough, he’ll also be atop that list in the future.

Joshua Jefferson is averaging 16.9 points, 7.6 rebounds and 4.9 and 1.7 steals per game this season. That’s a stat line no Big 12 player ever has averaged in a single campaign. And, per the Cyclones’ official game notes, only five players in Division I history have done so since steals began being tracked in 1974-75. It’s a list that includes Larry Bird and Penny Hardaway.

But Jefferson’s status for Sunday is unclear.

He injured his left ankle in the first half of Friday’s rout and did not return. Jefferson made it to the team’s bench in the second half using crutches, with a boot on his left foot.

If he’s unable to take the floor Sunday, other Cyclones will have to step up.

Two of his teammates fit the bill.

Forward Milan Momcilovic is arguably the deadliest 3-point shooter in college hoops. He already has Iowa State’s single-season mark in that category, with 130 entering Sunday. Prior to Friday’s games, his 127 were tied for first nationally alongside Samford’s Jadin Booth.

More remarkably, his volume hasn’t adversely affected his accuracy. At 49.6% on the season, he also paces Division I in that category.

In the backcourt, senior guard Tamin Lipsey averages 13.3 points, 4 rebounds and 5 assists per outing. He’s among the top 20 in the country in both assist-to-turnover ratio and steals per game.

If that’s not enough, he’s also the Cyclones’ career leader in steals (308) and games started (135).

Buy Kentucky NCAA Tournament tickets vs. Iowa State

Iowa State 71, Kentucky 68: With a healthy Joshua Jefferson, the Cyclones likely would be close to a double-digit favorite. But if he’s hobbled, that hurts Iowa State. And if he’s not able to play at all, that’s even tougher. Yet it’s not as if the Wildcats don’t have injury issues of their own. Starting point guard Jaland Lowe has been out since January. And forward Jayden Quaintance would need a miracle to be cleared Sunday.

Kentucky used up more energy — physically (going to OT) and emotionally (barely keeping its season alive) — than Iowa State.

It’ll be a bare-knuckled fight Sunday.

But Iowa State will eke out a narrow victory to bring down the curtains on Kentucky’s second season under Mark Pope.